LOCUS HSU22526 3206 bp mRNA linear HUM 23-AUG-1995
DEFINITION Human 2,3-oxidosqualene-lanosterol cyclase mRNA, complete cds.
ACCESSION U22526
VERSION U22526.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3206)
AUTHORS Baker,C.H., Matsuda,S.P., Liu,D.R. and Corey,E.J.
TITLE Molecular cloning of the human gene encoding lanosterol synthase
from a liver cDNA library
JOURNAL Biochem. Biophys. Res. Commun. 213 (1), 154-160 (1995)
PUBMED 7639730
REFERENCE 2 (bases 1 to 3206)
AUTHORS Baker,C.H.
TITLE Direct Submission
JOURNAL Submitted (14-MAR-1995) Charles H. Baker, Chemistry, Harvard
University, 12 Oxford Street, Cambridge, MA 02138, USA
FEATURES Location/Qualifiers
source 1..3206
/db_xref="H-InvDB:HIT000218688"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/sex="male"
/tissue_type="liver"
/clone_lib="Clontech catalog number HL1115a"
/dev_stage="adult"
CDS 152..2350
/EC_number="5.4.99.7"
/function="cholesterol biosynthesis"
/note="lanosterol synthase"
/codon_start=1
/product="2,3-oxidosqualene-lanosterol cyclase"
/protein_id="AAC50184.1"
/translation="MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERA
GREQTGLEAYALGLDTKNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPL
FLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVS
LRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLF
PDWAPAHPSTLWCHCRQVYLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQ
RNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSIS
IGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFA
IQALLEAGGHHRPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCG
WIVSDCTAEALKAVLLLQEKCPHVTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRG
GHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKRFPEHRAAEIRETLTQGLEF
CRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDGTACAEVSRACDFLLSRQM
ADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQL
PNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFSQLYPERALAGHP"
BASE COUNT 617 a 919 c 1005 g 665 t
ORIGIN
1 cccttgccta ctgctcatgg gtgtggagac tgatattctg gaagactgat aggcagattt
61 actattaaca aacacatagt ctgtggccca gcaaagccac cccaatccct gcacaagggt
121 aaaaggccag cattagagca ctgcagcagc aatgacggag ggcacgtgtc tgcggcgccg
181 agggggcccc tacaagaccg agcccgccac cgacctcggc cgctggcgac tcaactgcga
241 gaggggccgg cagacgtgga cctacctgca ggacgagcgc gccggccgcg agcagaccgg
301 cctggaagcc tacgccctgg ggctggacac caagaattac tttaaggact tgcccaaagc
361 ccacaccgcc tttgaggggg ctctgaacgg gatgacattt tacgtggggc tgcaggctga
421 ggatgggcac tggacgggtg attatggtgg cccacttttc ctcctgccag gcctcctgat
481 cacttgccac gtggcacgca tccctctgcc agccggatac agagaagaga ttgtgcggta
541 cctgcggtca gtgcagctcc ctgacggtgg ctggggcctg cacattgagg ataagtccac
601 cgtgtttggg actgcgctca actatgtgtc tctcagaatt ctgggtgttg ggcctgacga
661 tcctgacctg gtacgagccc ggaacattct tcacaagaaa ggtggtgctg tggccatccc
721 ctcctggggg aagttctggc tggctgtcct gaatgtttac agctgggaag gcctcaatac
781 cctgttccca gagatgtggc tgtttcctga ctgggcaccg gcacacccct ccacactctg
841 gtgccactgc cggcaggtgt acctgcccat gagctactgc tacgccgttc ggctgagtgc
901 cgcggaagac ccgctggtcc agagcctccg ccaggagctc tatgtggagg acttcgccag
961 cattgactgg ctggcgcaga ggaacaacgt ggcccccgac gagctgtaca cgccccacag
1021 ctggctgctc cgcgtggtat atgcgctcct caacctgtat gagcaccacc acagtgccca
1081 cctgcggcag cgggccgtgc agaagctgta tgaacacatt gtggccgacg accgattcac
1141 caagagcatc agcatcggcc cgatctcgaa aaccatcaac atgcttgtgc gctggtatgt
1201 ggacgggccc gcctccactg ccttccagga gcatgtctcc agaatcccgg actatctctg
1261 gatgggcctt gacggcatga aaatgcaggg caccaacggc tcacagatct gggacaccgc
1321 attcgccatc caggctctgc ttgaggcggg cgggcaccac aggcccgagt tttcgtcctg
1381 cctgcagaag gctcatgagt tcctgaggct ctcacaggtc ccagataacc ctcccgacta
1441 ccagaagtac taccgccaga tgcgcaaggg tggcttctcc ttcagtacgc tggactgcgg
1501 ctggatcgtt tctgactgca cggctgaggc cttgaaggct gtgctgctcc tgcaggagaa
1561 gtgtccccat gtcaccgagc acatccccag agaacggctc tgcgatgctg tggctgtgct
1621 gctgaacatg agaaatccag atggagggtt cgccacctat gagaccaagc gtggggggca
1681 cttgctggag ctgctgaacc cctcggaggt cttcggggac atcatgattg actacaccta
1741 tgtggagtgc acctcagccg tgatgcaggc gcttaagtat ttccacaagc gtttcccgga
1801 gcacagggca gcggagatcc gggagaccct cacgcagggc ttagagttct gtcggcggca
1861 gcagagggcc gatggctcct gggaaggctc ctggggagtt tgcttcacct acggcacctg
1921 gtttggcctg gaggccttcg cctgtatggg gcagacctac cgagatggga ctgcctgtgc
1981 agaggtctcc cgggcctgtg acttcctgct gtcccggcag atggcagacg gaggctgggg
2041 ggaggacttt gagtcctgcg aggagcggcg ttatttgcag agtgcccagt cccagatcca
2101 taacacatgc tgggccatga tggggctgat ggccgttcgg catcctgaca tcgaggccca
2161 ggagagagga gtccggtgtc tacttgagaa acagctcccc aatggcgact ggccgcagga
2221 aaacattgct ggggtcttca acaagtcctg tgccatctcc tacacgagct acaggaacat
2281 cttccccatc tgggccctcg gccgcttctc ccagctgtac cctgagagag cccttgctgg
2341 ccacccctga gaacatgcct acctgctggg tgccgtctgt gcgttccagt gaggccaagg
2401 ggtcctggcc gggttgggga gccctcccat aaccctgtct tgggctccaa cccctcaacc
2461 tctatctcat agatgtgaat ctgggggcca ggctggaggc agggatgggg acagggtggg
2521 tggcttagac tcttgatttt tactgtaggt tcatttctga aagtagcttg tcgggcttgg
2581 gtgaggaagg gggcacagga gccgtgaccc ctgaggaggc acagcgcctt ctgccacctc
2641 tgggcacggc ctcaaggtag tgaggctagg aggttttttc tgaccaatag ctgagttctt
2701 gggagaggag cagctgtgcc tgtgtgattc cttagtgtcg agtgggctct gggctggggt
2761 cggccctggg caggcttctc ctgcaccttt tgtctgctgg gctgagggac acgagggcaa
2821 ccctgtgaca atggcaggta gtgtgcatcc gtgaatagcc cagtgcgggg gttgctcatg
2881 gagcatcctg aggccgtgca gcagggagcc ccatgcccct gggtcgtgag cttgcctgcg
2941 tatggggtgg tgtcatggag cctcatgccc ctgggtcgtg agctcgcctg agtatggggt
3001 ggtgtcatgg agccgcatac ccctgggttg tgagctcgcc tgcatatgca gggtctgtca
3061 tggaacatcc caagtctgtg cagcagggag ccccatgccc ctgggacatg aacccacctg
3121 cgtggaatgc tgtttgtgag gtgtctacag ggtttatagt agtcttgtgg acacagaaat
3181 gcacagggga cacttacgga cacaga
//