LOCUS       HSU11091                1292 bp    mRNA    linear   HUM 02-JAN-1995
DEFINITION  Human hydroxyindole-O-methyltransferase promoter B-derived (HIOMT)
            mRNA, complete cds.
ACCESSION   U11091
VERSION     U11091.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1292)
  AUTHORS   Rodriguez,I.R., Mazuruk,K., Schoen,T.J. and Chader,G.J.
  TITLE     Structural analysis of the human hydroxyindole-O-methyltransferase
            gene: Presence of two distinct promoters
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1292)
  AUTHORS   Rodriguez,I.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-JUN-1994) Ignacio R. Rodriguez, National Eye
            Institute, NIH, LRCMB, Bldg. 6 Rm. 304, Bethesda, MD 20892, USA
FEATURES             Location/Qualifiers
     source          1..1292
                     /db_xref="H-InvDB:HIT000218029_03"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.3"
                     /clone_lib="Amplified product from human retina cDNA"
     gene            1..1292
                     /gene="HIOMT"
     5'UTR           1..103
                     /gene="HIOMT"
                     /note="promoter B derived 5' untranslated region"
     CDS             104..1225
                     /gene="HIOMT"
                     /note="alternatively spliced including exons 6 and 7"
                     /codon_start=1
                     /product="hydroxyindole-O-methyltransferase"
                     /protein_id="AAA58583.1"
                     /translation="MGSSEDQAYRLLNDYANGFMVSQVLFAACELGVFDLLAEAPGPL
                     DVAAVAAGVRASAHGTELLLDICVSLKLLKVETRGGKAFYRNTELSSDYLTTVSPTSQ
                     CSMLKYMGRTSYRCWGHLADAVREGRNQYLETFGVPAEELFTAIYRSEGERLQFMQAL
                     QEVWSVNGRSVLTAFDLSVFPLMCDLGGTRIKLETIILSKLSQGQKTKHRVFSLIGGA
                     GALAKECMSLYPGCKITVFDIPEVVWTAKQHFSFQEEEQIDFQEGDFFKDPLPEADLY
                     ILARVLHDWADGKCSHLLERIYHTCKPGGGILVIESLLDEDRRGPLLTQLYSLNMLVQ
                     TEGQERTPTHYHMLLSSAGFRDFQFKKTGAIYDAILARK"
     misc_feature    666..890
                     /gene="HIOMT"
                     /note="alternatively spliced exons 6 and 7; Three
                     alternatively spliced transcripts are observed: B+6+7,
                     B-6+7 and B-6-7"
     misc_feature    666..749
                     /gene="HIOMT"
                     /note="alternatively spliced exon 6"
     regulatory      1273..1278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIOMT"
BASE COUNT          307 a          350 c          365 g          270 t
ORIGIN      
        1 cagctgtgag cgggtggctc ttccccacct tgccagcagg ctctgtgctc cttgaagcaa
       61 gcgctccaga ggctccggaa gccacggctg gattggagac aagatgggat cctcagagga
      121 ccaggcctat cgcctcctta atgactacgc caacggcttc atggtgtccc aggttctctt
      181 cgccgcctgc gagctgggcg tgtttgacct tctcgccgag gccccagggc ccctggacgt
      241 ggcggcagtg gctgcaggtg tgagggccag cgcccatggg acagagctcc tgctggacat
      301 ctgtgtgtcc ctgaagctgc tgaaagtgga gacgagggga ggaaaagctt tctatcgaaa
      361 cacagagctg tccagcgact acctgaccac ggtcagcccg acgtcacaat gcagcatgct
      421 gaagtacatg ggcaggacca gctaccggtg ctggggccac ctggcagacg ccgtgagaga
      481 aggaaggaac cagtacctgg agacgtttgg cgttcccgct gaagagcttt ttacggccat
      541 ctacaggtcc gagggcgagc ggctacagtt catgcaagct ctgcaggagg tctggagcgt
      601 caacgggaga agcgtgctga ccgcctttga cctgtcagtg ttcccactta tgtgtgacct
      661 tggtgggaca cggataaagc tggaaaccat cattctcagc aaactatcgc aaggacagaa
      721 aaccaaacac cgcgtgttct cactcatagg tggggctgga gctctggcta aggaatgcat
      781 gtctctgtac cctggatgta agatcaccgt ttttgacatc ccagaagtgg tgtggacggc
      841 aaagcagcac ttctcattcc aggaggaaga acagattgac ttccaggaag gggatttctt
      901 caaagaccct cttccggaag ctgatctgta catcctggcc agggtcctcc atgactgggc
      961 agacggaaag tgctcacacc tgctggagag gatctaccac acttgcaagc caggtggtgg
     1021 cattctggta attgaaagcc tcctggatga agacaggcga ggtcctctgc tcacgcagct
     1081 ctactctctg aacatgcttg tgcagacgga agggcaggag aggaccccca cccactacca
     1141 catgctcctc tcttctgctg gcttcagaga cttccagttt aagaaaacag gagccattta
     1201 tgatgccatt ttagccagga aataactgtt tcttgtgacc tggaactaac gtcaaagcac
     1261 acaagacata ataataaaga catgtacctc ca
//