LOCUS HSU11870 4452 bp DNA linear HUM 28-MAR-1995
DEFINITION Human interleukin-8 receptor type A (IL8RBA) gene, promoter and
complete cds.
ACCESSION U11870
VERSION U11870.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4452)
AUTHORS Ahuja,S.K., Shetty,A., Tiffany,H.L. and Murphy,P.M.
TITLE Comparison of the genomic organization and promoter function for
human interleukin-8 receptors A and B
JOURNAL J. Biol. Chem. 269 (42), 26381-26389 (1994)
PUBMED 7929358
REFERENCE 2 (bases 1 to 4452)
AUTHORS Ahuja,S.K.
TITLE Direct Submission
JOURNAL Submitted (06-JUL-1994) Sunil K. Ahuja, Laboratory of Host
Defenses, National Institutes of Health, National Institute of
Allergy and Infectious Diseases, NIH, Bldg 10, Rm 11N109, Bethesda,
MD 20892, USA
FEATURES Location/Qualifiers
source 1..4452
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q34-35"
/clone="6e/IL8RA-gene"
/tissue_type="placenta"
regulatory 1..300
/regulatory_class="promoter"
/experiment="experimental evidence, no additional details
recorded"
protein_bind 65..70
/bound_moiety="NF-ATp"
protein_bind 96..101
/bound_moiety="NF-ATp"
protein_bind 205..212
/bound_moiety="GRE"
gene join(301..367,2024..4452)
/gene="IL8RA"
mRNA join(301..367,2024..4452)
/gene="IL8RA"
/experiment="experimental evidence, no additional details
recorded"
exon 301..367
/gene="IL8RA"
/number=1
intron 368..2023
/number=1
exon 2024..4452
/gene="IL8RA"
/number=2
CDS 2057..3109
/gene="IL8RA"
/experiment="experimental evidence, no additional details
recorded"
/note="neutrophil chemoattractant receptor; G-protein
coupled seven-transmembrane spanning receptor"
/codon_start=1
/product="interleukin-8 receptor type A"
/protein_id="AAA64378.1"
/translation="MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVII
AYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG
WIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGC
WGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVM
LFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQES
CERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARH
RVTSYTSSSVNVSSNL"
BASE COUNT 1067 a 1112 c 1078 g 1195 t
ORIGIN
1 aagcttccac aggtgatata ctagggaatt taggaataaa caaatggaaa taaattcaag
61 aaaaggaaaa taataaaaat gatcatccat agagtggaga attcagataa tggaccctca
121 accccagctt cacacctggg acccccactt ggtcatatgg accctggcag tctctaatca
181 caagtctgtg atcccttgac ttaaactgtt cttccccaaa tgtagacatg ggtggggctc
241 agaagggagg tgtcatctga tgtggtttcc ttatttccgt ttattcatca agtgccctct
301 agctgttaag tcactctgat ctctgactgc agctcctact gttggacaca cctggccggt
361 gcttcaggta ggaagccacc tctgtttgct aggactttct gtggggtagg gctgcttggc
421 ttgactttat tttggaaaat gtattcattt ctgtgggagc tgaggatttc tgctgcccgc
481 ttcctctctt gtgaccacca ctcatacatg gagttagcag gtgaacacca cagcctcctc
541 atccctcttt ttataccttg ccctttttgt gggaagaggc tgaccattcc caatttgagt
601 ttattgattc accttaagac tttgcttcag tgaaaatgca aatactggta gggagggaac
661 acactaaatg tgtggatctg agtggactca tcatacaccc tcaggcctgg cagcaaatga
721 gaggtggatg attatgtctt cctcgatttg cagatgagaa gactgaaatc tataggggta
781 cgagacccca ctcaaggtca tgagacttat ttatttattt atttatttat tttgagatgg
841 agtctcactc tgtcgcctag gctgtagtac tgtggcacga tctcggctca ctgcaacctc
901 catttccggg ttcaagtgat tctcctgcct cagcctcctg agtagttggg attacaggtg
961 cacgccacca cacccagcta atttttttgt atttttagta gagacggggt ttcatcattt
1021 tggtcaggct ggtctcgaac tcctgacttc atgatctgcc tgccttggcc tcccaaaggc
1081 tgggattaca cacgaaactt attaatggta gaatcaggat ggaatgaaga ctggatgcta
1141 ggtgtcttta caaccaacct cggtgacttt ccaaaggctt tcagacttct ctggagagtc
1201 ctggagcttt gaggggctct ttaggggcca tctgggttcg gagattagca cactctgccc
1261 cacagtggct cagcttttat ctgcttcaca tactgggctt ctgggaagat cttatttcag
1321 taaactattt cacaatagga aatatatttg aaactcttga atgattctgt ggattttttc
1381 aggggtggag ggtttcaggg accaagatgg agactttatc ttctcaaata cttaaaactc
1441 ctttagacag aggaacaaaa tatgtgctcc tcatttaaag aaggcttaaa atatacagtt
1501 taatgcaatg tgttgttatc acttccttcc cccagtagat tttaaggagg gtaaacaaga
1561 atcagggaga acataggaat agaaatagta gaaggggaca cctgggaaca ggtttgcctt
1621 cttgcatttt gcttaatgct ggcccttccc tgaatgtcta agaccaacct ggtccccaca
1681 tccaaatgca cagacacagc tgaggatgga gaaggctaaa gagggacaga ggtagagaca
1741 taggctgaga ggaggcagtt gtaggttgag ctagggctaa ggtgttttcc ccatattcca
1801 tcttacccca cactcaggcc aggccttaga gttgtggaag gtggagaaca ctgggaagcc
1861 aacctccgaa gaagaccagg ttggagtcaa aggaggaagg agagctctca ttgccaaacc
1921 aacagggaag ccaaggatat cccagtaact gctctcacat cattgatgag aatgccttga
1981 atccgagcta ctaaatcaca tttccttcct tctaaccttc cagttagatc aaaccattgc
2041 tgaaactgaa gaggacatgt caaatattac agatccacag atgtgggatt ttgatgatct
2101 aaatttcact ggcatgccac ctgcagatga agattacagc ccctgtatgc tagaaactga
2161 gacactcaac aagtatgttg tgatcatcgc ctatgcccta gtgttcctgc tgagcctgct
2221 gggaaactcc ctggtgatgc tggtcatctt atacagcagg gtcggccgct ccgtcactga
2281 tgtctacctg ctgaacctgg ccttggccga cctactcttt gccctgacct tgcccatctg
2341 ggccgcctcc aaggtgaatg gctggatttt tggcacattc ctgtgcaagg tggtctcact
2401 cctgaaggaa gtcaacttct acagtggcat cctgctgttg gcctgcatca gtgtggaccg
2461 ttacctggcc attgtccatg ccacacgcac actgacccag aagcgtcact tggtcaagtt
2521 tgtttgtctt ggctgctggg gactgtctat gaatctgtcc ctgcccttct tccttttccg
2581 ccaggcttac catccaaaca attccagtcc agtttgctat gaggtcctgg gaaatgacac
2641 agcaaaatgg cggatggtgt tgcggatcct gcctcacacc tttggcttca tcgtgccgct
2701 gtttgtcatg ctgttctgct atggattcac cctgcgtaca ctgtttaagg cccacatggg
2761 gcagaagcac cgagccatga gggtcatctt tgctgtcgtc ctcatcttcc tgctttgctg
2821 gctgccctac aacctggtcc tgctggcaga caccctcatg aggacccagg tgatccagga
2881 gagctgtgag cgccgcaaca acatcggccg ggccctggat gccactgaga ttctgggatt
2941 tctccatagc tgcctcaacc ccatcatcta cgccttcatc ggccaaaatt ttcgccatgg
3001 attcctcaag atcctggcta tgcatggcct ggtcagcaag gagttcttgg cacgtcatcg
3061 tgttacctcc tacacttctt cgtctgtcaa tgtctcttcc aacctctgaa aaccatcgat
3121 gaaggaatat ctcttctcag aaggaaagaa taaccaacac cctgaggttg tgtgtggaag
3181 gtgatctggc tctggacagg cactatctgg gttttggggg gacgctatag gatgtgggga
3241 agttaggaac tggtgtcttc aggggccaca ccaaccttct gaggagctgt tgaggtacct
3301 ccaaggaccg gcctttgcac ctccatggaa acgaagcacc atcattcccg ttgaacgtca
3361 catctttaac ccactaactg gctaattagc atggccacat ctgagccccg aatctgacat
3421 tagatgagag aacagggctg aagctgtgtc ctcatgaggg ctggatgctc tcgttgaccc
3481 tcacaggagc atctcctcaa ctctgagtgt taagcgttga gccaccaagc tggtggctct
3541 gtgtgctctg atccgagctc aggggggtgg ttttcccatc tcaggtgtgt tgcagtgtct
3601 gctggagaca ttgaggcagg cactgccaaa acatcaacct gccagctggc cttgtgagga
3661 gctggaaaca catgttcccc ttgggggtgg tggatgaaca aagagaaaga gggtttggaa
3721 gccagatcta tgccacaaga acccccttta cccccatgac caacatcgca gacacatgtg
3781 ctggccacct gctgagcccc aagtggaacg agacaagcag cccttagccc ttcccctctg
3841 cagcttccag gctggcgtgc agcatcagca tccctagaaa gccatgtgca gccaccagtc
3901 cattgggcag gcagatgttc ctaataaagc ttctgttccg tgcttgtccc tgtggaagta
3961 tcttggttgt gacagagtca agggtgtgtg cagcattgtt ggctgttcct gcagtagaat
4021 gggggcagca cctcctaaga aggcacctct ctgggttgaa gggcagtgtt ccctggggct
4081 ttaactcctg ctagaacagt ctcttgaggc acagaaactc ctgttcatgc ccatacccct
4141 ggccaaggaa gatccctttg tccacaagta aaaggaaatc ctcctccagg gagtctcagc
4201 ttcaccctga ggtgagcatc atcttctggg ttaggccttg cctaggcata gcctgcctca
4261 agctatgtga gctcaccagt ccctccccaa atgctttcca tgagttgcag ttttttccta
4321 gtctgttttc cctccttgga gaacagggcc ctgtcggttt gttcactgta tgtccttggt
4381 gcctggagcc tactaaatgc tcaataaata atgatcacag gaatgaatgc atgctgaaaa
4441 gaccactctt tt
//