LOCUS       HSU10860                2212 bp    mRNA    linear   HUM 11-JAN-1995
DEFINITION  Human guanosine 5'-monophosphate synthase mRNA, complete cds.
ACCESSION   U10860
VERSION     U10860.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2212)
  AUTHORS   Hirst,M., Haliday,E., Nakamura,J. and Lou,L.
  TITLE     Human GMP synthetase. Protein purification, cloning, and functional
            expression of cDNA
  JOURNAL   J. Biol. Chem. 269 (38), 23830-23837 (1994)
   PUBMED   8089153
REFERENCE   2  (bases 1 to 2212)
  AUTHORS   Lou,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-1994) Lillian Lou, Syntex Discovery Research,
            3401 Hillview Avenue, Mail Stop S3-1, Palo Alto, CA 94303, USA
FEATURES             Location/Qualifiers
     source          1..2212
                     /db_xref="H-InvDB:HIT000218016"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="GMPS.6"
                     /cell_line="A3.01"
                     /cell_type="T-lymphoblastoma"
                     /clone_lib="Strategene Lambda-ZAP-II"
                     /note="custom cDNA library made by Stratagene (La Jolla,
                     CA) using poly(A)+ RNA from A3.01 cells, catalog number
                     836201"
     mRNA            <1..>2212
                     /product="guanosine 5'-monophosphate synthetase"
     CDS             123..2204
                     /EC_number="6.3.5.2"
                     /function="de novo synthesis of GMP"
                     /standard_name="GMP synthase"
                     /note="located in the cytosol; a glutamine
                     amidotransferase (G-type)"
                     /codon_start=1
                     /product="guanosine 5'-monophosphate synthetase"
                     /protein_id="AAA60331.1"
                     /translation="MALCNGDSKLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRR
                     VRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLG
                     ICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKV
                     ADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFT
                     VQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMR
                     KRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPE
                     EKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHH
                     NDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICA
                     EEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLN
                     AFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNRVVYIFGP
                     PVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDP
                     LQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIMYDL
                     TSKPPGTTEWE"
BASE COUNT          661 a          455 c          515 g          581 t
ORIGIN      
        1 tgccggctgc tcctcgacca ggcctccttc tcaacctcag cccgcggcgc cgacccttcc
       61 ggcaccctcc cgccccgtct cgtactgtcg ccgtcaccgc cgcggctccg gccctggccc
      121 cgatggctct gtgcaacgga gactccaagc tggagaatgc tggaggagac cttaaggatg
      181 gccaccacca ctatgaagga gctgttgtca ttctggatgc tggtgctcag tacgggaaag
      241 tcatagaccg aagagtgagg gaactgttcg tgcagtctga aattttcccc ttggaaacac
      301 cagcatttgc tataaaggaa caaggattcc gtgctattat catctctgga ggacctaatt
      361 ctgtgtatgc tgaagatgct ccctggtttg atccagcaat attcactatt ggcaagcctg
      421 ttcttggaat ttgctatggt atgcagatga tgaataaggt atttggaggt actgtgcaca
      481 aaaaaagtgt cagagaagat ggagttttca acattagtgt ggataataca tgttcattat
      541 tcaggggcct tcagaaggaa gaagttgttt tgcttacaca tggagatagt gtagacaaag
      601 tagctgatgg attcaaggtt gtggcacgtt ctggaaacat agtagcaggc atagcaaatg
      661 aatctaaaaa gttatatgga gcacagttcc accctgaagt tggccttaca gaaaatggaa
      721 aagtaatact gaagaatttc ctttatgata tagctggatg cagtggaacc ttcaccgtgc
      781 agaacagaga acttgagtgt attcgagaga tcaaagagag agtaggcacg tcaaaagttt
      841 tggttttact cagtggtgga gtagactcaa cagtttgtac agctttgcta aatcgtgctt
      901 tgaaccaaga acaagtcatt gctgtgcaca ttgataatgg ctttatgaga aaacgagaaa
      961 gccagtctgt tgaagaggcc ctcaaaaagc ttggaattca ggtcaaagtg ataaatgctg
     1021 ctcattcttt ctacaatgga acaacaaccc taccaatatc agatgaagat agaaccccac
     1081 ggaaaagaat tagcaaaacg ttaaatatga ccacaagtcc tgaagagaaa agaaaaatca
     1141 ttggggatac ttttgttaag attgccaatg aagtaattgg agaaatgaac ttgaaaccag
     1201 aggaggtttt ccttgcccaa ggtactttac ggcctgatct aattgaaagt gcatcccttg
     1261 ttgcaagtgg caaagctgaa ctcatcaaaa cccatcacaa tgacacagag ctcatcagaa
     1321 agttgagaga ggagggaaaa gtaatagaac ctctgaaaga ttttcataaa gatgaagtga
     1381 gaattttggg cagagaactt ggacttccag aagagttagt ttccaggcat ccatttccag
     1441 gtcctggcct ggcaatcaga gtaatatgtg ctgaagaacc ttatatttgt aaggactttc
     1501 ctgaaaccaa caatattttg aaaatagtag ctgatttttc tgcaagtgtt aaaaagccac
     1561 ataccctatt acagagagtc aaagcctgca caacagaaga ggatcaggag aagctgatgc
     1621 aaattaccag tctgcattca ctgaatgcct tcttgctgcc aattaaaact gtaggtgtgc
     1681 agggtgactg tcgttcctac agttacgtgt gtggaatctc cagtaaagat gaacctgact
     1741 gggaatcact tatttttctg gctaggctta tacctcgcat gtgtcacaac gttaacagag
     1801 ttgtttatat atttggccca ccagttaaag aacctcctac agatgttact cccactttct
     1861 tgacaacagg ggtgctcagt actttacgcc aagctgattt tgaggcccat aacattctca
     1921 gggagtctgg gtatgctggg aaaatcagcc agatgccggt gattttgaca ccattacatt
     1981 ttgatcggga cccacttcaa aagcagcctt catgccagag atctgtggtt attcgaacct
     2041 ttattactag tgacttcatg actggtatac ctgcaacacc tggcaatgag atccctgtag
     2101 aggtggtatt aaagatggtc actgagatta agaagattcc tggtatttct cgaattatgt
     2161 atgacttaac atcaaagccc ccaggaacta ctgagtggga gtaataaact tc
//