LOCUS       HSU19251                6124 bp    mRNA    linear   HUM 13-MAR-1998
DEFINITION  Homo sapiens neuronal apoptosis inhibitory protein mRNA, complete
            cds.
ACCESSION   U19251
VERSION     U19251.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6124)
  AUTHORS   Roy,N., Mahadevan,M.S., McLean,M., Shutler,G., Yaraghi,Z.,
            Farahini,R., Tamai,K., Ioannou,P., de Jong,P.J., Ikeda,J.,
            Korneluk,R.G. and MacKenzie,A.
  TITLE     The gene for neuronal apoptosis inhibitory protein is partially
            deleted in individuals with spinal muscular atrophy
  JOURNAL   Cell 80 (1), 167-178 (1995)
   PUBMED   7813013
REFERENCE   2  (bases 1 to 6124)
  AUTHORS   Chen,Q., Baird,S.D., Mahadevan,M., Besner-Johnston,A., Farahani,R.,
            Xuan,J.-Y., Kang,X., Lefebvre,C., Ikeda,J.-E., Korneluk,R.G. and
            MacKenzie,A.E.
  TITLE     Sequence of a 131-kb region of 5q13.1 containing the spinal
            muscular atrophy candidate genes SMN and NAIP
  JOURNAL   Genomics 48 (1), 121-127 (1998)
   PUBMED   9503025
REFERENCE   3  (bases 1 to 6124)
  AUTHORS   Baird,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-DEC-1994) Stephen D. Baird, Children's Hospital of
            Eastern Ontario, Molecular Genetics, 401 Smyth Rd., Ottawa,
            Ontario, K1H 8L1, Canada
REFERENCE   4  (bases 1 to 6124)
  AUTHORS   Baird,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-NOV-1997) Stephen D. Baird, Children's Hospital of
            Eastern Ontario, Molecular Genetics, 401 Smyth Rd., Ottawa,
            Ontario, K1H 8L1, Canada
COMMENT     On Nov 24, 1997 this sequence version replaced gi:632544.
FEATURES             Location/Qualifiers
     source          1..6124
                     /db_xref="H-InvDB:HIT000218505_01"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.1"
                     /tissue_type="brain"
                     /dev_stage="fetus"
     exon            1..73
                     /number=1
     exon            74..162
                     /number=2
     exon            163..288
                     /number=3
     exon            289..859
                     /number=4
     CDS             292..4503
                     /function="inhibitor of apoptosis"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="deleted in people with spinal muscular atrophy SMA;
                     NAIP"
                     /codon_start=1
                     /product="neuronal apoptosis inhibitory protein"
                     /protein_id="AAC52045.1"
                     /translation="MATQQKASDERISQFDHNLLPELSALLGLDAVQLAKELEEEEQK
                     ERAKMQKGYNSQMRSEAKRLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQCFCCSL
                     ILFGAGLTRLPIEDHKRFHPDCGFLLNKDVGNIAKYDIRVKNLKSRLRGGKMRYQEEE
                     ARLASFRNWPFYVQGISPCVLSEAGFVFTGKQDTVQCFSCGGCLGNWEEGDDPWKEHA
                     KWFPKCEFLRSKKSSEEITQYIQSYKGFVDITGEHFVNSWVQRELPMASAYCNDSIFA
                     YEELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDD
                     HTRCFPNCPFLQNMKSSAEVTPDLQSRGELCELLETTSESNLEDSIAVGPIVPEMAQG
                     EAQWFQEAKNLNEQLRAAYTSASFRHMSLLDISSDLATDHLLGCDLSIASKHISKPVQ
                     EPLVLPEVFGNLNSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSS
                     TRPDEGLASIICDQLLEKEGSVTEMCMRNIIQQLKNQVLFLLDDYKEICSIPQVIGKL
                     IQKNHLSRTCLLIAVRTNRARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRK
                     FMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNKATA
                     EILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFY
                     RFLSPAFQEFLAGMRLIELLDSDRQEHQDLGLYHLKQINSPMMTVSAYNNFLNYVSSL
                     PSTKAGPKIVSHLLHLVDNKESLENISENDDYLKHQPEISLQMQLLRGLWQICPQAYF
                     SMVSEHLLVLALKTAYQSNTVAACSPFVLQFLQGRTLTLGALNLQYFFDHPESLSLLR
                     SIHFPIRGNKTSPRAHFSVLETCFDKSQVPTIDQDYASAFEPMNEWERNLAEKEDNVK
                     SYMDMQRRASPDLSTGYWKLSPKQYKIPCLEVDVNDIDVVGQDMLEILMTVFSASQRI
                     ELHLNHSRGFIESIRPALELSKASVTKCSISKLELSAAEQELLLTLPSLESLEVSGTI
                     QSQDQIFPNLDKFLCLKELSVDLEGNINVFSVIPEEFPNFHHMEKLLIQISAEYDPSK
                     LVKLIQNSPNLHVFHLKCNFFSDFGSLMTMLVSCKKLTEIKFSDSFFQAVPFVASLPN
                     FISLKILNLEGQQFPDEETSEKFAYILGSLSNLEELILPTGDGIYRVAKLIIQQCQQL
                     HCLRVLSFFKTLNDDSVVEIAKVAISGGFQKLENLKLSINHKITEEGYRNFFQALDNM
                     PNLQELDISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNMLSWLLDADDIALLNVMK
                     ERHPQSKYLTILQKWILPFSPIIQK"
     exon            860..959
                     /number=5
     exon            960..1041
                     /number=6
     exon            1042..1093
                     /number=7
     exon            1094..1213
                     /number=8
     exon            1214..1313
                     /number=9
     exon            1314..1395
                     /number=10
     exon            1396..1453
                     /number=11
     exon            1454..3565
                     /number=12
     exon            3566..3733
                     /number=13
     exon            3734..3889
                     /number=14
     exon            3890..3973
                     /number=15
     exon            3974..4138
                     /number=16
     exon            4139..6124
                     /number=17
BASE COUNT         1803 a         1298 c         1285 g         1738 t
ORIGIN      
        1 acaaaaggtc ctgtgctcac ctgggaccct tctggacgtt gccctgtgta cctcttcgac
       61 tgcctgttca tctacgacga accccgggta ttgaccccag acaacaatgc cacttcatat
      121 tggggacttc gtctgggatt ccaaggtgca ttcattgcaa agttccttaa atattttctc
      181 actgcttcct actaaaggac ggacagagca tttgttcttc agccacatac tttccttcca
      241 ctggccagca ttctcctcta ttagactaga actgtggata aacctcagaa aatggccacc
      301 cagcagaaag cctctgacga gaggatctcc cagtttgatc acaatttgct gccagagctg
      361 tctgctcttc tgggcctaga tgcagttcag ttggcaaagg aactagaaga agaggagcag
      421 aaggagcgag caaaaatgca gaaaggctac aactctcaaa tgcgcagtga agcaaaaagg
      481 ttaaagactt ttgtgactta tgagccgtac agctcatgga taccacagga gatggcggcc
      541 gctgggtttt acttcactgg ggtaaaatct gggattcagt gcttctgctg tagcctaatc
      601 ctctttggtg ccggcctcac gagactcccc atagaagacc acaagaggtt tcatccagat
      661 tgtgggttcc ttttgaacaa ggatgttggt aacattgcca agtacgacat aagggtgaag
      721 aatctgaaga gcaggctgag aggaggtaaa atgaggtacc aagaagagga ggctagactt
      781 gcgtccttca ggaactggcc attttatgtc caagggatat ccccttgtgt gctctcagag
      841 gctggctttg tctttacagg taaacaggac acggtacagt gtttttcctg tggtggatgt
      901 ttaggaaatt gggaagaagg agatgatcct tggaaggaac atgccaaatg gttccccaaa
      961 tgtgaatttc ttcggagtaa gaaatcctca gaggaaatta cccagtatat tcaaagctac
     1021 aagggatttg ttgacataac gggagaacat tttgtgaatt cctgggtcca gagagaatta
     1081 cctatggcat cagcttattg caatgacagc atctttgctt acgaagaact acggctggac
     1141 tcttttaagg actggccccg ggaatcagct gtgggagttg cagcactggc caaagcaggt
     1201 cttttctaca caggtataaa ggacatcgtc cagtgctttt cctgtggagg gtgtttagag
     1261 aaatggcagg aaggtgatga cccattagac gatcacacca gatgttttcc caattgtcca
     1321 tttctccaaa atatgaagtc ctctgcggaa gtgactccag accttcagag ccgtggtgaa
     1381 ctttgtgaat tactggaaac cacaagtgaa agcaatcttg aagattcaat agcagttggt
     1441 cctatagtgc cagaaatggc acagggtgaa gcccagtggt ttcaagaggc aaagaatctg
     1501 aatgagcagc tgagagcagc ttataccagc gccagtttcc gccacatgtc tttgcttgat
     1561 atctcttccg atctggccac ggaccacttg ctgggctgtg atctgtctat tgcttcaaaa
     1621 cacatcagca aacctgtgca agaacctctg gtgctgcctg aggtctttgg caacttgaac
     1681 tctgtcatgt gtgtggaggg tgaagctgga agtggaaaga cggtcctcct gaagaaaata
     1741 gcttttctgt gggcatctgg atgctgtccc ctgttaaaca ggttccagct ggttttctac
     1801 ctctccctta gttccaccag accagacgag gggctggcca gtatcatctg tgaccagctc
     1861 ctagagaaag aaggatctgt tactgaaatg tgcatgagga acattatcca gcagttaaag
     1921 aatcaggtct tattcctttt agatgactac aaagaaatat gttcaatccc tcaagtcata
     1981 ggaaaactga ttcaaaaaaa ccacttatcc cggacctgcc tattgattgc tgtccgtaca
     2041 aacagggcca gggacatccg ccgataccta gagaccattc tagagatcaa agcatttccc
     2101 ttttataata ctgtctgtat attacggaag ctcttttcac ataatatgac tcgtctgcga
     2161 aagtttatgg tttactttgg aaagaaccaa agtttgcaga agatacagaa aactcctctc
     2221 tttgtggcgg cgatctgtgc tcattggttt cagtatcctt ttgacccatc ctttgatgat
     2281 gtggctgttt tcaagtccta tatggaacgc ctttccttaa ggaacaaagc gacagctgaa
     2341 attctcaaag caactgtgtc ctcctgtggt gagctggcct tgaaagggtt tttttcatgt
     2401 tgctttgagt ttaatgatga tgatctcgca gaagcagggg ttgatgaaga tgaagatcta
     2461 accatgtgct tgatgagcaa atttacagcc cagagactaa gaccattcta ccggttttta
     2521 agtcctgcct tccaagaatt tcttgcgggg atgaggctga ttgaactcct ggattcagat
     2581 aggcaggaac atcaagattt gggactgtat catttgaaac aaatcaactc acccatgatg
     2641 actgtaagcg cctacaacaa ttttttgaac tatgtctcca gcctcccttc aacaaaagca
     2701 gggcccaaaa ttgtgtctca tttgctccat ttagtggata acaaagagtc attggagaat
     2761 atatctgaaa atgatgacta cttaaagcac cagccagaaa tttcactgca gatgcagtta
     2821 cttaggggat tgtggcaaat ttgtccacaa gcttactttt caatggtttc agaacattta
     2881 ctggttcttg ccctgaaaac tgcttatcaa agcaacactg ttgctgcgtg ttctccattt
     2941 gttttgcaat tccttcaagg gagaacactg actttgggtg cgcttaactt acagtacttt
     3001 ttcgaccacc cagaaagctt gtcattgttg aggagcatcc acttcccaat acgaggaaat
     3061 aagacatcac ccagagcaca tttttcagtt ctggaaacat gttttgacaa atcacaggtg
     3121 ccaactatag atcaggacta tgcttctgcc tttgaaccta tgaatgaatg ggagcgaaat
     3181 ttagctgaaa aagaggataa tgtaaagagc tatatggata tgcagcgcag ggcatcacca
     3241 gaccttagta ctggctattg gaaactttct ccaaagcagt acaagattcc ctgtctagaa
     3301 gtcgatgtga atgatattga tgttgtaggc caggatatgc ttgagattct aatgacagtt
     3361 ttctcagctt cacagcgcat cgaactccat ttaaaccaca gcagaggctt tatagaaagc
     3421 atccgcccag ctcttgagct gtctaaggcc tctgtcacca agtgctccat aagcaagttg
     3481 gaactcagcg cagccgaaca ggaactgctt ctcaccctgc cttccctgga atctcttgaa
     3541 gtctcaggga caatccagtc acaagaccaa atctttccta atctggataa gttcctgtgc
     3601 ctgaaagaac tgtctgtgga tctggagggc aatataaatg ttttttcagt cattcctgaa
     3661 gaatttccaa acttccacca tatggagaaa ttattgatcc aaatttcagc tgagtatgat
     3721 ccttccaaac tagtaaaatt aattcaaaat tctccaaacc ttcatgtttt ccatctgaag
     3781 tgtaacttct tttcggattt tgggtctctc atgactatgc ttgtttcctg taagaaactc
     3841 acagaaatta agttttcgga ttcatttttt caagccgtcc catttgttgc cagtttgcca
     3901 aattttattt ctctgaagat attaaatctt gaaggccagc aatttcctga tgaggaaaca
     3961 tcagaaaaat ttgcctacat tttaggttct cttagtaacc tggaagaatt gatccttcct
     4021 actggggatg gaatttatcg agtggccaaa ctgatcatcc agcagtgtca gcagcttcat
     4081 tgtctccgag tcctctcatt tttcaagact ttgaatgatg acagcgtggt ggaaattgcc
     4141 aaagtagcaa tcagtggagg tttccagaaa cttgagaacc taaagctttc aatcaatcac
     4201 aagattacag aggaaggata cagaaatttc tttcaagcac tggacaacat gccaaacttg
     4261 caggagttgg acatctccag gcatttcaca gagtgtatca aagctcaggc cacaacagtc
     4321 aagtctttga gtcaatgtgt gttacgacta ccaaggctca ttagactgaa catgttaagt
     4381 tggctcttgg atgcagatga tattgcattg cttaatgtca tgaaagaaag acatcctcaa
     4441 tctaagtact taactattct ccagaaatgg atactgccgt tctctccaat cattcagaaa
     4501 taaaagattc agctaaaaac tgctgaatca ataatttgtc ttggggcata ttgaggatgt
     4561 aaaaaaagtt gttgattaat gctaaaaacc aaattatcca aaattatttt attaaatatt
     4621 gcatacaaaa gaaaatgtgt aaggcttgct aaaaaacaaa acaaaacaaa acacagtcct
     4681 gcatactcac caccaagctc aagaaataaa tcatcaccaa tacctttgag gtccctgagt
     4741 aatccacccc agctaaaggc aaacccttca atcaagttta tacagcaaac cctccattgt
     4801 ccatggtcaa cagggaaggg gttggggaca ggtctgccaa tctatctaaa agccacaata
     4861 tggaagaagt attcaattta tataataaat ggctaactta acggttgaat cactttcata
     4921 catggatgaa acgggtttaa cacaggatcc acatgaatct tctgtgggcc aagagatgtt
     4981 ccttaatcct tgtagaacct gttttctata ttgaactagc tttggtacag tagagttaac
     5041 ttactttcca tttatccact gccaatataa agaggaaaca ggggttaggg aaaaatgact
     5101 tcattccaga ggcttctcag agttcaacat atgctataat ttagaatttt cttatgaatc
     5161 cactctactt gggtagaaaa tattttatct ctagtgattg catattattt ccatatcata
     5221 gtatttcata gtattatatt tgatatgagt gtctatatca atgtcagtgt ccagaatttc
     5281 gttcctacca gttaagtagt tttctgaacg gccagaagac cattcgaaat tcatgatact
     5341 actataagtt ggtaaacaac catactttta tcctcatttt tattctcact aagaaaaaag
     5401 tcaactcccc tccccttgcc caagtatgaa atatagggac agtatgtatg gtgtggtctc
     5461 atttgtttag aaaaccactt atgactgggt gcggtggctc acacctgtaa tcccagcact
     5521 ttgggaggct gaggcgggcg aatcatttga ggtgaggaat tcgagaccag cctggccagc
     5581 atggtgaaac cccatctcta ctaaaaatac aaaaattagc caggtgtggt ggcacatgcc
     5641 tgtagtccca gccactaggg cggctgagac gcaagacttg cttgaacccg ggaggcagag
     5701 gttgcagtga gccaagatgg cgccactgca ttccagcctg ggcaacagag caagaccctg
     5761 tctgtctcaa aacaaaaaac aaaaccactt atattgctag ctacattaag aatttctgaa
     5821 tatgttactg agcttgcttg tggtaaccat ttataatatc agaaagtata tgtacaccaa
     5881 aacatgttga acatccatgt tgtacaactg aaatataaat aattttgtca attataccta
     5941 aataaaactg gaaaaaaatt tctggaagtt tatatctaaa aatgttaata gtgcgtacct
     6001 ctaggaagtg ggcctggaag ccattcttac ttttcagtct ctcccattct gtactgtttt
     6061 ttgttttact ttcgtgcctg cattattttt ctatttaaaa caaaaataaa tctagtttag
     6121 cact
//