LOCUS HSU20760 5009 bp mRNA linear HUM 02-FEB-1996 DEFINITION Human extracellular calcium-sensing receptor mRNA, complete cds. ACCESSION U20760 VERSION U20760.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5009) AUTHORS Garrett,J.E., Capuano,I.V., Hammerland,L.G., Hung,B.C., Brown,E.M., Hebert,S.C., Nemeth,E.F. and Fuller,F. TITLE Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs JOURNAL J. Biol. Chem. 270 (21), 12919-12925 (1995) PUBMED 7759551 REFERENCE 2 (bases 1 to 5009) AUTHORS Garrett,J.E. TITLE Direct Submission JOURNAL Submitted (07-FEB-1995) James E. Garrett, Molecular Biology, NPS Pharmaceuticals, Inc., 420 Chipeta Way, Salt Lake City, UT 84108, USA FEATURES Location/Qualifiers source 1..5009 /db_xref="H-InvDB:HIT000218571" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="phPCaR-5.2" /sex="male" /cell_type="chief cells" /tissue_type="parathyroid" /clone_lib="lambdaZ-hPG2ss" 5'UTR 1..438 CDS 439..3705 /function="seven transmembrane domain G protein-coupled receptor that senses changes in extracellular calcium concentration" /codon_start=1 /product="extracellular calcium-sensing receptor" /protein_id="AAA86504.1" /translation="MAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGV AAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCN TVSKALEATLSFVAQNKIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLF YIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDY GRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDL EPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFL KKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFR PLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCA DIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEV GYYNVYAKKGERLFINEEKILWSGFSREPLTFVLSVLQVPFSNCSRDCLAGTRKGIIE GEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGI ALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEP QDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFL CTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAAICF FFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASF GLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSLGG STGSTPSSSISSKSNSEDPFPRPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQPRC KQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHQPLLPLQCGE TDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVTENVVNS " misc_feature 2047..2076 /note="30 bp insertion due to alternative splice site utilization. This insertion is unique to the phPCaR-5.2 clone, and results in a 10 amino acid in-frame insertion into the CaR protein" 3'UTR 3706..5009 regulatory 4988..4993 /regulatory_class="polyA_signal_sequence" polyA_site 5009 BASE COUNT 1228 a 1376 c 1223 g 1182 t ORIGIN 1 ggggctgctg tggccggacc cgaaggcggg cgccgggagc gcagcgagcc agacgcgcct 61 ctccaagacc gtgaccttgg catagggagc ggggctgcgc gcagtcctga gatcagacca 121 gagctcatcc tcgtggagac ccacggccga ggggccggag ctgcctctgt gcgagggagc 181 cctggccgcg gcgcagaagg catcacagga ggcctctgca tgatgtggct tccaaagact 241 caaggaccac ccacattaca agtctggatt gaggaaggca gaaatggaga ttcaaacacc 301 acgtcttcta ttattttatt aatcaatctg tagacatgtg tccccactgc agggagtgaa 361 ctgctccaag ggagaaactt ctgggagcct ccaaactcct agctgtctca tcccttgccc 421 tggagagacg gcagaaccat ggcattttat agctgctgct gggtcctctt ggcactcacc 481 tggcacacct ctgcctacgg gccagaccag cgagcccaaa agaaggggga cattatcctt 541 ggggggctct ttcctattca ttttggagta gcagctaaag atcaagatct caaatcaagg 601 ccggagtctg tggaatgtat caggtataat ttccgtgggt ttcgctggtt acaggctatg 661 atatttgcca tagaggagat aaacagcagc ccagcccttc ttcccaactt gacgctggga 721 tacaggatat ttgacacttg caacaccgtt tctaaggcct tggaagccac cctgagtttt 781 gttgctcaaa acaaaattga ttctttgaac cttgatgagt tctgcaactg ctcagagcac 841 attccctcta cgattgctgt ggtgggagca actggctcag gcgtctccac ggcagtggca 901 aatctgctgg ggctcttcta cattccccag gtcagttatg cctcctccag cagactcctc 961 agcaacaaga atcaattcaa gtctttcctc cgaaccatcc ccaatgatga gcaccaggcc 1021 actgccatgg cagacatcat cgagtatttc cgctggaact gggtgggcac aattgcagct 1081 gatgacgact atgggcggcc ggggattgag aaattccgag aggaagctga ggaaagggat 1141 atctgcatcg acttcagtga actcatctcc cagtactctg atgaggaaga gatccagcat 1201 gtggtagagg tgattcaaaa ttccacggcc aaagtcatcg tggttttctc cagtggccca 1261 gatcttgagc ccctcatcaa ggagattgtc cggcgcaata tcacgggcaa gatctggctg 1321 gccagcgagg cctgggccag ctcctccctg atcgccatgc ctcagtactt ccacgtggtt 1381 ggcggcacca ttggattcgc tctgaaggct gggcagatcc caggcttccg ggaattcctg 1441 aagaaggtcc atcccaggaa gtctgtccac aatggttttg ccaaggagtt ttgggaagaa 1501 acatttaact gccacctcca agaaggtgca aaaggacctt tacctgtgga cacctttctg 1561 agaggtcacg aagaaagtgg cgacaggttt agcaacagct cgacagcctt ccgacccctc 1621 tgtacagggg atgagaacat cagcagtgtc gagacccctt acatagatta cacgcattta 1681 cggatatcct acaatgtgta cttagcagtc tactccattg cccacgcctt gcaagatata 1741 tatacctgct tacctgggag agggctcttc accaatggct cctgtgcaga catcaagaaa 1801 gttgaggcgt ggcaggtcct gaagcaccta cggcatctaa actttacaaa caatatgggg 1861 gagcaggtga cctttgatga gtgtggtgac ctggtgggga actattccat catcaactgg 1921 cacctctccc cagaggatgg ctccatcgtg tttaaggaag tcgggtatta caacgtctat 1981 gccaagaagg gagaaagact cttcatcaac gaggagaaaa tcctgtggag tgggttctcc 2041 agggagccac tcacctttgt gctgtctgtc ctccaggtgc ccttctccaa ctgcagccga 2101 gactgcctgg cagggaccag gaaagggatc attgaggggg agcccacctg ctgctttgag 2161 tgtgtggagt gtcctgatgg ggagtatagt gatgagacag atgccagtgc ctgtaacaag 2221 tgcccagatg acttctggtc caatgagaac cacacctcct gcattgccaa ggagatcgag 2281 tttctgtcgt ggacggagcc ctttgggatc gcactcaccc tctttgccgt gctgggcatt 2341 ttcctgacag cctttgtgct gggtgtgttt atcaagttcc gcaacacacc cattgtcaag 2401 gccaccaacc gagagctctc ctacctcctc ctcttctccc tgctctgctg cttctccagc 2461 tccctgttct tcatcgggga gccccaggac tggacgtgcc gcctgcgcca gccggccttt 2521 ggcatcagct tcgtgctctg catctcatgc atcctggtga aaaccaaccg tgtcctcctg 2581 gtgtttgagg ccaagatccc caccagcttc caccgcaagt ggtgggggct caacctgcag 2641 ttcctgctgg ttttcctctg caccttcatg cagattgtca tctgtgtgat ctggctctac 2701 accgcgcccc cctcaagcta ccgcaaccag gagctggagg atgagatcat cttcatcacg 2761 tgccacgagg gctccctcat ggccctgggc ttcctgatcg gctacacctg cctgctggct 2821 gccatctgct tcttctttgc cttcaagtcc cggaagctgc cggagaactt caatgaagcc 2881 aagttcatca ccttcagcat gctcatcttc ttcatcgtct ggatctcctt cattccagcc 2941 tatgccagca cctatggcaa gtttgtctct gccgtagagg tgattgccat cctggcagcc 3001 agctttggct tgctggcgtg catcttcttc aacaagatct acatcattct cttcaagcca 3061 tcccgcaaca ccatcgagga ggtgcgttgc agcaccgcag ctcacgcttt caaggtggct 3121 gcccgggcca cgctgcgccg cagcaacgtc tcccgcaagc ggtccagcag ccttggaggc 3181 tccacgggat ccaccccctc ctcctccatc agcagcaaga gcaacagcga agacccattc 3241 ccacggcccg agaggcagaa gcagcagcag ccgctggccc taacccagca agagcagcag 3301 cagcagcccc tgaccctccc acagcagcaa cgatctcagc agcagcccag atgcaagcag 3361 aaggtcatct ttggcagcgg cacggtcacc ttctcactga gctttgatga gcctcagaag 3421 aacgccatgg cccacaggaa ttctacgcac cagaactccc tggaggccca gaaaagcagc 3481 gatacgctga cccgacacca gccattactc ccgctgcagt gcggggaaac ggacttagat 3541 ctgaccgtcc aggaaacagg tctgcaagga cctgtgggtg gagaccagcg gccagaggtg 3601 gaggaccctg aagagttgtc cccagcactt gtagtgtcca gttcacagag ctttgtcatc 3661 agtggtggag gcagcactgt tacagaaaac gtagtgaatt cataaaatgg aaggagaaga 3721 ctgggctagg gagaatgcag agaggtttct tggggtccca gggatgagga atcgccccag 3781 actcctttcc tctgaggaag aagggataat agacacatca aatgccccga atttagtcac 3841 accatcttaa atgacagtga attgacccat gttcccttta aaattaaaaa aaagaagagc 3901 cttgtgtttc tgtggttgca tttgtcaaag cattgagatc tccacggtca gatttgctgt 3961 tcacccacat ctaatgtctc ttcctctgtt ctatcccacc caacagctca gagatgaaac 4021 tatggcttta aactaccctc cagagtgtgc agactgatgg gacatcaaat ttgccaccac 4081 tagagctgag agtctgaaag acagaatgtc accagtcctg cccaatgcct tgacaacaga 4141 ctgaatttta aatgttcaca acataaggag aatgtatctc ctcctattta tgaaaaccat 4201 atgatatttt gtctcctacc tgctgctgct attatgtaac atccagaagg tttgcacccc 4261 tcctatacca tatgtctggt tctgtccagg acatgatact gatgccatgt ttagattcca 4321 ggatcacaag aatcacctca aattgttagg aagggactgc ataaaccaat gagctgtatc 4381 tgtaattaat attcctatat gtagctttat ccttaggaaa atgcttctgt tgtaatagtc 4441 catggacaat ataaactgaa aaatgtcagt ctggtttata taaggcagta ttattgagct 4501 ctatttcccc accccactat cctcactccc ataagctaag ccttatgtga gccccttcag 4561 ggactcaagg gtccagaagt ccctcccatc tctaccccaa agaattcctg aagccagatc 4621 caccctatcc ctgtacagag taagttctca attattggcc tgctaatagc tgctagggta 4681 ggaaagcgtg gttccaagaa agatccaccc tcaaatgtcg gagctatgtt ccctccagca 4741 gtggtattaa tactgccggt cacccaggct ctggagccag agagacagac cggggttcaa 4801 gccatggctt cgtcatttgc aagctgagtg actgtaggca gggaacctta acctctctaa 4861 gccacagctt cttcatcttt aaaataagga taataatcat tccttcccct cagagctctt 4921 atgtggatta aacgagataa tgtatataaa gtactttagc ctggtaccta gcacacaata 4981 agcattcaat aaatattagt taatattat //