LOCUS HSU20759 3783 bp mRNA linear HUM 02-FEB-1996
DEFINITION Human parathyroid cell calcium-sensing receptor mRNA, complete cds.
ACCESSION U20759
VERSION U20759.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3783)
AUTHORS Garrett,J.E., Capuano,I.V., Hammerland,L.G., Hung,B.C., Brown,E.M.,
Hebert,S.C., Nemeth,E.F. and Fuller,F.
TITLE Molecular cloning and functional expression of human parathyroid
calcium receptor cDNAs
JOURNAL J. Biol. Chem. 270 (21), 12919-12925 (1995)
PUBMED 7759551
REFERENCE 2 (bases 1 to 3783)
AUTHORS Garrett,J.E.
TITLE Direct Submission
JOURNAL Submitted (07-FEB-1995) James E. Garrett, Molecular Biology, NPS
Pharmaceuticals, Inc., 420 Chipeta Way, Salt Lake City, UT 84108,
USA
FEATURES Location/Qualifiers
source 1..3783
/db_xref="H-InvDB:HIT000218570"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="phPCaR-4.0"
/sex="male"
/tissue_type="parathyroid gland"
/clone_lib="lambdaZ-hPG2ss"
5'UTR 1..372
CDS 373..3609
/function="seven transmembrane domain G protein-coupled
receptor that senses changes in extracellular calcium
ions"
/codon_start=1
/product="parathyroid cell calcium-sensing receptor"
/protein_id="AAA86503.1"
/translation="MAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGV
AAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCN
TVSKALEATLSFVAQNKIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLF
YIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDY
GRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDL
EPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFL
KKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFR
PLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCA
DIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEV
GYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFECV
ECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGI
FLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQP
AFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICV
IWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLP
ENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNK
IYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSLGGSTGSTPSSSI
SSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQPRCKQKVIFGSGT
VTFSLSFDEPQKNAMAHGNSTHQNSLEAQKSSDTLTRHQPLLPLQCGETDLDLTVQET
GLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVTENVVNS"
3'UTR 3607..3783
polyA_site 3783
BASE COUNT 892 a 1067 c 975 g 849 t
ORIGIN
1 caacaggcac ctggctgcag ccaggaagga ccgcacgccc tttcgcgcag gagagtggaa
61 ggagggagct gtttgccagc accgaggtct tgcggcacag gcaacgcttg acctgagtct
121 tgcagaatga aaggcatcac aggaggcctc tgcatgatgt ggcttccaaa gactcaagga
181 ccacccacat tacaagtctg gattgaggaa ggcagaaatg gagattcaaa caccacgtct
241 tctattattt tattaatcaa tctgtagaca tgtgtcccca ctgcagggag tgaactgctc
301 caagggagaa acttctggga gcctccaaac tcctagctgt ctcatccctt gccctggaga
361 gacggcagaa ccatggcatt ttatagctgc tgctgggtcc tcttggcact cacctggcac
421 acctctgcct acgggccaga ccagcgagcc caaaagaagg gggacattat ccttgggggg
481 ctctttccta ttcattttgg agtagcagct aaagatcaag atctcaaatc aaggccggag
541 tctgtggaat gtatcaggta taatttccgt gggtttcgct ggttacaggc tatgatattt
601 gccatagagg agataaacag cagcccagcc cttcttccca acttgacgct gggatacagg
661 atatttgaca cttgcaacac cgtttctaag gccttggaag ccaccctgag ttttgttgct
721 caaaacaaaa ttgattcttt gaaccttgat gagttctgca actgctcaga gcacattccc
781 tctacgattg ctgtggtggg agcaactggc tcaggcgtct ccacggcagt ggcaaatctg
841 ctggggctct tctacattcc ccaggtcagt tatgcctcct ccagcagact cctcagcaac
901 aagaatcaat tcaagtcttt cctccgaacc atccccaatg atgagcacca ggccactgcc
961 atggcagaca tcatcgagta tttccgctgg aactgggtgg gcacaattgc agctgatgac
1021 gactatgggc ggccggggat tgagaaattc cgagaggaag ctgaggaaag ggatatctgc
1081 atcgacttca gtgaactcat ctcccagtac tctgatgagg aagagatcca gcatgtggta
1141 gaggtgattc aaaattccac ggccaaagtc atcgtggttt tctccagtgg cccagatctt
1201 gagcccctca tcaaggagat tgtccggcgc aatatcacgg gcaagatctg gctggccagc
1261 gaggcctggg ccagctcctc cctgatcgcc atgcctcagt acttccacgt ggttggcggc
1321 accattggat tcgctctgaa ggctgggcag atcccaggct tccgggaatt cctgaagaag
1381 gtccatccca ggaagtctgt ccacaatggt tttgccaagg agttttggga agaaacattt
1441 aactgccacc tccaagaagg tgcaaaagga cctttacctg tggacacctt tctgagaggt
1501 cacgaagaaa gtggcgacag gtttagcaac agctcgacag ccttccgacc cctctgtaca
1561 ggggatgaga acatcagcag tgtcgagacc ccttacatag attacacgca tttacggata
1621 tcctacaatg tgtacttagc agtctactcc attgcccacg ccttgcaaga tatatatacc
1681 tgcttacctg ggagagggct cttcaccaat ggctcctgtg cagacatcaa gaaagttgag
1741 gcgtggcagg tcctgaagca cctacggcat ctaaacttta caaacaatat gggggagcag
1801 gtgacctttg atgagtgtgg tgacctggtg gggaactatt ccatcatcaa ctggcacctc
1861 tccccagagg atggctccat cgtgtttaag gaagtcgggt attacaacgt ctatgccaag
1921 aagggagaaa gactcttcat caacgaggag aaaatcctgt ggagtgggtt ctccagggag
1981 gtgcccttct ccaactgcag ccgagactgc ctggcaggga ccaggaaagg gatcattgag
2041 ggggagccca cctgctgctt tgagtgtgtg gagtgtcctg atggggagta tagtgatgag
2101 acagatgcca gtgcctgtaa caagtgccca gatgacttct ggtccaatga gaaccacacc
2161 tcctgcattg ccaaggagat cgagtttctg tcgtggacgg agccctttgg gatcgcactc
2221 accctctttg ccgtgctggg cattttcctg acagcctttg tgctgggtgt gtttatcaag
2281 ttccgcaaca cacccattgt caaggccacc aaccgagagc tctcctacct cctcctcttc
2341 tccctgctct gctgcttctc cagctccctg ttcttcatcg gggagcccca ggactggacg
2401 tgccgcctgc gccagccggc ctttggcatc agcttcgtgc tctgcatctc atgcatcctg
2461 gtgaaaacca accgtgtcct cctggtgttt gaggccaaga tccccaccag cttccaccgc
2521 aagtggtggg ggctcaacct gcagttcctg ctggttttcc tctgcacctt catgcagatt
2581 gtcatctgtg tgatctggct ctacaccgcg cccccctcaa gctaccgcaa ccaggagctg
2641 gaggatgaga tcatcttcat cacgtgccac gagggctccc tcatggccct gggcttcctg
2701 atcggctaca cctgcctgct ggctgccatc tgcttcttct ttgccttcaa gtcccggaag
2761 ctgccggaga acttcaatga agccaagttc atcaccttca gcatgctcat cttcttcatc
2821 gtctggatct ccttcattcc agcctatgcc agcacctatg gcaagtttgt ctctgccgta
2881 gaggtgattg ccatcctggc agccagcttt ggcttgctgg cgtgcatctt cttcaacaag
2941 atctacatca ttctcttcaa gccatcccgc aacaccatcg aggaggtgcg ttgcagcacc
3001 gcagctcacg ctttcaaggt ggctgcccgg gccacgctgc gccgcagcaa cgtctcccgc
3061 aagcggtcca gcagccttgg aggctccacg ggatccaccc cctcctcctc catcagcagc
3121 aagagcaaca gcgaagaccc attcccacag cccgagaggc agaagcagca gcagccgctg
3181 gccctaaccc agcaagagca gcagcagcag cccctgaccc tcccacagca gcaacgatct
3241 cagcagcagc ccagatgcaa gcagaaggtc atctttggca gcggcacggt caccttctca
3301 ctgagctttg atgagcctca gaagaacgcc atggcccacg ggaattctac gcaccagaac
3361 tccctggagg cccagaaaag cagcgatacg ctgacccgac accagccatt actcccgctg
3421 cagtgcgggg aaacggactt agatctgacc gtccaggaaa caggtctgca aggacctgtg
3481 ggtggagacc agcggccaga ggtggaggac cctgaagagt tgtccccagc acttgtagtg
3541 tccagttcac agagctttgt catcagtggt ggaggcagca ctgttacaga aaacgtagtg
3601 aattcataaa atggaaggag aagactgggc tagggagaat gcagagaggt ttcttggggt
3661 cccagggatg aggaatcgcc ccagactcct ttcctctgag gaagaaggga taatagacac
3721 atcaaatgcc ccgaatttag tcacaccatc ttaaatgaca gtgaattgac ccatgttccc
3781 ttt
//