LOCUS HSU20938 4409 bp mRNA linear HUM 04-APR-1997 DEFINITION Human lymphocyte dihydropyrimidine dehydrogenase mRNA, complete cds. ACCESSION U20938 VERSION U20938.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4409) AUTHORS Diasio,R.B., Beavers,T.L. and Carpenter,J.T. TITLE Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity JOURNAL J. Clin. Invest. 81 (1), 47-51 (1988) PUBMED 3335642 REFERENCE 2 (bases 1 to 4409) AUTHORS Lu,Z.H., Zhang,R. and Diasio,R.B. TITLE Purification and characterization of dihydropyrimidine dehydrogenase from human liver JOURNAL J. Biol. Chem. 267 (24), 17102-17109 (1992) PUBMED 1512248 REFERENCE 3 (bases 1 to 4409) AUTHORS Johnson,M.R., Albin,N., Shahinian,H. and Diasio,R.B. TITLE Identification of a frameshift in the DNA coding for dihydropyrimidine dehydrogenase (DPD) in a DPD deficient patient exhibiting 5-fluorouracil toxicity JOURNAL Unpublished REFERENCE 4 (bases 1 to 4409) AUTHORS Johnson,M.R. TITLE Direct Submission JOURNAL Submitted (10-FEB-1995) Pharmacology, University of Alabama at Birmingham, 1670 University Blvd., Birmingham, AL 35294-0019, USA COMMENT On Apr 4, 1997 this sequence version replaced gi:693911. FEATURES Location/Qualifiers source 1..4409 /db_xref="H-InvDB:HIT000218575" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /cell_type="lymphocyte" CDS 102..3179 /EC_number="1.2.1.2" /note="DPD; dihydrouracil dehydrogenase" /codon_start=1 /product="dihydropyrimidine dehydrogenase" /protein_id="AAB51366.1" /translation="MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRN PDKNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFIT SIANKNYYGAAKMIFSDNPLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFAT EVFKAMSIPQIRNPSLPPPEKMSEAYSAKIALFGAGPASISCASFLARLGYSDITIFE KQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSLSVNEMTLSTLKEKGY KAAFIGIGLPEPNKDAIFQGLTQDQGFYTSKDFLPLVAKGSKAGMCACHSPLPSIRGV VIVLGAGDTAFDCATSALRCGARRVFIVFRKGFVNIRAVPEEMELAKEEKCEFLPFLS PRKVIVKGGRIVAMQFVRTEQDETGKWNEDEDQMVHLKADVVISAFGSVLSDPKVKEA LSPIKFNRWGLPEVDPETMQTSEAWVFAGGDVVGLANTTVESVNDGKQASWYIHKYVQ SQYGASVSAKPELPLFYTPIDLVDISVEMAGLKFINPFGLASATPATSTSMIRRAFEA GWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQS VTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDSGADALELNLSCPHGMGERGMGL ACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSIARAAKEGGANGVTATNTVSG LMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTSIARALPGFPILATGGIDS AESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELQDWDGQSPAT VSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQNVAFSPLKRNCFIP KRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCYMTCNDSGYQAIQ FDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGVPLSVNPVC" BASE COUNT 1317 a 845 c 949 g 1298 t ORIGIN 1 tttcgactcg cgctccggct gctgtcactt ggctctctgg ctggagcttg aggacgcaag 61 gagggtttgt cactggcaga ctcgagactg taggcactgc catggcccct gtgctcagta 121 aggactcggc ggacatcgag agtatcctgg ctttaaatcc tcgaacacaa actcatgcaa 181 ctctgtgttc cacttcggcc aagaaattag acaagaaaca ttggaaaaga aatcctgata 241 agaactgctt taattgtgag aagctggaga ataattttga tgacatcaag cacacgactc 301 ttggtgagcg aggagctctc cgagaagcaa tgagatgcct gaaatgtgca gatgccccgt 361 gtcagaagag ctgtccaact aatcttgata ttaaatcatt catcacaagt attgcaaaca 421 agaactatta tggagctgct aagatgatat tttctgacaa cccacttggt ctgacttgtg 481 gaatggtatg tccaacctct gatctttgtg taggtggatg caatttatat gccactgaag 541 agggacccat taatattggt ggattgcagc aatttgctac tgaggtattc aaagcaatga 601 gtatcccaca gatcagaaat ccttcgctgc ctcccccaga aaaaatgtct gaagcctatt 661 ctgcaaagat tgctcttttt ggtgctgggc ctgcaagtat aagttgtgct tcctttttgg 721 ctcgattggg gtactctgac atcactatat ttgaaaaaca agaatatgtt ggtggtttaa 781 gtacttctga aattcctcag ttccggctgc cgtatgatgt agtgaatttt gagattgagc 841 taatgaagga ccttggtgta aagataattt gcggtaaaag cctttcagtg aatgaaatga 901 ctcttagcac tttgaaagaa aaaggctaca aagctgcttt cattggaata ggtttgccag 961 aacccaataa agatgccatc ttccaaggcc tgacgcagga ccaggggttt tatacatcca 1021 aagacttttt gccacttgta gccaaaggca gtaaagcagg aatgtgcgcc tgtcactctc 1081 cattgccatc gatacgggga gtcgtgattg tacttggagc tggagacact gcctttgact 1141 gtgcaacatc tgctctacgt tgtggagctc gccgtgtgtt catcgtcttc agaaaaggct 1201 ttgttaatat aagagctgtc cctgaggaga tggaacttgc taaggaagaa aagtgtgaat 1261 ttctgccatt cctgtcccca cggaaggtta tagtaaaagg tgggagaatt gttgctatgc 1321 agtttgttcg gacagagcaa gatgaaactg gaaaatggaa tgaagatgaa gatcagatgg 1381 tccatctgaa agccgatgtg gtcatcagtg cctttggttc agttctgagt gatcctaaag 1441 taaaagaagc cttgagccct ataaaattta acagatgggg tctcccagaa gtagatccag 1501 aaactatgca aactagtgaa gcatgggtat ttgcaggtgg tgatgtcgtt ggtttggcta 1561 acactacagt ggaatcggtg aatgatggaa agcaagcttc ttggtacatt cacaaatacg 1621 tacagtcaca atatggagct tccgtttctg ccaagcctga actacccctc ttttacactc 1681 ctattgatct ggtggacatt agtgtagaaa tggccggatt gaagtttata aatccttttg 1741 gtcttgctag cgcaactcca gccaccagca catcaatgat tcgaagagct tttgaagctg 1801 gatggggttt tgccctcacc aaaactttct ctcttgataa ggacattgtg acaaatgttt 1861 cccccagaat catccgggga accacctctg gccccatgta tggccctgga caaagctcct 1921 ttctgaatat tgagctcatc agtgagaaaa cggctgcata ttggtgtcaa agtgtcactg 1981 aactaaaggc tgactttcca gacaacattg tgattgctag cattatgtgc agttacaata 2041 aaaatgactg gacggaactt gccaagaagt ctgaggattc tggagcagat gccctggagt 2101 taaatttatc atgtccacat ggcatgggag aaagaggaat gggcctggcc tgtgggcagg 2161 atccagagct ggtgcggaac atctgccgct gggttaggca agctgttcag attccttttt 2221 ttgccaagct gaccccaaat gtcactgata ttgtgagcat cgcaagagct gcaaaggaag 2281 gtggtgccaa tggcgttaca gccaccaaca ctgtctcagg tctgatggga ttaaaatctg 2341 atggcacacc ttggccagca gtggggattg caaagcgaac tacatatgga ggagtgtctg 2401 ggacagcaat cagacctatt gctttgagag ctgtgacctc cattgctcgt gctctgcctg 2461 gatttcccat tttggctact ggtggaattg actctgctga aagtggtctt cagtttctcc 2521 atagtggtgc ttccgtcctc caggtatgca gtgccattca gaatcaggat ttcactgtga 2581 tcgaagacta ctgcactggc ctcaaagccc tgctttatct gaaaagcatt gaagaactac 2641 aagactggga tggacagagt ccagctactg tgagtcacca gaaagggaaa ccagttccac 2701 gtatagctga actcatggac aagaaactgc caagttttgg accttatctg gaacagcgca 2761 agaaaatcat agcagaaaac aagattagac tgaaagaaca aaatgtagct ttttcaccac 2821 ttaagagaaa ctgttttatc cccaaaaggc ctattcctac catcaaggat gtaataggaa 2881 aagcactgca gtaccttgga acatttggtg aattgagcaa cgtagagcaa gttgtggcta 2941 tgattgatga agaaatgtgt atcaactgtg gtaaatgcta catgacctgt aatgattctg 3001 gctaccaggc tatacagttt gatccagaaa cccacctgcc caccataacc gacacttgta 3061 caggctgtac tctgtgtctc agtgtttgcc ctattgtcga ctgcatcaaa atggtttcca 3121 ggacaacacc ttatgaacca aagagaggcg tacccttatc tgtgaatccg gtgtgttaag 3181 gtgatttgtg aaacagttgc tgtgaacttt catgtcacct acatatgctg atcttttaaa 3241 atcatgatcc ttgtgttcag ctctttccaa attaaaacaa atatacattt tctaaataaa 3301 aatatgtaat ttcaaaatac atttgtaagt gtaaaaaatg tctcatgtca atgaccattc 3361 aattagtggt cataaaatag aataattctt ttctgaggat agtagttaaa taactgtgtg 3421 gcagttaatt ggatgttcac tgccagttgt cttatgtgaa aaattaactt ttttgtggca 3481 attagtgtga cagtttccaa attgccctat gctgtgctcc atatttgatt tctaattgta 3541 agtgaaatta agcattttga aacaaagtac tctttaacat acaagaaaat gtatccaagg 3601 aaacatttta tcattaaaaa ttacctttaa ttttaatgct gtttctaaga aaatgtagtt 3661 agctccataa agtacaaatg aagaaagtca aaaaattatt tgctatggca ggataagaaa 3721 gcctaaaatt gagtttgtag aactttatta agtaaaatcc ccttcgctga aattgcttat 3781 ttttggtgtt ggatagagga tagggagaat atttactaac taaataccat tcactactca 3841 tgcgtgagat gggtgtacaa actcatcctc ttttaatggc atttctcttt aaactatgtt 3901 cctaacaaaa tgagatgata ggatagatcc tggttaccac tcttttgctg tgcacatacg 3961 ggctctgact ggttttaata gtcaccttca tgattatagc aactaatgtt tgaacaaagc 4021 tcaaagtatg caatgcttca ttattcaaga atgaaaaata taatgttgat aatatatatt 4081 aagtgtgcca aatcagtttg actactctct gttttagtgt ttatgtttaa aagaaatata 4141 ttttttgtta ttattagata atatttttgt atttctctat tttcataatc agtaaatagt 4201 gtcatataaa ctcatttatc tcctcttcat ggcatcttca atatgaatct ataagtagta 4261 aatcagaaag taacaatcta tggcttattt ctatgacaaa ttcaagagct agaaaaataa 4321 aatgtttcat tatgcacttt tagaaatgca tatttgccac aaaacctgta ttactgaata 4381 atatcaaata aaatatcata aagcatttt //