LOCUS HSU14658 2697 bp mRNA linear HUM 12-OCT-1994
DEFINITION Human DNA mismatch repair gene homologue (hPMS2) mRNA, complete
cds.
ACCESSION U14658
VERSION U14658.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2697)
AUTHORS Bronner,C.E., Baker,S.M., Morrison,P.T., Warren,G., Smith,L.G.,
Lescoe,M.K., Kane,M., Earibino,C., Lipford,J., Linblom,A.,
Tannergard,P., Bollag,R.J., Godwin,A.R., Ward,D.C.,
Nordenskjold,M., Fishel,R., Kolodner,R.D. and Liskay,R.M.
TITLE Mutation in the DNA mismatch repair gene homologue hPMS2 is
associated with hereditary nonpolyposis colon cancer
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 2697)
AUTHORS Morrison,P.T.
TITLE Direct Submission
JOURNAL Submitted (14-SEP-1994) Paul T. Morrison, Molecular Biology Core
Facility, Dana-Farber Cancer Institute, 44 Binney Street, Boston,
MA 002115, USA
FEATURES Location/Qualifiers
source 1..2697
/db_xref="H-InvDB:HIT000218273"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..2697
/gene="hPMS2"
CDS 3..2591
/gene="hPMS2"
/function="DNA mismatch repair"
/note="similar to S. cerevisiae PMS1 Swiss-Prot Accession
Number P14242, S. cerevisiae MLH1 GenBank Accession Number
U07187, E. coli MUTL Swiss-Prot Accession Number P23367,
Salmonella typhimurium MUTL Swiss-Prot Accession Number
P14161, Streptococcus pneumoniae Swiss-Prot Accession
Number P14160"
/codon_start=1
/protein_id="AAA50390.1"
/translation="MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVE
NSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVE
TFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQ
QLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTG
GSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQC
THGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDI
NVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADL
EKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQK
RGMLSSSTSGAISDKGVLRSQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSI
PDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPETDDSFSDVDCHSNQEDTGCKFRVLP
QPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSS
LAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQF
NLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLI
ENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMC
RPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANL
GVISQN"
BASE COUNT 797 a 588 c 653 g 659 t
ORIGIN
1 ccatggagcg agctgagagc tcgagtacag aacctgctaa ggccatcaaa cctattgatc
61 ggaagtcagt ccatcagatt tgctctgggc aggtggtact gagtctaagc actgcggtaa
121 aggagttagt agaaaacagt ctggatgctg gtgccactaa tattgatcta aagcttaagg
181 actatggagt ggatcttatt gaagtttcag acaatggatg tggggtagaa gaagaaaact
241 tcgaaggctt aactctgaaa catcacacat ctaagattca agagtttgcc gacctaactc
301 aggttgaaac ttttggcttt cggggggaag ctctgagctc actttgtgca ctgagcgatg
361 tcaccatttc tacctgccac gcatcggcga aggttggaac tcgactgatg tttgatcaca
421 atgggaaaat tatccagaaa accccctacc cccgccccag agggaccaca gtcagcgtgc
481 agcagttatt ttccacacta cctgtgcgcc ataaggaatt tcaaaggaat attaagaagg
541 agtatgccaa aatggtccag gtcttacatg catactgtat catttcagca ggcatccgtg
601 taagttgcac caatcagctt ggacaaggaa aacgacagcc tgtggtatgc acaggtggaa
661 gccccagcat aaaggaaaat atcggctctg tgtttgggca gaagcagttg caaagcctca
721 ttccttttgt tcagctgccc cctagtgact ccgtgtgtga agagtacggt ttgagctgtt
781 cggatgctct gcataatctt ttttacatct caggtttcat ttcacaatgc acgcatggag
841 ttggaaggag ttcaacagac agacagtttt tctttatcaa ccggcggcct tgtgacccag
901 caaaggtctg cagactcgtg aatgaggtct accacatgta taatcgacac cagtatccat
961 ttgttgttct taacatttct gttgattcag aatgcgttga tatcaatgtt actccagata
1021 aaaggcaaat tttgctacaa gaggaaaagc ttttgttggc agttttaaag acctctttga
1081 taggaatgtt tgatagtgat gtcaacaagc taaatgtcag tcagcagcca ctgctggatg
1141 ttgaaggtaa cttaataaaa atgcatgcag cggatttgga aaagcccatg gtagaaaagc
1201 aggatcaatc cccttcatta aggactggag aagaaaaaaa agacgtgtcc atttccagac
1261 tgcgagaggc cttttctctt cgtcacacaa cagagaacaa gcctcacagc ccaaagactc
1321 cagaaccaag aaggagccct ctaggacaga aaaggggtat gctgtcttct agcacttcag
1381 gtgccatctc tgacaaaggc gtcctgagat ctcagaaaga ggcagtgagt tccagtcacg
1441 gacccagtga ccctacggac agagcggagg tggagaagga ctcggggcac ggcagcactt
1501 ccgtggattc tgaggggttc agcatcccag acacgggcag tcactgcagc agcgagtatg
1561 cggccagctc cccaggggac aggggctcgc aggaacatgt ggactctcag gagaaagcgc
1621 ctgaaactga cgactctttt tcagatgtgg actgccattc aaaccaggaa gataccggat
1681 gtaaatttcg agttttgcct cagccaacta atctcgcaac cccaaacaca aagcgtttta
1741 aaaaagaaga aattctttcc agttctgaca tttgtcaaaa gttagtaaat actcaggaca
1801 tgtcagcctc tcaggttgat gtagctgtga aaattaataa gaaagttgtg cccctggact
1861 tttctatgag ttctttagct aaacgaataa agcagttaca tcatgaagca cagcaaagtg
1921 aaggggaaca gaattacagg aagtttaggg caaagatttg tcctggagaa aatcaagcag
1981 ccgaagatga actaagaaaa gagataagta aaacgatgtt tgcagaaatg gaaatcattg
2041 gtcagtttaa cctgggattt ataataacca aactgaatga ggatatcttc atagtggacc
2101 agcatgccac ggacgagaag tataacttcg agatgctgca gcagcacacc gtgctccagg
2161 ggcagaggct catagcacct cagactctca acttaactgc tgttaatgaa gctgttctga
2221 tagaaaatct ggaaatattt agaaagaatg gctttgattt tgttatcgat gaaaatgctc
2281 cagtcactga aagggctaaa ctgatttcct tgccaactag taaaaactgg accttcggac
2341 cccaggacgt cgatgaactg atcttcatgc tgagcgacag ccctggggtc atgtgccggc
2401 cttcccgagt caagcagatg tttgcctcca gagcctgccg gaagtcggtg atgattggga
2461 ctgctctcaa cacaagcgag atgaagaaac tgatcaccca catgggggag atggaccacc
2521 cctggaactg tccccatgga aggccaacca tgagacacat cgccaacctg ggtgtcattt
2581 ctcagaactg accgtagtca ctgtatggaa taattggttt tatcgcagat ttttatgttt
2641 tgaaagacag agtcttcact aacctttttt gttttaaaat gaaacctgcg gccttcg
//