LOCUS HSU11091 1292 bp mRNA linear HUM 02-JAN-1995 DEFINITION Human hydroxyindole-O-methyltransferase promoter B-derived (HIOMT) mRNA, complete cds. ACCESSION U11091 VERSION U11091.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1292) AUTHORS Rodriguez,I.R., Mazuruk,K., Schoen,T.J. and Chader,G.J. TITLE Structural analysis of the human hydroxyindole-O-methyltransferase gene: Presence of two distinct promoters JOURNAL Unpublished REFERENCE 2 (bases 1 to 1292) AUTHORS Rodriguez,I.R. TITLE Direct Submission JOURNAL Submitted (22-JUN-1994) Ignacio R. Rodriguez, National Eye Institute, NIH, LRCMB, Bldg. 6 Rm. 304, Bethesda, MD 20892, USA FEATURES Location/Qualifiers source 1..1292 /db_xref="H-InvDB:HIT000218029_03" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="X" /map="Xp22.3" /clone_lib="Amplified product from human retina cDNA" gene 1..1292 /gene="HIOMT" 5'UTR 1..103 /gene="HIOMT" /note="promoter B derived 5' untranslated region" CDS 104..1225 /gene="HIOMT" /note="alternatively spliced including exons 6 and 7" /codon_start=1 /product="hydroxyindole-O-methyltransferase" /protein_id="AAA58583.1" /translation="MGSSEDQAYRLLNDYANGFMVSQVLFAACELGVFDLLAEAPGPL DVAAVAAGVRASAHGTELLLDICVSLKLLKVETRGGKAFYRNTELSSDYLTTVSPTSQ CSMLKYMGRTSYRCWGHLADAVREGRNQYLETFGVPAEELFTAIYRSEGERLQFMQAL QEVWSVNGRSVLTAFDLSVFPLMCDLGGTRIKLETIILSKLSQGQKTKHRVFSLIGGA GALAKECMSLYPGCKITVFDIPEVVWTAKQHFSFQEEEQIDFQEGDFFKDPLPEADLY ILARVLHDWADGKCSHLLERIYHTCKPGGGILVIESLLDEDRRGPLLTQLYSLNMLVQ TEGQERTPTHYHMLLSSAGFRDFQFKKTGAIYDAILARK" misc_feature 666..890 /gene="HIOMT" /note="alternatively spliced exons 6 and 7; Three alternatively spliced transcripts are observed: B+6+7, B-6+7 and B-6-7" misc_feature 666..749 /gene="HIOMT" /note="alternatively spliced exon 6" regulatory 1273..1278 /regulatory_class="polyA_signal_sequence" /gene="HIOMT" BASE COUNT 307 a 350 c 365 g 270 t ORIGIN 1 cagctgtgag cgggtggctc ttccccacct tgccagcagg ctctgtgctc cttgaagcaa 61 gcgctccaga ggctccggaa gccacggctg gattggagac aagatgggat cctcagagga 121 ccaggcctat cgcctcctta atgactacgc caacggcttc atggtgtccc aggttctctt 181 cgccgcctgc gagctgggcg tgtttgacct tctcgccgag gccccagggc ccctggacgt 241 ggcggcagtg gctgcaggtg tgagggccag cgcccatggg acagagctcc tgctggacat 301 ctgtgtgtcc ctgaagctgc tgaaagtgga gacgagggga ggaaaagctt tctatcgaaa 361 cacagagctg tccagcgact acctgaccac ggtcagcccg acgtcacaat gcagcatgct 421 gaagtacatg ggcaggacca gctaccggtg ctggggccac ctggcagacg ccgtgagaga 481 aggaaggaac cagtacctgg agacgtttgg cgttcccgct gaagagcttt ttacggccat 541 ctacaggtcc gagggcgagc ggctacagtt catgcaagct ctgcaggagg tctggagcgt 601 caacgggaga agcgtgctga ccgcctttga cctgtcagtg ttcccactta tgtgtgacct 661 tggtgggaca cggataaagc tggaaaccat cattctcagc aaactatcgc aaggacagaa 721 aaccaaacac cgcgtgttct cactcatagg tggggctgga gctctggcta aggaatgcat 781 gtctctgtac cctggatgta agatcaccgt ttttgacatc ccagaagtgg tgtggacggc 841 aaagcagcac ttctcattcc aggaggaaga acagattgac ttccaggaag gggatttctt 901 caaagaccct cttccggaag ctgatctgta catcctggcc agggtcctcc atgactgggc 961 agacggaaag tgctcacacc tgctggagag gatctaccac acttgcaagc caggtggtgg 1021 cattctggta attgaaagcc tcctggatga agacaggcga ggtcctctgc tcacgcagct 1081 ctactctctg aacatgcttg tgcagacgga agggcaggag aggaccccca cccactacca 1141 catgctcctc tcttctgctg gcttcagaga cttccagttt aagaaaacag gagccattta 1201 tgatgccatt ttagccagga aataactgtt tcttgtgacc tggaactaac gtcaaagcac 1261 acaagacata ataataaaga catgtacctc ca //