LOCUS HSU22431 3678 bp mRNA linear HUM 28-JUN-1995
DEFINITION Human hypoxia-inducible factor 1 alpha (HIF-1 alpha) mRNA, complete
cds.
ACCESSION U22431
VERSION U22431.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3678)
AUTHORS Wang,G.L., Jiang,B.H., Rue,E.A. and Semenza,G.L.
TITLE Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS
heterodimer regulated by cellular O2 tension
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (12), 5510-5514 (1995)
PUBMED 7539918
REFERENCE 2 (bases 1 to 3678)
AUTHORS Wang,G.L., Jiang,B.-H., Rue,E.A. and Semenza,G.L.
TITLE Direct Submission
JOURNAL Submitted (09-MAR-1995) Gregg L. Semenza, Center for Medical
Genetics, The Johns Hopkins University School of Medicine, 600 N.
Wolfe St., Baltimore, MD 21287-3914, USA
FEATURES Location/Qualifiers
source 1..3678
/db_xref="H-InvDB:HIT000218685"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="Hep3B"
/cell_type="hepatoblastoma"
gene 1..3678
/gene="HIF-1 alpha"
CDS 29..2509
/gene="HIF-1 alpha"
/standard_name="hypoxia-inducible factor 1, alpha subunit"
/note="basic helix-loop-helix transcription factor"
/codon_start=1
/product="hypoxia-inducible factor 1 alpha"
/protein_id="AAC50152.1"
/translation="MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQL
PLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMV
LTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKE
QNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMT
CLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIY
EYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQC
IVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKK
EPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAM
SPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQ
SSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYI
PMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDEL
KTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEK
SHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKRKMEHDGSLFQAVGIGTLLQQ
PDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLLGQSMDESGLPQLTSY
DCEVNAPIQGSRNLLQGEELLRALDQVN"
polyA_site 3678
/gene="HIF-1 alpha"
/note="42 A nucleotides"
BASE COUNT 1197 a 695 c 675 g 1111 t
ORIGIN
1 gtgaagacat cgcggggacc gattcaccat ggagggcgcc ggcggcgcga acgacaagaa
61 aaagataagt tctgaacgtc gaaaagaaaa gtctcgagat gcagccagat ctcggcgaag
121 taaagaatct gaagtttttt atgagcttgc tcatcagttg ccacttccac ataatgtgag
181 ttcgcatctt gataaggcct ctgtgatgag gcttaccatc agctatttgc gtgtgaggaa
241 acttctggat gctggtgatt tggatattga agatgacatg aaagcacaga tgaattgctt
301 ttatttgaaa gccttggatg gttttgttat ggttctcaca gatgatggtg acatgattta
361 catttctgat aatgtgaaca aatacatggg attaactcag tttgaactaa ctggacacag
421 tgtgtttgat tttactcatc catgtgacca tgaggaaatg agagaaatgc ttacacacag
481 aaatggcctt gtgaaaaagg gtaaagaaca aaacacacag cgaagctttt ttctcagaat
541 gaagtgtacc ctaactagcc gaggaagaac tatgaacata aagtctgcaa catggaaggt
601 attgcactgc acaggccaca ttcacgtata tgataccaac agtaaccaac ctcagtgtgg
661 gtataagaaa ccacctatga cctgcttggt gctgatttgt gaacccattc ctcacccatc
721 aaatattgaa attcctttag atagcaagac tttcctcagt cgacacagcc tggatatgaa
781 attttcttat tgtgatgaaa gaattaccga attgatggga tatgagccag aagaactttt
841 aggccgctca atttatgaat attatcatgc tttggactct gatcatctga ccaaaactca
901 tcatgatatg tttactaaag gacaagtcac cacaggacag tacaggatgc ttgccaaaag
961 aggtggatat gtctgggttg aaactcaagc aactgtcata tataacacca agaattctca
1021 accacagtgc attgtatgtg tgaattacgt tgtgagtggt attattcagc acgacttgat
1081 tttctccctt caacaaacag aatgtgtcct taaaccggtt gaatcttcag atatgaaaat
1141 gactcagcta ttcaccaaag ttgaatcaga agatacaagt agcctctttg acaaacttaa
1201 gaaggaacct gatgctttaa ctttgctggc cccagccgct ggagacacaa tcatatcttt
1261 agattttggc agcaacgaca cagaaactga tgaccagcaa cttgaggaag taccattata
1321 taatgatgta atgctcccct cacccaacga aaaattacag aatataaatt tggcaatgtc
1381 tccattaccc accgctgaaa cgccaaagcc acttcgaagt agtgctgacc ctgcactcaa
1441 tcaagaagtt gcattaaaat tagaaccaaa tccagagtca ctggaacttt cttttaccat
1501 gccccagatt caggatcaga cacctagtcc ttccgatgga agcactagac aaagttcacc
1561 tgagcctaat agtcccagtg aatattgttt ttatgtggat agtgatatgg tcaatgaatt
1621 caagttggaa ttggtagaaa aactttttgc tgaagacaca gaagcaaaga acccattttc
1681 tactcaggac acagatttag acttggagat gttagctccc tatatcccaa tggatgatga
1741 cttccagtta cgttccttcg atcagttgtc accattagaa agcagttccg caagccctga
1801 aagcgcaagt cctcaaagca cagttacagt attccagcag actcaaatac aagaacctac
1861 tgctaatgcc accactacca ctgccaccac tgatgaatta aaaacagtga caaaagaccg
1921 tatggaagac attaaaatat tgattgcatc tccatctcct acccacatac ataaagaaac
1981 tactagtgcc acatcatcac catatagaga tactcaaagt cggacagcct caccaaacag
2041 agcaggaaaa ggagtcatag aacagacaga aaaatctcat ccaagaagcc ctaacgtgtt
2101 atctgtcgct ttgagtcaaa gaactacagt tcctgaggaa gaactaaatc caaagatact
2161 agctttgcag aatgctcaga gaaagcgaaa aatggaacat gatggttcac tttttcaagc
2221 agtaggaatt ggaacattat tacagcagcc agacgatcat gcagctacta catcactttc
2281 ttggaaacgt gtaaaaggat gcaaatctag tgaacagaat ggaatggagc aaaagacaat
2341 tattttaata ccctctgatt tagcatgtag actgctgggg caatcaatgg atgaaagtgg
2401 attaccacag ctgaccagtt atgattgtga agttaatgct cctatacaag gcagcagaaa
2461 cctactgcag ggtgaagaat tactcagagc tttggatcaa gttaactgag ctttttctta
2521 atttcattcc tttttttgga cactggtggc tcactaccta aagcagtcta tttatatttt
2581 ctacatctaa ttttagaagc ctggctacaa tactgcacaa acttggttag ttcaattttt
2641 gatccccttt ctacttaatt tacattaatg ctctttttta gtatgttctt taatgctgga
2701 tcacagacag ctcattttct cagttttttg gtatttaaac cattgcattg cagtagcatc
2761 attttaaaaa atgcaccttt ttatttattt atttttggct agggagttta tccctttttc
2821 gaattatttt taagaagatg ccaatataat ttttgtaaga aggcagtaac ctttcatcat
2881 gatcataggc agttgaaaaa tttttacacc ttttttttca cattttacat aaataataat
2941 gctttgccag cagtacgtgg tagccacaat tgcacaatat attttcttaa aaaataccag
3001 cagttactca tggaatatat tctgcgttta taaaactagt ttttaagaag aaattttttt
3061 tggcctatga aattgttaaa cctggaacat gacattgtta atcatataat aatgattctt
3121 aaatgctgta tggtttatta tttaaatggg taaagccatt tacataatat agaaagatat
3181 gcatatatct agaaggtatg tggcatttat ttggataaaa ttctcaattc agagaaatca
3241 tctgatgttt ctatagtcac tttgccagct caaaagaaaa caatacccta tgtagttgtg
3301 gaagtttatg ctaatattgt gtaactgata ttaaacctaa atgttctgcc taccctgttg
3361 gtataaagat attttgagca gactgtaaac aagaaaaaaa aaatcatgca ttcttagcaa
3421 aattgcctag tatgttaatt tgctcaaaat acaatgtttg attttatgca ctttgtcgct
3481 attaacatcc tttttttcat gtagatttca ataattgagt aattttagaa gcattatttt
3541 aggaatatat agttgtcaca gtaaatatct tgttttttct atgtacattg tacaaatttt
3601 tcattccttt tgctctttgt ggttggatct aacactaact gtattgtttt gttacatcaa
3661 ataaacatct tctgtgga
//