LOCUS       HSU18299                4193 bp    mRNA    linear   HUM 20-JAN-1996
DEFINITION  Human damage-specific DNA binding protein DDBa p127 subunit (DDB1)
            mRNA, complete cds.
ACCESSION   U18299
VERSION     U18299.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4193)
  AUTHORS   Dualan,R., Brody,T., Keeney,S., Nichols,A.F., Admon,A. and Linn,S.
  TITLE     Chromosomal localization and cDNA cloning of the genes (DDB1 and
            DDB2) for the p127 and p48 subunits of a human damage-specific DNA
            binding protein
  JOURNAL   Genomics 29 (1), 62-69 (1995)
   PUBMED   8530102
REFERENCE   2  (bases 1 to 4193)
  AUTHORS   Nichols,A.F. and Linn,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-DEC-1994) Stuart Linn, University of California,
            Berkeley, 401 Barker Hall, Berkeley, CA 94720-3202, USA
FEATURES             Location/Qualifiers
     source          1..4193
                     /db_xref="H-InvDB:HIT000218448"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolate="skin fibroblast CRL 1262; lung fibroblast
                     IMR-90"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12-11q13.2"
                     /cell_line="IMR-90"
                     /cell_type="fibroblast"
                     /tissue_type="epidermal; fetal lung"
                     /dev_stage="fetal"
                     /note="same sequence in both tissues"
     gene            1..4193
                     /gene="DDB1"
     CDS             101..3523
                     /gene="DDB1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="damage-specific DNA binding protein p127 subunit;
                     implicated in Xeroderma pigmentosum group E"
                     /codon_start=1
                     /product="DDBa p127"
                     /protein_id="AAC50349.1"
                     /translation="MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVV
                     TAEGLRPVKEVGMYGKIAVMELFRPKGESKDLLFILTAKYNACILEYKQSGESIDIIT
                     RAHGNVQDRIGRPSETGIIGIIDPECRMIGLRLYDGLFKVIPLDRDNKELKAFNIRLE
                     ELHVIDVKFLYGCQAPTICFVYQDPQGRHVKTYEVSLREKEFNKGPWKQENVEAEASM
                     VIAVPEPFGGAIIIGQESITYHNGDKYLAIAPPIIKQSTIVCHNRVDPNGSRYLLGDM
                     EGRLFMLLLEKEEQMDGTVTLKDLRVELLGETSIAECLTYLDNGVVFVGSRLGDSQLV
                     KLNVDSNEQGSYVVAMETFTNLGPIVDMCVVDLERQGQGQLVTCSGAFKEGSLRIIRN
                     GIGIHEHASIDLPGIKGLWPLRSDPNRETDDTLVLSFVGQTRVLMLNGEEVEETELMG
                     FVDDQQTFFCGNVAHQQLIQITSASVRLVSQEPKALVSEWKEPQAKNISVASCNSSQV
                     VVAVGRALYYLQIHPQELRQISHTEMEHEVACLDITPLGDSNGLSPLCAIGLWTDISA
                     RILKLPSFELLHKEMLGGEIIPRSILMTTFESSHYLLCALGDGALFYFGLNIETGLLS
                     DRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPL
                     NSDGYPDSLALANNSTLTIGTIDEIQKLHIRTVPLYESPRKICYQEVSQCFGVLSSRI
                     EVQDTSGGTTALRPSASTQALSSSVSSSKLFSSSTAPHETSFGEEVEVHNLLIIDQHT
                     FEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEEAEPKQGRIVVFQYSDG
                     KLQTVAEKEVKGAVYSMVEFNGKLLASINSTVRLYEWTTEKELRTECNHYNNIMALYL
                     KTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEILDDDNFLGAENAF
                     NLFVCQKDSAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGETSTPTQGSVLF
                     GTVNGMIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTERKTEPATGF
                     IDGDLIESFLDISRPKMQEVVANLQYDDGSGMKREATADDLIKVVEELTRIH"
     regulatory      4184..4189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDB1"
BASE COUNT          979 a         1057 c         1127 g         1030 t
ORIGIN      
        1 gtggagttcg ctgcggctgt tgggggccac ctgtcttttc gcttgtgccc ctctttctag
       61 tgtcgcgctc gagtcccgac gggccgctcc aagcctcgac atgtcgtaca actacgtggt
      121 aacggcccag aagcccaccg ccgtgaacgg ctgcgtgacc ggacacttta cttcggccga
      181 agacttaaac ctgttgattg ccaaaaacac gagattagag atctatgtgg tcaccgccga
      241 ggggcttcgg cccgtcaaag aggtgggcat gtatgggaag attgcggtca tggagctttt
      301 caggcccaag ggggagagca aggacctgct gtttatcttg acagcgaagt acaatgcctg
      361 catcctggag tataaacaga gtggcgagag cattgacatc attacgcgag cccatggcaa
      421 tgtccaggac cgcattggcc gcccctcaga gaccggcatt attggcatca ttgaccctga
      481 gtgccggatg attggcctgc gtctctatga tggccttttc aaggttattc cactagatcg
      541 cgataataaa gaactcaagg ccttcaacat ccgcctggag gagctgcatg tcattgatgt
      601 caagttccta tatggttgcc aagcacctac tatttgcttt gtctaccagg accctcaggg
      661 gcggcacgta aaaacctatg aggtgtctct ccgagaaaag gaattcaata agggcccttg
      721 gaaacaggaa aatgtcgaag ctgaagcttc catggtgatc gcagtcccag agccctttgg
      781 gggggccatc atcattggac aggagtcaat cacctatcac aatggtgaca aatacctggc
      841 tattgcccct cctatcatca agcaaagcac gattgtgtgc cacaatcgag tggaccctaa
      901 tggctcaaga tacctgctgg gagacatgga aggccggctc ttcatgctgc ttttggagaa
      961 ggaggaacag atggatggca ccgtcactct caaggatctc cgtgtagaac tccttggaga
     1021 gacctctatt gctgagtgct tgacatacct tgataatggt gttgtgtttg tcgggtctcg
     1081 cctgggtgac tcccagcttg tgaagctcaa cgttgacagt aatgaacaag gctcctatgt
     1141 agtggccatg gaaaccttta ccaacttagg acccattgtc gatatgtgcg tggtggacct
     1201 ggagaggcag gggcaggggc agctggtcac ttgctctggg gctttcaagg aaggttcttt
     1261 gcggatcatc cggaatggaa ttggaatcca cgagcatgcc agcattgact taccaggcat
     1321 caaaggatta tggccactgc ggtctgaccc taatcgtgag actgatgaca ctttggtgct
     1381 ctcttttgtg ggccagacaa gagttctcat gttaaatgga gaggaggtag aagaaaccga
     1441 actgatgggt ttcgtggatg atcagcagac tttcttctgt ggcaacgtgg ctcatcagca
     1501 gcttatccag atcacttcag catcggtgag gttggtctct caagaaccca aagctctggt
     1561 cagtgaatgg aaggagcctc aggccaagaa catcagtgtg gcctcctgca atagcagcca
     1621 ggtggtggtg gctgtaggca gggccctcta ctatctgcag atccatcctc aggagctccg
     1681 gcagatcagc cacacagaga tggaacatga agtggcttgc ttggacatca ccccattagg
     1741 agacagcaat ggactgtccc ctctttgtgc cattggcctc tggacggaca tctcggctcg
     1801 tatcttgaag ttgccctctt ttgaactact gcacaaggag atgctgggtg gagagatcat
     1861 tcctcgctcc atcctgatga ccacctttga gagtagccat tacctccttt gtgccttggg
     1921 agatggagcg cttttctact ttgggctcaa cattgagaca ggtctgttga gcgaccgtaa
     1981 gaaggtgact ttgggcaccc agcccaccgt attgaggact tttcgttctc tttctaccac
     2041 caacgtcttt gcttgttctg accgccccac tgtcatctat agcagcaacc acaaattggt
     2101 cttctcaaat gtcaacctca aggaagtgaa ctacatgtgt cccctcaatt cagatggcta
     2161 tcctgacagc ctggcgctgg ccaacaatag caccctcacc attggcacca tcgatgagat
     2221 ccagaagctg cacattcgca cagttcccct ctatgagtct ccaaggaaga tctgctacca
     2281 ggaagtgtcc cagtgtttcg gggtcctctc cagccgcatt gaagtccaag acacgagtgg
     2341 gggcacgaca gccttgaggc ccagcgctag cacccaggct ctgtccagca gtgtaagctc
     2401 cagcaagctg ttctccagca gcactgctcc tcatgagacc tcctttggag aagaggtgga
     2461 ggtgcacaac ctacttatca ttgaccaaca cacctttgaa gtgcttcatg cccaccagtt
     2521 tctgcagaat gaatatgccc tcagtctggt ttcctgcaag ctgggcaaag accccaacac
     2581 ttacttcatt gtgggcacag caatggtgta tcctgaagag gcagagccca agcagggtcg
     2641 cattgtggtc tttcagtatt cggatggaaa actacagact gtggctgaaa aggaagtgaa
     2701 aggggccgtg tactctatgg tggaatttaa cgggaagctg ttagccagca tcaatagcac
     2761 ggtgcggctc tatgagtgga caacagagaa ggagctgcgc actgagtgca accactacaa
     2821 caacatcatg gccctctacc tgaagaccaa gggcgacttc atcctggtgg gcgaccttat
     2881 gcgctcagtg ctgctgcttg cctacaagcc catggaagga aactttgaag agattgctcg
     2941 agactttaat cccaactgga tgagtgctgt ggaaatcttg gatgatgaca attttctggg
     3001 ggctgaaaat gcctttaact tgtttgtgtg tcaaaaggat agcgctgcca ccactgacga
     3061 ggagcggcag cacctccagg aggttggtct tttccacctg ggcgagtttg tcaatgtctt
     3121 ttgccacggc tctctggtaa tgcagaatct gggtgagact tccaccccca cacaaggctc
     3181 ggtgctcttc ggcacggtca acggcatgat agggctggtg acctcactgt cagagagctg
     3241 gtacaacctc ctgctggaca tgcagaatcg actcaataaa gtcatcaaaa gtgtggggaa
     3301 gatcgagcac tccttctgga gatcctttca caccgagcgg aagacagaac cagccacagg
     3361 tttcatcgac ggtgacttga ttgagagttt cctggatatt agccgcccca agatgcagga
     3421 ggtggtggca aacctacagt atgacgatgg cagcggtatg aagcgagagg ccactgcaga
     3481 cgacctcatc aaggttgtgg aggagctaac tcggatccat tagccaaggg cagggggccc
     3541 cctttctgac cctccccaaa ggctttgccc tgctgccctc cccctcctct ccaccatcgt
     3601 cttcttggcc atgggaggcc tttccctaag ccagctgccc ccagagccac agttccccta
     3661 tgtggaagtg gggcgggctt catagagact tgggaatgag ctgaaggtga aacattttct
     3721 ccctggattt ttaccagtct cacatgattc cagccatcac cttagaccac caagccttga
     3781 ttggtgttgc cagttgtcct ccttccgggg aaggattttg cagttctttg gctgaaagga
     3841 agctgtgcgt gtgtgtgtgt gtatgtgtgt gtgtgtatgt gtatctcaca ctcatgcaat
     3901 gtcctctttt tatttagatt ggcagtgtag ggagttgtgg gtagtgggga agagggttag
     3961 gagggtttca ttgtctgtga agtgagacct tccttttact tttcttctat tgcctctgag
     4021 agcatcagcc tagaggcctg actgccaagc catgggtagc ctgggtgtaa aacctggaga
     4081 tggtggatga tccccacgcc acagcccttt tgtctctgca aactgccttc ttcggaaaga
     4141 agaaggtggg aggatgtgaa ttgttagttt ctgagtttta ccaaataaag tag
//