LOCUS HSU21943 2721 bp mRNA linear HUM 16-FEB-1996
DEFINITION Human organic anion transporting polypeptide (OATP) mRNA, complete
cds.
ACCESSION U21943
VERSION U21943.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2721)
AUTHORS Kullak-Ublick,G.A., Hagenbuch,B., Stieger,B., Schteingart,C.D.,
Hofmann,A.F., Wolkoff,A.W. and Meier,P.J.
TITLE Molecular and functional characterization of an organic anion
transporting polypeptide cloned from human liver
JOURNAL Gastroenterology 109 (4), 1274-1282 (1995)
PUBMED 7557095
REFERENCE 2 (bases 1 to 2721)
AUTHORS Hagenbuch,B.
TITLE Direct Submission
JOURNAL Submitted (01-MAR-1995) Bruno Hagenbuch, Division of Clinical
Pharmacology and Toxicology, Internal Medicine, University
Hospital, Zurich Ch-8091, Switzerland
FEATURES Location/Qualifiers
source 1..2721
/db_xref="H-InvDB:HIT000218667"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="hepatocyte"
/tissue_type="liver"
/dev_stage="adult"
gene 1..2721
/gene="OATP"
regulatory 45..57
/regulatory_class="other"
/gene="OATP"
/note="Kozak sequence"
CDS 54..2066
/gene="OATP"
/function="mediates transport of organic anions"
/experiment="experimental evidence, no additional details
recorded"
/codon_start=1
/product="organic anion transporting polypeptide"
/protein_id="AAA87732.1"
/translation="MGETEKRIETHRIRCLSKLKMFLLAITCAFVSKTLSGSYMNSML
TQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFL
KSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRPTQDPSECTKEVKSLMWVY
VLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCA
NVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPNTLPKEGLE
TNADIIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVN
MISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGC
WLSLLEYLLYFLSFLMTCENSSVVGINTSYEGIPQDLYVENDIFADCNVDCNCPSKIW
DPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSSAVLGLCDKGPDCSL
MLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIY
FGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSSFVPALIILILLR
KCHLPGENASSGTELIETKVKGKENECKDIYQKSTVLKDDELKTKL"
polyA_site 2721
/gene="OATP"
BASE COUNT 831 a 479 c 492 g 919 t
ORIGIN
1 aagacatatc aagatttaaa acataaatag cttggaacac cctgaagagc aacatgggag
61 aaactgagaa aagaattgaa acccatagaa taagatgtct ttccaagttg aagatgtttc
121 tgttggcaat aacatgtgca tttgtatcca aaacactgtc tggatcttat atgaattcca
181 tgctcacaca aatagagaga caattcaaca tcccaacatc tctagttgga ttcattaatg
241 gaagctttga gattggaaat cttttgttga ttatatttgt gagttatttt ggaaccaaac
301 tgcatagacc tataatgatt ggcattggat gtgtggttat gggcttaggc tgtttcttaa
361 aatcactacc tcatttcctc atgaaccaat atgaatatga atctacagtt tcagtttcag
421 gcaacttgtc ctcaaacagt ttcttgtgta tggaaaatgg aacccagatt ttaagaccaa
481 cgcaggatcc atcagagtgt acaaaggaag ttaaatcatt aatgtgggtg tacgtcctag
541 taggcaatat tgtacgtgga atgggtgaaa ctcccatcct gcctttgggt atttcctata
601 tagaagattt tgccaaattt gaaaattctc ctttatatat tgggcttgta gaaacaggag
661 ctattattgg tcctttgatt ggacttttgt tggcatcatt ctgtgcaaat gtttatgttg
721 acactggatt tgtgaacaca gatgatctga tcataactcc cactgacact cgttgggtcg
781 gtgcatggtg gtttggcttt ctgatttgtg caggagttaa cgtgctcact gccattcctt
841 ttttcttttt gcccaacaca cttccaaagg aaggactaga gactaatgct gacatcatta
901 aaaatgaaaa tgaagacaaa caaaaagaag aggtcaagaa ggaaaaatat ggaatcacta
961 aagattttct acctttcatg aaaagtcttt cctgcaatcc aatttatatg cttttcatac
1021 ttgtaagtgt gatacagttc aatgcattcg ttaacatgat ctccttcatg cctaaatacc
1081 tagaacagca atatggaata tcatcttcag atgcaatctt tctaatgggt atttataact
1141 tacctccaat atgtattgga tatataattg gtggtttaat tatgaagaag ttcaagatta
1201 ctgtcaaaca agctgcccac ataggatgtt ggttatcctt acttgagtat cttctctatt
1261 ttttatcttt tctcatgact tgtgaaaatt cttcagttgt tggaataaat acctcttatg
1321 aaggaattcc acaagattta tatgtggaaa atgacatctt tgctgattgc aatgtggatt
1381 gcaactgtcc atctaaaata tgggatcctg tgtgtggaaa caatggcttg tcatatctgt
1441 cagcttgtct tgctggttgt gagacatcca ttggaacggg aataaacatg gtgttccaaa
1501 attgcagctg tattcaaaca tcaggaaatt catctgcagt tcttgggctg tgcgacaaag
1561 gacctgactg ttccttgatg ctccagtact tcctaatctt gtcagcgatg agcagtttca
1621 tttattcttt ggctgccata cctggatata tggttctctt gaggtgtatg aaatctgaag
1681 agaagtccct tggtgtggga ttacatacat tttgcacaag agtatttgct ggcattcctg
1741 cacctatata ttttggcgct ttaatggatt ccacatgttt acactgggga actttgaaat
1801 gtggtgagtc aggggcatgc aggatatatg attccaccac cttcagatac atctacctcg
1861 gattgccggc agcactaaga ggatcaagct ttgttccagc cttaatcatc ttaattcttt
1921 tgaggaagtg tcatctacct ggtgaaaatg cctcttcagg aacagagctt atagagacaa
1981 aagtcaaagg gaaggaaaat gagtgcaaag atatatacca aaagtccacg gttttgaaag
2041 atgatgaatt gaaaactaaa ttgtaattgt cctattatat tacttttttc agaattagag
2101 aacatgctgt acaacttaat tgttttaaaa atcagtagag atataataga taactttttc
2161 ttgtctttaa gaacctaaaa aacctcttaa ctcaaaataa taaaatgttc actaatgata
2221 tttctaaggt atcagtgaca cttgagtttt cctaggaggg acatcaataa cagcccccta
2281 aagaagattc ttagagccag ctttattttt atgttgaaac agcaatttcc cttaattcat
2341 cgaagtaagg gtgtacttcc tacatctcct tctactaata cttctaaaaa ttttctgtta
2401 tgaaaaccta tttaattcca ctaaatttgt tctttgatat tggaattatt cagatgccta
2461 aattctcatt ctgttatgtg aagatttaaa tattttattc aagtttatcg cttccatgtg
2521 agagaagcct acatcttctt attctattta ggaatcgttc tttaactctt cttattcatt
2581 ctaggcatga ctcctatata atagattact cataaatata ccctcctact ttcaattttt
2641 tcttttcttt attactcata catttgctca atttgtacag aatactgaca aacttaagca
2701 ggttattaaa catcatgagg c
//