LOCUS HSU10117 1057 bp mRNA linear HUM 14-FEB-1995
DEFINITION Human endothelial-monocyte activating polypeptide II mRNA, complete
cds.
ACCESSION U10117
VERSION U10117.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1057)
AUTHORS Kao,J., Houck,K., Fan,Y., Haehnel,I., Libutti,S.K., Kayton,M.L.,
Grikscheit,T., Chabot,J., Nowygrod,R., Greenberg,S., Kuang,W.-J.,
Leung,D.W., Hayward,J.R., Kisiel,W., Heath,M., Brett,J. and
Stern,D.M.
TITLE Characterization of a novel tumor-derived cytokine.
Endothelial-monocyte activating polypeptide II
JOURNAL J. Biol. Chem. 269 (40), 25106-25119 (1994)
PUBMED 7929199
REFERENCE 2 (bases 1 to 1057)
AUTHORS Kao,J., Fan,Y., Haehnel,I., Brett,J., Greenberg,S., Clauss,M.,
Kayton,M., Houck,K., Kisiel,W., Seljelid,R., Burnier,J. and
Stern,D.
TITLE A peptide derived from the amino terminus of
endothelial-monocyte-activating polypeptide II modulates
mononuclear and polymorphonuclear leukocyte functions, defines an
apparently novel cellular interaction site, and induces an acute
inflammatory response
JOURNAL J. Biol. Chem. 269 (13), 9774-9782 (1994)
PUBMED 7545917
REFERENCE 3 (bases 1 to 1057)
AUTHORS Kao,J., Ryan,J., Brett,G., Chen,J., Shen,H., Fan,Y., Godman,G.,
Familletti,P.C., Wang,F., Pan,Y.E., Stern,D. and Clauss,M.
TITLE Endothelial monocyte-activating polypeptide II. A novel
tumor-derived polypeptide that activates host-response mechanisms
JOURNAL J. Biol. Chem. 267 (28), 20239-20247 (1992)
PUBMED 1400342
REFERENCE 4 (bases 1 to 1057)
AUTHORS Houck,K.A.
TITLE Direct Submission
JOURNAL Submitted (27-MAY-1994) Keith A. Houck, Molecular Biology, Sphinx
Pharmaceuticals Corp., P.O. Box 52330, Durham, NC 27717, USA
FEATURES Location/Qualifiers
source 1..1057
/db_xref="H-InvDB:HIT000217987"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="U937"
/cell_type="histiocytic lymphoma"
mRNA 1..1057
CDS 50..988
/standard_name="EMAP II"
/codon_start=1
/product="endothelial-monocyte activating polypeptide II"
/protein_id="AAA62202.1"
/translation="MANNDAVLKRLEQKGAEADQIIEYLKQQVSLLKEKAILQATLRE
EKKLRVENAKLKKEIEELKQELIQAEIQNGVKQIAFPSGTPLHANSMVSENVIQSTAV
TTVSSGTKEQIKGGTGDEKKAKEKIEKKGEKKEKKQQSIAGSADSKPIDVSRLDLRIG
CIITARKHPDADSLYVEEVDVGEIAPRTVVSGLVNHVPLEQMQNRMVILLCNLKPAKM
RGVLSQAMVMCASSPEKIEILAPPNGSVPGDRITFDAFPGEPDKELNPKKKIWEQIQP
DLHTNDECVATYKGVPFEVKGKGVCRAQTMSNSGIK"
mat_peptide 488..985
/product="endothelial-monocyte activating polypeptide II"
/standard_name="EMAP II"
/inference="non-experimental evidence, no additional
details recorded"
regulatory 1032..1037
/regulatory_class="polyA_signal_sequence"
BASE COUNT 371 a 183 c 252 g 251 t
ORIGIN
1 ggaacccgtg gtcctccgct tcatgatttt ctgccgtctc ttggcaaaaa tggcaaataa
61 tgatgctgtt ctgaagagac tggagcagaa gggtgcagag gcagatcaaa tcattgaata
121 tcttaagcag caagtttctc tacttaagga gaaagcaatt ttgcaggcaa ctttgaggga
181 agagaagaaa cttcgagttg aaaatgctaa actgaagaaa gaaattgaag aactgaaaca
241 agagctaatt caggcagaaa ttcaaaatgg agtgaagcaa atagcatttc catctggtac
301 tccactgcac gctaattcta tggtttctga aaatgtgata cagtctacag cagtaacaac
361 cgtatcttct ggtaccaaag aacagataaa aggaggaaca ggagacgaaa agaaagcgaa
421 agagaaaatt gaaaagaaag gagagaagaa ggagaaaaaa cagcaatcaa tagctggaag
481 tgccgactct aagccaatag atgtttcccg tctggatctt cgaattggtt gcatcataac
541 tgctagaaaa caccctgatg cagattcttt gtatgtggaa gaagtagatg tcggagaaat
601 agccccaagg acagttgtca gtggcctggt gaatcatgtt cctcttgaac agatgcaaaa
661 tcggatggtg attttacttt gtaacctgaa acctgcaaag atgaggggag tattatctca
721 agcaatggtc atgtgtgcta gttcaccaga gaaaattgaa atcttggctc ctccaaatgg
781 gtctgttcct ggagacagaa ttacttttga tgctttccca ggagagcctg acaaggagct
841 gaatcctaag aagaagattt gggagcagat ccagcctgat cttcacacta atgatgagtg
901 tgtggctaca tacaaaggag ttccctttga ggtgaaaggg aagggagtat gtagggctca
961 aaccatgagc aacagtggaa tcaaataaaa tgcttccact accaaaagac attagagaaa
1021 accttaaaag taataaagag aaatatattt gtcactt
//