LOCUS U18121 6474 bp mRNA linear HUM 12-OCT-2005
DEFINITION Homo sapiens p136 (K88dsRBP) mRNA, complete cds.
ACCESSION U18121
VERSION U18121.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6474)
AUTHORS Patterson,J.B. and Samuel,C.E.
TITLE Expression and regulation by interferon of a
double-stranded-RNA-specific adenosine deaminase from human cells:
evidence for two forms of the deaminase
JOURNAL Mol. Cell. Biol. 15 (10), 5376-5388 (1995)
PUBMED 7565688
REFERENCE 2 (bases 1 to 6474)
AUTHORS Patterson,J.B., Thomis,D.C., Hans,S.L. and Samuel,C.E.
TITLE Mechanism of interferon action: double-stranded RNA-specific
adenosine deaminase from human cells is inducible by alpha and
gamma interferons
JOURNAL Virology 210 (2), 508-511 (1995)
PUBMED 7618288
REFERENCE 3 (bases 1 to 6474)
AUTHORS Kim,U., Wang,Y., Sanford,T., Zeng,Y. and Nishikura,K.
TITLE Molecular cloning of cDNA for double-stranded RNA adenosine
deaminase, a candidate enzyme for nuclear RNA editing
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (24), 11457-11461 (1994)
PUBMED 7972084
REFERENCE 4 (bases 1 to 6474)
AUTHORS Samuel,C.E.
TITLE Direct Submission
JOURNAL Submitted (05-DEC-1994) Charles E. Samuel, Biological Sciences,
Division of Molecular, Cellular and Developmental Biology,
University of California at Santa Barbara, Santa Barbara, CA 93106,
USA
FEATURES Location/Qualifiers
source 1..6474
/db_xref="H-InvDB:HIT000218436"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="interferon-treated U cells"
/tissue_type="kidney"
/dev_stage="adult"
gene 1..6474
/gene="K88dsRBP"
5'UTR <1..47
/gene="K88dsRBP"
misc_difference 29
/gene="K88dsRBP"
/note="conflict"
/citation=[2]
/replace="a"
CDS 48..3728
/gene="K88dsRBP"
/function="double-stranded RNA binding protein"
/codon_start=1
/product="p136"
/protein_id="AAC13782.1"
/translation="MNPRQGYSLSGYYTHPFQGYEHRQLRYQQPGPGSSPSSFLLKQI
EFLKGQLPEAPVIGKQTPSLPPSLPGLRPRFPVLLASSTRGRQVDIRGVPRGVHLGSQ
GLQRGFQHPSPRGRSLPQRGVDCLSSHFQELSIYQDQEQRILKFLEELGEGKATTAHD
LSGKLGTPKKEINRVLYSLAKKGKLQKEAGTPPLWKIAVSTQAWNQHSGVVRPDGHSQ
GAPNSDPSLEPEDRNSTSVSEDLLEPFIAVSAQAWNQHSGVVRPDSHSQGSPNSDPGL
EPEDSNSTSALEDPLEFLDMAEIKEKICDYLFNVSDSSALNLAKNIGLTKARDINAVL
IDMERQGDVYRQGTTPPIWHLTDKKRERMQIKRNTNSVPETAPAAIPETRRNAEFLTC
NIPTSNASNNMVTTEKVENGQEPVIKLENRQEARPEPARLKPPVHYNGPSKAGYVDFE
NGQWATDDIPDDLNSIRAAPGEFRAIMEMPSFYSHGLPRCSPYKKLTECQLKNPISGL
LEYAQFASQTCEFNMIEQSGPPHEPRFKFQVVINGREFPPAEAGSKKVAKQDAAMKAM
TILLEEAKAKDSGKSEESSHYSTEKESEKTAESQTPTPSATSFFSGKSPVTTLLECMH
KLGNSCEFRLLSKEGPAHEPKFQYCVAVGAQTFPSVSAPSKKVAKQMAAEEAMKALHG
EATNSMASDNQPEGMISESLDNLESMMPNKVRKIGELVRYLNTNPVGGLLEYARSHGF
AAEFKLVDQSGPPHEPKFVYQAKVGGRWFPAVCAHSKKQGKQEAADAALRVLIGENEK
AERMGFTEVTPVTGASLRRTMLLLSRSPEAQPKTLPLTGSTFHDQIAMLSHRCFNTLT
NSFQPSLLGRKILAAIIMKKDSEDMGVVVSLGTGNRCVKGDSLSLKGETVNDCHAEII
SRRGFIRFLYSELMKYNSQTAKDSIFEPAKGGEKLQIKKTVSFHLYISTAPCGDGALF
DKSCSDRAMESTESRHYPVFENPKQGKLRTKVENGEGTIPVESSDIVPTWDGIRLGER
LRTMSCSDKILRWNVLGLQGALLTHFLQPIYLKSVTLGYLFSQGHLTRAICCRVTRDG
SAFEDGLRHPFIVNHPKVGRVSIYDSKRQSGKTKETSVNWCLADGYDLEILDGTRGTV
DGPRNELSRVSKKNIFLLFKKLCSFRYRRDLLRLSYGEAKKAARDYETAKNYFKKGLK
DMGYGNWISKPQEEKNFYLCPV"
repeat_region 636..929
/gene="K88dsRBP"
/rpt_type=tandem
/rpt_unit_range=636..782
misc_difference 1198
/gene="K88dsRBP"
/note="conflict"
/citation=[2]
/replace="a"
misc_feature 1704..1754
/gene="K88dsRBP"
/note="encodes RNA binding domain core, copy R1"
misc_feature 2037..2087
/gene="K88dsRBP"
/note="encodes RNA binding domain core, copy R2"
misc_feature 2373..2423
/gene="K88dsRBP"
/note="encodes RNA binding domain core, copy R3"
3'UTR 3729..>6474
/gene="K88dsRBP"
misc_difference 4348
/gene="K88dsRBP"
/note="conflict"
/citation=[2]
/replace="c"
misc_difference 4586
/gene="K88dsRBP"
/note="conflict"
/citation=[2]
/replace="c"
repeat_region 5104..5335
/gene="K88dsRBP"
/rpt_type=direct
misc_difference 5519
/gene="K88dsRBP"
/note="conflict"
/citation=[2]
/replace="a"
misc_difference 5672
/gene="K88dsRBP"
/note="conflict"
/citation=[2]
/replace=""
misc_difference 6047..6054
/gene="K88dsRBP"
/note="conflict"
/citation=[2]
/replace=""
repeat_region 6199..6432
/gene="K88dsRBP"
/rpt_type=direct
regulatory 6435..6440
/regulatory_class="polyA_signal_sequence"
/gene="K88dsRBP"
/note="putative"
regulatory 6452..6457
/regulatory_class="polyA_signal_sequence"
/gene="K88dsRBP"
/note="putative"
BASE COUNT 1697 a 1632 c 1577 g 1568 t
ORIGIN
1 gggtcgtgcc gccggcgggt cgggccgggc aatgcctcgc gggcgcaatg aatccgcggc
61 aggggtattc cctcagcgga tactacaccc atccatttca aggctatgag cacagacagc
121 tcagatacca gcagcctggg ccaggatctt cccccagtag tttcctgctt aagcaaatag
181 aatttctcaa ggggcagctc ccagaagcac cggtgattgg aaagcagaca ccgtcactgc
241 caccttccct cccaggactc cggccaaggt ttccagtact acttgcctcc agtaccagag
301 gcaggcaagt ggacatcagg ggtgtcccca ggggcgtgca tctcggaagt caggggctcc
361 agagagggtt ccagcatcct tcaccacgtg gcaggagtct gccacagaga ggtgttgatt
421 gcctttcctc acatttccag gaactgagta tctaccaaga tcaggaacaa aggatcttaa
481 agttcctgga agagcttggg gaagggaagg ccaccacagc acatgatctg tctgggaaac
541 ttgggactcc gaagaaagaa atcaatcgag ttttatactc cctggcaaag aagggcaagc
601 tacagaaaga ggcaggaaca ccccctttgt ggaaaatcgc ggtctccact caggcttgga
661 accagcacag cggagtggta agaccagacg gtcatagcca aggagcccca aactcagacc
721 cgagtttgga accggaagac agaaactcca catctgtctc agaagatctt cttgagcctt
781 ttattgcagt ctcagctcag gcttggaacc agcacagcgg agtggtaaga ccagacagtc
841 atagccaagg atccccaaac tcagacccag gtttggaacc tgaagacagc aactccacat
901 ctgccttgga agatcctctt gagtttttag acatggccga gatcaaggag aaaatctgcg
961 actatctctt caatgtgtct gactcctctg ccctgaattt ggctaaaaat attggcctta
1021 ccaaggcccg agatataaat gctgtgctaa ttgacatgga aaggcagggg gatgtctata
1081 gacaagggac aacccctccc atatggcatt tgacagacaa gaagcgagag aggatgcaaa
1141 tcaagagaaa tacgaacagt gttcctgaaa ccgctccagc tgcaatccct gagaccagaa
1201 gaaacgcaga gttcctcacc tgtaatatac ccacatcaaa tgcctcaaat aacatggtaa
1261 ccacagaaaa agtggagaat gggcaggaac ctgtcataaa gttagaaaac aggcaagagg
1321 ccagaccaga accagcaaga ctgaaaccac ctgttcatta caatggcccc tcaaaagcag
1381 ggtatgttga ctttgaaaat ggccagtggg ccacagatga catcccagat gacttgaata
1441 gtatccgcgc agcaccaggt gagtttcgag ccatcatgga gatgccctcc ttctacagtc
1501 atggcttgcc acggtgttca ccctacaaga aactgacaga gtgccagctg aagaacccca
1561 tcagcgggct gttagaatat gcccagttcg ctagtcaaac ctgtgagttc aacatgatag
1621 agcagagtgg accaccccat gaacctcgat ttaaattcca ggttgtcatc aatggccgag
1681 agtttccccc agctgaagct ggaagcaaga aagtggccaa gcaggatgca gctatgaaag
1741 ccatgacaat tctgctagag gaagccaaag ccaaggacag tggaaaatca gaagaatcat
1801 cccactattc cacagagaaa gaatcagaga agactgcaga gtcccagacc cccacccctt
1861 cagccacatc cttcttttct gggaagagcc ccgtcaccac actgcttgag tgtatgcaca
1921 aattggggaa ctcctgcgaa ttccgtctcc tgtccaaaga aggccctgcc catgaaccca
1981 agttccaata ctgtgttgca gtgggagccc aaactttccc cagtgtgagt gctcccagca
2041 agaaagtggc aaagcagatg gccgcagagg aagccatgaa ggccctgcat ggggaggcga
2101 ccaactccat ggcttctgat aaccagcctg aaggtatgat ctcagagtca cttgataact
2161 tggaatccat gatgcccaac aaggtcagga agattggcga gctcgtgaga tacctgaaca
2221 ccaaccctgt gggtggcctt ttggagtacg cccgctccca tggctttgct gctgaattca
2281 agttggtcga ccagtccgga cctcctcacg agcccaagtt cgtttaccaa gcaaaagttg
2341 ggggtcgctg gttcccagcc gtctgcgcac acagcaagaa gcaaggcaag caggaagcag
2401 cagatgcggc tctccgtgtc ttgattgggg agaacgagaa ggcagaacgc atgggtttca
2461 cagaggtaac cccagtgaca ggggccagtc tcagaagaac tatgctcctc ctctcaaggt
2521 ccccagaagc acagccaaag acactccctc tcactggcag caccttccat gaccagatag
2581 ccatgctgag ccaccggtgc ttcaacactc tgactaacag cttccagccc tccttgctcg
2641 gccgcaagat tctggccgcc atcattatga aaaaagactc tgaggacatg ggtgtcgtcg
2701 tcagcttggg aacagggaat cgctgtgtga aaggagattc tctcagccta aaaggagaaa
2761 ctgtcaatga ctgccatgca gaaataatct cccggagagg cttcatcagg tttctctaca
2821 gtgagttaat gaaatacaac tcccagactg cgaaggatag tatatttgaa cctgctaagg
2881 gaggagaaaa gctccaaata aaaaagactg tgtcattcca tctgtatatc agcactgctc
2941 cgtgtggaga tggcgccctc tttgacaagt cctgcagcga ccgtgctatg gaaagcacag
3001 aatcccgcca ctaccctgtc ttcgagaatc ccaaacaagg aaagctccgc accaaggtgg
3061 agaacggaga aggcacaatc cctgtggaat ccagtgacat tgtgcctacg tgggatggca
3121 ttcggctcgg ggagagactc cgtaccatgt cctgtagtga caaaatccta cgctggaacg
3181 tgctgggcct gcaaggggca ctgttgaccc acttcctgca gcccatttat ctcaaatctg
3241 tcacattggg ttaccttttc agccaagggc atctgacccg tgctatttgc tgtcgtgtga
3301 caagagatgg gagtgcattt gaggatggac tacgacatcc ctttattgtc aaccacccca
3361 aggttggcag agtcagcata tatgattcca aaaggcaatc cgggaagact aaggagacaa
3421 gcgtcaactg gtgtctggct gatggctatg acctggagat cctggacggt accagaggca
3481 ctgtggatgg gccacggaat gaattgtccc gggtctccaa aaagaacatt tttcttctat
3541 ttaagaagct ctgctccttc cgttaccgca gggatctact gagactctcc tatggtgagg
3601 ccaagaaagc tgcccgtgac tacgagacgg ccaagaacta cttcaaaaaa ggcctgaagg
3661 atatgggcta tgggaactgg attagcaaac cccaggagga aaagaacttt tatctctgcc
3721 cagtatagta tgctccagtg acagatggat tagggtgtgt catactaggg tgtgagagag
3781 gtaggtcgta gcattcctca tcacatggtc aggggatttt tttttctcct tttttttttc
3841 tttttaagcc ataattggtg atactgaaaa ctttgggttc ccatttatcc tgctttcttt
3901 gggattgcta ggcaaggtct ggccaggccc cccttttttc ccccaagtga agaggcagaa
3961 acctaagaag ttatcttttc tttctaccca aagcatacat agtcactgag cacctgcggt
4021 ccatttcctc ttaaaagttt tgttttgatt tgtttccatt tcctttccct ttgtgtttgc
4081 tacactgacc tcttgcggtc ttgattaggt ttcagtcaac tctggatcat gtcagggact
4141 gataatttca tttgtggatt acgcagaccc ctctacttcc cctctttccc ttctgagatt
4201 ctttccttgt gatctgaatg tctccttttc cccctcagag ggcaaagagg tgaacataaa
4261 ggatttggtg aaacatttgt aagggtagga gttgaaaact gcagttccca gtgccacgga
4321 agtgtgattg gagcctgcag ataatgctca gccatcctcc catcctgcac tttagccagc
4381 tgcagggcgg gcaaggcaag gaaagctgct tccctggaag tgtatcactt tctccggcag
4441 ctgggaagtc tagaaccagc cagactgggt taagggagct gctcaagcaa tagcagaggt
4501 ttcacccggc aggatgacac agaccacttc ccagggagca cgggcatgcc ttggaatatt
4561 gccaagcttc cagctgcctc ttctcttaaa gcattcctag gaatattttc cccgccaatg
4621 ctgggcgtac accctagcca acgggacaaa tcctagaggg tataaaatca tctctgctca
4681 gataatcatg acttagcaag aataagggca aaaaatcctg ttggcttaac gtcactgttc
4741 cacccggtgt aatatctctc atgacagtga caccaaggga agttgactaa gtcacatgta
4801 aattaggagt gttttaaaga atgccataga tgttgattct taactgctac agataacctg
4861 taattgagca gatttaaaat tcaggcatac ttttccattt atccaagtgc tttcattttt
4921 ccagatggct tcagaagtag gctcgtgggc agggcgcaga cctgatcttt atagggttga
4981 catagaaagc agtagttgtg ggtgaaaggg caggttgtct tcaaactctg tgaggtagaa
5041 tcctttgtct atacctccat gaacattgac tcgtgtgttc agagcctttg gcctctctgt
5101 ggagtctggc tctctggctc ctgtgcattc tttgaatagt cactcgtaaa aactgtcagt
5161 gcttgaaact gtttccttta ctcatgttga agggactttg ttggctttta gagtgttggt
5221 catgactcca agagcagagc agggaagagc ccaagcatag acttggtgcc gtggtgatgg
5281 ctgcagtcca gttttgtgat gctgctttta cgtgtccctc gataacagtc agctagacac
5341 actcaggagg actactgagg ctctgcgacc ttcaggagct gagcctgcct ctctccttta
5401 gatgacagac cttcatctgg gaacgtgctg agccagcacc ctcagatgat ttccctccaa
5461 actgctgact aggtcatcct ctgtctggta gagacattca catctttgct tttattctgt
5521 gctctctgta cttttgacca aaaattgacc aaagtaagaa aatgcaagtt ctaaaaatag
5581 actaaggatg cctttgcaga acaccaaagc atcccaagga actggtaggg aagtggcgcc
5641 tgtctcctgg agtggaagag gcctgctccc tggctctggg tctgctgggg gcacagtaaa
5701 tcagtcttgg cacccacatc cagggcagag aggtctgtgg ttctcagcat cagaaggcag
5761 cgcagcccct ctcctcttca ggctacaggg ttgtcacctg ctgagtcctc aggttgtttg
5821 gcctctctgg tccatcttgg gcattaggtt ctccagcaga gctctggcca gctgcctctt
5881 ctttaactgg gaacacaggc tctcacaaga tcagaacccc cactcacccc caagatctta
5941 tctagcaagc ctgtagtatt cagtttctgt tgtaggaaga gagcgaggca tccctgaatt
6001 ccacgcatct gctggaaacg agccgtgtca gatcgcacat ccctgcgccc ccatgccccc
6061 atgcccctct gagtcacaca ggacagagga ggcagagctt ctgcccactg ttatcttcac
6121 tttctttgtc cagtcttttg tttttaataa gcagtgaccc tccctactct tctttttaat
6181 gatttttgta gttgatttgt ctgaactgtg gctactgtgc attccttgaa taatcacttg
6241 taaaaattgt cagtgcttga agctgtttcc tttactcaca ttgaagggac ttcgttggtt
6301 ttttggagtc ttggttgtga ctccaagagc agagtgagga agacccccaa gcatagactc
6361 gggtactgtg atgatggctg cagtccagtt ttatgattct gcttttatgt gtcccttgat
6421 aacagtgact taacaatata cattcctcat aaataaaaaa aaaacaagaa tctg
//