LOCUS HSU08015 2743 bp mRNA linear HUM 08-JUL-1994
DEFINITION Human NF-ATc mRNA, complete cds.
ACCESSION U08015
VERSION U08015.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2743)
AUTHORS Northrop,J.P., Ho,S.N., Chen,L., Thomas,D.J., Timmerman,L.A.,
Nolan,G.P., Admon,A. and Crabtree,G.R.
TITLE NF-AT components define a family of transcription factors targeted
in T-cell activation
JOURNAL Nature 369 (6480), 497-502 (1994)
PUBMED 8202141
REFERENCE 2 (bases 1 to 2743)
AUTHORS Ho,S.N.
TITLE Direct Submission
JOURNAL Submitted (24-MAR-1994) Steffan N. Ho, Department of Pathology,
Stanford University, Howard Hughes Medical Institute, Beckman
Center for Molecular and Genetic Medicine, Stanford, CA 94305, USA
FEATURES Location/Qualifiers
source 1..2743
/db_xref="H-InvDB:HIT000217822"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="clones 2.1, 1.9, 6/11 and 27"
/cell_line="Jurkat T cell leukemia line"
/cell_type="T-lymophocyte"
/clone_lib="Jurkat cDNA lib of D. Thomas and human
peripheral blood cDNA lib of A. Krensky"
mRNA 1..2743
CDS 240..2390
/standard_name="T cell transcription factor NF-ATc"
/note="cytosolic component of the nuclear factor of
activated T cells"
/codon_start=1
/product="NF-ATc"
/protein_id="AAA19601.1"
/translation="MPSTSFPVPSKFPLGPAAAVFGRGETLGPAPRAGGTMKSAEEEH
YGYASSNVSPALPLPTAHSTLPAPCHNLQTSTPGIIPPADHPSGYGAALDGGPAGYFL
SSGHTRPDGAPALESPRIEITSCLGLYHNNNQFFHDVEVEDVLPSSKRSPSTATLSLP
SLEAYRDPSCLSPASSLSSRSCNSEASSYESNYSYPYASPQTSPWQSPCVSPKTTDPE
EGFPRGLGACTLLGSPQHSPSTSPRASVTEESWLGARSSRPASPCNKRKYSLNGRQPP
YSPHHSPTPSPHGSPRVSVTDDSWLGNTTQYTSSAIVAAINALTTDSSLDLGDGVPVK
SRKTTLEQPPSVALKVEPVGEDLGSPPPPADFAPEDYSSFQHIRKGGFCDQYLAVPQH
PYQWAKPKPLSPTSYMSPTLPALDWQLPSHSGPYELRIEVQPKSHHRAHYETEGSRGA
VKASAGGHPIVQLHGYLENEPLMLQLFIGTADDRLLRPHAFYQVHRITGKTVSTTSHE
AILSNTKVLEIPLLPENSMRAVIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRV
HVPQPSGRTLSLQVASNPIECSQRSAQELPLVEKQSTDSYPVVGGKKMVLSGHNFLQD
SKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVVEIPPFRNQRITSPVHVSFYVCNGK
RKRSQYQRFTYLPANGNAIFLTVSREHERVGCFF"
regulatory 2727..2732
/regulatory_class="polyA_signal_sequence"
polyA_site 2743
/note="46 A residues"
BASE COUNT 529 a 959 c 788 g 467 t
ORIGIN
1 gaattccgca gggcgcgggc accggggcgc gggcagggct cggagccacc gcgcaggtcc
61 tagggccgcg gccgggcccc gccacgcgcg cacacgcccc tcgatgactt tcctccgggg
121 cgcgcggcgc tgagcccggg gcgagggctg tcttcccgga gacccgaccc cggcagcgcg
181 gggcggccac ttctcctgtg cctccgcccg ctgctccact ccccgccgcc gccgcgcgga
241 tgccaagcac cagctttcca gtcccttcca agtttccact tggccctgcg gctgcggtct
301 tcgggagagg agaaactttg gggcccgcgc cgcgcgccgg cggcaccatg aagtcagcgg
361 aggaagaaca ctatggctat gcatcctcca acgtcagccc cgccctgccg ctccccacgg
421 cgcactccac cctgccggcc ccgtgccaca accttcagac ctccacaccg ggcatcatcc
481 cgccggcgga tcacccctcg gggtacggag cagctttgga cggtgggccc gcgggctact
541 tcctctcctc cggccacacc aggcctgatg gggcccctgc cctggagagt cctcgcatcg
601 agataacctc gtgcttgggc ctgtaccaca acaataacca gtttttccac gatgtggagg
661 tggaagacgt cctccctagc tccaaacggt ccccctccac ggccacgctg agtctgccca
721 gcctggaggc ctacagagac ccctcgtgcc tgagcccggc cagcagcctg tcctcccgga
781 gctgcaactc agaggcctcc tcctacgagt ccaactactc gtacccgtac gcgtcccccc
841 agacgtcgcc atggcagtct ccctgcgtgt ctcccaagac cacggacccc gaggagggct
901 ttccccgcgg gctgggggcc tgcacactgc tgggttcccc gcagcactcc ccctccacct
961 cgccccgcgc cagcgtcact gaggagagct ggctgggtgc ccgctcctcc agacccgcgt
1021 ccccttgcaa caagaggaag tacagcctca acggccggca gccgccctac tcaccccacc
1081 actcgcccac gccgtccccg cacggctccc cgcgggtcag cgtgaccgac gactcgtggt
1141 tgggcaacac cacccagtac accagctcgg ccatcgtggc cgccatcaac gcgctgacca
1201 ccgacagcag cctggacctg ggagatggcg tccctgtcaa gtcccgcaag accaccctgg
1261 agcagccgcc ctcagtggcg ctcaaggtgg agcccgtcgg ggaggacctg ggcagccccc
1321 cgcccccggc cgacttcgcg cccgaagact actcctcttt ccagcacatc aggaagggcg
1381 gcttctgcga ccagtacctg gcggtgccgc agcaccccta ccagtgggcg aagcccaagc
1441 ccctgtcccc tacgtcctac atgagcccga ccctgcccgc cctggactgg cagctgccgt
1501 cccactcagg cccgtatgag cttcggattg aggtgcagcc caagtcccac caccgagccc
1561 actacgagac ggagggcagc cggggggccg tgaaggcgtc ggccggagga caccccatcg
1621 tgcagctgca tggctacttg gagaatgagc cgctgatgct gcagcttttc attgggacgg
1681 cggacgaccg cctgctgcgc ccgcacgcct tctaccaggt gcaccgcatc acagggaaga
1741 ccgtgtccac caccagccac gaggctatcc tctccaacac caaagtcctg gagatcccac
1801 tcctgccgga gaacagcatg cgagccgtca ttgactgtgc cggaatcctg aaactcagaa
1861 actccgacat tgaacttcgg aaaggagaga cggacatcgg gaggaagaac acacgggtac
1921 ggctggtgtt ccgcgttcac gtcccgcaac ccagcggccg cacgctgtcc ctgcaggtgg
1981 cctccaaccc catcgaatgc tcccagcgct cagctcagga gctgcctctg gtggagaagc
2041 agagcacgga cagctatccg gtcgtgggcg ggaagaagat ggtcctgtct ggccacaact
2101 tcctgcagga ctccaaggtc attttcgtgg agaaagcccc agatggccac catgtctggg
2161 agatggaagc gaaaactgac cgggacctgt gcaagccgaa ttctctggtg gttgagatcc
2221 cgccatttcg gaatcagagg ataaccagcc ccgttcacgt cagtttctac gtctgcaacg
2281 ggaagagaaa gcgaagccag taccagcgtt tcacctacct tcccgccaac ggtaacgcca
2341 tctttctaac cgtaagccgt gaacatgagc gcgtggggtg ctttttctaa agacgcagaa
2401 acgacgtcgc cgtaaagcag cgtggcgtgt tgcacattta actgtgtgat gtcccgttag
2461 tgagaccgag ccatcgatgc cctgaaaagg aaaggaaaag ggaagcttcg gatgcatttt
2521 ccttgatccc tgttgggggt ggggggcggg ggttgcatac tcagatagtc acggttattt
2581 tgcttcttgc gaatgtataa cagccaaggg gaaaacatgg ctcttctgct ccaaaaaact
2641 gagggggtcc tggtgtgcat ttgcacccta aagctgctta cggtgaaaag gcaaataggt
2701 atagctattt tgcaggcacc tttaggaata aactttgctt tta
//