LOCUS HSU21847 2872 bp mRNA linear HUM 16-JAN-1996
DEFINITION Human TGF-beta inducible early protein (TIEG) mRNA, complete cds.
ACCESSION U21847
VERSION U21847.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2872)
AUTHORS Subramaniam,M., Harris,S.A., Oursler,M.J., Rasmussen,K., Riggs,B.L.
and Spelsberg,T.C.
TITLE Identification of a novel TGF-beta-regulated gene encoding a
putative zinc finger protein in human osteoblasts
JOURNAL Nucleic Acids Res. 23 (23), 4907-4912 (1995)
PUBMED 8532536
REFERENCE 2 (bases 1 to 2872)
AUTHORS Subramaniam,M.
TITLE Direct Submission
JOURNAL Submitted (27-FEB-1995) Malayannan Subramaniam, Biochemistry and
Molecular Biology, Mayo Clinic, 1615 Guggenheim, Rochester, NY
55905, USA
FEATURES Location/Qualifiers
source 1..2872
/db_xref="H-InvDB:HIT000218656"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/sex="female"
/cell_line="osteoblast primary culture"
/dev_stage="55 year old female"
gene 1..2872
/gene="TIEG"
CDS 87..1529
/gene="TIEG"
/codon_start=1
/product="TGF-beta inducible early protein"
/protein_id="AAC50340.1"
/translation="MLNFGASLQQTAEERMEMISERPKESMYSWNKTAEKSDFEAVEA
LMSMSCSWKSDFKKYVENRPVTPVSDLSEEENLLPGTPDFHTIPAFCLTPPYSPSDFE
PSQVSNLMAPAPSTVHFKSLSDTAKPHIAAPFKEEEKSPVSAPKLPKAQATSVIRHTA
DAQLCNHQTCPMKAASILNYQNNSFRRRTHLNVEAARKNIPCAAVSPNRSKCERNTVA
DVDEKASAALYDFSVPSSETVICRSQPAPVSPQQKSVLVSPPAVSAGGVPPMPVICQM
VPLPANNPVVTTVVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFVVPQPVVQSSKPPVV
SPNGTRLSPIAPAPGFSPSAAKVTPQIDSSRIRSHICSHPGCGKTYFKSSHLKAHTRT
HTGEKPFSCSWKGCERRFARSDELSRHRRTHTGEKKFACPMCDRRFMRSDHLTKHARR
HLSAKKLPNWQMEVSKLNDIALPPTPAPTQ"
misc_feature 234..359
/gene="TIEG"
/note="encodes proline-rich region"
misc_feature 247..346
/gene="TIEG"
/note="encodes SH3 binding motifs"
misc_feature 371..451
/gene="TIEG"
/note="encodes zinc finger domain"
regulatory 2852..2857
/regulatory_class="polyA_signal_sequence"
/gene="TIEG"
polyA_site 2872
/gene="TIEG"
/note="9 A nucleotides"
BASE COUNT 830 a 630 c 606 g 806 t
ORIGIN
1 gaattcggca cgagcgcccg tctgtggcca agcagccagc agcctagcag ccagtcagct
61 tgccgccggc ggccaagcag ccaaccatgc tcaacttcgg tgcctctctc cagcagactg
121 cggaggaaag aatggaaatg atttctgaaa ggccaaaaga gagtatgtat tcctggaaca
181 aaactgcaga gaaaagtgat tttgaagctg tagaagcact tatgtcaatg agctgcagtt
241 ggaagtctga ttttaagaaa tacgttgaaa acagacctgt tacaccagta tctgatttgt
301 cagaggaaga gaatctgctt ccgggaacac ctgattttca tacaatccca gcattttgtt
361 tgactccacc ttacagtcct tctgactttg aaccctctca agtgtcaaat ctgatggcac
421 cagcgccatc tactgtacac ttcaagtcac tctcagatac tgccaaacct cacattgccg
481 cacctttcaa agaggaagaa aagagcccag tatctgcccc caaactcccc aaagctcagg
541 caacaagtgt gattcgtcat acagctgatg cccagctatg taaccaccag acctgcccaa
601 tgaaagcagc cagcatcctc aactatcaga acaattcttt tagaagaaga acccacctaa
661 atgttgaggc tgcaagaaag aacataccat gtgccgctgt gtcaccaaac agatccaaat
721 gtgagagaaa cacagtggca gatgttgatg agaaagcaag tgctgcactt tatgactttt
781 ctgtgccttc ctcagagacg gtcatctgca ggtctcagcc agcccctgtg tccccacaac
841 agaagtcagt gttggtctct ccacctgcag tatctgcagg gggagtgcca cctatgccgg
901 tcatctgcca gatggttccc cttcctgcca acaaccctgt tgtgacaaca gtcgttccca
961 gcactcctcc cagccagcca ccagccgttt gcccccctgt tgtgttcatg ggcacacaag
1021 tccccaaagg cgctgtcatg tttgtggtac cccagcccgt tgtgcagagt tcaaagcctc
1081 cggtggtgag cccgaatggc accagactct ctcccattgc ccctgctcct gggttttccc
1141 cttcagcagc aaaagtcact cctcagattg attcatcaag gataaggagt cacatctgta
1201 gccacccagg atgtggcaag acatacttta aaagttccca tctgaaggcc cacacgagga
1261 cgcacacagg agaaaagcct ttcagctgta gctggaaagg ttgtgaaagg aggtttgccc
1321 gttctgatga actgtccaga cacaggcgaa cccacacggg tgagaagaaa tttgcgtgcc
1381 ccatgtgtga ccggcggttc atgaggagtg accatttgac caagcatgcc cggcgccatc
1441 tatcagccaa gaagctacca aactggcaga tggaagtgag caagctaaat gacattgctc
1501 tacctccaac ccctgctccc acacagtgac agaccggaaa gtgaagagtc agaactaact
1561 ttggtctcag cgggagccag tggtgatgta aaaatgcttc cactgcaagt ctgtggcccc
1621 acaacgtggg cttaaagcag aagccccaca gcctggcacg aaggccccgc ctgggttagg
1681 tgactaaaag ggcttcggcc acaggcaggt cacagaaagg caggtttcat ttcttatcac
1741 ataagagaga tgagaaagct tttattcctt tgaatatttt ttgaaggttt cagatgaggt
1801 caacacaggt agcacagatt ttgaatctgt gtgcatattt gttactttac ttttgctgtt
1861 tatacttgag accaactttt caatgtgatt cttctaaagc actggtttca agaatatgga
1921 agctggaagg aaataaacat tacggtacag acatggagat gtaaaatgag tttgtattat
1981 tacaaatatt gtcatctttt tctagagtta tcttctttat tattcctagt ctttccagtc
2041 aacatcgtgg atgtagtgat taaatatatc tagaactatc atttttacac tattgtgaat
2101 atttggaatt gaacgactgt atattgctaa gagggcccaa agaattggaa tcctccttaa
2161 tttaattgct ttgaagcata gctacaattt gtttttgcat ttttgttttg aaagtttaac
2221 aaatgactgt atctaggcat ttcattatgc tttgaacttt agtttgcctg cagtttcttg
2281 tgtagatttg aaaattgtat accaatgtgt tttctgtaga ctctaagata cactgcactt
2341 tgtttagaaa aaaaactgaa gatgaaatat atattgtaaa gaagggatat taagaatctt
2401 agataacttc ttgaaaaaga tggcttatgt catcagtaaa gtacctttat gttatgagga
2461 tataatgtgt gctttattga attagaaaat tagtgaccat tattcacagg tggacaaatg
2521 ttcgtcctgt taatttatag gagttttttg gggatgtgga ggtagttggg tagaaaaatt
2581 attagaacat tcacttttgt taacagtatt tctcttttat tctgttatat agtggatgat
2641 atacacagtg gcaaaacaaa agtacattgc ttaaaatata tagtgaaaaa tgtcactata
2701 tcttcccatt taacattgtt tttgtatatt gggtgtagat ttctgacatc aaaacttgga
2761 cccttggaaa acaaaagttt taattaaaaa aaatccttgt gacttacaat ttgcacaata
2821 tttcttttgt tgtactttat atcttgttta caataaagaa ttccctttgg ca
//