LOCUS HSU10324 3505 bp mRNA linear HUM 24-AUG-1994
DEFINITION Human nuclear factor NF90 mRNA, complete cds.
ACCESSION U10324
VERSION U10324.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3505)
AUTHORS Kao,P.N., Chen,L., Brock,G., Ng,J., Kenny,J., Smith,A.J. and
Corthesy,B.
TITLE Cloning and expression of cyclosporin A- and FK506-sensitive
nuclear factor of activated T-cells: NF45 and NF90
JOURNAL J. Biol. Chem. 269 (32), 20691-20699 (1994)
PUBMED 7519613
REFERENCE 2 (bases 1 to 3505)
AUTHORS St Johnston,D., Brown,N.H., Gall,J.G. and Jantsch,M.
TITLE A conserved double-stranded RNA-binding domain
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (22), 10979-10983 (1992)
PUBMED 1438302
REFERENCE 3 (bases 1 to 3505)
AUTHORS Kao,P.N.
TITLE Direct Submission
JOURNAL Submitted (02-JUN-1994) Peter N. Kao, Pulmonary and Critical Care
Medicine, Stanford University, MSLS P312, Stanford, CA 94305-5487,
USA
FEATURES Location/Qualifiers
source 1..3505
/db_xref="H-InvDB:HIT000217992"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="pBS II KS+ NF90.3"
/cell_line="Jurkat T-cell"
/clone_lib="2H Stim Jurkat T-cells, lambda gt11 cDNA
library from J.N. Northrop"
CDS 265..2280
/function="involved in DNA-binding with NF45 protein to
NF-AT target DNA sequence in interleukin-2 enhancer"
/codon_start=1
/product="NF90 protein"
/protein_id="AAA20994.1"
/translation="MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKA
VSDWIHEQEKGSSEQAESDNMDVPPEDDSKEGAGEQKTEHMTRTCRGVMRAGPGGQSA
SYSRGTWIWSWCCCVRRSPQPALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKN
TKEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCFAALASLRHAKWFQ
ARANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRV
LECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHKV
LGMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGEEKSPSKKKKKIQ
KKEEKAEPPQAMNALMRLNQLKPGLQYKLVSQTGPVHAPIFTMSVEVDGNSFEASGPS
KKTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEETEAKPAVVAPAPVVEAVSTPSA
AFPSDATAENVKQQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEV
DGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLSPLMPTKRREPQYPSEGDRNLLLSH
ITLASAWEAPCTTKCPHPPTFEGGEEAGRSGDEGAGEDLVAPTMEAT"
misc_structure 1519..1656
/note="encodes double-stranded RNA-binding domain"
/citation=[2]
misc_structure 1867..2076
/note="encodes double-stranded RNA-binding domain"
/citation=[2]
BASE COUNT 866 a 958 c 1011 g 670 t
ORIGIN
1 cgccgcctgc ccgcccgccc gctcgccccc ggtccggact cctcctcctc ctcttctcgc
61 attgcagttg aacccagcag cccgccccac cggtggcttt tgggggcaga ccccggcggc
121 tgtggcagga gggcggcggc ggcggctgcg gtcgaagaag gggacgccga caagagttga
181 agtattgata acaccaagga actctatcac aatttgaaaa gataagcaaa agtttgattt
241 ccagacacta cagaagaagt aaaaatgcgt ccaatgcgaa tttttgtgaa tgatgaccgc
301 catgtgatgg caaagcattc ttccgtttat ccaacacaag aggagctgga ggcagtccag
361 aacatggtgt cccacacgga gcgggcgctc aaagctgtgt ccgactggat acacgagcag
421 gaaaagggta gcagcgagca ggcagagtcc gataacatgg atgtgccccc agaggacgac
481 agtaaagaag gggctgggga acagaagacg gagcacatga ccagaacctg tcggggagtg
541 atgcgggctg ggcctggtgg ccaaagtgcc tcctactcaa gggggacttg gatctggagc
601 tggtgctgct gtgtaaggag aagcccacaa ccggccctcc tggacaaggt ggccgacaac
661 ctggccatcc agcttgctgc tgtaacagaa gacaagtacg aaatactgca atctgtcgac
721 gatgctgcga ttgtgataaa aaacacaaaa gagcctccat tgtccctgac catccacctg
781 acatcccctg ttgtcagaga agaaatggag aaagtattag ctggagaaac gctatcagtc
841 aacgaccccc cggacgttct ggacaggcag aaatgctttg ctgccttggc gtccctccga
901 cacgccaagt ggttccaggc cagagccaac gggctgaagt cttgtgtcat tgtgatccgg
961 gtcttgaggg acctgtgcac tcgcgtgccc acctggggtc ccctccgagg ctggcctctc
1021 gagctcctgt gtgagaaatc cattggcacg gccaacagac cgatgggtgc tggcgaggcc
1081 ctgcggagag tgctggagtg cctggcgtcg ggcatcgtga tgccagatgg ttctggcatt
1141 tatgaccctt gtgaaaaaga agccactgat gctattgggc atctagacag acagcaacgg
1201 gaagatatca cacagagtgc gcagcacgca ctgcggctcg ccgcgttcgg ccagctccat
1261 aaagtcctag gcatggaccc tctgccttcc aagatgccca agaaaccaaa gaatgaaaac
1321 ccagtggact acaccgttca gatcccacca agcaccacct atgccattac gcccatgaaa
1381 cgcccaatgg aggaggacgg ggaggagaag tcgcccagca aaaagaagaa gaagattcag
1441 aagaaagagg agaaggcaga gcccccccag gctatgaatg ccctgatgcg gttgaaccag
1501 ctgaagccag ggctgcagta caagctggtg tcccagactg ggcccgtcca tgcccccatc
1561 tttaccatgt ctgtggaggt tgatggcaat tcattcgagg cctctgggcc ctccaaaaag
1621 acggccaagc tgcacgtggc cgttaaggtg ttacaggaca tgggcttgcc gacgggtgct
1681 gaaggcaggg actcgagcaa gggggaggac tcggctgagg agaccgaggc gaagccagca
1741 gtggtggccc ctgccccagt ggtagaagct gtctccaccc ctagtgcggc ctttccctca
1801 gatgccactg ccgagaacgt aaaacagcag gggccgatcc tgacaaagca cggcaagaac
1861 ccagtcatgg agctgaacga gaagaggcgt gggctcaagt acgagctcat ctccgagacc
1921 gggggcagcc acgacaagcg cttcgtcatg gaggtcgaag tggatggaca gaagttccaa
1981 ggtgctggtt ccaacaaaaa ggtggcgaag gcctacgctg ctcttgctgc cctagaaaag
2041 cttttccctg acacccctct ctcgcccttg atgccaacaa aaagaagaga gccccagtac
2101 ccgtcagagg gggaccgaaa tttgctgcta agccacataa ccctggcttc ggcatgggag
2161 gccccatgca caacgaagtg cccccacccc ccaaccttcg agggcgggga agaggcggga
2221 cgatccgggg acgagggcgc gggcgaggat ttggtggcgc caaccatgga ggctacatga
2281 atgccggtgc tgggtatgga agctatgggt acggaggcaa ctctgcgaca gcaggctaca
2341 gtcagttcta cagcaacgga gggcattctg ggaatgccag tggcggtggc ggcgggggcg
2401 gtggtggctc ctccggctat ggctcctact accaaggtga caactacaac tcaccggtgc
2461 ccccaaaaca cgctgggaag aagcagccgc acgggggcca gcagaagccc tcctacggct
2521 cgggctacca gtcccaccag ggccagcagc agtcctacaa ccagagcccc tacagcaact
2581 atggccctcc acagggcaag cagaaaggct ataaccatgg acaaggcagc tactcctact
2641 cgaactccta caactctccc gggggcgggc gcggatccga ctacaactac gagagcaaat
2701 tcaactacag tggtagtgga ggccgaagcg gcgggaacag ctacggctca ggcggggcat
2761 cctacaaccc agggtcacac gggggctacg gcggaggttc tgggggcggc tcctcatacc
2821 aaggcaaaca aggaggctgc tcacagtcga actacagctc ccggggtccg gccagaacta
2881 cagtggccct cccagctcct accagtcctc acaaggcggc tatggcagaa acgcagacca
2941 cagcatgaac taccagtaca gataagcccc gcgcggagat ttctaccttc tgcacttact
3001 ccccatcaga agatcgagtt ttatgcatca cagttaacat gtcagctgcc tgcgctccag
3061 gcccccgccc ccatcccgtc cacgttgctg tgtcgtgagg tgcagcgggt caccctgtgg
3121 cccgtcctgt gacccatatt tagccgtgtt tgggactccg tgtcttcaat ggtttgttag
3181 ttgccattac aactttgtct gggtagagtt tttgagtttt tgcagttcag tatccctctg
3241 tctattcaca cttcgtgtta gtggtaactc agtttgtctt taaatagtta cagaagggat
3301 acgtcatttg ttaatgcttt ttgttgaagt gagttaaacg agcttttctg tattttaatg
3361 ctttagtgtt tcagttttat aagtgaagat tttattttaa aaaccagtgg gaaagagtgg
3421 ggggtttctt tttatgtctg ggtcattcag gcagtacatc tgaattaagc tgaatgtaga
3481 caaataaaga aaaacaaaac tgaaa
//