LOCUS HSU09579 2120 bp mRNA linear HUM 26-JAN-1996
DEFINITION Human melanoma differentiation associated (mda-6) mRNA, complete
cds.
ACCESSION U09579
VERSION U09579.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2120)
AUTHORS Jiang,H. and Fisher,P.B.
TITLE Use of a sensitive and efficient subtraction hybridization protocol
for the identification of genes differentially regulated during the
induction of differentiation in human melanoma cells
JOURNAL Mol. Cell. Differ. 1, 285-299 (1993)
REFERENCE 2 (bases 1 to 2120)
AUTHORS Jiang,H., Lin,J., Su,Z.Z., Herlyn,M., Kerbel,R.S., Weissman,B.E.,
Welch,D.R. and Fisher,P.B.
TITLE The melanoma differentiation-associated gene mda-6, which encodes
the cyclin-dependent kinase inhibitor p21, is differentially
expressed during growth, differentiation and progression in human
melanoma cells
JOURNAL Oncogene 10 (9), 1855-1864 (1995)
PUBMED 7753561
REFERENCE 3 (bases 1 to 2120)
AUTHORS Fisher,P.B.
TITLE Direct Submission
JOURNAL Submitted (11-MAY-1994) Paul B. Fisher, Department of Pathology and
Urology, Columbia University/College of Physicians and Surgeons,
630 West 168th Street, New York, NY 10032, USA
FEATURES Location/Qualifiers
source 1..2120
/db_xref="H-InvDB:HIT000217922"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="p49c13, p49r3, p49r8, p49r23"
/cell_line="HO-1"
/cell_type="melanoma"
/clone_lib="cDNA library for differentiated HO-1 cells,
RACE library"
gene 1..2120
/gene="mda-6"
CDS 95..589
/gene="mda-6"
/experiment="experimental evidence, no additional details
recorded"
/note="alternate gene name=WAF1"
/codon_start=1
/protein_id="AAA85641.1"
/translation="MSEPAGDVRQNPCGSKACRRLFGPVDSEQLSRDCDALMAGCIQE
ARERWNFDFVTETPLEGDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALL
QGTAEEDHVDLSLSCTLVPRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFS
KRKP"
polyA_site 2120
/gene="mda-6"
/note="27 A residues"
BASE COUNT 403 a 633 c 583 g 501 t
ORIGIN
1 agctgaggtg tgagcagctg ccgaagtcag ttccttgtgg agccggagct gggcgcggat
61 tcgccgaggc accgaggcac tcagaggagg cgccatgtca gaaccggctg gggatgtccg
121 tcagaaccca tgcggcagca aggcctgccg ccgcctcttc ggcccagtgg acagcgagca
181 gctgagccgc gactgtgatg cgctaatggc gggctgcatc caggaggccc gtgagcgatg
241 gaacttcgac tttgtcaccg agacaccact ggagggtgac ttcgcctggg agcgtgtgcg
301 gggccttggc ctgcccaagc tctaccttcc cacggggccc cggcgaggcc gggatgagtt
361 gggaggaggc aggcggcctg gcacctcacc tgctctgctg caggggacag cagaggaaga
421 ccatgtggac ctgtcactgt cttgtaccct tgtgcctcgc tcaggggagc aggctgaagg
481 gtccccaggt ggacctggag actctcaggg tcgaaaacgg cggcagacca gcatgacaga
541 tttctaccac tccaaacgcc ggctgatctt ctccaagagg aagccctaat ccgcccacag
601 gaagcctgca gtcctggaag cgcgagggcc tcaaaggccc gctctacatc ttctgcctta
661 gtctcagttt gtgtgtctta attattattt gtgttttaat ttaaacacct cctcatgtac
721 ataccctggc cgccccctgc cccccagcct ctggcattag aattatttaa acaaaaacta
781 ggcggttgaa tgagaggttc ctaagagtgc tgggcatttt tattttatga aatactattt
841 aaagcctcct catcccgtgt tctccttttc ctctctcccg gaggttgggt gggccggctt
901 catgccagct acttcctcct ccccacttgt ccgctgggtg gtaccctctg gaggggtgtg
961 gctccttccc atcgctgtca caggcggtta tgaaattcac cccctttcct ggacactcag
1021 acctgaattc tttttcattt gagaagtaaa cagatggcac tttgaagggg cctcaccgag
1081 tgggggcatc atcaaaaact ttggagtccc ctcacctcct ctaaggttgg gcagggtgac
1141 cctgaagtga gcacagccta gggctgagct ggggacctgg taccctcctg gctcttgata
1201 cccccctctg tcttgtgaag gcagggggaa ggtggggtcc tggagcagac caccccgcct
1261 gccctcatgg cccctctgac ctgcactggg gagcccgtct cagtgttgag ccttttccct
1321 ctttggctcc cctgtacctt ttgaggagcc ccagctaccc ttcttctcca gctgggctct
1381 gcaattcccc tctgctgctg tccctccccc ttgtcctttc ccttcagtac cctctcagct
1441 ccaggtggct ctgaggtgcc tgtcccaccc ccacccccag ctcaatggac tggaagggga
1501 agggacacac aagaagaagg gcaccctagt tctacctcag gcagctcaag cagcgaccgc
1561 cccctcctct agctgtgggg gtgagggtcc catgtggtgg cacaggcccc cttgagtggg
1621 gttatctctg tgttaggggt atatgatggg ggagtagatc tttctaggag ggagacactg
1681 gcccctcaaa tcgtccagcg accttcctca tccaccccat ccctccccag ttcattgcac
1741 tttgattagc agcggaacaa ggagtcagac attttaagat ggtggcagta gaggctatgg
1801 acagggcatg ccacgtgggc tcatatgggg ctgggagtag ttgtctttcc tggcactaac
1861 gttgagcccc tggaggcact gaagtgctta gtgtacttgg agtattgggg tctgacccca
1921 aacaccttcc agctcctgta acatactggc ctggactgtt ttctctcggc tccccatgtg
1981 tcctggttcc cgtttctcca cctagactgt aaacctctcg agggcaggga ccacaccctg
2041 tactgttctg tgtctttcac agctcctccc acaatgctga ataaacagca ggtgctcaat
2101 aaatgattct tagtgacttt
//