LOCUS HSU18259 6672 bp mRNA linear HUM 22-FEB-1996
DEFINITION Human clone CIITA-8 MHC class II transactivator CIITA mRNA,
complete cds.
ACCESSION U18259
VERSION U18259.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6672)
AUTHORS Riley,J.L., Westerheide,S.D., Price,J.A., Brown,J.A. and Boss,J.M.
TITLE Activation of class II MHC genes requires both the X box region and
the class II transactivator (CIITA)
JOURNAL Immunity 2 (5), 533-543 (1995)
PUBMED 7749984
REFERENCE 2 (bases 1 to 6672)
AUTHORS Boss,J.M.
TITLE Direct Submission
JOURNAL Submitted (07-DEC-1994) Jeremy M. Boss, Microbiology and
Immunology, Emory University, 1510 Clifton Rd., Atlanta, GA 30322,
USA
FEATURES Location/Qualifiers
source 1..6672
/db_xref="H-InvDB:HIT000218444"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="CIITA-8"
/cell_type="B-lymphocyte"
/clone_lib="cDNA library of M. Buchwald, Nature 356,
763-767 (1992)"
5'UTR <1..138
CDS 139..3531
/codon_start=1
/product="MHC class II transactivator CIITA"
/protein_id="AAA88861.1"
/translation="MRCLAPRPAGSYLSEPQGSSQCATMELGPLEGGYLELLNSDADP
LCLYHFYDQMDLAGEEEIELYSEPDTDTINCDQFSRLLCDMEGDEETREAYANIAELD
QYVFQDSQLEGLSKDIFKHIGPDEVIGESMEMPAEVGQKSQKRPFPEELPADLKHWKP
AEPPTVVTGSLLVGPVSDCSTLPCLPLPALFNQEPASGQMRLEKTDQIPMPFSSSSLS
CLNLPEGPIQFVPTISTLPHGLWQISEAGTGVSSIFIYHGEVPQASQVPPPSGFTVHG
LPTSPDRPGSTSPFAPSATDLPSMPEPALTSRANMTEHKTSPTQCPAAGEVSNKLPKW
PEPVEQFYRSLQDTYGAEPAGPDGILVEVDLVQARLERSSSKSLERELATPDWAERQL
AQGGLAEVLLAAKEHRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGRLPQYDFVFS
VPCHCLNRPGDAYGLQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDAFEELEAQD
GFLHSTCGPAPAEPCSLRGLLAGLFQKKLLRGCTLLLTARPRGRLVQSLSKADALFEL
SGFSMEQAQAYVMRYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEAL
LELGEDAKLPSTLTGLYVGLLGRAALDSPPGALAELAKLAWELGRRHQSTLQEDQFPS
ADVRTWAMAKGLVQHPPRAAESELAFPSFLLQCFLGALWLALSGEIKDKELPQYLALT
PRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRLQP
GTLRARQLLELLHCAHEAEEAGIWQHVVQELPGRLSFLGTRLTPPDAHVLGKALEAAG
QDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSDTVALWESLRQHGETKLLQAAEEK
FTIEPFKAKSLKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPVSGPQA
FPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDL
GAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAG
AQQLAASLRRCPHVETLAMWTPTIPFSVQEHLQQQDSRISLR"
3'UTR 3532..>6672
BASE COUNT 1392 a 1954 c 1868 g 1458 t
ORIGIN
1 cctcccaact ggtgactggt tagtgatgag gctgtgtgct tctgagctgg gcatccgaag
61 gcatccttgg ggaagctgag ggcacgagga ggggctgcca gactccggga gctgctgcct
121 ggctgggatt cctacacaat gcgttgcctg gctccacgcc ctgctgggtc ctacctgtca
181 gagccccaag gcagctcaca gtgtgccacc atggagttgg ggcccctaga aggtggctac
241 ctggagcttc ttaacagcga tgctgacccc ctgtgcctct accacttcta tgaccagatg
301 gacctggctg gagaagaaga gattgagctc tactcagaac ccgacacaga caccatcaac
361 tgcgaccagt tcagcaggct gttgtgtgac atggaaggtg atgaagagac cagggaggct
421 tatgccaata tcgcggaact ggaccagtat gtcttccagg actcccagct ggagggcctg
481 agcaaggaca ttttcaagca cataggacca gatgaagtga tcggtgagag tatggagatg
541 ccagcagaag ttgggcagaa aagtcagaaa agacccttcc cagaggagct tccggcagac
601 ctgaagcact ggaagccagc tgagcccccc actgtggtga ctggcagtct cctagtggga
661 ccagtgagcg actgctccac cctgccctgc ctgccactgc ctgcgctgtt caaccaggag
721 ccagcctccg gccagatgcg cctggagaaa accgaccaga ttcccatgcc tttctccagt
781 tcctcgttga gctgcctgaa tctccctgag ggacccatcc agtttgtccc caccatctcc
841 actctgcccc atgggctctg gcaaatctct gaggctggaa caggggtctc cagtatattc
901 atctaccatg gtgaggtgcc ccaggccagc caagtacccc ctcccagtgg attcactgtc
961 cacggcctcc caacatctcc agaccggcca ggctccacca gccccttcgc tccatcagcc
1021 actgacctgc ccagcatgcc tgaacctgcc ctgacctccc gagcaaacat gacagagcac
1081 aagacgtccc ccacccaatg cccggcagct ggagaggtct ccaacaagct tccaaaatgg
1141 cctgagccgg tggagcagtt ctaccgctca ctgcaggaca cgtatggtgc cgagcccgca
1201 ggcccggatg gcatcctagt ggaggtggat ctggtgcagg ccaggctgga gaggagcagc
1261 agcaagagcc tggagcggga actggccacc ccggactggg cagaacggca gctggcccaa
1321 ggaggcctgg ctgaggtgct gttggctgcc aaggagcacc ggcggccgcg tgagacacga
1381 gtgattgctg tgctgggcaa agctggtcag ggcaagagct attgggctgg ggcagtgagc
1441 cgggcctggg cttgtggccg gcttccccag tacgactttg tcttctctgt cccctgccat
1501 tgcttgaacc gtccggggga tgcctatggc ctgcaggatc tgctcttctc cctgggccca
1561 cagccactcg tggcggccga tgaggttttc agccacatct tgaagagacc tgaccgcgtt
1621 ctgctcatcc tagacgcctt cgaggagctg gaagcgcaag atggcttcct gcacagcacg
1681 tgcggaccgg caccggcgga gccctgctcc ctccgggggc tgctggccgg ccttttccag
1741 aagaagctgc tccgaggttg caccctcctc ctcacagccc ggccccgggg ccgcctggtc
1801 cagagcctga gcaaggccga cgccctattt gagctgtccg gcttctccat ggagcaggcc
1861 caggcatacg tgatgcgcta ctttgagagc tcagggatga cagagcacca agacagagcc
1921 ctgacgctcc tccgggaccg gccacttctt ctcagtcaca gccacagccc tactttgtgc
1981 cgggcagtgt gccagctctc agaggccctg ctggagcttg gggaggacgc caagctgccc
2041 tccacgctca cgggactcta tgtcggcctg ctgggccgtg cagccctcga cagccccccc
2101 ggggccctgg cagagctggc caagctggcc tgggagctgg gccgcagaca tcaaagtacc
2161 ctacaggagg accagttccc atccgcagac gtgaggacct gggcgatggc caaaggctta
2221 gtccaacacc caccgcgggc cgcagagtcc gagctggcct tccccagctt cctcctgcaa
2281 tgcttcctgg gggccctgtg gctggctctg agtggcgaaa tcaaggacaa ggagctcccg
2341 cagtacctag cattgacccc aaggaagaag aggccctatg acaactggct ggagggcgtg
2401 ccacgctttc tggctgggct gatcttccag cctcccgccc gctgcctggg agccctactc
2461 gggccatcgg cggctgcctc ggtggacagg aagcagaagg tgcttgcgag gtacctgaag
2521 cggctgcagc cggggacact gcgggcgcgg cagctgcttg agctgctgca ctgcgcccac
2581 gaggccgagg aggctggaat ttggcagcac gtggtacagg agctccccgg ccgcctctct
2641 tttctgggca cccgcctcac gcctcctgat gcacatgtac tgggcaaggc cttggaggcg
2701 gcgggccaag acttctccct ggacctccgc agcactggca tttgcccctc tggattgggg
2761 agcctcgtgg gactcagctg tgtcacccgt ttcagggctg ccttgagcga cacggtggcg
2821 ctgtgggagt ccctgcggca gcatggggag accaagctac ttcaggcagc agaggagaag
2881 ttcaccatcg agcctttcaa agccaagtcc ctgaaggatg tggaagacct gggaaagctt
2941 gtgcagactc agaggacgag aagttcctcg gaagacacag ctggggagct ccctgctgtt
3001 cgggacctaa agaaactgga gtttgcgctg ggccctgtct caggccccca ggctttcccc
3061 aaactggtgc ggatcctcac ggccttttcc tccctgcagc atctggacct ggatgcgctg
3121 agtgagaaca agatcgggga cgagggtgtc tcgcagctct cagccacctt cccccagctg
3181 aagtccttgg aaaccctcaa tctgtcccag aacaacatca ctgacctggg tgcctacaaa
3241 ctcgccgagg ccctgccttc gctcgctgca tccctgctca ggctaagctt gtacaataac
3301 tgcatctgcg acgtgggagc cgagagcttg gctcgtgtgc ttccggacat ggtgtccctc
3361 cgggtgatgg acgtccagta caacaagttc acggctgccg gggcccagca gctcgctgcc
3421 agccttcgga ggtgtcctca tgtggagacg ctggcgatgt ggacgcccac catcccattc
3481 agtgtccagg aacacctgca acaacaggat tcacggatca gcctgagatg atcccagctg
3541 tgctctggac aggcatgttc tctgaggaca ctaaccacgc tggaccttga actgggtact
3601 tgtggacaca gctcttctcc aggctgtatc ccatgagcct cagcatcctg gcacccggcc
3661 cctgctggtt cagggttggc ccctgcccgg ctgcggaatg aaccacatct tgctctgctg
3721 acagacacag gcccggctcc aggctccttt agcgcccagt tgggtggatg cctggtggca
3781 gctgcggtcc acccaggagc cccgaggcct tctctgaagg acattgcgga cagccacggc
3841 caggccagag ggagtgacag aggcagcccc attctgcctg cccaggcccc tgccaccctg
3901 gggagaaagt acttcttttt ttttattttt agacagggtc tcactgttgc ccaggctggc
3961 gtgcagtggt gcgatctggg ttcactgcaa cctccgcctc ttgggttcaa gcgattcttc
4021 tgcttcagcc tcccgagtag ctgggactac aggcacccac catcatgtct ggctaatttt
4081 tcatttttgg tagagacagg gttttgccgt gttggccggg ctggtctcga actcttgacc
4141 tcgggtgatc cacccacctc agcctcccaa agtgctggga ttacaagcgt gagccactgc
4201 accgggccac agagaaagta cttctccacc ctgctctccg accagacacc ttgacagggc
4261 acaccgggca ctcagaagac actgatgggc aacccccagc ctgctaattc cccagattgc
4321 aacaggctgg gcttcagtgg cagctgcttt tgtctatggg actcaatgca ctgacattgt
4381 tggccaaagc caaagctagg cctggccaga tgcaccagcc cttagcaggg aaacagctaa
4441 tgggacacta atggggcggt gagaggggaa cagactggaa gcacagcttc atttcctgtg
4501 tcttttttca ctacattata aatgtctctt taatgtcaca ggcaggtccc agggtttgag
4561 ttcataccct gttaccattt tggggtaccc actgctctgg ttatctaata tgtaacaagc
4621 caccccaaat catagtggct taaaacaaca ctcacattta ttctgctcac atatctgtca
4681 tttgagcagg gctcagcggg gacagctcct tctgtcctac tctgtgtcag gtggggcagc
4741 ttgagggttg ggctggtgtc acctgaagac tcattcttct gtacgtctga caggcaatgc
4801 tggctgttgg ctgggggcct cagtgcacta cggaatagtt ggctaggacc cctccatgtg
4861 ggctagttgg gcttcctcat aagtatggtg gctgggttgg agggtgtccc aaaaagaaag
4921 gaggggatag agagagacca cttttcataa cctagcctta gaagtcacac agtattactt
4981 ctgctacata tatatgtttt aagaggcagg gtctcactct gtgcccccag tctggaatcc
5041 agtggtatga tcacggctca ctgcagcctc aacctcctgg gctaagtgat cctcccacct
5101 cagcctcccg aatagctggg actacaggtg tgagtcacca aagcccagtt aatctttagt
5161 tttcattttt gtagagccag ggtctcacta tgttgcccag gcaggtcttg aactcctggc
5221 ctcaagtgat tctcctgcct cagcctccca aagtgctggg attacaggtg tgaaccacca
5281 cacccagccc acttctgcca tattctgttg gccagtgtga caaggattgc tactgtccta
5341 cccaccctcc tttccaccac atgtgcacat gcacgtgtgt gcacgtacac acacatacac
5401 acacacgcgt gcacacacca gagcccacct tggctcaagt cctcttttct gagaggactt
5461 ttctttgtgg cttcctaaaa ttcagtggaa aattaattgt ttggggatga gaaaggttga
5521 agcaccaaaa gcttaccaag gggaatgttt gcctctgcct ctgacacaca gctctgtcct
5581 gggagtgagc tggtttttag cggagacgga gtcccacctt ggctgcaggg agtcgaaagg
5641 acttggaagc tccgctttct acccagcgag cccctggtgg cagtgggagc tgcctgttca
5701 gctccagctc accagcccca gtgcccacag gatcagtctg attcccaagc tctgctcctc
5761 tccccagcaa gtgagagctg ggtgtcaaga gggtctgagg aatccagacc cggctgcgtg
5821 gttgatgatc tttgcagaca ggcaagcacc tcctgcctcg aactggctgc aaagggtatc
5881 aggtgctgcc atccaggttc agcttgtaaa tagctcaggt gtaccctgca cttgcagact
5941 ctacagaggc catgggctcc tgtgtgtgcg gctacaggag tgagcactga ggtgtgctct
6001 gatcatccac tgtgccatgt gccaggtttt tggtctgacc cactgctttt ggtctgtgtg
6061 atgatgaaat gaggtcagag cctcgagtta ttaacactaa cgatttgtta atgatagcta
6121 ctgtttatta ttttatttaa tttttttgag acagagtttt cactcttatg cccacgctgg
6181 agtgcagtga gccgagatca cgccactgca ctatagccta ggtgacagag tgagactctg
6241 tctcaaaaaa acacaaaagt ttctcttttt caaaacattt tactttaaaa ggagccaatt
6301 taaagaaaac tgttaatagt tcaggtaaca ggcagataca ggaaaagctg ctgacagtgt
6361 tgtatgaggt ttgaggattt tgatccaagc tggtccactc agtccatagc agagaatgaa
6421 agggcccaga gagggtggtg acctctgcct gaagtcacac agtgagtcga ggacagggag
6481 gtgaccccag gtttctatgt gtagggcggg aggatgttct gggacacagt tcaattctca
6541 tttgtcacac actttggcta ttagagatca accccttcgc tcctgtgtct tgcaatggca
6601 gccttggcaa acgctaaatg aaaatcgtga caacacttgt gttatgaagc atttactttg
6661 tgttcacctt gt
//