LOCUS       HSU11090                1334 bp    mRNA    linear   HUM 02-JAN-1995
DEFINITION  Human hydroxyindole-O-methyltransferase promoter A-derived (HIOMT)
            mRNA, complete cds.
ACCESSION   U11090
VERSION     U11090.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1334)
  AUTHORS   Rodriguez,I.R., Mazuruk,K., Schoen,T.J. and Chader,G.J.
  TITLE     Structural analysis of the human hydroxyindole-O-methyltransferase
            gene: Presence of two distinct promoters
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1334)
  AUTHORS   Rodriguez,I.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-JUN-1994) Ignacio R. Rodriguez, National Eye
            Institute, NIH, LRCMB, Bldg. 6 Rm. 304, Bethesda, MD 20892, USA
FEATURES             Location/Qualifiers
     source          1..1334
                     /db_xref="H-InvDB:HIT000218028_03"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.3"
                     /clone_lib="Amplified from human retina cDNA immobilized
                     on Dynabeads"
     gene            1..1334
                     /gene="HIOMT"
     5'UTR           1..145
                     /gene="HIOMT"
                     /note="promoter A derived 5' untranslated region"
     CDS             146..1267
                     /gene="HIOMT"
                     /note="alternatively spliced including exons 6 and 7"
                     /codon_start=1
                     /product="hydroxyindole-O-methyltransferase"
                     /protein_id="AAA58582.1"
                     /translation="MGSSEDQAYRLLNDYANGFMVSQVLFAACELGVFDLLAEAPGPL
                     DVAAVAAGVRASAHGTELLLDICVSLKLLKVETRGGKAFYRNTELSSDYLTTVSPTSQ
                     CSMLKYMGRTSYRCWGHLADAVREGRNQYLETFGVPAEELFTAIYRSEGERLQFMQAL
                     QEVWSVNGRSVLTAFDLSVFPLMCDLGGTRIKLETIILSKLSQGQKTKHRVFSLIGGA
                     GALAKECMSLYPGCKITVFDIPEVVWTAKQHFSFQEEEQIDFQEGDFFKDPLPEADLY
                     ILARVLHDWADGKCSHLLERIYHTCKPGGGILVIESLLDEDRRGPLLTQLYSLNMLVQ
                     TEGQERTPTHYHMLLSSAGFRDFQFKKTGAIYDAILARK"
     misc_feature    707..791
                     /gene="HIOMT"
                     /note="alternatively spliced exon 6, line-1 element"
     misc_feature    792..932
                     /gene="HIOMT"
                     /note="alternatively spliced exon 7; Three alternatively
                     spliced transcripts are observed: A+6+7, A-6+7 and A-6-7"
     regulatory      1315..1320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIOMT"
BASE COUNT          336 a          348 c          386 g          264 t
ORIGIN      
        1 tcaggaactg gagcagcaaa gagaagaaca aaagcgcaga gagaaggaag cggaggagag
       61 gcagcgagcg gaggaaagca ggctctgtgc tccttgaagc aagcgctcca gaggctccgg
      121 aagccacggc tggattggag acaagatggg atcctcagag gaccaggcct atcgcctcct
      181 taatgactac gccaacggct tcatggtgtc ccaggttctc ttcgccgcct gcgagctggg
      241 cgtgtttgac cttctcgccg aggccccagg gcccctggac gtggcggcag tggctgcagg
      301 tgtgagggcc agcgcccatg ggacagagct cctgctggac atctgtgtgt ccctgaagct
      361 gctgaaagtg gagacgaggg gaggaaaagc tttctatcga aacacagagc tgtccagcga
      421 ctacctgacc acggtcagcc cgacgtcaca atgcagcatg ctgaagtaca tgggcaggac
      481 cagctaccgg tgctggggcc acctggcaga cgccgtgaga gaaggaagga accagtacct
      541 ggagacgttt ggcgttcccg ctgaagagct ttttacggcc atctacaggt ccgagggcga
      601 gcggctacag ttcatgcaag ctctgcagga ggtctggagc gtcaacggga gaagcgtgct
      661 gaccgccttt gacctgtcag tgttcccact tatgtgtgac cttggtggga cacggataaa
      721 gctggaaacc atcattctca gcaaactatc gcaaggacag aaaaccaaac accgcgtgtt
      781 ctcactcata ggtggggctg gagctctggc taaggaatgc atgtctctgt accctggatg
      841 taagatcacc gtttttgaca tcccagaagt ggtgtggacg gcaaagcagc acttctcatt
      901 ccaggaggaa gaacagattg acttccagga aggggatttc ttcaaagacc ctcttccgga
      961 agctgatctg tacatcctgg ccagggtcct ccatgactgg gcagacggaa agtgctcaca
     1021 cctgctggag aggatctacc acacttgcaa gccaggtggt ggcattctgg taattgaaag
     1081 cctcctggat gaagacaggc gaggtcctct gctcacgcag ctctactctc tgaacatgct
     1141 tgtgcagacg gaagggcagg agaggacccc cacccactac cacatgctcc tctcttctgc
     1201 tggcttcaga gacttccagt ttaagaaaac aggagccatt tatgatgcca ttttagccag
     1261 gaaataactg tttcttgtga cctggaacta acgtcaaagc acacaagaca taataataaa
     1321 gacatgtacc tcca
//