LOCUS HSU18087 2091 bp mRNA linear HUM 30-APR-1996
DEFINITION Human 3',5'-cyclic AMP phosphodiesterase HPDE4A6 mRNA, complete
cds.
ACCESSION U18087
VERSION U18087.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2091)
AUTHORS Horton,Y.M., Sullivan,M. and Houslay,M.D.
TITLE Molecular cloning of a novel splice variant of human type IVA
(PDE-IVA) cyclic AMP phosphodiesterase and localization of the gene
to the p13.2-q12 region of human chromosome 19 [corrected]
JOURNAL Biochem. J. 308 (Pt 2), 683-691 (1995)
PUBMED 7772058
REFERENCE 2 (bases 1 to 2091)
AUTHORS Sullivan,M., Egerton,M., Shakur,Y., Marquardsen,A. and Houslay,M.D.
TITLE Molecular cloning and expression, in both COS-1 cells and S.
cerevisiae, of a human cytosolic type-IVA, cyclic AMP specific
phosphodiesterase (hPDE-IVA-h6.1)
JOURNAL Cell. Signal. 6 (7), 793-812 (1994)
PUBMED 7888306
REFERENCE 3 (bases 1 to 2091)
AUTHORS Houslay,M.D.
TITLE Direct Submission
JOURNAL Submitted (05-DEC-1994) Miles D. Houslay, Biochemistry and
Molecular Biology IBLS, University of Glasgow, Glasgow, Scotland
G12 8QQ, UK
FEATURES Location/Qualifiers
source 1..2091
/db_xref="H-InvDB:HIT000218434"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="6.1 and 2.2"
/clone_lib="Clontech Cat. HL1101b Human Jurkat cells"
CDS 10..2070
/EC_number="3.1.4.17"
/note="refered to in publication as either h6.1 or
hPDE4Ah6.1 but by nomenclature committee rules as HPDE4A6"
/codon_start=1
/product="3',5'-cyclic AMP phosphodiesterase HPDE4A6"
/protein_id="AAC50458.1"
/translation="MCPFPVTTVPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQ
LETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPS
PTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTD
QEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTY
MLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVD
HPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLR
KMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADL
SNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIV
HPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQ
FELTLEEEEEEEISMAQIPCTAQEALTEQGLSGVEEALDATIAWEASPAQESLEVMAQ
EASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAW
RTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSG
GDPT"
BASE COUNT 488 a 637 c 592 g 374 t
ORIGIN
1 ggatccacca tgtgcccgtt cccagtaaca acggtcccgc tgggcgggcc cacccctgtc
61 tgcaaggcca cgctgtcaga agaaacgtgt cagcagttgg cccgggagac tctggaggag
121 ctggactggt gtctggagca gctggagacc atgcagacct atcgctctgt cagcgagatg
181 gcctcgcaca agttcaaaag gatgttgaac cgtgagctca cacacctgtc agaaatgagc
241 aggtccggaa accaggtctc agagtacatt tccacaacat tcctggacaa acagaatgaa
301 gtggagatcc catcacccac gatgaaggaa cgagaaaaac agcaagcgcc gcgaccaaga
361 ccctcccagc cgcccccgcc ccctgtacca cacttacagc ccatgtccca aatcacaggg
421 ttgaaaaagt tgatgcatag taacagcctg aacaactcta acattccccg atttggggtg
481 aagaccgatc aagaagagct cctggcccaa gaactggaga acctgaacaa gtggggcctg
541 aacatctttt gcgtgtcgga ttacgctgga ggccgctcac tcacctgcat catgtacatg
601 atattccagg agcgggacct gctgaagaaa ttccgcatcc ctgtggacac gatggtgaca
661 tacatgctga cgctggagga tcactaccac gctgacgtgg cctaccataa cagcctgcac
721 gcagctgacg tgctgcagtc cacccacgta ctgctggcca cgcctgcact agatgcagtg
781 ttcacggacc tggagattct cgctgccctc ttcgcggctg ccatccacga tgtggatcac
841 cctggggtct ccaaccagtt cctcatcaac accaattcgg agctggcgct catgtacaac
901 gatgagtcgg tgctcgagaa tcaccacctg gccgtgggct tcaagctgct gcaggaggac
961 aactgcgaca tcttccagaa cctcagcaag cgccagcggc agagcctacg caagatggtc
1021 atcgacatgg tgctggccac ggacatgtcc aagcacatga ccctcctggc tgacctgaag
1081 accatggtgg agaccaagaa agtgaccagc tcaggggtcc tcctgctaga taactactcc
1141 gaccgcatcc aggtcctccg gaacatggtg cactgtgccg acctcagcaa ccccaccaag
1201 ccgctggagc tgtaccgcca gtggacagac cgcatcatgg ccgagttctt ccagcagggt
1261 gaccgagagc gcgagcgtgg catggaaatc agccccatgt gtgacaagca cactgcctcc
1321 gtggagaagt ctcaggtggg ttttattgac tacattgtgc acccattgtg ggagacctgg
1381 gcggaccttg tccacccaga tgcccaggag atcttggaca ctttggagga caaccgggac
1441 tggtactaca gcgccatccg gcagagccca tctccgccac ccgaggagga gtcaaggggg
1501 ccaggccacc cacccctgcc tgacaagttc cagtttgagc tgacgctgga ggaggaagag
1561 gaggaagaaa tatcaatggc ccagataccg tgcacagccc aagaggcatt gactgagcag
1621 ggattgtcag gagtcgagga agctctggat gcaaccatag cctgggaggc atccccggcc
1681 caggagtcgt tggaagttat ggcacaggaa gcatccctgg aggccgagct ggaggcagtg
1741 tatttgacac agcaggcaca gtccacaggc agtgcacctg tggctccgga tgagttctcg
1801 tcccgggagg aattcgtggt tgctgtaagc cacagcagcc cctctgccct ggctcttcaa
1861 agcccccttc tccctgcttg gaggaccctg tctgtttcag agcatgcccc gggcctcccg
1921 ggcctcccct ccacggcggc cgaggtggag gcccaacgag agcaccaggc tgccaagagg
1981 gcttgcagtg cctgcgcagg gacatttggg gaggacacat ccgcactccc agctcctggt
2041 ggcggggggt caggtggaga ccctacctga tccccagacc tctgtgtcga c
//