LOCUS       HSU08021                 952 bp    mRNA    linear   HUM 20-JUL-1994
DEFINITION  Human nicotinamide N-methyltransferase (NNMT) mRNA, complete cds.
ACCESSION   U08021
VERSION     U08021.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 952)
  AUTHORS   Aksoy,S., Szumlanski,C.L. and Weinshilboum,R.M.
  TITLE     Human liver nicotinamide N-methyltransferase. cDNA cloning,
            expression, and biochemical characterization
  JOURNAL   J. Biol. Chem. 269 (20), 14835-14840 (1994)
   PUBMED   8182091
REFERENCE   2  (bases 1 to 952)
  AUTHORS   Aksoy,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-MAR-1994) Saime Aksoy, Pharmacology, Mayo Medical
            School, Mayo Clinic, Mayo Foundation, Rochester, MN 55905, USA
FEATURES             Location/Qualifiers
     source          1..952
                     /db_xref="H-InvDB:HIT000217823"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /tissue_type="liver"
     gene            1..952
                     /gene="NNMT"
     CDS             118..912
                     /gene="NNMT"
                     /EC_number="2.1.1.1"
                     /function="N-methylation, nicotinamide methylation"
                     /note="cytosolic protein, 29 KDa monomer"
                     /codon_start=1
                     /product="nicotinamide N-methyltransferase"
                     /protein_id="AAA19904.1"
                     /translation="MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKN
                     LFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEP
                     EAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCV
                     LSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGR
                     EAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLSRPL"
     regulatory      927..932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NNMT"
BASE COUNT          235 a          242 c          262 g          213 t
ORIGIN      
        1 tgaactctgg atgctgttag cctgagactc aggaagacaa cttctgcagg gtcactccct
       61 ggcttctgga ggaaagagaa ggagggcagt gctccagtgg tacagaagtg agacataatg
      121 gaatcaggct tcacctccaa ggacacctat ctaagccatt ttaaccctcg ggattaccta
      181 gaaaaatatt acaagtttgg ttctaggcac tctgcagaaa gccagattct taagcacctt
      241 ctgaaaaatc ttttcaagat attctgccta gacggtgtga agggagacct gctgattgac
      301 atcggctctg gccccactat ctatcagctc ctctctgctt gtgaatcctt taaggagatc
      361 gtcgtcactg actactcaga ccagaacctg caggagctgg agaagtggct gaagaaagag
      421 ccagaggcct ttgactggtc cccagtggtg acctatgtgt gtgatcttga agggaacaga
      481 gtcaagggtc cagagaagga ggagaagttg agacaggcgg tcaagcaggt gctgaagtgt
      541 gatgtgactc agagccagcc actgggggcc gtccccttac ccccggctga ctgcgtgctc
      601 agcacactgt gtctggatgc cgcctgccca gacctcccca cctactgcag ggcgctcagg
      661 aacctcggca gcctactgaa gccagggggc ttcctggtga tcatggatgc gctcaagagc
      721 agctactaca tgattggtga gcagaagttc tccagcctcc ccctgggccg ggaggcagta
      781 gaggctgctg tgaaagaggc tggctacaca atcgaatggt ttgaggtgat ctcgcaaagt
      841 tattcttcca ccatggccaa caacgaagga cttttctccc tggtggcgag gaagctgagc
      901 agacccctgt gatgcctgtg acctcaatta aagcaattcc tttgacctgt ca
//