LOCUS       HSU19970                 590 bp    mRNA    linear   HUM 09-AUG-1995
DEFINITION  Human antimicrobial LPS-binding protein CAP18 precursor mRNA,
            complete cds.
ACCESSION   U19970
VERSION     U19970.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 590)
  AUTHORS   Larrick,J.W., Hirata,M., Balint,R.F., Lee,J., Zhong,J. and
            Wright,S.C.
  TITLE     Human CAP18: a novel antimicrobial lipopolysaccharide-binding
            protein
  JOURNAL   Infect. Immun. 63 (4), 1291-1297 (1995)
   PUBMED   7890387
REFERENCE   2  (bases 1 to 590)
  AUTHORS   Balint,R.F.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-1995) Robert F. Balint, Palo Alto Institute of
            Molecular Medicine, 2462 Wyandotte Street, Mountain View, CA 94043,
            USA
FEATURES             Location/Qualifiers
     source          1..590
                     /db_xref="H-InvDB:HIT000218541"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /tissue_type="bone marrow"
                     /dev_stage="adult"
     CDS             16..528
                     /function="antimicrobial LPS-binding protein"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /codon_start=1
                     /product="CAP18 precursor"
                     /protein_id="AAA74084.1"
                     /translation="MKTQRDGHSLGRWSLVLLLLGLVMPLAIIAQVLSYKEAVLRAID
                     GINQRSSDANLYRLLDLDPRPTMDGDPDTPKPVSFTVKETVCPRTTQQSPEDCDFKKD
                     GLVKRCMGTVTLNQARGSFDISCDKDNKRFALLGDFFRKSKEKIGKEFKRIVQRIKDF
                     LRNLVPRTES"
     sig_peptide     16..105
     mat_peptide     106..525
                     /product="Holo-CAP18"
                     /function="antimicrobial LPS-binding protein"
                     /experiment="experimental evidence, no additional details
                     recorded"
     misc_feature    106..414
                     /product="conserved N-terminal domain"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /function="unknown"
     misc_feature    415..525
                     /product="non-conserved C-terminal domain"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /function="antimicrobial LPS-binding domain"
     polyA_site      590
                     /note="9 A nucleotides"
BASE COUNT          146 a          148 c          171 g          125 t
ORIGIN      
        1 gcagacatgg ggaccatgaa gacccaaagg gatggccact ccctggggcg gtggtcactg
       61 gtgctcctgc tgctgggcct ggtgatgcct ctggccatca ttgcccaggt cctcagctac
      121 aaggaagctg tgcttcgtgc tatagatggc atcaaccagc ggtcctcgga tgctaacctc
      181 taccgcctcc tggacctgga ccccaggccc acgatggatg gggacccaga cacgccaaag
      241 cctgtgagct tcacagtgaa ggagacagtg tgccccagga cgacacagca gtcaccagag
      301 gattgtgact tcaagaagga cgggctggtg aagcggtgta tggggacagt gaccctcaac
      361 caggccaggg gctcctttga catcagttgt gataaggata acaagagatt tgccctgctg
      421 ggtgatttct tccggaaatc taaagagaag attggcaaag agtttaaaag aattgtccag
      481 agaatcaagg attttttgcg gaatcttgta cccaggacag agtcctagtg tgtgccctac
      541 cctggctcag gcttctgggc tctgagaaat aaactatgag agcaatttca
//