LOCUS HSU10886 5117 bp mRNA linear HUM 26-NOV-1996
DEFINITION Human density enhanced phosphatase-1 mRNA, complete cds.
ACCESSION U10886
VERSION U10886.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5117)
AUTHORS Ostman,A., Yang,Q. and Tonks,N.K.
TITLE Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase,
is enhanced with increasing cell density
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (21), 9680-9684 (1994)
PUBMED 7937872
REFERENCE 2 (bases 1 to 5117)
AUTHORS Ostman,A.
TITLE Direct Submission
JOURNAL Submitted (15-JUN-1994) Arne Ostman, Ludwig Institute for Cancer
Research, Biomedical Center, Uppsala, S-751 24, Sweden
COMMENT On Nov 26, 1996 this sequence version replaced gi:558754.
FEATURES Location/Qualifiers
source 1..5117
/db_xref="H-InvDB:HIT000218018"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="Hela"
/clone_lib="Lambda GT10 cDNA library"
CDS 350..4363
/note="transmembrane protein"
/codon_start=1
/product="density enhanced phosphatase-1"
/protein_id="AAB36687.1"
/translation="MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIP
DPSVATVATGENGITQISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQG
SNGTDGASQKTPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENE
KTITVVHQPWCNITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALT
GVRKAALSWSNGNGTASCRVLLESIGSHEELTQDSRLQVNISDLKPGVQYNINPYLLQ
SNKTKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLVGPVDPSSGQQSRDTEVLLVG
LEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTLIWKVSDNE
SSSNYTYKIHVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVCPVLGDIEGTPGFLQV
HTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHITQEGAGNSRVEITTNQSIIIGG
LFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPDGA
SEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYT
RPSNVSNIDVSTNTTAATLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDA
TVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKW
TCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITTVSC
GKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEASHGPIKAYAVILTT
GEAGHPSADVLKYTYDDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEIDVGNESTT
LGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRYSDAVSLPQDPGV
ICGAVFGCIFGALVIVTVGGFIFWRKKRKDAKNNEVSFSQIKPKKSKLIRVENFEAYF
KKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQT
HSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGR
TKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWP
DHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENE
NTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIY
ENLAPVTTFGKTNGYIA"
sig_peptide 350..457
misc_feature 458..3277
/note="encodes the extracellular domain of the translated
peptide sequence"
misc_feature 764..2716
/note="encodes eight fibronectin III repeats"
misc_feature 3278..3337
/note="encodes the transmembrane domain of the translated
peptide sequence"
misc_feature 3338..4363
/note="encodes the intracellular domain of the translated
peptide sequence"
misc_feature 3527..4237
/note="encodes the protein-tyrosine phosphatase domain"
BASE COUNT 1315 a 1295 c 1293 g 1214 t
ORIGIN
1 ccccagccgc atgacgcgcg gaggaggcag cgggacgagc gcgggagccg ggaccgggta
61 gccgcgcgct gggggtgggc gccgctcgct ccgccccgcg aagcccctgc gcgctcaggg
121 acgcggcccc cccgcggcag ccgcgctagg ctccggcgtg tggccgcggc cgccgccgcg
181 ctgccatgtc tccgggcaag ccggggcggg cggagcgggg acgaggcgga ccggctggcg
241 gaggaggagg cgaaggagac ggcaggaggc ggcgacgacg gtgcccgggc tcgggcgcac
301 ggcggggccc gattcgcgcg tccggggcac gttccagggc gcgcggggca tgaagccggc
361 ggcgcgggag gcgcggctgc ctccgcgctc gcccgggctg cgctgggcgc tgccgctgct
421 gctgctgctg ctgcgcctgg gccagatcct gtgcgcaggt ggcaccccta gtccaattcc
481 tgacccttca gtagcaactg ttgccacagg ggaaaatggc ataacgcaga tcagcagtac
541 agcagaatcc tttcataaac agaatggaac tggaacacct caggtggaaa caaacaccag
601 tgaggatggt gaaagctctg gagccaacga tagtttaaga acacctgaac aaggatctaa
661 tgggactgat ggggcatctc aaaaaactcc cagtagcact gggcccagtc ctgtgtttga
721 cattaaagct gtttccatca gtccaaccaa tgtgatctta acttggaaaa gtaatgacac
781 agctgcttct gagtacaagt atgtagtaaa gcataagatg gaaaatgaga agacaattac
841 tgttgtgcat caaccatggt gtaacatcac aggcttacgt ccagcgactt catatgtatt
901 ctccatcact ccaggaatag gcaatgagac ttggggagat cccagagtca taaaagtcat
961 cacagagccg atcccagttt ctgatctccg tgttgccctc acgggtgtga ggaaggctgc
1021 tctctcctgg agcaatggca atggcaccgc ctcctgccgg gttcttcttg aaagcattgg
1081 aagccatgag gagttgactc aagactcaag acttcaggtc aatatctcgg acctgaagcc
1141 aggggttcaa tacaacatca acccgtatct tctacaatca aataagacaa agggagaccc
1201 cttgggcaca gaaggtggct tggatgccag caatacagag agaagccggg cagggagccc
1261 caccgcccct gtgcatgatg agtccctcgt gggacctgtg gacccatcct ccggccagca
1321 gtcccgagac acggaagtcc tgcttgtcgg gttagagcct ggcacccgat acaatgccac
1381 cgtttattcc caagcagcga atggcacaga aggacagccc caggccatag agttcaggac
1441 aaatgctatt caggtttttg acgtcaccgc tgtgaacatc agtgccacaa gcctgaccct
1501 gatctggaaa gtcagcgata acgagtcgtc atctaactat acctacaaga tacatgtggc
1561 gggggagaca gattcttcca atctcaacgt cagtgagcct cgcgctgtca tccccggact
1621 ccgctccagc accttctaca acatcacagt gtgtcctgtc ctaggtgaca tcgagggcac
1681 gccgggcttc ctccaagtgc acaccccccc tgttccagtt tctgacttcc gagtgacagt
1741 ggtcagcacg acggagatcg gcttagcatg gagcagccat gatgcagaat catttcagat
1801 gcatatcaca caggagggag ctggcaattc tcgggtagaa ataaccacca accaaagtat
1861 tatcattggt ggcttgttcc ctggaaccaa gtattgcttt gaaatagttc caaaaggacc
1921 aaatgggact gaaggggcat ctcggacagt ttgcaataga actgttccca gtgcagtgtt
1981 tgacatccac gtggtctacg tcaccaccac ggagatgtgg ctggactgga agagccctga
2041 cggtgcttcc gagtatgtct accatttagt catagagtcc aagcatggct ctaaccacac
2101 aagcacgtat gacaaagcga ttactctcca gggcctgatt ccgggcacct tatataacat
2161 caccatctct ccagaagtgg accacgtctg gggggacccc aactccactg cacagtacac
2221 acggcccagc aatgtgtcca acattgatgt aagtaccaac accacagcag caactttaag
2281 ttggcagaac tttgatgacg cctctcccac gtactcctac tgccttctta ttgagaaggc
2341 tggaaattcc agcaacgcaa cacaagtagt cacggacatt ggaattactg acgctacagt
2401 cactgaatta atacctggct catcatacac agtggagatc tttgcacaag taggggatgg
2461 gatcaagtca ctggaacctg gccggaagtc attctgtaca gatcctgcgt ccatggcctc
2521 cttcgactgc gaagtggtcc ccaaagagcc agccctggtt ctcaaatgga cctgccctcc
2581 tggcgccaat gcaggctttg agctggaggt cagcagtgga gcctggaaca atgcgaccca
2641 cctggagagc tgctcctctg agaatggcac tgagtataga acggaagtca cgtatttgaa
2701 tttttctacc tcgtacaaca tcagcatcac cactgtgtcc tgtggaaaga tggcagcccc
2761 cacccggaac acctgcacta ctggcatcac agatccccct cctccagatg gatcccctaa
2821 tattacatct gtcagtcaca attcagtaaa ggtcaagttc agtggatttg aagccagcca
2881 cggacccatc aaagcctatg ctgtcattct caccaccggg gaagctggtc acccttctgc
2941 agatgtcctg aaatacacgt atgacgattt caaaaaggga gcctcagata cttatgtgac
3001 atacctcata agaacagaag aaaagggacg ttctcagagc ttgtctgaag ttttgaaata
3061 tgaaattgac gttgggaatg agtcaaccac acttggttat tacaatggga agctggaacc
3121 tctgggctcc taccgggctt gtgtggctgg cttcaccaac attaccttcc accctcaaaa
3181 caaggggctc attgatgggg ctgagagcta tgtgtccttc agtcgctact cagatgctgt
3241 ttccttgccc caggatccag gtgtcatctg tggagcggtt tttggctgta tctttggtgc
3301 cctggttatt gtgactgtgg gaggcttcat cttctggaga aagaagagga aagatgcaaa
3361 gaataatgaa gtgtcctttt ctcaaattaa acctaaaaaa tctaagttaa tcagagtgga
3421 gaattttgag gcctacttca agaagcagca agctgactcc aactgtgggt tcgcagagga
3481 atacgaagat ctgaagcttg ttggaattag tcaacctaaa tatgcagcag aactggctga
3541 gaatagagga aagaatcgct ataataatgt tctgccctat gatatttccc gtgtcaaact
3601 ttcggtccag acccattcaa cggatgacta catcaatgcc aactacatgc ctggctacca
3661 ctccaagaaa gattttattg ccacacaagg acctttaccg aacactttga aagatttttg
3721 gcgtatggtt tgggagaaaa atgtatatgc catcattatg ttgactaaat gtgttgaaca
3781 gggaagaacc aaatgtgagg agtattggcc ctccaagcag gctcaggact atggagacat
3841 aactgtggca atgacatcag aaattgttct tccggaatgg accatcagag atttcacagt
3901 gaaaaatatc cagacaagtg agagtcaccc tctgagacag ttccatttca cctcctggcc
3961 agaccacggt gttcccgaca ccactgacct gctcatcaac ttccggtacc tcgttcgtga
4021 ctacatgaag cagagtcctc ccgaatcgcc gattctggtg cattgcagtg ctggggtcgg
4081 aaggacgggc actttcattg ccattgatcg tctcatctac cagatagaga atgagaacac
4141 cgtggatgtg tatgggattg tgtatgacct tcgaatgcat aggcctttaa tggtgcagac
4201 agaggaccag tatgttttcc tcaatcagtg tgttttggat attgtcagat cccagaaaga
4261 ctcaaaagta gatcttatct accagaacac aactgcaatg acaatctatg aaaaccttgc
4321 gcccgtgacc acatttggaa agaccaatgg ttacatcgcc taattccaaa ggaataacct
4381 ttctggagtg aaccagaccg tcgcacccac agcgaaggca catgccccga tgtcgacatg
4441 tttttatatg tctaatatct taattctttg ttctgttttg tgagaactaa ttttgagggc
4501 atgaagctgc atatgataga tgacaaattg gggctgtcgg gggctgtgga tgggtgggga
4561 gcaaatcatc tgcattcctg atgaccaatg ggatgaggtc actttttttt ttttccccct
4621 tgaggattgc ggaaaaccag gaaaagggat ctatgatttt tttttccaaa acaatttctt
4681 ttttaaaaag actattttat atgattcaca tgctaaagcc aggattgtgt tgggttgaat
4741 atattttaag tatcagaggt ctatttttac ctactgtgtc ttggaatcta gccgatggaa
4801 aatacctaat tgtggatgat gattgcgcag ggaggggtac gtggcacctc ttccgaatgg
4861 gttttctatt tgaacatgtg ccttttctga attatgcttc cacaggcaaa actcagtaga
4921 gatctatatt tttgtactga atctcataat tggaatatac ggaatattta aacagtagct
4981 tagcatcaga ggtttgcttc ctcagtaaca tttctgttct catttgatca ggggaggcct
5041 ctttgccccg gccccgcttc ccctgccccc gtgtgatttg tgctccattt tttcttccct
5101 tttccctccc agttttc
//