LOCUS HSU22377 6229 bp mRNA linear HUM 08-MAR-1996
DEFINITION Human Zn-15 related zinc finger protein (rlf) mRNA, complete cds.
ACCESSION U22377
VERSION U22377.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6228)
AUTHORS Makela,T.P., Hellsten,E., Vesa,J., Hirvonen,H., Palotie,A.,
Peltonen,L. and Alitalo,K.
TITLE The rearranged L-myc fusion gene (RLF) encodes a Zn-15 related zinc
finger protein
JOURNAL Oncogene 11 (12), 2699-2704 (1995)
PUBMED 8545128
REFERENCE 2 (bases 1 to 6229)
AUTHORS Makela,T.P.
TITLE Direct Submission
JOURNAL Submitted (08-MAR-1995) Tomi P. Makela, Whitehead Institute for
Biomedical Research, 9, Cambridge Center, Cambridge, MA 02142, USA
FEATURES Location/Qualifiers
source 1..6229
/db_xref="H-InvDB:HIT000218677"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="K562 leukemia cell line; HEL leukemia cell
line"
gene 1..6229
/gene="rlf"
CDS 13..5757
/gene="rlf"
/note="Zn-15 related zinc finger protein"
/codon_start=1
/product="RLF"
/protein_id="AAC50396.1"
/translation="MADGKGDAAAVAGAGAEAPAVAGAGDGVETESMVRGHRPVSPAP
GASGLRPCLWQLETELREQEVSEVSSLNYCRSFCQTLLQYASNKNASEHIVYLLEVYR
LAIQSFASARPYLTTECEDVLLVLGRLVLSCFELLLSVSESELPCEVWLPFLQSLQES
HDALLEFGNNNLQILVHVTKEGVWKNPVLLKILSQQPVETEEVNKLIAQEGPSFLQMR
IKHLLKSNCIPQATALSKLCAESKEISNVSSFQQAYITCLCSMLPNEDAIKEIAKVDC
KEVLDIICNLESEGQDNTAFVLCTTYLTQQLQTASVYCSWELTLFWSKLQRRIDPSLD
TFLERCRQFGVIAKTQQHLFCLIRVIQTEAQDAGLGVSILLCVRALQLRSSEDEEMKA
SVCKTIACLLPEDLEVRRACQLTEFLIEPSLDGFNMLEELYLQPDQKFDEENAPVPNS
LRCELLLALKAHWPFDPEFWDWKTLKRHCHQLLGQEASDSDDDLSGYEMSINDTDVLE
SFLSDYDEGKEDKQYRRRDLTDQHKEKRDKKPIGSSERYQRWLQYKFFCLLCKRECIE
ARILHHSKMHMEDGIYTCPVCIKKFKRKEMFVPHVMEHVKMPPSRRDRSKKKLLLKGS
QKGICPKSPSAIPEQNHSLNDQAKGESHEYVTFSKLEDCHLQDRDLYPCPGTDCSRVF
KQFKYLSVHLKAEHQNNDENAKHYLDMKNRREKCTYCRRHFMSAFHLREHEQVHCGPQ
PYMCVSIDCYARFGSVNELLNHKQKHDDLRYKCELNGCNIVFSDLGQLYHHEAQHFRD
ASYTCNFLGCKKFYYSKIEYQNHLSMHNVENSNGDIKKSVKLEESATGEKQDCINQPH
LLNQTDKSHLPEDLFCAESANSQIDTETAENLKENSDSNSSDQLSHSSSASMNEELID
TLDHSETMQDVLLSNEKVFGPSSLKEKCSSMAVCFDGTKFTCGFDGCGSTYKNARGMQ
KHLRKVHPYHFKPKKIKTKDLFPSLGNEHNQTTEKLDAEPKPCSDTNSDSPDEGLDHN
IHIKCKREHQGYSSESSICASKRPCTEDTMLELLLRLKHLSLKNSITHGSFSGSLQGY
PSSGAKSLQSVSSISDLNFQNQDENMPSQYLAQLAAKPFFCELQGCKYEFVTREALLM
HYLKKHNYSKEKVLQLTMFQHRYSPFQCHICQRSFTRKTHLRIHYKNKHQIGSDRATH
KLLDNEKCDHEGPCSVDRLKGDCSAELGGDPSSNSEKPHCHPKKDECSSETDLESSCE
ETESKTSDISSPIGSHREEQEGREGRGSRRTVAKGNLCYILNKYHKPFHCIHKTCNSS
FTNLKGLIRHYRTVHQYNKEQLCLEKDKARTKRELVKCKKIFACKYKECNKRFLCSKA
LAKHCSDSHNLDHIEEPKVLSEAGSAARFSCNQPQCPAVFYTFNKLKHHLMEQHNIEG
EIHSDYEIHCDLNGCGQIFTHRSNYSQHVYYRHKDYYDDLFRSQKVANERLLRSEKVC
QTADTQGHEHQTTRRSFNAKSKKCGLIKEKKAPISFKTRAEALHMCVEHSELSLYPCM
VQGCLSVVKLESSIVRHYKRTHQMSSAYLEQQMENLVVCVKYGTKIKEEPPSEADPCI
KKEENRSCESERTEHSHSPGDSSAPIQNTDCCHSSERDGGQKGCIESSSVFDADTLLY
RGTLKCNHSSKTTSLEQCNIVQPPPPCKIENSIPNPNGTESGTYFTSFQLPLPRIKES
ETRQHSSGQENTVKNPTHVPKENFRKHSQPRSFDLKTYKPMGFESSFLKFIQESEEKE
DDFDDWEPSEHLTLSNSSQSSNDLTGNVVANNMVNDSEPEVDIPHSSSDSTIHENLTA
IPPLIVAETTTVPSLENLRVVLDKALTDCGELALKQLHYLRPVVVLERSKFSTPILDL
FPTKKTDELCVGSS"
misc_feature 249
/gene="rlf"
/note="end of region involved in rlf-L-myc rearrangements"
exon 961..1101
/gene="rlf"
/note="alternative exon"
regulatory 6218..6223
/regulatory_class="polyA_signal_sequence"
/gene="rlf"
polyA_site 6229
/gene="rlf"
BASE COUNT 2022 a 1173 c 1304 g 1730 t
ORIGIN
1 cgccgtggga agatggcgga cggaaaggga gacgccgccg ctgtcgccgg ggctggggct
61 gaggctccgg cggtagcggg agccggagat ggagtcgaga ctgagtccat ggttcggggt
121 catcgccccg tatctccagc gccgggagcc tcgggactgc ggccgtgtct gtggcagctg
181 gagacagagc tgagggagca agaggtgtcg gaggtctcat ctttgaacta ctgccggagc
241 ttctgccaga ctttattgca atatgcaagc aacaagaatg catcagaaca tattgtgtat
301 cttctggagg tatatcgact tgccatccaa agctttgcca gtgcacgtcc atacttaact
361 actgaatgtg aagatgtcct cttagtgctt ggcagattag tactgagttg tttcgaatta
421 ctgctttcag tgtctgaaag tgaactgcca tgtgaagtct ggctaccatt ccttcagtct
481 ctacaggagt cacatgatgc attattggaa tttgggaata ataacctaca aatattggtt
541 catgttacca aggaaggggt gtggaaaaac ccagttcttc ttaaaattct gtctcaacag
601 ccagtagaaa cggaggaagt caataaattg attgcacaag aaggaccttc ctttctgcaa
661 atgcgaataa aacatttgtt gaaatctaac tgcatccccc aggctactgc tttatcaaaa
721 ctatgtgcag aatctaaaga aatttcaaat gtgtcatctt ttcagcaagc ctatatcaca
781 tgtttatgtt ctatgctccc taatgaagat gctattaagg agattgcaaa ggtcgactgc
841 aaggaagtac tagacatcat ttgtaatctg gaatctgagg ggcaggataa cacagcattt
901 gttctttgta cgacttacct tacccagcag ctccaaactg caagtgtata ttgttcttgg
961 gaactgactc ttttttggag taaactgcaa agaagaattg acccttcttt agatactttt
1021 ttggagcgct gtcgtcagtt tggtgtcata gctaaaacgc agcagcattt attttgcctc
1081 attagagtta tacaaactga agcacaagat gctggtcttg gggtgtcaat tttactgtgt
1141 gtcagagctc ttcaactcag atcaagtgaa gatgaggaaa tgaaggcatc agtttgtaaa
1201 acaattgcct gtcttttacc agaagattta gaagttagac gagcctgtca gcttacagaa
1261 ttcttaattg aacccagttt ggatggattt aatatgttag aagaactata tttgcaacca
1321 gatcaaaaat ttgatgaaga aaatgcaccg gttccaaatt ctcttcgatg tgagctctta
1381 ctagctttaa aagcccactg gccttttgat cctgagtttt gggactggaa aactttaaaa
1441 cgacactgcc accaactttt aggacaagaa gcctcagatt ctgatgatga tttaagtggc
1501 tatgaaatgt ccattaatga cacagatgtt ttagagtcat ttctcagtga ctatgatgag
1561 ggtaaagaag ataaacaata tagaagaaga gatttgacag atcagcataa ggagaaaaga
1621 gacaaaaaac ctattggctc ttctgaaaga tatcagaggt ggcttcagta caagtttttc
1681 tgtttgttat gtaagcggga atgtatagag gctagaattc ttcatcattc taagatgcat
1741 atggaagatg gaatttacac ctgtccagtt tgtattaaaa aatttaagag aaaagaaatg
1801 tttgttcctc atgtgatgga gcatgttaaa atgccaccaa gcagaaggga ccgctctaaa
1861 aagaaattac tgttaaaagg ctctcaaaag ggtatttgtc ctaagagccc ctctgcaatc
1921 ccagagcaaa accattcatt gaatgaccaa gccaaaggag agtctcatga atacgtcaca
1981 ttcagcaaat tagaagattg ccacctgcaa gacagagatt tgtatccatg tcccggtaca
2041 gactgttccc gtgtgtttaa gcaatttaaa tacttaagtg tgcatcttaa agctgaacac
2101 caaaataatg atgaaaatgc caagcactac ttggatatga aaaatagaag agagaagtgt
2161 acttactgtc gacgacattt tatgtctgct tttcaccttc gagagcacga acaagtgcat
2221 tgtgggcctc agccttatat gtgtgtatct atagattgct atgctaggtt tggatcagta
2281 aatgaactac ttaaccataa acaaaagcat gacgatctgc gttacaaatg tgaattaaat
2341 ggctgtaata ttgttttcag tgacttggga cagctttacc accatgaagc acaacacttt
2401 agggatgcat cttacacatg caacttcctt ggctgtaaaa agttctatta ctccaaaatt
2461 gaataccaga atcacctctc aatgcataat gttgaaaatt caaatggaga cataaagaaa
2521 tcagtgaaac ttgaggagtc tgcaacaggt gaaaagcaag attgtattaa tcagccccat
2581 ctacttaacc aaactgataa atcacattta cctgaagatc ttttctgtgc agaatcagct
2641 aattctcaaa tagatacaga aactgcagaa aacctgaaag aaaacagtga cagtaattct
2701 agtgatcagt taagtcatag ctcttcagct tcaatgaatg aagagctaat tgacacacta
2761 gatcactctg aaactatgca ggatgtattg ttatctaatg agaaagtctt tgggccctcc
2821 agtttaaaag aaaaatgttc cagtatggca gtttgttttg acgggactaa gtttacctgt
2881 ggttttgatg gctgtggttc cacatacaaa aatgcaagag gaatgcagaa acatttacgg
2941 aaggttcatc cataccattt caagcccaaa aagataaaga cgaaagatct gtttccctct
3001 ttgggtaatg aacataatca gacaactgaa aagttggatg cagaacctaa accctgctca
3061 gatacaaaca gtgactcccc agatgaaggt ctagatcaca atattcacat taaatgtaaa
3121 cgagaacatc aaggttattc ctcagaatcc tccatttgtg cttctaaaag gccctgtaca
3181 gaggatacca tgttggaact tctgttacgc ttgaaacatt taagcttgaa aaactcaata
3241 acacatggat ctttctcagg gtcattgcag gggtacccat ccagtggtgc taagtctctt
3301 cagtcagttt catctatctc agaccttaat tttcagaatc aagatgaaaa catgccaagt
3361 cagtaccttg cacagttggc ggctaagccg tttttctgtg agcttcaagg atgcaaatat
3421 gaatttgtga ccagagaggc tctgttaatg cattatctta aaaagcataa ttattcaaaa
3481 gaaaaagtcc ttcagttaac catgttccaa catcggtatt ccccatttca gtgtcatatt
3541 tgccaaaggt catttacaag aaaaacacac cttaggattc attataaaaa taaacatcaa
3601 attggcagtg acagagcaac tcacaaacta ttagataatg aaaagtgtga tcatgaaggc
3661 ccatgttcag tagataggtt gaaaggtgat tgttctgcag aacttggagg tgatcccagt
3721 agtaactctg agaaaccaca ctgtcatcct aaaaaggatg aatgtagttc tgaaacagat
3781 ttggaatcat cttgtgaaga aacagaaagt aaaacatctg acatttcatc accaataggc
3841 agccatagag aagaacaaga aggaagagag ggcagaggta gcaggcgaac tgttgctaaa
3901 ggaaatctgt gttatatttt gaataaatac cacaaaccat tccattgtat tcataaaact
3961 tgcaactcct cattcaccaa tctaaaaggc ttaattcgcc attacagaac tgtacatcag
4021 tacaacaaag aacagttatg tttggagaaa gacaaagcaa gaaccaaaag ggaacttgtc
4081 aaatgtaaaa agatatttgc ttgcaaatat aaggaatgta ataaacgctt cctgtgttcc
4141 aaagctcttg ctaagcactg tagtgattct cataacctag accatattga agagcctaaa
4201 gtactttccg aagctggatc tgcagcaagg ttttcttgta accagcctca gtgccctgct
4261 gttttttata cattcaacaa gttgaagcac cacttgatgg aacagcataa tattgaaggg
4321 gaaatacatt cagattatga aattcattgt gatcttaatg gctgtggcca gattttcacc
4381 catcgcagta attactcaca acatgtatat taccgacata aagactatta tgatgatttg
4441 tttagaagcc agaaagtagc aaatgagaga ctactaagga gtgaaaaggt atgtcaaaca
4501 gctgatactc aggggcatga acatcagacc accaggagat catttaatgc taagtctaaa
4561 aaatgtggct taatcaaaga aaagaaagcc ccaataagtt ttaaaaccag agctgaggcc
4621 ctccatatgt gtgtggagca ctctgagctc tctctgtacc cctgcatggt tcaaggatgc
4681 ttatctgtgg tgaagttgga gagcagcatt gtgaggcatt acaaacgcac tcatcagatg
4741 agtagtgcct atttagagca acagatggag aatcttgttg tttgcgttaa gtacggtacc
4801 aaaattaagg aggaaccccc ttctgaagca gatccctgta taaagaaaga agaaaataga
4861 agctgtgaat cagagcgcac agaacacagc cattccccgg gtgacagtag tgcacccatc
4921 cagaacactg attgctgtca ttcaagtgaa agggatggag gtcagaaagg gtgcatagaa
4981 agcagctcag tatttgatgc agatactctg ctctacaggg gaactttgaa atgtaatcat
5041 agttccaaaa ccacttccct agaacagtgt aatatagttc agcctcctcc tccttgtaaa
5101 atagaaaatt ccatacctaa tcccaatggg actgaaagtg ggacttattt cacaagtttc
5161 cagctgcctt taccaaggat caaagaatca gaaactaggc agcatagttc agggcaagaa
5221 aacactgtaa aaaatccaac ccatgtccca aaagagaatt ttaggaaaca ttcacagccc
5281 cggtcatttg atttgaagac ttacaaacct atgggatttg aatcttcatt tctgaaattt
5341 attcaggaaa gtgaagagaa agaagatgat tttgatgatt gggagccttc agagcactta
5401 acattaagta attcttcaca gtccagtaat gatttaacag ggaatgttgt ggcaaataat
5461 atggtgaatg acagtgaacc tgaagttgac atacctcatt cttccagtga ctctacaatt
5521 catgagaacc tgactgcaat cccaccttta atagtagctg aaacaacaac agttccttcc
5581 ttggaaaacc tgagggttgt attggacaaa gcattaacag actgtggaga gcttgcctta
5641 aaacagcttc attatcttcg gccagtggtg gttcttgaaa gatctaagtt ttccacacca
5701 attttagact tatttccaac aaaaaagaca gatgagcttt gtgtaggaag ttcataagta
5761 gcaattttgt tttagtaaca gactggctcc aacactgcaa catggggaca tttgccaact
5821 cgaacaaagg ctgagaagca gccacaccgt tgtttagggt agaataggct gtgtatttac
5881 atgaatgtat aatatctatg tcagcagtat tggctgagtc cattagctct ccagttggtt
5941 taatgattgg gtttattttt gtttgtttgt ttattaaaaa aatggaactg tacacttgtt
6001 tggtgctaat taatacatca aaatatactg gggcttcctt tttcaaatta agtgtgcatg
6061 attgtatatg gaacaaatac taaggtccca gggtgggagg gctagggaaa gggatatgga
6121 gttcttactt gacttgaatg tgcacctgag ggtgctttgt gtaatatatt gtacactaca
6181 gcatcttata ttttttgagt tgagtttcaa taaattacaa tttttcacc
//