LOCUS HSU20141 3946 bp mRNA linear HUM 12-AUG-1995
DEFINITION Human inducible nitric oxide synthase mRNA, complete cds.
ACCESSION U20141
VERSION U20141.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3946)
AUTHORS Guo,F.H., De Raeve,H.R., Rice,T.W., Stuehr,D.J., Thunnissen,F.B.
and Erzurum,S.C.
TITLE Continuous nitric oxide synthesis by inducible nitric oxide
synthase in normal human airway epithelium in vivo
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (17), 7809-7813 (1995)
PUBMED 7544004
REFERENCE 2 (bases 1 to 3946)
AUTHORS Erzurum,S.C.
TITLE Direct Submission
JOURNAL Submitted (20-JAN-1995) Serpil C. Erzurum, Pulmonary & Critical
Care Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue,
Cleveland, OH 44195, USA
FEATURES Location/Qualifiers
source 1..3946
/db_xref="H-InvDB:HIT000218543"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="pCCF21, pCCF25-28"
/tissue_type="respiratory epithelium"
CDS 1..3462
/EC_number="1.14.13.39"
/experiment="experimental evidence, no additional details
recorded"
/note="inducible isoform"
/codon_start=1
/product="nitric oxide synthase"
/protein_id="AAB60366.1"
/translation="MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDL
QYHNLSKQQNESPQPLVETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHH
KAKGILTCRSKSCLGSIMTPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIE
EHLARVEAVTKEIETTGTYQLTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCS
TAREMFEHICRHVRYSTNNGNIRSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGS
IRGDPANVEFTQLCIDLGWKPKYGRFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHP
KYEWFRELELKWYALPAVANMLLEVGGLEFPGCPFNGWYMGTEIGVRDFCDVQRYNIL
EEVGRRMGLETHKLASLWKDQAVVEINIAVLHSFQKQNVTIMDHHSAAESFMKYMQNE
YRSRGGCPADWIWLVPPMSGSITPVFHQEMLNYVLSPFYYYQVEAWKTHVWQDEKRRP
KRREIPLKVLVKAVLFACMLMRKTMASRVRVTILFATETGKSEALAWDLGALFSCAFN
PKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPGNGEKLKKSLFMLKELNNKFRYAVF
GLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGDELSGQEDAFRSWAVQIFKAACE
TFDVRGKQHIQIPKLYTSNVTWDPHHYRLVQDSQPLDLSKALSSMHAKNVFTMRLKSR
QNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQPALVQGILERVVDGPTPH
QTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQLLLQKLAQVATEEPER
QRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQLPILKPRFYSISSSR
DHTPTEIHLTVAVVTYHTGDGQGPLHHGVCSTWLNSLKPQDPVPCFVRNASAFHLPED
PSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPDEDHIYQEEML
EMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLYVCGDVRMA
RDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFGAVFPYEAKKDRVAVQPS
SLEMSAL"
misc_difference 1905
/note="conflict"
/replace="c"
misc_difference 2027
/note="conflict"
/replace="c"
3'UTR 3463..3946
polyA_site 3946
BASE COUNT 918 a 1149 c 1073 g 806 t
ORIGIN
1 atggcctgtc cttggaaatt tctgttcaag accaaattcc accagtatgc aatgaatggg
61 gaaaaagaca tcaacaacaa tgtggagaaa gccccctgtg ccacctccag tccagtgaca
121 caggatgacc ttcagtatca caacctcagc aagcagcaga atgagtcccc gcagcccctc
181 gtggagacgg gaaagaagtc tccagaatct ctggtcaagc tggatgcaac cccattgtcc
241 tccccacggc atgtgaggat caaaaactgg ggcagcggga tgactttcca agacacactt
301 caccataagg ccaaagggat tttaacttgc aggtccaaat cttgcctggg gtccattatg
361 actcccaaaa gtttgaccag aggacccagg gacaagccta cccctccaga tgagcttcta
421 cctcaagcta tcgaatttgt caaccaatat tacggctcct tcaaagaggc aaaaatagag
481 gaacatctgg ccagggtgga agcggtaaca aaggagatag aaacaacagg aacctaccaa
541 ctgacgggag atgagctcat cttcgccacc aagcaggcct ggcgcaatgc cccacgctgc
601 attgggagga tccagtggtc caacctgcag gtcttcgatg cccgcagctg ttccactgcc
661 cgggaaatgt ttgaacacat ctgcagacac gtgcgttact ccaccaacaa tggcaacatc
721 aggtcggcca tcaccgtgtt cccccagcgg agtgatggca agcacgactt ccgggtgtgg
781 aatgctcagc tcatccgcta tgctggctac cagatgccag atggcagcat cagaggggac
841 cctgccaacg tggaattcac tcagctgtgc atcgacctgg gctggaagcc caagtacggc
901 cgcttcgatg tggtccccct ggtcctgcag gccaatggcc gtgaccctga gctcttcgaa
961 atcccacctg accttgtgct tgaggtggcc atggaacatc ccaaatacga gtggtttcgg
1021 gaactggagc taaagtggta cgccctgcct gcagtggcca acatgctgct tgaggtgggc
1081 ggcctggagt tcccagggtg ccccttcaat ggctggtaca tgggcacaga gatcggagtc
1141 cgggacttct gtgacgtcca gcgctacaac atcctggagg aagtgggcag gagaatgggc
1201 ctggaaacgc acaagctggc ctcgctctgg aaagaccagg ctgtcgttga gatcaacatt
1261 gctgtgctcc atagtttcca gaagcagaat gtgaccatca tggaccacca ctcggctgca
1321 gaatccttca tgaagtacat gcagaatgaa taccggtccc gtgggggctg cccggcagac
1381 tggatttggc tggtccctcc catgtctggg agcatcaccc ccgtgtttca ccaggagatg
1441 ctgaactacg tcctgtcccc tttctactac tatcaggtag aggcctggaa aacccatgtc
1501 tggcaggacg agaagcggag acccaagaga agagagattc cattgaaagt cttggtcaaa
1561 gctgtgctct ttgcctgtat gctgatgcgc aagacaatgg cgtcccgagt cagagtcacc
1621 atcctctttg cgacagagac aggaaaatca gaggcgctgg cctgggacct gggggcctta
1681 ttcagctgtg ccttcaaccc caaggttgtc tgcatggata agtacaggct gagctgcctg
1741 gaggaggaac ggctgctgtt ggtggtgacc agtacgtttg gcaatggaga ctgccctggc
1801 aatggagaga aactgaagaa atcgctcttc atgctgaaag agctcaacaa caaattcagg
1861 tacgctgtgt ttggcctcgg ctccagcatg taccctcggt tctgtgcctt tgctcatgac
1921 attgatcaga agctgtccca cctgggggcc tctcagctca ccccgatggg agaaggggat
1981 gagctcagtg ggcaggagga cgccttccgc agctgggccg tgcaaatctt caaggcagcc
2041 tgtgagacgt ttgatgtccg aggcaaacag cacattcaga tccccaagct ctacacctcc
2101 aatgtgacct gggacccgca ccactacagg ctcgtgcagg actcacagcc tttggacctc
2161 agcaaagccc tcagcagcat gcatgccaag aacgtgttca ccatgaggct caaatctcgg
2221 cagaatctac aaagtccgac atccagccgt gccaccatcc tggtggaact ctcctgtgag
2281 gatggccaag gcctgaacta cctgccgggg gagcaccttg gggtttgccc aggcaaccag
2341 ccggccctgg tccaaggtat cctggagcga gtggtggatg gccccacacc ccaccagaca
2401 gtgcgcctgg aggccctgga tgagagtggc agctactggg tcagtgacaa gaggctgccc
2461 ccctgctcac tcagccaggc cctcacctac ttcctggaca tcaccacacc cccaacccag
2521 ctgctgctcc aaaagctggc ccaggtggcc acagaagagc ctgagagaca gaggctggag
2581 gccctgtgcc agccctcaga gtacagcaag tggaagttca ccaacagccc cacattcctg
2641 gaggtgctag aggagttccc gtccctgcgg gtgtctgctg gcttcctgct ttcccagctc
2701 cccattctga agcccaggtt ctactccatc agctcctccc gggatcacac gcccacagag
2761 atccacctga ctgtggccgt ggtcacctac cacaccggag atggccaggg tcccctgcac
2821 cacggtgtct gcagcacatg gctcaacagc ctgaagcccc aagacccagt gccctgcttt
2881 gtgcggaatg ccagcgcctt ccacctcccc gaggatccct cccatccttg catcctcatc
2941 gggcctggca caggcatcgc gcccttccgc agtttctggc agcaacggct ccatgactcc
3001 cagcacaagg gagtgcgggg aggccgcatg accttggtgt ttgggtgccg ccgcccagat
3061 gaggaccaca tctaccagga ggagatgctg gagatggccc agaagggggt gctgcatgcg
3121 gtgcacacag cctattcccg cctgcctggc aagcccaagg tctatgttca ggacatcctg
3181 cggcagcagc tggccagcga ggtgctccgt gtgctccaca aggagccagg ccacctctat
3241 gtttgcgggg atgtgcgcat ggcccgggac gtggcccaca ccctgaagca gctggtggct
3301 gccaagctga aattgaatga ggagcaggtc gaggactatt tctttcagct caagagccag
3361 aagcgctatc acgaagatat ctttggtgct gtatttcctt acgaggcgaa gaaggacagg
3421 gtggcggtgc agcccagcag cctggagatg tcagcgctct gagggcctac aggaggggtt
3481 aaagctgccg gcacagaact taaggatgga gccagctctg cattatctga ggtcacaggg
3541 cctggggaga tggaggaaag tgatatcccc cagcctcaag tcttatttcc tcaacgttgc
3601 tccccatcaa gccctttact tgacctccta acaagtagca ccctggattg atcggagcct
3661 cctctctcaa actggggcct ccctggtccc ttggagacaa aatcttaaat gccaggcctg
3721 gcaagtgggt gaaagatgga acttgctgct gagtgcacca cttcaagtga ccaccaggag
3781 gtgctatcgc accactgtgt atttaactgc cttgtgtaca gttatttatg cctctgtatt
3841 taaaaaacta acacccagtc tgttccccat ggccacttgg gtcttccctg tatgattcct
3901 tgatggagat atttacatga attgcatttt actttaatca cactgt
//