LOCUS HSU18088 1770 bp mRNA linear HUM 02-NOV-2000 DEFINITION Human 3',5'-cyclic AMP phosphodiesterase inactive splice variant HSPDE4A7A mRNA, complete cds. ACCESSION U18088 VERSION U18088.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1770) AUTHORS Horton,Y.M., Sullivan,M. and Houslay,M.D. TITLE Molecular cloning of a novel splice variant of human type IVA (PDE-IVA) cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19 [corrected] JOURNAL Biochem. J. 308 (Pt 2), 683-691 (1995) PUBMED 7772058 REFERENCE 2 (bases 1 to 1770) AUTHORS Houslay,M.D. TITLE Direct Submission JOURNAL Submitted (05-DEC-1994) Miles D. Houslay, Biochemistry and Molecular Biology IBLS, University of Glasgow, Glasgow, Scotland G12 8QQ, UK FEATURES Location/Qualifiers source 1..1770 /db_xref="H-InvDB:HIT000218435" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="19" /map="19p13.2-q12" /clone_lib="T cell Jurkat Clontech Cat. HL1016b" CDS 333..1304 /EC_number="3.1.4.17" /note="suggested nomenclature name HSPDE4A7A; this is an inactive splice variant due to termination in putative catalytic domain; also referred to as 2EL in the publication" /codon_start=1 /product="3',5'-cyclic AMP phosphodiesterase HSPDE4A7A" /protein_id="AAA98540.1" /translation="MVLPSDQGFKLLGNVLQGPEPYRLLTSGLRLHQELENLNKWGLN IFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSL HAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELAL MYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTL LADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIM AEFFQQGDRERERGMEISPMCDKHTASVEKSQVQARGIDGRAQGGFY" misc_feature 333..431 /note="5' region derived by alternative splicing, which forms a unique N-terminal domain in HSPDE4A7A" misc_feature 1257..1295 /note="34bp insert in this splice variant causing premature termination within the putative catalytic unit" BASE COUNT 403 a 509 c 501 g 357 t ORIGIN 1 ggagagacat ggaaaataag cccttcttcc tttctcccct ggggctcgtg aacagcttag 61 ctaagaggct gagctgtgct gggggccagt cgtgctggtt cctatcctag ctttgccact 121 tatgagctgc atgatcttgg agaagtcaca tcgcctctct gagccttggt gccttcacct 181 gccaaacgag atcaagtgct tagagcaata cttggcagat cataagtact caaaagacag 241 tggctgtgat tgctttcgct attttgcagc ccagtaggac gagggcagta cattctgtgc 301 tgttgaacct gtcacccact gggtgagcaa taatggtgct tccttcagac caaggcttca 361 aactcctagg aaatgttctc cagggccctg agccttacag gcttctgacc tctggcctcc 421 gtctccacca ggaactggag aacctgaaca agtggggcct gaacatcttt tgcgtgtcgg 481 attacgctgg aggccgctca ctcacctgca tcatgtacat gatattccag gagcgggacc 541 tgttgaagaa attccgcatc cctgtggaca cgatggtgac atacatgctg acgctggagg 601 atcactacca cgctgacgtg gcctaccata acagcctgca cgcagctgac gtgctgcagt 661 ccacccacgt actgctggcc acgcctgcac tagatgcagt gttcacggac ctggagattc 721 tcgccgccct cttcgcggct gccatccacg atgtggatca ccctggggtc tccaaccagt 781 tcctcatcaa caccaattcg gagctggcgc tcatgtacaa cgatgagtcg gtgctcgaga 841 atcaccacct ggccgtgggc ttcaagctgc tgcaggagga caactgcgac atcttccaga 901 acctcagcaa gcgccagcgg cagagcctac gcaagatggt catcgacatg gtgctggcca 961 cggacatgtc caagcacatg accctcctgg ctgacctgaa gaccatggtg gagaccaaga 1021 aagtgaccag ctcaggggtc ctcctgctag ataactactc cgaccgcatc caggtcctcc 1081 ggaacatggt gcactgtgcc gacctcagca accccaccaa gccgctggag ctgtaccgcc 1141 agtggacaga ccgcatcatg gccgagttct tccagcaggg tgaccgagag cgcgagcgtg 1201 gcatggaaat cagccccatg tgtgacaagc acactgcctc cgtggagaag tctcaggtac 1261 aggctcgggg cattgatgga cgggcacagg gtgggtttta ttgactacat tgtgcaccca 1321 ttgtgggaga cctgggcgga ccttgtccac ccagatgccc aggagatctt ggacactttg 1381 gaggacaacc gggactggta ctacagcgcc atccggcaga gcccatctcc gccacccgag 1441 gaggagtcaa gggggccagg ccacccaccc ctgcctgaca agttccagtt tgagctgacg 1501 ctggaggagg aagaggagga agaaatatca atggcccaga taccgtgcac agcccaagag 1561 gcattgactg cgcagggatt gtcaggagtc gaggaagctc tggatgcaac catagcctgg 1621 gaggcatccc cggcccagga gtcgttggaa gttatggcac aggaagcatc cctggaggcc 1681 gagctggagg cagtgtattt gacacagcag gcacagtcca caggcagtgc acctgtggct 1741 ccggatgagt tctcgtcccg ggaggaattc //