LOCUS HSU11090 1334 bp mRNA linear HUM 02-JAN-1995 DEFINITION Human hydroxyindole-O-methyltransferase promoter A-derived (HIOMT) mRNA, complete cds. ACCESSION U11090 VERSION U11090.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1334) AUTHORS Rodriguez,I.R., Mazuruk,K., Schoen,T.J. and Chader,G.J. TITLE Structural analysis of the human hydroxyindole-O-methyltransferase gene: Presence of two distinct promoters JOURNAL Unpublished REFERENCE 2 (bases 1 to 1334) AUTHORS Rodriguez,I.R. TITLE Direct Submission JOURNAL Submitted (22-JUN-1994) Ignacio R. Rodriguez, National Eye Institute, NIH, LRCMB, Bldg. 6 Rm. 304, Bethesda, MD 20892, USA FEATURES Location/Qualifiers source 1..1334 /db_xref="H-InvDB:HIT000218028_03" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="X" /map="Xp22.3" /clone_lib="Amplified from human retina cDNA immobilized on Dynabeads" gene 1..1334 /gene="HIOMT" 5'UTR 1..145 /gene="HIOMT" /note="promoter A derived 5' untranslated region" CDS 146..1267 /gene="HIOMT" /note="alternatively spliced including exons 6 and 7" /codon_start=1 /product="hydroxyindole-O-methyltransferase" /protein_id="AAA58582.1" /translation="MGSSEDQAYRLLNDYANGFMVSQVLFAACELGVFDLLAEAPGPL DVAAVAAGVRASAHGTELLLDICVSLKLLKVETRGGKAFYRNTELSSDYLTTVSPTSQ CSMLKYMGRTSYRCWGHLADAVREGRNQYLETFGVPAEELFTAIYRSEGERLQFMQAL QEVWSVNGRSVLTAFDLSVFPLMCDLGGTRIKLETIILSKLSQGQKTKHRVFSLIGGA GALAKECMSLYPGCKITVFDIPEVVWTAKQHFSFQEEEQIDFQEGDFFKDPLPEADLY ILARVLHDWADGKCSHLLERIYHTCKPGGGILVIESLLDEDRRGPLLTQLYSLNMLVQ TEGQERTPTHYHMLLSSAGFRDFQFKKTGAIYDAILARK" misc_feature 707..791 /gene="HIOMT" /note="alternatively spliced exon 6, line-1 element" misc_feature 792..932 /gene="HIOMT" /note="alternatively spliced exon 7; Three alternatively spliced transcripts are observed: A+6+7, A-6+7 and A-6-7" regulatory 1315..1320 /regulatory_class="polyA_signal_sequence" /gene="HIOMT" BASE COUNT 336 a 348 c 386 g 264 t ORIGIN 1 tcaggaactg gagcagcaaa gagaagaaca aaagcgcaga gagaaggaag cggaggagag 61 gcagcgagcg gaggaaagca ggctctgtgc tccttgaagc aagcgctcca gaggctccgg 121 aagccacggc tggattggag acaagatggg atcctcagag gaccaggcct atcgcctcct 181 taatgactac gccaacggct tcatggtgtc ccaggttctc ttcgccgcct gcgagctggg 241 cgtgtttgac cttctcgccg aggccccagg gcccctggac gtggcggcag tggctgcagg 301 tgtgagggcc agcgcccatg ggacagagct cctgctggac atctgtgtgt ccctgaagct 361 gctgaaagtg gagacgaggg gaggaaaagc tttctatcga aacacagagc tgtccagcga 421 ctacctgacc acggtcagcc cgacgtcaca atgcagcatg ctgaagtaca tgggcaggac 481 cagctaccgg tgctggggcc acctggcaga cgccgtgaga gaaggaagga accagtacct 541 ggagacgttt ggcgttcccg ctgaagagct ttttacggcc atctacaggt ccgagggcga 601 gcggctacag ttcatgcaag ctctgcagga ggtctggagc gtcaacggga gaagcgtgct 661 gaccgccttt gacctgtcag tgttcccact tatgtgtgac cttggtggga cacggataaa 721 gctggaaacc atcattctca gcaaactatc gcaaggacag aaaaccaaac accgcgtgtt 781 ctcactcata ggtggggctg gagctctggc taaggaatgc atgtctctgt accctggatg 841 taagatcacc gtttttgaca tcccagaagt ggtgtggacg gcaaagcagc acttctcatt 901 ccaggaggaa gaacagattg acttccagga aggggatttc ttcaaagacc ctcttccgga 961 agctgatctg tacatcctgg ccagggtcct ccatgactgg gcagacggaa agtgctcaca 1021 cctgctggag aggatctacc acacttgcaa gccaggtggt ggcattctgg taattgaaag 1081 cctcctggat gaagacaggc gaggtcctct gctcacgcag ctctactctc tgaacatgct 1141 tgtgcagacg gaagggcagg agaggacccc cacccactac cacatgctcc tctcttctgc 1201 tggcttcaga gacttccagt ttaagaaaac aggagccatt tatgatgcca ttttagccag 1261 gaaataactg tttcttgtga cctggaacta acgtcaaagc acacaagaca taataataaa 1321 gacatgtacc tcca //