LOCUS HSU22322 2810 bp mRNA linear HUM 26-MAR-1995
DEFINITION Human nuclear tyrosine protein kinase Rak mRNA, complete cds.
ACCESSION U22322
VERSION U22322.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2810)
AUTHORS Cance,W.G., Craven,R.J., Bergman,M., Xu,L., Alitalo,K. and Liu,E.T.
TITLE Rak, a novel nuclear tyrosine kinase expressed in epithelial cells
JOURNAL Cell Growth Differ. 5 (12), 1347-1355 (1994)
PUBMED 7696183
REFERENCE 2 (sites)
AUTHORS Cance,W.G., Craven,R.J., Weiner,T.M. and Liu,E.T.
TITLE Novel protein kinases expressed in human breast cancer
JOURNAL Int. J. Cancer 54 (4), 571-577 (1993)
PUBMED 8099900
REFERENCE 3 (bases 1 to 2810)
AUTHORS Cance,W.G.
TITLE Direct Submission
JOURNAL Submitted (06-MAR-1995) William G. Cance, Surgery Dept., University
of North Carolina, Chapel Hill, NC 27599, USA
FEATURES Location/Qualifiers
source 1..2810
/db_xref="H-InvDB:HIT000218676"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="BT-20 breast cancer cell line"
CDS 410..1927
/note="nuclear tyrosine protein kinase"
/codon_start=1
/product="Rak"
/protein_id="AAC50116.1"
/translation="MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHG
HYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPS
NYVAEDRSLQAEAWFFGAIRRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGA
VVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFD
LSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLR
EAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDM
AAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHE
IKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNY
RLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSDANNFIR"
misc_feature 910..952
/note="putative protein nuclear localization sequence"
polyA_site 2810
/note="16 A nucleotides"
BASE COUNT 866 a 554 c 612 g 778 t
ORIGIN
1 ttttaatttt attttatttt tgttgtggga ttcttaagca gataagaaga aaagacacct
61 tcctagtgag cagctgccca gctcctgctc agttttgcct cggggtagca cctccagcca
121 cagaaagcaa gccggtaagt ctctccaggt aggacttgct gcaaccccag ctcctgctca
181 gttttgcctc ggggttagca ccttccagcc acagaacgaa gccggtagtc tctcagtaga
241 cttggtgcaa cccagctgct ggactgatct gaaacggact ttgcatactc tccgaagtat
301 ggtgagttgg tgctgacttc aaagttgcct ggtgaaccaa gataaggtgg atcgcagaga
361 ctaaggggag agggagaagc cctgctcctc ttctccccac caaggcacaa tgagcaacat
421 ctgtcagagg ctctgggagt acctagaacc ctatctcccc tgtttgtcca cggaggcaga
481 caagtcaacc gtgattgaaa atccaggggc cctttgctct ccccagtcac agaggcatgg
541 ccactacttt gtggctttgt ttgattacca ggctcggact gctgaggact tgagcttccg
601 agcaggtgac aaacttcaag ttctggacac tttgcatgag ggctggtggt ttgccagaca
661 cttggagaaa agacgagatg gctccagtca gcaactacaa ggctatattc cttctaacta
721 cgtggctgag gacagaagcc tacaggcaga ggcgtggttc tttggagcaa tcagaagatc
781 agatgcagag aaacaactat tatattcaga aaacaagacc ggttcctttc taatcagaga
841 aagtgaaagc caaaaaggag aattctctct ttcagtttta gatggagcag ttgtaaaaca
901 ctacagaatt aaaagactgg atgaaggggg attttttctc acgcgaagaa gaatcttttc
961 aacactgaac gaatttgtga gccactacac caagacaagt gacggcctgt gtgtcaagct
1021 ggggaaacca tgcttaaaga tccaggtccc agctccattt gatttgtcgt ataaaaccgt
1081 ggaccaatgg gagatagacc gcaactccat acagcttctg aagcgattgg gatctggtca
1141 gtttggcgaa gtatgggaag gtctgtggaa caataccact ccagtagcag tgaaaacatt
1201 aaaaccaggt tcaatggatc caaatgactt cctgagggag gcacagataa tgaagaacct
1261 aagacatcca aagcttatcc agctttatgc tgtttgcact ttagaagatc caatttatat
1321 tattacagag ttgatgagac atggaagtct gcaagaatat ctccaaaatg acactggatc
1381 aaaaatccat ctgactcaac aggtagacat ggcggcacag gttgcctctg gaatggccta
1441 tctggagtct cggaactaca ttcacagaga tctggctgcc agaaatgtcc tcgttggtga
1501 acataatatc tacaaagtag cagattttgg acttgccaga gtttttaagg tagataatga
1561 agacatctat gaatcaagac acgaaataaa gctaccggtg aagtggactg cgcccgaagc
1621 cattcgtagt aataaattca gcattaagtc cgatgtatgg tcatttggaa tccttcttta
1681 tgaaatcatt acttatggca aaatgcctta cagtggtatg acaggtgccc aggtaatcca
1741 gatgttggct caaaactata gacttccgca accatccaac tgtccacagc aattttacaa
1801 catcatgttg gagtgctgga atgcagagcc taaggaacga cctacatttg agacactgcg
1861 ttggaaactt gaagactatt ttgaaacaga ctcttcatat tcagatgcaa ataacttcat
1921 aagatgaaca ctggagaaga atatcaaata ataaagtagc aaaacaaatt caaataataa
1981 tccattccaa aatacaatgt tatcaaccaa ctgcacaatc agtttatcct gacatattca
2041 agtgatagga taaagttggc catgtattat gaaaaagatt atttgtgcat tttattgact
2101 gggcaacact gcaggacagt caaggtgata tataatttcc tcactgcctg gtaaaattaa
2161 gcacactaaa ccaagttatt tttcttttta agagatactt acatttccat ttattgtttg
2221 aaatgtcgat caagagaatc aacagatgat agtccaattt ttactcagtg actgttgtag
2281 cattttcctg tttactgatt agagtggtta tcattattcc tcagattgct gaatcccatc
2341 aggctgttat tatgaaggaa tttgattgct ttgctgcaca gcaggacctg tgctttgaga
2401 tttttttttc tcttttaaaa tatcctgtaa ctacaatgat ggtaaagcca tgttaaatga
2461 cttgattgta cttggagtaa ttgcacattt tttttctatg cataaaaaaa tgatgcagct
2521 gttgagaaaa cgaagtcttt ttcattttgc agaaggaaat gatggaattt ttctgtactt
2581 cagtatgtgt caactgagag tcatatacat tagttttaat ctcttaatat tgagaatcag
2641 gttgcaaacg gatgagttat tatctatgaa atgtgagaaa tgtctaatag cccataagtc
2701 tgagaaatag gtatcaaaat agtttaggaa aatgagagga gaacagtagg attgctgtgg
2761 cctagacttc tggtaattaa taaagaaaaa gaagtaccct ttggcctaca
//