LOCUS HSU22662 1528 bp mRNA linear HUM 27-JAN-1996
DEFINITION Human nuclear orphan receptor LXR-alpha mRNA, complete cds.
ACCESSION U22662
VERSION U22662.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1528)
AUTHORS Willy,P.J., Umesono,K., Ong,E.S., Evans,R.M., Heyman,R.A. and
Mangelsdorf,D.J.
TITLE LXR, a nuclear receptor that defines a distinct retinoid response
pathway
JOURNAL Genes Dev. 9 (9), 1033-1045 (1995)
PUBMED 7744246
REFERENCE 2 (bases 1 to 1528)
AUTHORS Mangelsdorf,D.J.
TITLE Direct Submission
JOURNAL Submitted (14-MAR-1995) David J. Mangelsdorf, Howard Hughes Medical
Institute, University of Texas Southwestern Medical Center at
Dallas, 5323 Harry Hines Blvd., Dallas, TX 75235-9050, USA
FEATURES Location/Qualifiers
source 1..1528
/db_xref="H-InvDB:HIT000218689"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="pXR2-deltaRV"
/tissue_type="liver"
/dev_stage="adult"
CDS 36..1379
/codon_start=1
/product="nuclear orphan receptor LXR-alpha"
/protein_id="AAA85856.1"
/translation="MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEA
RMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCG
DKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQ
AGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRRSSPPQILPQLSPEQLGMIEKLV
AAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLP
GFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVE
FINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAY
VSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE"
polyA_site 1528
/note="33 A nucleotides"
BASE COUNT 340 a 454 c 439 g 295 t
ORIGIN
1 cagtgccttg gtaatgacca gggctccaga aagagatgtc cttgtggctg ggggcccctg
61 tgcctgacat tcctcctgac tctgcggtgg agctgtggaa gccaggcgca caggatgcaa
121 gcagccaggc ccagggaggc agcagctgca tcctcagaga ggaagccagg atgccccact
181 ctgctggggg tactgcaggg gtggggctgg aggctgcaga gcccacagcc ctgctcacca
241 gggcagagcc cccttcagaa cccacagaga tccgtccaca aaagcggaaa aaggggccag
301 cccccaaaat gctggggaac gagctatgca gcgtgtgtgg ggacaaggcc tcgggcttcc
361 actacaatgt tctgagctgc gagggctgca agggattctt ccgccgcagc gtcatcaagg
421 gagcgcacta catctgccac agtggcggcc actgccccat ggacacctac atgcgtcgca
481 agtgccagga gtgtcggctt cgcaaatgcc gtcaggctgg catgcgggag gagtgtgtcc
541 tgtcagaaga acagatccgc ctgaagaaac tgaagcggca agaggaggaa caggctcatg
601 ccacatcctt gccccccagg cgttcctcac ccccccaaat cctgccccag ctcagcccgg
661 aacaactggg catgatcgag aagctcgtcg ctgcccagca acagtgtaac cggcgctcct
721 tttctgaccg gcttcgagtc acgccttggc ccatggcacc agatccccat agccgggagg
781 cccgtcagca gcgctttgcc cacttcactg agctggccat cgtctctgtg caggagatag
841 ttgactttgc taaacagcta cccggcttcc tgcagctcag ccgggaggac cagattgccc
901 tgctgaagac ctctgcgatc gaggtgatgc ttctggagac atctcggagg tacaaccctg
961 ggagtgagag tatcaccttc ctcaaggatt tcagttataa ccgggaagac tttgccaaag
1021 cagggctgca agtggaattc atcaacccca tcttcgagtt ctccagggcc atgaatgagc
1081 tgcaactcaa tgatgccgag tttgccttgc tcattgctat cagcatcttc tctgcagacc
1141 ggcccaacgt gcaggaccag ctccaggtgg agaggctgca gcacacatat gtggaagccc
1201 tgcatgccta cgtctccatc caccatcccc atgaccgact gatgttccca cggatgctaa
1261 tgaaactggt gagcctccgg accctgagca gcgtccactc agagcaagtg tttgcactgc
1321 gtctgcagga caaaaagctc ccaccgctgc tctctgagat ctgggatgtg cacgaatgac
1381 tgttctgtcc ccatattttc tgttttcttg gccggatggc tgaggcctgg tggctgcctc
1441 ctagaagtgg aacagactga gaagggcaaa cattcctggg agctgggcaa ggagatcctc
1501 ccgtggcatt aaaagagagt caaagggt
//