LOCUS HSU10037 1590 bp mRNA linear HUM 18-MAR-1995
DEFINITION Human glucagon-like peptide-1 receptor mRNA, complete cds.
ACCESSION U10037
VERSION U10037.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1590)
AUTHORS Wei,Y. and Mojsov,S.
TITLE Tissue-specific expression of the human receptor for glucagon-like
peptide-I: brain, heart and pancreatic forms have the same deduced
amino acid sequences
JOURNAL FEBS Lett. 358 (3), 219-224 (1995)
PUBMED 7843404
REFERENCE 2 (bases 1 to 1590)
AUTHORS Thorens,B., Porret,A., Buhler,L., Deng,S.P., Morel,P. and
Widmann,C.
TITLE Cloning and functional expression of the human islet GLP-1
receptor. Demonstration that exendin-4 is an agonist and
exendin-(9-39) an antagonist of the receptor
JOURNAL Diabetes 42 (11), 1678-1682 (1993)
PUBMED 8405712
REFERENCE 3 (bases 1 to 1590)
AUTHORS Mojsov,S. and Wei,Y.
TITLE Direct Submission
JOURNAL Submitted (25-MAY-1994) Svetlana Mojsov and Yang Wei, Rockefeller
University, 1230 York Avenue, New York, NY 10021, USA
FEATURES Location/Qualifiers
source 1..1590
/db_xref="H-InvDB:HIT000217984"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="1x106 clones"
/tissue_type="pancreas"
5'UTR 1..126
CDS 127..1518
/function="increase of insulin secretion"
/standard_name="GLP-1 receptor"
/note="G-protein linked receptor; shares sequence
similarity with glucagon-like peptide-1 receptors, GenBank
Accession Numbers L23505, U01156 and U01104"
/codon_start=1
/product="glucagon-like peptide-1 receptor"
/protein_id="AAA63787.1"
/translation="MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRR
QCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYR
FCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALV
IASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLL
SYLDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGV
PLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSK
LKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTS
FQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAG
SSMYTATCQASCS"
3'UTR 1519..1590
BASE COUNT 287 a 507 c 443 g 353 t
ORIGIN
1 gaattccggg tttgtgcatc cactctggaa ccgctcgtgt gtggcctgtc ggaatgacat
61 cgccctcatc agtctccgca cgcgttcccg aggtggcagc gatggcccag tcctgaactc
121 cccgccatgg ccggcgcccc cggcccgctg cgccttgcgc tgctgctgct cgggatggtg
181 ggcagggccg gcccccgccc ccagggtgcc actgtgtccc tctgggagac ggtgcagaaa
241 tggcgagaat accgacgcca gtgccagcgc tccctgactg aggatccacc tcctgccaca
301 gacttgttct gcaaccggac cttcgatgaa tacgcctgct ggccagatgg ggagccaggc
361 tcgttcgtga atgtcagctg cccctggtac ctgccctggg ccagcagtgt gccgcagggc
421 cacgtgtacc ggttctgcac agctgaaggc ctctggctgc agaaggacaa ctccagcctg
481 ccctggaggg acttgtcgga gtgcgaggag tccaagcgag gggagagaag ctccccggag
541 gagcagctcc tgttcctcta catcatctac acggtgggct acgcactctc cttctctgct
601 ctggttatcg cctctgcgat cctcctcggc ttcagacacc tgcactgcac caggaactac
661 atccacctga acctgtttgc atccttcatc ctgcgagcat tgtccgtctt catcaaggac
721 gcagccctga agtggatgta tagcacagcc gcccagcagc accagtggga tgggctcctc
781 tcctacctgg actctctgag ctgccgcctg gtgtttctgc tcatgcagta ctgtgtggcg
841 gccaattact actggctctt ggtggagggc gtgtacctgt acacactgct ggccttctcg
901 gtcttatctg agcaatggat cttcaggctc tacgtgagca taggctgggg tgttcccctg
961 ctgtttgttg tcccctgggg cattgtcaag tacctctatg aggacgaggg ctgctggacc
1021 aggaactcca acatgaacta ctggctcatt atccggctgc ccattctctt tgccattggg
1081 gtgaacttcc tcatctttgt tcgggtcatc tgcatcgtgg tatccaaact gaaggccaat
1141 ctcatgtgca agacagacat caaatgcaga cttgccaagt ccacgctgac actcatcccc
1201 ctgctgggga ctcatgaggt catctttgcc tttgtgatgg acgagcacgc ccgggggacc
1261 ctgcgcttca tcaagctgtt tacagagctc tccttcacct ccttccaggg gctgatggtg
1321 gccatattat actgctttgt caacaatgag gtccagctgg aatttcggaa gagctgggag
1381 cgctggcggc ttgagcactt gcacatccag agggacagca gcatgaagcc cctcaagtgt
1441 cccaccagca gcctgagcag tggagccacg gcgggcagca gcatgtacac agccacttgc
1501 caggcctcct gcagctgaga ctccagcgcc tgccctccct ggggtccttg ctgcagccgg
1561 gtggccaatc cagcctcccc cacaaatacc
//