LOCUS HSU12255 1440 bp mRNA linear HUM 06-JAN-1995
DEFINITION Human IgG Fc receptor hFcRn mRNA, complete cds.
ACCESSION U12255
VERSION U12255.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1440)
AUTHORS Story,C.M., Mikulska,J.E. and Simister,N.E.
TITLE A major histocompatibility complex class I-like Fc receptor cloned
from human placenta: possible role in transfer of immunoglobulin G
from mother to fetus
JOURNAL J. Exp. Med. 180 (6), 2377-2381 (1994)
PUBMED 7964511
REFERENCE 2 (bases 1 to 1440)
AUTHORS Simister,N.E.
TITLE Direct Submission
JOURNAL Submitted (12-JUL-1994) Neil E. Simister, Biology Department,
Brandeis University, 415 South Street, Waltham, MA 02254-9110, USA
FEATURES Location/Qualifiers
source 1..1440
/db_xref="H-InvDB:HIT000218077"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="11 and 3"
/tissue_type="placenta"
/clone_lib="Clontech library"
5'UTR 1..125
regulatory 122..129
/regulatory_class="other"
/standard_name="Kozak consensus sequence"
/note="other"
CDS 126..1223
/function="Fc receptor for IgG"
/codon_start=1
/product="hFcRn"
/protein_id="AAA58958.1"
/translation="MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGT
PAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAF
KALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAI
SQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSV
LTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCI
VQHAGLAQPLRVELESPAKSSVLVVGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWIS
LRGDDTGVLLPTPGEAQDADLKDVNVIPATA"
sig_peptide 126..194
3'UTR 1224..1440
regulatory 1385..1390
/regulatory_class="polyA_signal_sequence"
/note="non-canonical"
regulatory 1413..1418
/regulatory_class="polyA_signal_sequence"
/note="non-canonical"
polyA_site 1436
/note="4 A nucleotides"
BASE COUNT 247 a 462 c 447 g 284 t
ORIGIN
1 cgggcgcaga agcccctcct cggcgtcctg gtcccggccg tgcccgcggt gtcccgggag
61 gaaggggcgg gccgggggtc gggaggagtc acgtgccccc tcccgcccca ggtcgtcctc
121 tcagcatggg ggtcccgcgg cctcagccct gggcgctggg gctcctgctc tttctccttc
181 ctgggagcct gggcgcagaa agccacctct ccctcctgta ccaccttacc gcggtgtcct
241 cgcctgcccc ggggactcct gccttctggg tgtccggctg gctgggcccg cagcagtacc
301 tgagctacaa tagcctgcgg ggcgaggcgg agccctgtgg agcttgggtc tgggaaaacc
361 aggtgtcctg gtattgggag aaagagacca cagatctgag gatcaaggag aagctctttc
421 tggaagcttt caaagctttg gggggaaaag gtccctacac tctgcagggc ctgctgggct
481 gtgaactggg ccctgacaac acctcggtgc ccaccgccaa gttcgccctg aacggcgagg
541 agttcatgaa tttcgacctc aagcagggca cctggggtgg ggactggccc gaggccctgg
601 ctatcagtca gcggtggcag cagcaggaca aggcggccaa caaggagctc accttcctgc
661 tattctcctg cccgcaccgc ctgcgggagc acctggagag gggccgcgga aacctggagt
721 ggaaggagcc cccctccatg cgcctgaagg cccgacccag cagccctggc ttttccgtgc
781 ttacctgcag cgccttctcc ttctaccctc cggagctgca acttcggttc ctgcggaatg
841 ggctggccgc tggcaccggc cagggtgact tcggccccaa cagtgacgga tccttccacg
901 cctcgtcgtc actaacagtc aaaagtggcg atgagcacca ctactgctgc attgtgcagc
961 acgcggggct ggcgcagccc ctcagggtgg agctggaatc tccagccaag tcctccgtgc
1021 tcgtggtggg aatcgtcatc ggtgtcttgc tactcacggc agcggctgta ggaggagctc
1081 tgttgtggag aaggatgagg agtgggctgc cagccccttg gatctccctt cgtggagacg
1141 acaccggggt cctcctgccc accccagggg aggcccagga tgctgatttg aaggatgtaa
1201 atgtgattcc agccaccgcc tgaccatccg ccattccgac tgctaaaagc gaatgtagtc
1261 aggccccttt catgctgtga gacctcctgg aacactggca tctctgagcc tccagaaggg
1321 gttctgggcc tagttgtcct ccctctggag ccccgtcctg tggtctgcct cagtttcccc
1381 tcctaataca tatggctgtt ttccacctcg ataatataac acgagtttgg gcccgaaaaa
//