LOCUS HSU20537 1313 bp mRNA linear HUM 27-JUL-1995
DEFINITION Human cysteine protease Mch2 isoform beta (Mch2) mRNA, complete
cds.
ACCESSION U20537
VERSION U20537.1
KEYWORDS Ced-3; ICE; Apoptosis.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1313)
AUTHORS Fernandes-Alnemri,T., Litwack,G. and Alnemri,E.S.
TITLE Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease
gene family
JOURNAL Cancer Res. 55 (13), 2737-2742 (1995)
PUBMED 7796396
REFERENCE 2 (bases 1 to 1313)
AUTHORS Fernandes-Alnemri,T., Litwack,G. and Alnemri,E.S.
TITLE CPP32, a novel human apoptotic protein with homology to
Caenorhabditis elegans cell death protein Ced-3 and mammalian
interleukin-1 beta-converting enzyme
JOURNAL J. Biol. Chem. 269 (49), 30761-30764 (1994)
PUBMED 7983002
REFERENCE 3 (bases 1 to 1313)
AUTHORS Alnemri,E.S.
TITLE Direct Submission
JOURNAL Submitted (01-FEB-1995) Emad S. Alnemri, Pharmacology, Thomas
Jefferson University, Jefferson Cancer Institute, 233 S. Tenth
Street, Philadelphia, PA 19107, USA
FEATURES Location/Qualifiers
source 1..1313
/db_xref="H-InvDB:HIT000218562"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/note="human"
source 1..1200
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="Mch12.1"
/cell_line="Jurkat"
/cell_type="T-lymphocyte"
gene 1..1313
/gene="Mch2"
CDS 1..615
/gene="Mch2"
/note="The gene product of this sequence is a new member
of the interleukin 1-beta converting enzyme gene family of
cysteine proteases; cysteine protease Mch2 isoform beta"
/codon_start=1
/product="cysteine protease Mch2 isoform beta"
/protein_id="AAC50169.1"
/translation="MSSASGLRRGHPAVSTVSHADADCFVCVFLSHGEGNHIYAYDAK
IEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITE
VDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELL
TLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN"
BASE COUNT 388 a 267 c 297 g 361 t
ORIGIN
1 atgagctcgg cctcggggct ccgcaggggg cacccggcag tgtcaactgt tagccacgca
61 gatgccgatt gctttgtgtg tgtcttcctg agccatggcg aaggcaatca catttatgca
121 tatgatgcta aaatcgaaat tcagacatta actggcttgt tcaaaggaga caagtgtcac
181 agcctggttg gaaaacccaa gatatttatc atccaggcat gtcggggaaa ccagcacgat
241 gtgccagtca ttcctttgga tgtagtagat aatcagacag agaagttgga caccaacata
301 actgaggtgg atgcagcctc cgtttacacg ctgcctgctg gagctgactt cctcatgtgt
361 tactctgttg cagaaggata ttattctcac cgggaaactg tgaacggctc atggtacatt
421 caagatttgt gtgagatgtt gggaaaatat ggctcctcct tagagttcac agaactcctc
481 acactggtga acaggaaagt ttctcagcgc cgagtggact tttgcaaaga cccaagtgca
541 attggaaaga agcaggttcc ctgttttgcc tcaatgctaa ctaaaaagct gcatttcttt
601 ccaaaatcta attaattaat agaggctatc taatttcaca ctctgtattg aaaatggctt
661 tctcagccag gcgtggttac tcacacctgt aatcccagca ctttgggagt ccaaggtggg
721 cggatcacct gaggtcggga gttcgagacc agcctgacca acatggcaga agccccgcct
781 ctactaaaaa tgcaaaaaaa aatttagcta ggcatggcgg cgcatgcctg caatcccagc
841 tacttggaag gctgaggcag gagaatcact tgaacccagg aggtggaggc tgcggtgagc
901 cgagcattgc gccattgcac tccagcctgg gcaacgagtg aaactccgtc tcaaaaaaaa
961 agaaaatgtc tttctcttcc ttttatataa atatcgttag ggtgaagcat tatggtctaa
1021 tgattcaaat gttttaaagt ttaatgccta gcagagaact gccttaaaaa aaaaaagttc
1081 atgttggcca tggtgaaagg gtttgatatg gagaaacaaa atcctcagga aattagataa
1141 atagaaattt ataagcattt gtattatttt ttaataaact gcagggttac accaaaatct
1201 agctgattta acttgtattt tgtcactttt ttataaaagt ttattgtttg atgtttttaa
1261 aggtttttga aatccaggaa ttaaatcatc ccttaataaa atattcgaaa ttc
//