LOCUS HSU08023 3608 bp mRNA linear HUM 30-OCT-1996
DEFINITION Human cellular proto-oncogene (c-mer) mRNA, complete cds.
ACCESSION U08023
VERSION U08023.1
KEYWORDS proto-oncogene; tyrosine-kinase; receptor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (sites)
AUTHORS Graham,D.K., Dawson,T.L., Mullaney,D.L., Snodgrass,H.R. and
Earp,H.S.
TITLE Cloning and mRNA expression analysis of a novel human
protooncogene, c-mer
JOURNAL Cell Growth Differ. 5 (6), 647-657 (1994)
PUBMED 8086340
REFERENCE 2 (bases 1 to 3608)
AUTHORS Earp,H.S.
TITLE Direct Submission
JOURNAL Submitted (25-MAR-1994) H. Shelton Earp, Cancer Research,
University of North Carolina at Chapel Hill, Lineberger
Comprehensive Cancer Center, Chapel Hill, NC 27599-7295, USA
FEATURES Location/Qualifiers
source 1..3608
/db_xref="H-InvDB:HIT000217824"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q13"
/clone="mNTK1.2"
/sex="male"
/cell_type="monocyte"
/tissue_type="peripheral blood leukocyte"
/note="this sequence represents a correction to the
sequence published in citation [1]"
gene 1..3608
/gene="c-mer"
CDS 138..3137
/gene="c-mer"
/note="novel cellular proto-oncogene"
/codon_start=1
/protein_id="AAB60430.1"
/translation="MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQ
TDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGH
IILSEHKGVKFNCSINVPNIYQDTTISWWKDGKELLGGHHRITQFYPDDEVTAIIASF
SITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTC
QAVGPPEPVNIFWVQNSSRVNEQPEKSPGVLTVPGLTEMAVFSCEAHNDKGLTVSQGV
QINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLGNGSVMI
FNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTV
FLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISV
QVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGC
FCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHS
LGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLD
NSSHREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTY
LLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVA
DFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIRTRGM
TPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEK
LLESLPDVRNQADVIYVNTQLLESSEGLAQGPTLAPLDLNIDPDSIIASCTPRAAISV
VTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHS
SMLPLGSSLPDELLFADDSSEGSEVLM"
sig_peptide 138..191
/gene="c-mer"
misc_feature 405..683
/gene="c-mer"
/note="shows immunoglobulin domain similarity"
misc_feature 731..934
/gene="c-mer"
/note="shows immunoglobulin domain similarity"
misc_feature 984..1253
/gene="c-mer"
/note="shows fibronectin type III domain similarity"
misc_feature 1263..1577
/gene="c-mer"
/note="shows fibronectin type III domain similarity"
misc_difference 1281^1282
/gene="c-mer"
/note="insertion site of this sequence, which is
alternatively spliced into a small portion of mer
transcripts"
/replace="ctttcaaatatgtgttgaaatctctcttctactgttgactcctctttg
cctt"
misc_feature 1635..1700
/gene="c-mer"
/note="encodes transmembrane region"
polyA_site 3608
/gene="c-mer"
/note="27 A residues"
BASE COUNT 969 a 844 c 857 g 938 t
ORIGIN
1 gaattcgtgt ctcggcactc actcccggcc gcccggacag ggagctttcg ctggcgcgct
61 tggccggcga caggacaggt tcgggacgtc catctgtcca tccgtccgga gagaaattac
121 agatccgcag ccccgggatg gggccggccc cgctgccgct gctgctgggc ctcttcctcc
181 ccgcgctctg gcgtagagct atcactgagg caagggaaga agccaagcct tacccgctat
241 tcccgggacc ttttccaggg agcctgcaaa ctgaccacac accgctgtta tcccttcctc
301 acgccagtgg gtaccagcct gccttgatgt tttcaccaac ccagcctgga agaccacata
361 caggaaacgt agccattccc caggtgacct ctgtcgaatc aaagccccta ccgcctcttg
421 ccttcaaaca cacagttgga cacataatac tttctgaaca taaaggtgtc aaatttaatt
481 gctcaatcaa tgtacctaat atataccagg acaccacaat ttcttggtgg aaagatggga
541 aggaattgct tgggggacat catcgaatta cacagtttta tccagatgat gaagttacag
601 caataatcgc ttccttcagc ataaccagtg tgcagcgttc agacaatggg tcgtatatct
661 gtaagatgaa aataaacaat gaagagatcg tgtctgatcc catctacatc gaagtacaag
721 gacttcctca ctttactaag cagcctgaga gcatgaatgt caccagaaac acagccttca
781 acctcacctg tcaggctgtg ggcccgcctg agcccgtcaa cattttctgg gttcaaaaca
841 gtagccgtgt taacgaacag cctgaaaaat cccccggcgt gctaactgtt ccaggcctga
901 cggagatggc ggtcttcagt tgtgaggccc acaatgacaa agggctgacc gtgtcccagg
961 gagtgcagat caacatcaaa gcaattccct ccccaccaac tgaagtcagc atccgtaaca
1021 gcactgcaca cagcattctg atctcctggg ttcctggttt tgatggatac tccccgttca
1081 ggaattgcag cattcaggtc aaggaagctg atccgctggg taatggctca gtcatgattt
1141 ttaacacctc tgccttacca catctgtacc aaatcaagca gctgcaagcc ctggctaatt
1201 acagcattgg tgtttcctgc atgaatgaaa taggctggtc tgcagtgagc ccttggattc
1261 tagcaagcac gactgaagga gccccatcag tagcaccttt aaatgtcact gtgtttctga
1321 atgaatctag tgataatgtg gacatcagat ggatgaagcc tccgactaag cagcaggatg
1381 gagaactggt gggctaccgg atatcccacg tgtggcagag tgcagggatt tccaaagagc
1441 tcttggagga agttggccag aatggcagcc gagctcggat ctctgttcaa gtccacaatg
1501 ctacgtgcac agtgaggatt gcagccgtca ccagaggggg agttgggccc ttcagtgatc
1561 cagtgaaaat atttatccct gcacacggtt gggtagatta tgccccctct tcaactccgg
1621 cgcctggcaa cgcagatcct gtgctcatca tctttggctg cttttgtgga tttattttga
1681 ttgggttgat tttatacatc tccttggcca tcagaaaaag agtccaggag acaaagtttg
1741 ggaatgcatt cacagaggag gattctgaat tagtggtgaa ttatatagca aagaaatcct
1801 tctgtcggcg agccattgaa cttaccttac atagcttggg agtcagtgag gaactacaaa
1861 ataaactaga agatgttgtg attgacagga atcttctaat tcttggaaaa attctgggtg
1921 aaggagagtt tgggtctgta atggaaggaa atcttaagca ggaagatggg acctctctga
1981 aagtggcagt gaagaccatg aagttggaca actcttcaca tcgggagatc gaggagtttc
2041 tcagtgaggc agcgtgcatg aaagacttca gccacccaaa tgtcattcga cttctaggtg
2101 tgtgtataga aatgagctct caaggcatcc caaagcccat ggtaatttta cccttcatga
2161 aatacgggga cctgcatact tacttacttt attcccgatt ggagacagga ccaaagcata
2221 ttcctctgca gacactattg aagttcatgg tggatattgc cctgggaatg gagtatctga
2281 gcaacaggaa ttttcttcat cgagatttag ctgctcgaaa ctgcatgttg cgagatgaca
2341 tgactgtctg tgttgcggac ttcggcctct ctaagaagat ttacagtggc gattattacc
2401 gccaaggccg cattgctaag atgcctgtta aatggatcgc catagaaagt cttgcagacc
2461 gagtctacac aagtaaaagt gatgtgtggg catttggcgt gaccatgtgg gaaatacgta
2521 cgcggggaat gactccctat cctggggtcc agaaccatga gatgtatgac tatcttctcc
2581 atggccacag gttgaagcag cccgaagact gcctggatga actgtatgaa ataatgtact
2641 cttgctggag aaccgatccc ttagaccgcc ccaccttttc agtattgagg ctgcagctag
2701 aaaaactctt agaaagtttg cctgacgttc ggaaccaagc agacgttatt tacgtcaata
2761 cacagttgct ggagagctct gagggcctgg cccagggccc cacccttgct ccactggact
2821 tgaacatcga ccctgactct ataattgcct cctgcactcc ccgcgctgcc atcagtgtgg
2881 tcacagcaga agttcatgac agcaaacctc atgaaggacg gtacatcctg aatgggggca
2941 gtgaggaatg ggaagatctg acttctgccc cctctgctgc agtcacagct gaaaagaaca
3001 gtgttttacc gggggagaga cttgttagga atggggtctc ctggtcccat tcgagcatgc
3061 tgcccttggg aagctcattg cccgatgaac ttttgtttgc tgacgactcc tcagaaggct
3121 cagaagtcct gatgtgagga gaggtgcggg gagacattcc aaaaatcaag ccaattcttc
3181 tgctgtagga gaatccaatt gtacctgatg tttttggtat ttgtcttcct taccaagtga
3241 actccatggc cccaaagcac cagatgaatg ttgttaagga agctgtcatt aaaaatacat
3301 aatatatatt tatttaaaga gaaaaaatat gtgtatatca tgaaaaagac aaggatattt
3361 taataaaaca ttacttattt catttcactt atcttgcata tcttaaaatt aagcttcagc
3421 tgctccttga tattaacctt tgtacagagt tgaagttgtt ttttcaactt cttttctttt
3481 tcattactat taaatgtaaa aatatttgta aaatgaaatg ccatatttga cttggcttct
3541 ggtcttgatg tatttgataa gaatgattaa ttttctgata tggcttccat aataaaattg
3601 aaatagga
//