LOCUS       HSU18088                1770 bp    mRNA    linear   HUM 02-NOV-2000
DEFINITION  Human 3',5'-cyclic AMP phosphodiesterase inactive splice variant
            HSPDE4A7A mRNA, complete cds.
ACCESSION   U18088
VERSION     U18088.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1770)
  AUTHORS   Horton,Y.M., Sullivan,M. and Houslay,M.D.
  TITLE     Molecular cloning of a novel splice variant of human type IVA
            (PDE-IVA) cyclic AMP phosphodiesterase and localization of the gene
            to the p13.2-q12 region of human chromosome 19 [corrected]
  JOURNAL   Biochem. J. 308 (Pt 2), 683-691 (1995)
   PUBMED   7772058
REFERENCE   2  (bases 1 to 1770)
  AUTHORS   Houslay,M.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-DEC-1994) Miles D. Houslay, Biochemistry and
            Molecular Biology IBLS, University of Glasgow, Glasgow, Scotland
            G12 8QQ, UK
FEATURES             Location/Qualifiers
     source          1..1770
                     /db_xref="H-InvDB:HIT000218435"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2-q12"
                     /clone_lib="T cell Jurkat Clontech Cat. HL1016b"
     CDS             333..1304
                     /EC_number="3.1.4.17"
                     /note="suggested nomenclature name HSPDE4A7A; this is an
                     inactive splice variant due to termination in putative
                     catalytic domain; also referred to as 2EL in the
                     publication"
                     /codon_start=1
                     /product="3',5'-cyclic AMP phosphodiesterase HSPDE4A7A"
                     /protein_id="AAA98540.1"
                     /translation="MVLPSDQGFKLLGNVLQGPEPYRLLTSGLRLHQELENLNKWGLN
                     IFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSL
                     HAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELAL
                     MYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTL
                     LADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIM
                     AEFFQQGDRERERGMEISPMCDKHTASVEKSQVQARGIDGRAQGGFY"
     misc_feature    333..431
                     /note="5' region derived by alternative splicing, which
                     forms a unique N-terminal domain in HSPDE4A7A"
     misc_feature    1257..1295
                     /note="34bp insert in this splice variant causing
                     premature termination within the putative catalytic unit"
BASE COUNT          403 a          509 c          501 g          357 t
ORIGIN      
        1 ggagagacat ggaaaataag cccttcttcc tttctcccct ggggctcgtg aacagcttag
       61 ctaagaggct gagctgtgct gggggccagt cgtgctggtt cctatcctag ctttgccact
      121 tatgagctgc atgatcttgg agaagtcaca tcgcctctct gagccttggt gccttcacct
      181 gccaaacgag atcaagtgct tagagcaata cttggcagat cataagtact caaaagacag
      241 tggctgtgat tgctttcgct attttgcagc ccagtaggac gagggcagta cattctgtgc
      301 tgttgaacct gtcacccact gggtgagcaa taatggtgct tccttcagac caaggcttca
      361 aactcctagg aaatgttctc cagggccctg agccttacag gcttctgacc tctggcctcc
      421 gtctccacca ggaactggag aacctgaaca agtggggcct gaacatcttt tgcgtgtcgg
      481 attacgctgg aggccgctca ctcacctgca tcatgtacat gatattccag gagcgggacc
      541 tgttgaagaa attccgcatc cctgtggaca cgatggtgac atacatgctg acgctggagg
      601 atcactacca cgctgacgtg gcctaccata acagcctgca cgcagctgac gtgctgcagt
      661 ccacccacgt actgctggcc acgcctgcac tagatgcagt gttcacggac ctggagattc
      721 tcgccgccct cttcgcggct gccatccacg atgtggatca ccctggggtc tccaaccagt
      781 tcctcatcaa caccaattcg gagctggcgc tcatgtacaa cgatgagtcg gtgctcgaga
      841 atcaccacct ggccgtgggc ttcaagctgc tgcaggagga caactgcgac atcttccaga
      901 acctcagcaa gcgccagcgg cagagcctac gcaagatggt catcgacatg gtgctggcca
      961 cggacatgtc caagcacatg accctcctgg ctgacctgaa gaccatggtg gagaccaaga
     1021 aagtgaccag ctcaggggtc ctcctgctag ataactactc cgaccgcatc caggtcctcc
     1081 ggaacatggt gcactgtgcc gacctcagca accccaccaa gccgctggag ctgtaccgcc
     1141 agtggacaga ccgcatcatg gccgagttct tccagcaggg tgaccgagag cgcgagcgtg
     1201 gcatggaaat cagccccatg tgtgacaagc acactgcctc cgtggagaag tctcaggtac
     1261 aggctcgggg cattgatgga cgggcacagg gtgggtttta ttgactacat tgtgcaccca
     1321 ttgtgggaga cctgggcgga ccttgtccac ccagatgccc aggagatctt ggacactttg
     1381 gaggacaacc gggactggta ctacagcgcc atccggcaga gcccatctcc gccacccgag
     1441 gaggagtcaa gggggccagg ccacccaccc ctgcctgaca agttccagtt tgagctgacg
     1501 ctggaggagg aagaggagga agaaatatca atggcccaga taccgtgcac agcccaagag
     1561 gcattgactg cgcagggatt gtcaggagtc gaggaagctc tggatgcaac catagcctgg
     1621 gaggcatccc cggcccagga gtcgttggaa gttatggcac aggaagcatc cctggaggcc
     1681 gagctggagg cagtgtattt gacacagcag gcacagtcca caggcagtgc acctgtggct
     1741 ccggatgagt tctcgtcccg ggaggaattc
//