LOCUS HSU11700 6642 bp mRNA linear HUM 23-MAR-1996
DEFINITION Human copper transporting ATPase mRNA, complete cds.
ACCESSION U11700
VERSION U11700.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 258)
AUTHORS Petrukhin,K., Lutsenko,S., Chernov,I., Ross,B.M., Kaplan,J.H. and
Gilliam,T.C.
TITLE Characterization of the Wilson disease gene encoding a P-type
copper transporting ATPase: genomic organization, alternative
splicing, and structure/function predictions
JOURNAL Hum. Mol. Genet. 3 (9), 1647-1656 (1994)
PUBMED 7833924
REFERENCE 2 (bases 259 to 6641)
AUTHORS Tanzi,R.E., Petrukhin,K., Chernov,I., Pellequer,J.L., Wasco,W.,
Ross,B., Romano,D.M., Parano,E., Pavone,L., Brzustowicz,L.M.,
Devoto,M., Peppercorn,J., Bush,A.I., Sternlieb,I., Pirastu,M.,
Gusella,J.F., Evgrafov,O., Penchaszadeh,G.K., Honig,B.,
Edelman,I.S., Soare,M.B., Scheinberg,I.H. and Gilliam,T.C.
TITLE The Wilson disease gene is a copper transporting ATPase with
homology to the Menkes disease gene
JOURNAL Nat. Genet. 5 (4), 344-350 (1993)
PUBMED 8298641
REFERENCE 3 (sites)
AUTHORS Petrukhin,K., Fischer,S.G., Pirastu,M., Tanzi,R.E., Chernov,I.,
Devoto,M., Brzustowicz,L.M., Canyanis,E., Vitale,E., Russo,J.J.,
Matseoane,D., Boukhgalter,B., Wasco,W., Figus,A.L., Loudianos,J.,
Cao,A., Sternlieb,I., Evgrafov,O., Parano,E., Pavone,L.,
Warburton,D., Ott,J., Penchaszadeh,G.K., Scheinberg,I.H. and
Gilliam,T.C.
TITLE Mapping, cloning and genetic characterization of the region
containing the Wilson disease gene
JOURNAL Nat. Genet. 5 (4), 338-343 (1993)
PUBMED 8298640
REFERENCE 4 (bases 1 to 6642)
AUTHORS Petrukhin,K.
TITLE Direct Submission
JOURNAL Submitted (30-JUN-1994) Konstantin Petrukhin, Psychiatry, Columbia
University, 722 West 168th Street, New York, NY 10032, USA
FEATURES Location/Qualifiers
source 1..6642
/db_xref="H-InvDB:HIT000218048"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="13"
/map="13q14.3"
5'UTR 1..162
CDS 163..4560
/codon_start=1
/product="copper transporting ATPase"
/protein_id="AAA92667.1"
/translation="MPEQERQITAREGASRKILSKLSLPTRAWEPAMKKSFAFDNVGY
EGGLDGLGPSSQVATSTVRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQDSATVKY
VPSVVCLQQVCHQIGDMGFEASIAEGKAASWPSRSLPAQEAVVKLRVEGMTCQSCVSS
IEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLS
LGPIDIERLQSTNPKRPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIE
ENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGS
GTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISV
SLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTD
GTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIER
NLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGNI
ELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEE
IGFHASLAQRNPNAHHLDHKMEIKQWKKSFLCSLVFGIPVMALMIYMLIPSNEPHQSM
VLDHNIIPGLSILNLIFFILCTFVQLLGGWYFYVQAYKSLRHRSANMDVLIVLATSIA
YVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSL
QATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTMADESL
ITGEAMPVTKKPGSTVIARSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQ
QLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQKYFPNPNKHISQTEVIIRFAF
QTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTG
TITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETL
GYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNEAGSLPAEKDAVPQTFSV
LIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAAL
AVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKV
AMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRR
IRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKK
PDLERYEAQAHGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQVSYVSQVSLSSLTSD
KPSRHSAAADDDGDKWSLLLNGRDEEQYI"
3'UTR 4561..6642
polyA_site 6642
/note="12 A nucleotides"
BASE COUNT 1539 a 1710 c 1745 g 1648 t
ORIGIN
1 ttcccggacc cctgtttgct ttagagccga gccgcgccgc gccgatgccc tcacactctg
61 cgcctcctct cccgggactt taacaccacg ctctcctcca ccgaccaggt gaccttttgc
121 tctgagccag atcagagaag aattcggtgt ccgtgcggga cgatgcctga gcaggagaga
181 cagatcacag ccagagaagg ggccagtcgg aaaatcttat ctaagctttc tttgcctacc
241 cgtgcctggg aaccagcaat gaagaagagt tttgcttttg acaatgttgg ctatgaaggt
301 ggtctggatg gcctgggccc ttcttctcag gtggccacca gcacagtcag gatcttgggc
361 atgacttgcc agtcatgtgt gaagtccatt gaggacagga tttccaattt gaaaggcatc
421 atcagcatga aggtttccct ggaacaagac agtgccactg tgaaatatgt gccatcggtt
481 gtgtgcctgc aacaggtttg ccatcaaatt ggggacatgg gcttcgaggc cagcattgca
541 gaaggaaagg cagcctcctg gccctcaagg tccttgcctg cccaggaggc tgtggtcaag
601 ctccgggtgg agggcatgac ctgccagtcc tgtgtcagct ccattgaagg caaggtccgg
661 aaactgcaag gagtagtgag agtcaaagtc tcactcagca accaagaggc cgtcatcact
721 tatcagcctt atctcattca gcccgaagac ctcagggacc atgtaaatga catgggattt
781 gaagctgcca tcaagagcaa agtggctccc ttaagcctgg gaccaattga tattgagcgg
841 ttacaaagca ctaacccaaa gagaccttta tcttctgcta accagaattt taataattct
901 gagaccttgg ggcaccaagg aagccatgtg gtcaccctcc aactgagaat agatggaatg
961 cattgtaagt cttgcgtctt gaatattgaa gaaaatattg gccagctcct aggggttcaa
1021 agtattcaag tgtccttgga gaacaaaact gcccaagtaa agtatgaccc ttcttgtacc
1081 agcccagtgg ctctgcagag ggctatcgag gcacttccac ctgggaattt taaagtttct
1141 cttcctgatg gagccgaagg gagtgggaca gatcacaggt cttccagttc tcattcccct
1201 ggctccccac cgagaaacca ggtccagggc acatgcagta ccactctgat tgccattgcc
1261 ggcatgacct gtgcatcctg tgtccattcc attgaaggca tgatctccca actggaaggg
1321 gtgcagcaaa tatcggtgtc tttggccgaa gggactgcaa cagttcttta taatccctct
1381 gtaattagcc cagaagaact cagagctgct atagaagaca tgggatttga ggcttcagtc
1441 gtttctgaaa gctgttctac taaccctctt ggaaaccaca gtgctgggaa ttccatggtg
1501 caaactacag atggtacacc tacatctgtg caggaagtgg ctccccacac tgggaggctc
1561 cctgcaaacc atgccccgga catcttggca aagtccccac aatcaaccag agcagtggca
1621 ccgcagaagt gcttcttaca gatcaaaggc atgacctgtg catcctgtgt gtctaacata
1681 gaaaggaatc tgcagaaaga agctggtgtt ctctccgtgt tggttgcctt gatggcagga
1741 aaggcagaga tcaagtatga cccagaggtc atccagcccc tcgagatagc tcagttcatc
1801 caggacctgg gttttgaggc agcagtcatg gaggactacg caggctccga tggcaacatt
1861 gagctgacaa tcacagggat gacctgcgcg tcctgtgtcc acaacataga gtccaaactc
1921 acgaggacaa atggcatcac ttatgcctcc gttgcccttg ccaccagcaa agcccttgtt
1981 aagtttgacc cggaaattat cggtccacgg gatattatca aaattattga ggaaattggc
2041 tttcatgctt ccctggccca gagaaacccc aacgctcatc acttggacca caagatggaa
2101 ataaagcagt ggaagaagtc tttcctgtgc agcctggtgt ttggcatccc tgtcatggcc
2161 ttaatgatct atatgctgat acccagcaac gagccccacc agtccatggt cctggaccac
2221 aacatcattc caggactgtc cattctaaat ctcatcttct ttatcttgtg tacctttgtc
2281 cagctcctcg gtgggtggta cttctacgtt caggcctaca aatctctgag acacaggtca
2341 gccaacatgg acgtgctcat cgtcctggcc acaagcattg cttatgttta ttctctggtc
2401 atcctggtgg ttgctgtggc tgagaaggcg gagaggagcc ctgtgacatt cttcgacacg
2461 ccccccatgc tctttgtgtt cattgccctg ggccggtggc tggaacactt ggcaaagagc
2521 aaaacctcag aagccctggc taaactcatg tctctccaag ccacagaagc caccgttgtg
2581 acccttggtg aggacaattt aatcatcagg gaggagcaag tccccatgga gctggtgcag
2641 cggggcgata tcgtcaaggt ggtccctggg ggaaagtttc cagtggatgg gaaagtcctg
2701 gaaggcaata ccatggctga tgagtccctc atcacaggag aagccatgcc agtcactaag
2761 aaacccggaa gcactgtaat tgcgaggtct ataaatgcac atggctctgt gctcattaaa
2821 gctacccacg tgggcaatga caccactttg gctcagattg tgaaactggt ggaagaggct
2881 cagatgtcaa aggcacccat tcagcagctg gctgaccggt ttagtggata ttttgtccca
2941 tttatcatca tcatgtcaac tttgacgttg gtggtatgga ttgtaatcgg ttttatcgat
3001 tttggtgttg ttcagaaata ctttcctaac cccaacaagc acatctccca gacagaggtg
3061 atcatccggt ttgctttcca gacgtccatc acggtgctgt gcattgcctg cccctgctcc
3121 ctggggctgg ccacgcccac ggctgtcatg gtgggcaccg gggtggccgc gcagaacggc
3181 atcctcatca agggaggcaa gcccctggag atggcgcaca agataaagac tgtgatgttt
3241 gacaagactg gcaccattac ccatggcgtc cccagggtca tgcgggtgct cctgctgggg
3301 gatgtggcca cactgcccct caggaaggtt ctggctgtgg tggggactgc ggaggccagc
3361 agtgaacacc ccttgggcgt ggcagtcacc aaatactgta aagaggaact tggaacagag
3421 accttgggat actgcacgga cttccaggca gtgccaggct gtggaattgg gtgcaaagtc
3481 agcaacgtgg aaggcatcct ggcccacagt gagcgccctt tgagtgcacc ggccagtcac
3541 ctgaatgagg ctggcagcct tcccgcagaa aaagatgcag tcccccagac cttctctgtg
3601 ctgattggaa accgtgagtg gctgaggcgc aacggtttaa ccatttctag cgatgtcagc
3661 gacgctatga cagaccacga gatgaaagga cagacagcca tcctggtggc tattgacggt
3721 gtgctctgtg ggatgatcgc aatcgcagac gctgtcaagc aggaggctgc cctggctgtg
3781 cacacgctgc agagcatggg tgtggacgtg gttctgatca cgggggacaa ccggaagaca
3841 gccagagcta ttgccaccca ggttggcatc aacaaagtct ttgcagaggt gctgccttcg
3901 cacaaggtgg ccaaggtcca ggagctccag aataaaggga agaaagtcgc catggtgggg
3961 gatggggtca atgactcccc ggccttggcc caggcagaca tgggtgtggc cattggcacc
4021 ggcacggatg tggccatcga ggcagccgac gtcgtcctta tcagaaatga tttgctggat
4081 gtggtggcta gcattcacct ttccaagagg actgtccgaa ggatacgcat caacctggtc
4141 ctggcactga tttataacct ggttgggata cccattgcag caggtgtctt catgcccatc
4201 ggcattgtgc tgcagccctg gatgggctca gcggccatgg cagcctcctc tgtgtctgtg
4261 gtgctctcat ccctgcagct caagtgctat aagaagcctg acctggagag gtatgaggca
4321 caggcgcatg gccacatgaa gcccctgacg gcatcccagg tcagtgtgca cataggcatg
4381 gatgacaggt ggcgggactc ccccagggcc acaccatggg accaggtcag ctatgtcagc
4441 caggtgtcgc tgtcctccct gacgtccgac aagccatctc ggcacagcgc tgcagcagac
4501 gatgatgggg acaagtggtc tctgctcctg aatggcaggg atgaggagca gtacatctga
4561 tgacttcagg caggcggccc ggggcaggga cttgcctcca ctcaccacaa gctgagcagg
4621 acagccagca gcaggatggg ctgagctagc ctccagcttt ggggacttcc gctccctgga
4681 tatgtccagt catcctgccc tgcagcacgc ggccttgtct gggtgcagct gggcttggcc
4741 tggagaggac ggccctgcct gcctcttggc ctcacgggac cgtcagcatg ggctttgtct
4801 tggactctag tccttggctg gactgtagaa ggtgagaggc gagtcaccct cctcacagac
4861 ctctgcttgg agtatttagg atgactgctg tgaaatggag aacagtttca tcaggaccaa
4921 aaaacctcac tgggcctttc cagagaactg cagacctcac tgtcagggtc tttctgatga
4981 cgcctgtctg tgtgcatcat gtttctgaga ccacagttta cctcaggtgt gcctgttgct
5041 ttcttcctgc atagtctgtt cctttcttcg tacatagtct gttccttttc tctcctgtgt
5101 gcttgtcagt ggggacccct cgcaaccctg cctgtcacct gggagggtgg gaccaatgtc
5161 cttgtggtct ttgctgctgc tctcaggcgc ttctccaatg ctctggagtg tgcatttcag
5221 cttgaacctg cttcctggct cacacatccc cagccaggga gcttgccaca ctcttcttca
5281 agttgaggag agttcttttt tgcttaaagc ccccttctcc atggagtgtt ggcttctcaa
5341 tagagtgttg ttgctgacca gctggagtga gggcctcaga gcctgacctg agagtccgta
5401 ctcggcttcc tgtggggtgt aggttctcgc gattcaggac gtccttccat atccctgccc
5461 agcctgtggt gcttgaaacg tttgccccat gggaaacgta tgtgtgcagg agcctccctg
5521 cacggcccaa ggggcttcgt tttcagtctt ctgactgtca cctcgtgggg ttcagtagag
5581 aattcaatta ctagcgcctg gccttgtgtg gcttggagga aatggtactg cccaaatagg
5641 aggaaaacac agcctccctg agcctgcatt ctgcacgctg cccaggggct tcagaaaagg
5701 agtggccaca gcaccccgaa gggagcatct atttacctgg cagtggctct cagagcagca
5761 gaacgggttc agttttagac tctgaagttg gttgtgattg acagaaccct ttgggagcaa
5821 actagtagag ttggattaaa ttctgggtga aacccttttc tcccacacaa aatagtttta
5881 gtgatttttt tcattgtcca ttacttgcca ggggcagttt tagcagcact tttgatagat
5941 tacgtctaat cctcccaacc aaccagcagg gtagctatta ctgtccacat tttacaggca
6001 aggaaacagg ctccaagagg ctgaggactt tgcccaggat gacatagcca atggacaagc
6061 agtgtctgtc agctgtgaag gcttcactct tattgtcctt ctaccttgaa tagaagtttt
6121 cctgataaga ataaacgagg aaaaggtcct tgcctcctgg aagaacaaat ctaccaggtg
6181 atctattcat tgtttcaact cagaatgcac ttgattcagg aggtcatctg accttcacct
6241 tggatggtta gtttcacttt ttacatatag tttttgcagg gttttatttt ataaaatcca
6301 agcgcgctgt tgattgtgtt ttccttgttt tcagcccccc gactccagcc cgcagcacat
6361 ttccgctgtc cgtcagtaat tgtgtcctct ctttatgctt gcttggggaa tgttgttttc
6421 tgactaggct gatcattatc taaagaatct aattctgttg atttttaaaa cttttaggac
6481 cataaacgtt gtgttcatat atggacatgg aaatatttat ataattttat agaaaataac
6541 cttttagatg gtcaaagtgt aaggagtttt tttgtcagat aatcatttct acttcaaaaa
6601 catttcatgc aatattagaa taaagttcct gtcattcctc ta
//