LOCUS HSU12128 8287 bp mRNA linear HUM 12-OCT-1994
DEFINITION Human protein tyrosine phosphatase 1E (PTP1E) mRNA, complete cds.
ACCESSION U12128
VERSION U12128.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8287)
AUTHORS Banville,D., Ahmad,S., Stocco,R. and Shen,S.H.
TITLE A novel protein-tyrosine phosphatase with homology to both the
cytoskeletal proteins of the band 4.1 family and
junction-associated guanylate kinases
JOURNAL J. Biol. Chem. 269 (35), 22320-22327 (1994)
PUBMED 8071359
REFERENCE 2 (bases 1 to 8287)
AUTHORS Maekawa,K., Imagawa,N., Nagamatsu,M. and Harada,S.
TITLE Molecular cloning of a novel protein-tyrosine phosphatase
containing a membrane-binding domain and GLGF repeats
JOURNAL FEBS Lett. 337 (2), 200-206 (1994)
PUBMED 8287977
REFERENCE 2 (bases 1 to 8287)
AUTHORS Banville,D.
TITLE Direct Submission
JOURNAL Submitted (08-JUL-1994) Denis Banville, Biotechnology Research
Institute, Pharmaceutical Biotechnology, 6100 Royalmount, Montreal,
Quebec H4P 2R2, Canada
COMMENT On Oct 12, 1994 this sequence version replaced gi:515682.
FEATURES Location/Qualifiers
source 1..8287
/db_xref="H-InvDB:HIT000218068"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone_lib="ZR-75-1 breast carcinoma cDNA library"
gene 1..8287
/gene="PTP1E"
5'UTR <1..217
/gene="PTP1E"
/experiment="experimental evidence, no additional details
recorded"
/note="nucleotide sequence 1-212 is one of five types of
hPTP1E 5' non-coding sequences identified by 5' RACE PCR"
CDS 218..7690
/gene="PTP1E"
/note="similar to PTP-BAS1 gene, GenBank Accession Number
D21209"
/codon_start=1
/product="protein tyrosine phosphatase 1E"
/protein_id="AAB60339.1"
/translation="MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADP
AALGFIISPWSLLLLPSGSVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIY
SLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNS
NCAPSFSYVKHLVKLVLGNLSGTDQLSCNSEQKPDRSQAIRDRLRGKGLPTGRSSTSD
VLDIQKPPLSHQTFLNKGLSKSMGFLSIKDTQDENYFKDILSDNSGREDSENTFSPYQ
FKTSGPEKKPIPGIDVLSKKKIWASSMDLLCTADRDFSSGETATYRRCHPEAVTVRTS
TTPRKKEARYSDGSIALDIFGPQKMDPIYHTRELPTSSAISSALDRIRERQKKLQVLR
EAMNVEEPVRRYKTYHGDVFSTSSESPSIISSESDFRQVRRSEASKRFESSSGLPGVD
ETLSQGQSQRPSRQYETPFEGNLINQEIMLKRQEEELMQLQAKMALRQSRLSLYPGDT
IKASMLDITRDPLREIALETAMTQRKLRNFFGPEFVKMTIEPFISLDLPRSILTKKGK
NEDNRRKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYF
FVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQ
LRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDL
SYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVC
SKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQY
LLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLAS
STLNKLAVRPLSVQAEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHD
LSQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASL
NRSPERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPE
REITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLIS
VNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSS
YMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVN
GFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGD
SDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSL
GISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATH
KQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVK
DYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGK
IDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQ
SPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDL
VTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFE
DSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLE
DFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKV
NDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGF
SLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDM
SLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAG
EEINEISYPKGKCSTYQIKGSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEA
QNLLNENNAAGYSCGPGTLKMNGKLSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCE
EKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVK
VLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRY
KNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQK
STVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLED
IQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGT
LICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAEE
EQKQQPQLLK"
misc_difference 4368..4382
/gene="PTP1E"
/note="conflict; nucleotides 4368..4382 not present in
sequence of PTP-BAS1 gene, GenBank Accession Number
D21209"
/citation=[2]
/replace=""
3'UTR 7691..8287
/gene="PTP1E"
polyA_site 8287
/gene="PTP1E"
/note="14 A residues"
BASE COUNT 2643 a 1694 c 1780 g 2170 t
ORIGIN
1 ctgattatga agtgcctcag agccaaccta ttaagcttgg agatcatctc aacagcatac
61 tgcttggaat gtgtgaggat gttatttacg ctcgagtttc tgttcggact gtgctggatg
121 cttgcagtgc ccacattagg aatagcaatt gtgcaccctc attttcctac gtgaaacact
181 tggtaaaact ggttctggga aatctttctg gggtaatatg cacgtgtcac tagctgaggc
241 cctggaggtt cggggtggac cacttcagga ggaagaaata tgggctgtat taaatcaaag
301 tgctgaaagt ctccaagaat tattcagaaa agtaagccta gctgatcctg ctgcccttgg
361 cttcatcatt tctccatggt ctctgctgtt gctgccatct ggtagtgtgt catttacaga
421 tgaaaatatt tccaatcagg atcttcgagc attcactgca ccagaggttc ttcaaaatca
481 gtcactaact tctctctcag atgttgaaaa gatccacatt tattctcttg gaatgacact
541 gtattggggg gctgattatg aagtgcctca gagccaacct attaagcttg gagatcatct
601 caacagcata ctgcttggaa tgtgtgagga tgttatttac gctcgagttt ctgttcggac
661 tgtgctggat gcttgcagtg cccacattag gaatagcaat tgtgcaccct cattttccta
721 cgtgaaacac ttggtaaaac tggttctggg aaatctttct gggacagatc agctttcctg
781 taacagtgaa caaaagcctg atcgaagcca ggctattcga gatcgattgc gaggaaaagg
841 attaccaaca ggaagaagct ctacttctga tgtactagac atacaaaagc ctccactctc
901 tcatcagacc tttcttaaca aagggcttag taaatctatg ggatttctgt ccatcaaaga
961 tacacaagat gagaattatt tcaaggacat tttatcagat aattctggac gtgaagattc
1021 tgaaaataca ttctcccctt accagttcaa aactagtggc ccagaaaaaa aacccatccc
1081 tggcattgat gtgctttcta agaagaagat ctgggcttca tccatggact tgctttgtac
1141 agctgacaga gacttctctt caggagagac tgccacatat cgtcgttgtc accctgaggc
1201 agtaacagtg cggacttcaa ctactcctag aaaaaaggag gcaagatact cagatggaag
1261 tatagccttg gatatctttg gccctcagaa aatggatcca atatatcaca ctcgagaatt
1321 gcccacctcc tcagcaatat caagtgcttt ggaccgaatc cgagagagac aaaagaaact
1381 tcaggttctg agggaagcca tgaatgtaga agaaccagtt cgaagataca aaacttatca
1441 tggtgatgtc tttagtacct ccagtgaaag tccatctatt atttcctctg aatcagattt
1501 cagacaagtg agaagaagtg aagcctcaaa gaggtttgaa tccagcagtg gtctcccagg
1561 ggtagatgaa accttaagtc aaggccagtc acagagaccg agcagacaat atgaaacacc
1621 ctttgaaggc aacttaatta atcaagagat catgctaaaa cggcaagagg aagaactgat
1681 gcagctacaa gccaaaatgg cccttagaca gtctcggttg agcctatatc caggagacac
1741 aatcaaagcg tccatgcttg acatcaccag ggatccgtta agagaaattg ccctagaaac
1801 agccatgact caaagaaaac tgaggaattt ctttggccct gagtttgtga aaatgacaat
1861 tgaaccattt atatctttgg atttgccacg gtctattctt actaagaaag ggaagaatga
1921 ggataaccga aggaaagtaa acataatgct tctgaacggg caaagactgg aactgacctg
1981 tgataccaaa actatatgta aagatgtgtt tgatatggtt gtggcacata ttggcttagt
2041 agagcatcat ttgtttgctt tagctaccct caaagataat gaatatttct ttgttgatcc
2101 tgacttaaaa ttaaccaaag tggccccaga gggatggaaa gaagaaccaa agaaaaagac
2161 caaagccact gttaatttta ctttgttttt cagaattaaa ttttttatgg atgatgttag
2221 tctaatacaa catactctga cgtgtcatca gtattacctt cagcttcgaa aagatatttt
2281 ggaggaaagg atgcactgtg atgatgagac ttccttattg ctggcatcct tggctctcca
2341 ggctgagtat ggagattatc aaccagaggt tcatggtgtg tcttacttta gaatggagca
2401 ctatttgccc gccagagtga tggagaaact tgatttatcc tatatcaaag aagagttacc
2461 caaattgcat aatacctatg tgggagcttc tgaaaaagag acagagttag aatttttaaa
2521 ggtctgccaa agactgacag aatatggagt tcattttcac cgagtgcacc ctgagaagaa
2581 gtcacaaaca ggaatattgc ttggagtctg ttctaaaggt gtccttgtgt ttgaagttca
2641 caatggagtg cgcacattgg tccttcgctt tccatggagg gaaaccaaga aaatatcttt
2701 ttctaaaaag aaaatcacat tgcaaaatac atcagatgga ataaaacatg gcttccagac
2761 agacaacagt aagatatgcc agtacctgct gcacctctgc tcttaccagc ataagttcca
2821 gctacagatg agagcaagac agagcaacca agatgcccaa gatattgaga gagcttcgtt
2881 taggagcctg aatctccaag cagagtctgt tagaggattt aatatgggac gagcaatcag
2941 cactggcagt ctggccagca gcaccctcaa caaacttgct gttcgacctt tatcagttca
3001 agctgagatt ctgaagaggc tatcctgctc agagctgtcg ctttaccagc cattgcaaaa
3061 cagttcaaaa gagaagaatg acaaagcttc atgggaggaa aagcctagag agatgagtaa
3121 atcataccat gatctcagtc aggcctctct ctatccacat cggaaaaatg tcattgttaa
3181 catggaaccc ccaccacaaa ccgttgcaga gttggtggga aaaccttctc accagatgtc
3241 aagatctgat gcagaatctt tggcaggagt gacaaaactt aataattcaa agtctgttgc
3301 gagtttaaat agaagtcctg aaaggaggaa acatgaatca gactcctcat ccattgaaga
3361 ccctgggcaa gcatatgttc taggaatgac tatgcatagt tctggaaact cttcatccca
3421 agtaccctta aaagaaaatg atgtgctaca caaaagatgg agcatagtat cttcaccaga
3481 aagggagatc accttagtga acctgaaaaa agatgcaaag tatggcttgg gatttcaaat
3541 tattggtggg gagaagatgg gaagactgga cctaggcata tttatcagtt cagttgcccc
3601 tggaggacca gctgacttgg atggatgctt gaagccagga gaccgtttga tatctgtgaa
3661 tagtgtgagt ctggagggag tcagccacca tgctgcaatt gaaattttgc aaaatgcacc
3721 tgaagatgtg acacttgtta tctctcagcc aaaagaaaag atatccaaag tgccttctac
3781 tcctgtgcat ctcaccaatg agatgaaaaa ctacatgaag aaatcttcct acatgcaaga
3841 cagtgctata gattcttctt ccaaggatca ccactggtca cgtggtaccc tgaggcacat
3901 ctcggagaac tcctttgggc cgtctggggg cctgcgggaa ggaagcctga gttctcaaga
3961 ttccaggact gagagtgcca gcttgtctca aagccaggtc aatggtttct ttgccagcca
4021 tttaggtgac caaacctggc aggaatcaca gcatggcagc ccttccccat ctgtaatatc
4081 caaagccacc gagaaagaga ctttcactga tagtaaccaa agcaaaacta aaaagccagg
4141 catttctgat gtaactgatt actcagaccg tggagattca gacatggatg aagccactta
4201 ctccagcagt caggatcatc aaacaccaaa acaggaatct tcctcttcag tgaatacatc
4261 caacaagatg aattttaaaa ctttttcttc atcacctcct aagcctggag atatctttga
4321 ggttgaactg gctaaaaatg ataacagctt ggggataagt gtcacggtac tgtttgacaa
4381 gggaggtgtg aatacgagtg tcagacatgg tggcatttat gtgaaagctg ttattcccca
4441 gggagcagca gagtctgatg gtagaattca caaaggtgat cgcgtcctag ctgtcaatgg
4501 agttagtcta gaaggagcca cccataagca agctgtggaa acactgagaa atacaggaca
4561 ggtggttcat ctgttattag aaaagggaca atctccaaca tctaaagaac atgtcccggt
4621 aaccccacag tgtacccttt cagatcagaa tgcccaaggt caaggcccag aaaaagtgaa
4681 gaaaacaact caggtcaaag actacagctt tgtcactgaa gaaaatacat ttgaggtaaa
4741 attatttaaa aatagctcag gtctaggatt cagtttttct cgagaagata atcttatacc
4801 ggagcaaatt aatgccagca tagtaagggt taaaaagctc tttcctggac agccagcagc
4861 agaaagtgga aaaattgatg taggagatgt tatcttgaaa gtgaatggag cctctttgaa
4921 aggactatct cagcaggaag tcatatctgc tctcagggga actgctccag aagtattctt
4981 gcttctctgc agacctccac ctggtgtgct accggaaatt gatactgcgc ttttgacccc
5041 acttcagtct ccagcacaag tacttccaaa cagcagtaaa gactcttctc agccatcatg
5101 tgtggagcaa agcaccagct cagatgaaaa tgaaatgtca gacaaaagca aaaaacagtg
5161 caagtcccca tccagaagag acagttacag tgacagcagt gggagtggag aagatgactt
5221 agtgacagct ccagcaaaca tatcaaattc gacctggagt tcagctttgc atcagactct
5281 aagcaacatg gtatcacagg cacagagtca tcatgaagca cccaagagtc aagaagatac
5341 catttgtacc atgttttact atcctcagaa aattcccaat aaaccagagt ttgaggacag
5401 taatccttcc cctctaccac cggatatggc tcctgggcag agttatcaac cccaatcaga
5461 atctgcttcc tctagttcga tggataagta tcatatacat cacatttctg aaccaactag
5521 acaagaaaac tggacacctt tgaaaaatga cttggaaaat caccttgaag actttgaact
5581 ggaagtagaa ctcctcatta ccctaattaa atcagaaaaa ggaagcctgg gttttacagt
5641 aaccaaaggc aatcagagaa ttggttgtta tgttcatgat gtcatacagg atccagccaa
5701 aagtgatgga aggctaaaac ctggggaccg gctcataaag gttaatgata cagatgttac
5761 taatatgact catacagatg cagttaatct gctccgggct gcatccaaaa cagtcagatt
5821 agttattgga cgagttctag aattacccag aataccaatg ttgcctcatt tgctaccgga
5881 cataacacta acgtgcaaca aagaggagtt gggtttttcc ttatgtggag gtcatgacag
5941 cctttatcaa gtggtatata ttagtgatat taatccaagg tccgtcgcag ccattgaggg
6001 taatctccag ctattagatg tcatccatta tgtgaacgga gtcagcacac aaggaatgac
6061 cttggaggaa gttaacagag cattagacat gtcacttcct tcattggtat tgaaagcaac
6121 aagaaatgat cttccagtgg tccccagctc aaagaggtct gctgtttcag ctccaaagtc
6181 aaccaaaggc aatggttcct acagtgtggg gtcttgcagc cagcctgccc tcactcctaa
6241 tgattcattc tccacggttg ctggggaaga aataaatgaa atatcgtacc ccaaaggaaa
6301 atgttctact tatcagataa agggatcacc aaacttgact ctgcccaaag aatcttatat
6361 acaagaagat gacatttatg atgattccca agaagctgaa gttatccagt ctctgctgga
6421 tgttgtggat gaggaagccc agaatctttt aaacgaaaat aatgcagcag gatactcctg
6481 tggtccaggt acattaaaga tgaatgggaa gttatcagaa gagagaacag aagatacaga
6541 ctgcgatggt tcacctttac ctgagtattt tactgaggcc accaaaatga atggctgtga
6601 agaatattgt gaagaaaaag taaaaagtga aagcttaatt cagaagccac aagaaaagaa
6661 gactgatgat gatgaaataa catggggaaa tgatgagttg ccaatagaga gaacaaacca
6721 tgaagattct gataaagatc attcctttct gacaaacgat gagctcgctg tactccctgt
6781 cgtcaaagtg cttccctctg gtaaatacac gggtgccaac ttaaaatcag tcattcgagt
6841 cctgcggggt ttgctagatc aaggaattcc ttctaaggag ctggagaatc ttcaagaatt
6901 aaaacctttg gatcagtgtc taattgggca aactaaggaa aacagaagga agaacagata
6961 taaaaatata cttccctatg atgctacaag agtgcctctt ggagatgaag gtggctatat
7021 caatgccagc ttcattaaga taccagttgg gaaagaagag ttcgtttaca ttgcctgcca
7081 aggaccactg cctacaactg ttggagactt ctggcagatg atttgggagc aaaaatccac
7141 agtgatagcc atgatgactc aagaagtaga aggagaaaaa atcaaatgcc agcgctattg
7201 gcccaacatc ctaggcaaaa caacaatggt cagcaacaga cttcgactgg ctcttgtgag
7261 aatgcagcag ctgaagggct ttgtggtgag ggcaatgacc cttgaagata ttcagaccag
7321 agaggtgcgc catatttctc atctgaattt cactgcctgg ccagaccatg atacaccttc
7381 tcaaccagat gatctgctta cttttatctc ctacatgaga cacatccaca gatcaggccc
7441 aatcattacg cactgcagtg ctggcattgg acgttcaggg accctgattt gcatagatgt
7501 ggttctggga ttaatcagtc aggatcttga ttttgacatc tctgatttgg tgcgctgcat
7561 gagactacaa agacacggaa tggttcagac agaggatcaa tatattttct gctatcaagt
7621 catcctttat gtcctgacac gtcttcaagc agaagaagag caaaaacagc agcctcagct
7681 tctgaagtga catgaaaaga gcctctggat gcatttccat ttctctcctt aacctccagc
7741 agactcctgc tctctatcca aaataagatc acagagcagc aagttcatac aacatgcatg
7801 ttctcctcta tcttagaggg gtattcttct tgaaaataaa aaatattgaa atgctgtatt
7861 tttacagcta ctttaaccta tgataattat ttacaaaatt ttaacactaa ccaaacaatg
7921 cagatcttag ggatgattaa aggcagcatt tgatgatagc agacattgtt acaaggacat
7981 ggtgagtcta tttttaatgc accaatcttg tttatagcaa aaatgttttc caatatttta
8041 ataaagtagt tattttatag gggatacttg aaaccagtat ttaagcttta aatgacagta
8101 atattggcat agaaaaaagt agcaaatgtt tactgtatca atttctaatg tttactatat
8161 agaatttcct gtaatatatt tatatacttt ttcatgaaaa tggagttatc agttatctgt
8221 ttgttactgc atcatctgtt tgtaatcatt atctcacttt gtaaataaaa acacacctta
8281 aaacatg
//