LOCUS HSU14631 1873 bp mRNA linear HUM 12-MAR-1996
DEFINITION Human 11 beta-hydroxysteroid dehydrogenase type II mRNA, complete
cds.
ACCESSION U14631
VERSION U14631.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1873)
AUTHORS Albiston,A.L., Obeyesekere,V.R., Smith,R.E. and Krozowski,Z.S.
TITLE Cloning and tissue distribution of the human 11 beta-hydroxysteroid
dehydrogenase type 2 enzyme
JOURNAL Mol. Cell. Endocrinol. 105 (2), R11-R17 (1994)
PUBMED 7859916
REFERENCE 2 (bases 1 to 1873)
AUTHORS Krozowski,Z., Albiston,A.L., Obeyesekere,V.R., Andrews,R.K. and
Smith,R.E.
TITLE The human 11 beta-hydroxysteroid dehydrogenase type II enzyme:
comparisons with other species and localization to the distal
nephron
JOURNAL J. Steroid Biochem. Mol. Biol. 55 (5-6), 457-464 (1995)
PUBMED 8547170
REFERENCE 3 (bases 1 to 1873)
AUTHORS Krozowski,Z.
TITLE Direct Submission
JOURNAL Submitted (13-SEP-1994) Zygmunt S. Krozowski, Baker Medical
Research Institute, Prahran, Victoria, Australia
COMMENT On Mar 12, 1996 this sequence version replaced gi:565081.
FEATURES Location/Qualifiers
source 1..1873
/db_xref="H-InvDB:HIT000218267"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/sex="female"
/tissue_type="kidney"
CDS 111..1328
/note="member of the short chain alcohol dehydrogenase
superfamily"
/codon_start=1
/product="11 beta-hydroxysteroid dehydrogenase type II"
/protein_id="AAA91969.1"
/translation="MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAAL
DWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKL
DSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRLLEFTKAHTTSTG
LWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVG
SPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQW
EKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARP
RRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQD
PNLSPGPSPAVAR"
polyA_site 1873
/note="10 A residues"
BASE COUNT 330 a 668 c 518 g 357 t
ORIGIN
1 cgcgccccag gccggtgtac ccccgcactc cgcgccccgg cctagaagct ctctctcccc
61 gctccccggc ccggcccccg ccccgccccg ccccagcccg ctgggccgcc atggagcgct
121 ggccttggcc gtcgggcggc gcctggctgc tcgtggctgc ccgcgcgctg ctgcagctgc
181 tgcgctcaga cctgcgtctg ggccgcccgc tgctggcggc gctggcgctg ctggccgcgc
241 tcgactggct gtgccagcgc ctgctgcccc cgccggccgc actcgccgtg ctggccgccg
301 ccggctggat cgcgttgtcc cgcctggcgc gcccgcagcg cctgccggtg gccactcgcg
361 cggtgctcat caccggctgt gactctggtt ttggcaagga gacggccaag aaactggact
421 ccatgggctt cacggtgctg gccaccgtat tggagttgaa cagccccggt gccatcgagc
481 tgcgtacctg ctgctcccct cgcctaaggc tgctgcagat ggacctgacc aaaccaggag
541 acattagccg cttgctagag ttcaccaagg cccacaccac cagcaccggc ctgtggggcc
601 tcgtcaacaa cgcaggccac aatgaagtag ttgctgatgc ggagctgtct ccagtggcca
661 ctttccgtag ctgcatggag gtgaatttct ttggcgcgct cgagctgacc aagggcctcc
721 tgcccctgct gcgcagctca aggggccgca tcgtgactgt ggggagccca gcgggggaca
781 tgccatatcc gtgcttgggg gcctatggaa cctccaaagc ggccgtggcg ctactcatgg
841 acacattcag ctgtgaactc cttccctggg gggtcaaggt cagcatcatc cagcctggct
901 gcttcaagac agagtcagtg agaaacgtgg gtcagtggga aaagcgcaag caattgctgc
961 tggccaacct gcctcaagag ctgctgcagg cctacggcaa ggactacatc gagcacttgc
1021 atgggcagtt cctgcactcg ctacgcctgg ccatgtccga cctcacccca gttgtagatg
1081 ccatcacaga tgcgctgctg gcagctcggc cccgccgccg ctattacccc ggccagggcc
1141 tggggctcat gtacttcatc cactactacc tgcctgaagg cctgcggcgc cgcttcctgc
1201 aggccttctt catcagtcac tgtctgcctc gagcactgca gcctggccag cctggcacta
1261 ccccaccaca ggacgcagcc caggacccaa acctgagccc cggcccttcc ccagcagtgg
1321 ctcggtgagc catgtgcacc tatggcccag ccactgcagc acaggaggct ccgtgagcct
1381 tggttcctcc ccgaaaaccc ccagcattac gatcccccaa gtgtcctgga ccctggccta
1441 aagaatccca cccccacttc atgcccactg ccgatgccca atccaggccc ggtgaggcca
1501 aggtttccca gtgagcctct gcgcctctcc actgtttcat gagcccaaac accctcctgg
1561 cacaacgctc taccctgcag cttggagaac tccgctggat gggagtctca tgcaagactt
1621 cactgcagcc tttcacagga ctctgcagat agtgcctctg caaactaagg agtgactagg
1681 tgggttgggg accccctcag gattgtttct cggcaccagt gcctcagtgc tgcaattgag
1741 ggctaaatcc caagtgtctc ttgactggct caagaattag ggccccaact acacaccccc
1801 aagccacagg gaagcatgta ctgtacttcc caattgccac attttaaata aagacaaatt
1861 tttatttctt cta
//