LOCUS AH005384 5661 bp DNA linear HUM 10-JUN-2016
DEFINITION Homo sapiens clone 9I interleukin-8 receptor type B (IL8RB) gene,
complete cds.
ACCESSION AH005384 U11866 U11867 U11868 U11869
VERSION AH005384.3
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5661)
AUTHORS Ahuja,S.K., Shetty,A., Tiffany,H.L. and Murphy,P.M.
TITLE Comparison of the genomic organization and promoter function for
human interleukin-8 receptors A and B
JOURNAL J. Biol. Chem. 269 (42), 26381-26389 (1994)
PUBMED 7929358
REFERENCE 2 (bases 1 to 5661)
AUTHORS Ahuja,S.K.
TITLE Direct Submission
JOURNAL Submitted (06-JUL-1994) Sunil K. Ahuja, Laboratory of Host
Defenses, National Institutes of Health, National Institute of
Allergy and Infectious Diseases, NIH, Bldg 10, Rm 11N109, Bethesda,
MD 20892, USA
COMMENT On or before Jun 10, 2016 this sequence version replaced U11866.1,
U11867.1, U11868.1, U11869.1, AH005384.2.
FEATURES Location/Qualifiers
source 1..5661
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q34-35"
/clone="9I"
/tissue_type="placenta"
regulatory 1..1134
/regulatory_class="promoter"
/experiment="experimental evidence, no additional details
recorded"
/note="promoter 1"
protein_bind 516..521
/bound_moiety="NF-ATp"
protein_bind 733..742
/bound_moiety="NFkB"
protein_bind 776..785
/bound_moiety="NFkB"
regulatory 1017..1022
/regulatory_class="TATA_box"
gene 1064..5661
/gene="IL8RB"
mRNA join(1064..1148,2077..2139,2373..2424,3967..5661)
/gene="IL8RB"
/note="alternatively spliced variant IL8RB1, exons 1,6,8
and 11"
exon 1064..1148
/gene="IL8RB"
/experiment="experimental evidence, no additional details
recorded"
/number=1
regulatory 1114..1882
/regulatory_class="promoter"
/gene="IL8RB"
/experiment="experimental evidence, no additional details
recorded"
/note="promoter 2"
intron 1149..1491
/gene="IL8RB"
/experiment="experimental evidence, no additional details
recorded"
/number=1
mRNA join(1492..1568,2077..2139,2373..2424,3967..5661)
/gene="IL8RB"
/note="alternatively spliced variant IL8RB2, exons 2,6,8
and 11"
exon 1492..1568
/gene="IL8RB"
/experiment="experimental evidence, no additional details
recorded"
/number=2
intron 1569..1805
/gene="IL8RB"
/experiment="experimental evidence, no additional details
recorded"
/number=2
mRNA join(1806..1815,1856..2139,2373..2424,3967..5661)
/gene="IL8RB"
/note="alternatively spliced variant IL8RB3, exons 3,5,6,8
and 11"
exon 1806..1815
/gene="IL8RB"
/experiment="experimental evidence, no additional details
recorded"
/number=3
mRNA join(1816..1855,2077..2139,2373..2424,3967..5661)
/gene="IL8RB"
/note="alternatively spliced variant IL8RB4, exons 4,6,8
and 11"
exon 1816..1855
/gene="IL8RB"
/experiment="experimental evidence, no additional details
recorded"
/number=4
exon 1856..2076
/gene="IL8RB"
/experiment="experimental evidence, no additional details
recorded"
/number=5
exon 2077..2139
/gene="IL8RB"
/experiment="experimental evidence, no additional details
recorded"
/number=6
intron 2140..>2253
/gene="IL8RB"
/experiment="experimental evidence, no additional details
recorded"
/number=3
gap 2254..2353
/estimated_length=unknown
intron <2354..2368
/gene="IL8RB"
/number=3
mRNA join(2369..2424,3967..5661)
/gene="IL8RB"
/note="alternatively spliced variant IL8RB7, exons 7,8 and
11"
exon 2369..2372
/gene="IL8RB"
/experiment="experimental evidence, no additional details
recorded"
/number=7
exon 2373..2424
/gene="IL8RB"
/experiment="experimental evidence, no additional details
recorded"
/number=8
intron 2425..>2441
/gene="IL8RB"
/number=4
gap 2442..2541
/estimated_length=unknown
intron <2542..2556
/gene="IL8RB"
/number=4
mRNA join(2557..2709,3967..5661)
/gene="IL8RB"
/note="alternatively spliced variant IL8RB9, exons 9 and
11"
exon 2557..2709
/gene="IL8RB"
/experiment="experimental evidence, no additional details
recorded"
/number=9
intron 2710..>2714
/gene="IL8RB"
/number=5
gap 2715..2814
/estimated_length=unknown
intron <2815..3785
/gene="IL8RB"
/number=5
mRNA 3786..5661
/gene="IL8RB"
/note="alternatively spliced variant IL8RB10, exons 10 and
11"
exon 3786..3966
/gene="IL8RB"
/experiment="experimental evidence, no additional details
recorded"
/number=10
exon 3967..5661
/gene="IL8RB"
/experiment="experimental evidence, no additional details
recorded"
/number=11
CDS 3992..5074
/gene="IL8RB"
/experiment="experimental evidence, no additional details
recorded"
/note="neutrophil chemoattractant receptor"
/codon_start=1
/product="interleukin-8 receptor type B"
/protein_id="AAB60656.1"
/translation="MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESL
EINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLP
IWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRY
LVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSF
GFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTL
MRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGL
ISKDSLPKDSRPSFVGSSSGHTSTTL"
BASE COUNT 1338 a 1353 c 1289 g 1381 t
ORIGIN
1 aagcttacct cattctctcg tggggtactc tttatttatt tatttaattt ttccccagta
61 ttttacttac tgagttgatg attcaggctt tggaccagta ggggaagtat ccctgggtag
121 gcaccagatg tagctaaagt aggtgggtag gcaccggttg tagctaaagc aggtgggcag
181 agatcccagc cttgatgaga gtgcctggga gagctctcaa ttagatgtgc tgaggttttg
241 tcagggtgaa gggtaggagc tacctcaggt cccccactag gccagctgga aagctatcca
301 cctcccagct tcactccttt cccagtgttc cagctattca gatcagacag gcagttattt
361 tcatctgtag aaatgttgat gttccaagta gagaggaatt gtgactgcct gtcatgcaaa
421 cctgaatctg gggagtgctc ctcccgtggg gatgcaatca ccctgatttg ttccaggaag
481 gctgtctata ggtgcatcaa tgctgcgttc ctttgggaga agccccagct ctgtctgcag
541 tggcgtacca gggggaacaa ggatcccttc tctaagaccc ttcacaatac cagaggctgc
601 ctgcctattg ggtagaggtg caaactttcc cccactctgc ccagcacagc aattgtctct
661 gcaataggaa acttcccacc agtgaaaaga tctgggactc aagccctgcc attcagattc
721 ttttgttcca cagggtattc ccttgatgtg atgttcttcc ccttcctcta ggaatgggac
781 ttcctggaag ccagactaca gtgctcttct gggtctagcc acccagtggg cctaccagac
841 tctgggctgg tgctagggaa tgtctgcaag ggatccagtg gtgttacctg tcttcaagac
901 tcccagcagt gaataccagc accatctctg acagaagtgg gaggggagtg atgcaaactc
961 tgcaagattc cttggttgta gatagactta gagtattgac tttctcaaat gctggttata
1021 attatagtga acttatcacg tggacagacg caggacttct ggttagccag ggtgttgtaa
1081 gcagtggtga tagctgagaa tatgcagccg ttttctcctt cctgggtaca gtgctattct
1141 gcctagaggt gagtttttgc ctgtctcaca gagtaggctg cagcctgcca cttctttcaa
1201 aagttctgtg gattctttca gctttcctgt tcagttcctg cattcgttcc tggagaaaaa
1261 aaaattatag tgtgaatctc tacacgctat tctgtccttc cagatgggag aggcatgcta
1321 atgctgcctc caatctgttg tcttgggggg aaagaaaaca atttgttttg tttttttttt
1381 aatggatttg ctgggtttag taacccagag gtcattggga accttggcga aagttatttc
1441 agtggagcag taggaaggaa gccagttgca gtgtctttgt tgagcagcag aggggaggtg
1501 aggaagtgga gagagcagct gtggtggctg aagggtgcta ggacagaggg agcatgataa
1561 agccataagt aagatgtggt agaagggaaa gagccaggac agaggggaga gaaagcagga
1621 tcctcaagga ccagagaggc agtgggtcct acagtcaggt gcggggattc aacagaaaca
1681 gaaggaggga cgcttctcac tctgaccccg gaaagaagga agaaactgcg tgcgagttca
1741 gacaagtccg ttggcggggg ctgggatgcc tgcatcttcc ttgttaaaaa aggaagtgca
1801 ggttcaaaac attcagagac agaaggtgga tagacaaatc tccaccttca gactggtagg
1861 ctcctccaga agccatcaga caggaagatg tgaaaatccc cagcactcat cccagaatca
1921 ctaagtggca cctgtcctgg gccaaagtcc caggacagac ctcattgttc ctctgtggga
1981 atacctcccc aggaggcatc ctggatttcc cccttgcaac ccaggtcaga agtttcatcg
2041 tcaaggttgt ttcatctttt ttttcctgtc taacagctct gactaccacc caaccttgag
2101 gcacagtgaa gacatcggtg gccactccaa taacagcagg taggtgactt gttcagtctg
2161 agatgctggc aacatatttc taatggaaga gatctggaaa cttcagcctc ctctgaggcc
2221 cctgagaact ggggtgatga agtgtagaag cttnnnnnnn nnnnnnnnnn nnnnnnnnnn
2281 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2341 nnnnnnnnnn nnncaccacc tccctttcat aggtcacagc tgctcttctg gaggtgtcct
2401 acaggtgaaa agcccagcga cccagtaagt cttggaacac cnnnnnnnnn nnnnnnnnnn
2461 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2521 nnnnnnnnnn nnnnnnnnnn nctggaggtc actggcgacc tggttctcct tgctgagttc
2581 tctaccttct gtcctgactt gcatgctctc cctctggaac ctgaagctga cccataatgc
2641 ctgggagcat gagctcaccc atacacctcc agcccacccc cagcacagct gagcactgga
2701 ttatccacag tgagnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2761 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnncaccct
2821 ccacacccag gcttccccag agcaggatct gtgctgtccc tgtggcaagg gcagagcccc
2881 aggagctaga ctaaatctga gaggaacagg ggagtcaagg ctagatggag gcacacatgc
2941 aggacaggaa gggtctccag cagggctgaa agcaccaagc aagggtagtg caaaccctgt
3001 cttctctgct tcctgctgcc cctctcttat tgggtagcag actggctgtg tctgcttatc
3061 ccgcatggtg gcacatggct gcccagagct ccccaaataa cctgttacgt ttccacccac
3121 agggagaatc aggcagcccg cttgcttatt gtttttaata tacttttcca aactacacag
3181 acattcccaa agcgggtctc cttctaccca aaagagaaac gctgggcctt actaattaac
3241 tgaagactct gctagctcga gccttccaaa actccatgcc acaattgttc aaaccatttt
3301 ccagaataca tcttttaaaa taacttttag aaaattgaac aaagggattc atgtctcagc
3361 tttatagtca aaccatgatc ttttctgagg gtatagccca tttggagttc ctgcttaatc
3421 ccctgattaa aaactgaatg gggctgagtg cagtgctcat gcctatattc ccagcacttt
3481 gggagacaga ggcaggagaa ttacttaagg tcaggagttt aagaccatcc tgagcaacat
3541 aacaagtccc catctctaag acaaaaaaaa aagaactgag tgacatctca catctcacat
3601 ttctgaacat taaacccagc cttgatagcc aaagatgctc gccactgaag gatccaggta
3661 gtattgaggg ttctgtgggg attatccaaa gagaactttc tacaaagttt taggtgatgg
3721 cgatgctaaa agaaatgcta agaatttctc tcttatatta aagagaacta tggtcctctc
3781 ataaaatgta ccatttatca ccaaatttat ctcataacct aagagctacc acttacaaat
3841 ttgaagggaa aaattactac attgtaatac tcaagccaac acaaagaatc ctatcccagt
3901 ttcttgagtg gatgggcaag aatatgggga atttattatg cagtaacctt catctctctt
3961 ctataggtca ggatttaagt ttacctcaaa aatggaagat tttaacatgg agagtgacag
4021 ctttgaagat ttctggaaag gtgaagatct tagtaattac agttacagct ctaccctgcc
4081 cccttttcta ctagatgccg ccccatgtga accagaatcc ctggaaatca acaagtattt
4141 tgtggtcatt atctatgccc tggtattcct gctgagcctg ctgggaaact ccctcgtgat
4201 gctggtcatc ttatacagca gggtcggccg ctccgtcact gatgtctacc tgctgaacct
4261 agccttggcc gacctactct ttgccctgac cttgcccatc tgggccgcct ccaaggtgaa
4321 tggctggatt tttggcacat tcctgtgcaa ggtggtctca ctcctgaagg aagtcaactt
4381 ctatagtggc atcctgctac tggcctgcat cagtgtggac cgttacctgg ccattgtcca
4441 tgccacacgc acactgaccc agaagcgcta cttggtcaaa ttcatatgtc tcagcatctg
4501 gggtctgtcc ttgctcctgg ccctgcctgt cttacttttc cgaaggaccg tctactcatc
4561 caatgttagc ccagcctgct atgaggacat gggcaacaat acagcaaact ggcggatgct
4621 gttacggatc ctgccccagt cctttggctt catcgtgcca ctgctgatca tgctgttctg
4681 ctacggattc accctgcgta cgctgtttaa ggcccacatg gggcagaagc accgggccat
4741 gcgggtcatc tttgctgtcg tcctcatctt cctgctctgc tggctgccct acaacctggt
4801 cctgctggca gacaccctca tgaggaccca ggtgatccag gagacctgtg agcgccgcaa
4861 tcacatcgac cgggctctgg atgccaccga gattctgggc atccttcaca gctgcctcaa
4921 ccccctcatc tacgccttca ttggccagaa gtttcgccat ggactcctca agattctagc
4981 tatacatggc ttgatcagca aggactccct gcccaaagac agcaggcctt cctttgttgg
5041 ctcttcttca gggcacactt ccactactct ctaagacctc ctgcctaagt gcagcccgtg
5101 gggttcctcc cttctcttca cagtcacatt ccaagcctca tgtccactgg ttcttcttgg
5161 tctcagtgtc aatgcagccc ccattgtggt cacaggaagt agaggaggcc acgttcttac
5221 tagtttccct tgcatggttt agaaagcttg ccctggtgcc tcaccccttg ccataattac
5281 tatgtcattt gctggagctc tgcccatcct gcccctgagc ccatggcact ctatgttcta
5341 agaagtgaaa atctacactc cagtgagaca gctctgcata ctcattagga tggctagtat
5401 caaaagaaag aaaatcaggc tggccaacgg gatgaaaccc tgtctctact aaaaatacaa
5461 aaaaaaaaaa aaaaattagc cgggcgtggt ggtgagtgcc tgtaatcaca gctacttggg
5521 aggctgagat gggagaatca cttgaacccg ggaggcagag gttgcagtga gccgagattg
5581 tgcccctgca ctccagcctg agcgacagtg agactctgtc tcagtccatg aagatgtaga
5641 ggagaaactg gaactctcga g
//