LOCUS       HSU07932                3282 bp    mRNA    linear   HUM 30-AUG-1994
DEFINITION  Human AF-17 mRNA, complete cds.
ACCESSION   U07932
VERSION     U07932.1
KEYWORDS    t[11-17] chromosome translocation; oncogenes; protein-protein
            interactions.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3282)
  AUTHORS   Prasad,R., Leshkowitz,D., Gu,Y., Alder,H., Nakamura,T., Saito,H.,
            Huebner,K., Berger,R., Croce,C.M. and Canaani,E.
  TITLE     Leucine-zipper dimerization motif encoded by the AF17 gene fused to
            ALL-1 (MLL) in acute leukemia
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 91 (17), 8107-8111 (1994)
   PUBMED   8058765
REFERENCE   2  (bases 1 to 3282)
  AUTHORS   Gu,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-MAR-1994) Yansong Gu, Jefferson Cancer Institute,
            Thomas Jefferson University, 233 South 10th. Street, Philadelphia,
            PA 19107, USA
FEATURES             Location/Qualifiers
     source          1..3282
                     /db_xref="H-InvDB:HIT000217812"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21"
                     /clone="a4, cl1, cl3, cl13"
                     /cell_line="ALL-1, KCL-22"
                     /cell_type="Ph-positive acute lymphocytic leukemia myeloid
                     acute phase of chronic myeloid leukemia"
     gene            1..3282
                     /gene="AF-17"
     CDS             1..3282
                     /gene="AF-17"
                     /function="unknown"
                     /codon_start=1
                     /protein_id="AAA21145.1"
                     /translation="MKEMVGGCCVCSDERGWAENPLVYCDGHACSVAVHQACYGIVQV
                     PTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVLT
                     MEPIVLQYVPHDRFNKTCYICEETGRESKAASGACMTCNRHGCRQAFHVTCAQMAGLL
                     CEEEVLEVDNVKYCGYCKYHFSKMKTSRHSSGGGGGGAGGGGGSMGGGGSGFISGRRS
                     RSASPSTQQEKHPTHHERGQKKSRKDKERLKQKHKKRPESPPSILTPPVVPTADKVSS
                     SASSSSHHEASTQETSESSRESKGKKSSSHSLSHKGKKLSSGKGVSSFTSASSSSSSS
                     SSSSGGPFQPAVSSLQSSPDFSAFPKLEQPEEDKYSKPTAPAPSAPPSPSAPEPPKAD
                     LFEQKVVFSGFGPIMRFSTTTSSSGRARAPSPGDYKSPHVTGSGASAGTHKRMPALSA
                     TPVPADETPETGLKEKKHKASKRSRHGPGRPKGSRNKEGTGGPAAPSLPSAQLAGFTA
                     TAASPFSGGSLVSSGLGGLSSRTFGPSGSLPSLSLESPLLGAGIYTSNKDPISHSGGM
                     LRAVCSTPLSSSLLGPPGTSALPRLSRSPFTSTLPSSSASISTTQVFSLAGSTFSLPS
                     THIFGTPMGAVNPLLSQAESSHTEPDLEDCSFRCRGTSPQESLSSMSPISSLPALFDQ
                     TASAPCGGGQLDPAAPGTTNMEQLLEKQGDGEAGVNIVEMLKALHALQKENQRLQEQI
                     LSLTAKKERLQILNVQLSVPFPALPAALPAANGPVPGPYGLPPQAGSSDSLSTSKSPP
                     GKSSLGLDNSLSTSSEDPHSGCPSRSSSSLSFHSTPPPLPLLQQSPATLPLALPGAPA
                     PLPPQPQNGLGRAPGAAGLGAMPMAEGLLGGLAGSGGLPLNGLLGGLNGAAAPNPASL
                     SQAGGAPTLQLPGCLNSLTEQQRHLLQQQEQQLQQLQQLLASPQLTPEHQTVVYQMIQ
                     QIQQKRELQRLQMAGGSQLPMASLLAGSSTPLLSAGTPGLLPTASAPPLLPAGALVAP
                     SLGNNTSLMAAAAAAAAVAAAGGPPVLTAQTNPFLSLSGAEGSGGGPKGGTADKGASA
                     NQEKG"
     misc_feature    2185..2292
                     /gene="AF-17"
                     /note="encodes a leucine zipper motif, amino acids
                     729-764"
BASE COUNT          628 a         1141 c          959 g          554 t
ORIGIN      
        1 atgaaggaga tggtaggagg ctgctgcgta tgttcggacg agaggggctg ggccgagaac
       61 ccgctggtct actgcgatgg gcacgcgtgc agcgtggccg tccaccaagc ttgctatggc
      121 atcgttcagg tgccaacggg accctggttc tgccggaaat gtgaatctca ggagcgagca
      181 gccagggtga ggtgtgagct gtgcccacac aaagacgggg cattgaagag gactgataat
      241 ggaggctggg cacacgtggt gtgtgccctc tacatccccg aggtgcaatt tgccaacgtg
      301 ctcaccatgg agcccatcgt gctgcagtac gtgcctcatg atcgcttcaa caagacctgt
      361 tacatctgcg aggagacggg ccgggagagc aaggcggcct cgggagcctg catgacctgt
      421 aaccgccatg gatgtcgaca agctttccac gtcacctgtg cccaaatggc aggcttgctg
      481 tgtgaggaag aagtgctgga ggtggacaac gtcaagtact gcggctactg caaataccac
      541 ttcagcaaga tgaagacatc ccggcacagc agcgggggag gcggaggagg cgctggagga
      601 ggaggtggca gcatgggggg aggtggcagt ggtttcatct ctgggaggag aagccggtca
      661 gcctcaccat ccacgcagca ggagaagcac cccacccacc acgagagggg ccagaagaag
      721 agtcgaaagg acaaagaacg ccttaagcag aagcacaaga agcggcctga gtcgcccccc
      781 agcatcctca ccccgcccgt ggtccccact gctgacaagg tctcctcctc ggcttcctct
      841 tcctcccacc acgaggccag cacgcaggag acctctgaga gcagcaggga gtcaaagggg
      901 aaaaagtctt ccagccatag cctgagtcat aaagggaaga aactgagcag tgggaaaggt
      961 gtgagcagtt ttacctccgc ctcctcttct tcctcctcct cttcctcctc ctctgggggg
     1021 cccttccagc ctgcagtctc gtccctgcag agctcccctg acttctctgc attccccaag
     1081 ctggagcagc cagaggagga caagtactcc aagcccacag cccccgcccc ttcagcccct
     1141 ccttctccct cagctcccga gccccccaag gctgaccttt ttgagcagaa ggtggtcttc
     1201 tctggctttg ggcccatcat gcgcttctcc accaccacct ccagctcagg ccgggcccgg
     1261 gcgccctccc ctggggacta taagtctccc cacgtcacgg ggtctggggc ctcggcaggc
     1321 acccacaaac ggatgcccgc actgagtgcc acccctgtgc ctgctgatga gacccctgag
     1381 acaggcctga aggagaagaa gcacaaagcc agcaagagga gccgccatgg gccaggccgt
     1441 cccaagggca gccggaacaa ggagggcact gggggcccag ctgccccatc cttgcccagt
     1501 gcccagctgg ctggctttac cgccactgct gcctcaccct tctctggagg ttccctggtc
     1561 agctccggcc tgggaggtct gtcctcccga acctttgggc cttctgggag cttgcccagc
     1621 ttgagcctgg agtccccctt actaggggca ggcatctaca ccagtaataa ggaccccatc
     1681 tcccacagtg gcgggatgct gcgggctgtc tgcagcaccc ctctctcctc cagcctcctg
     1741 gggcccccag ggacctcggc cctgccccgc ctcagccgct ccccgttcac cagcaccctc
     1801 ccctcctctt ctgcttctat ctccaccact caggtgtttt ctctggctgg ctctaccttt
     1861 agcctccctt ctacccacat ctttggaacc cccatgggtg ccgttaatcc cctcctctcc
     1921 caagctgaga gcagccacac agagccagac ctggaggact gcagcttccg gtgtcggggg
     1981 acctcccctc aggagagtct gtcttccatg tcccccatca gcagcctccc cgcactcttc
     2041 gaccagacag cctctgcacc ctgtgggggc ggccagttag acccggcggc cccagggacg
     2101 actaacatgg agcagcttct ggagaagcag ggcgacgggg aggccggcgt caacatcgtg
     2161 gagatgctga aggcgctgca cgcgctgcag aaggagaacc agcggctgca agagcagatc
     2221 ctgagcctga cggccaaaaa ggagcggctg cagattctca acgtgcagct ctctgtgccc
     2281 ttccctgccc tgcctgctgc cctgcctgcc gccaacggcc ctgtccctgg gccctatggc
     2341 ctgcctcccc aagccgggag cagcgactcc ttgagcacca gcaagagccc tccgggaaag
     2401 agcagcctcg gcctggacaa ctcgctgtcc acttcttctg aggacccaca ctcaggctgc
     2461 ccgagccgca gcagctcgtc gctgtccttc cacagcacgc ccccaccgct gcccctcctc
     2521 cagcagagcc ctgccactct gcccctggcc ctgcctgggg cccctgcccc actcccgccc
     2581 cagccgcaga acgggttggg ccgggcaccc ggggcagcgg ggctgggggc catgcccatg
     2641 gctgaggggc tgttgggggg gctggcaggc agtgggggcc tgcccctcaa tgggctcctt
     2701 ggggggttga atggggccgc tgcccccaac cccgcaagct tgagccaggc tggcggggcc
     2761 cccacgctgc agctgccagg ctgtctcaac agccttacag agcagcagag acatctcctt
     2821 cagcagcaag agcagcagct ccagcaactc cagcagctcc tggcctcccc gcagctgacc
     2881 ccggaacacc agactgttgt ctaccagatg atccagcaga tccagcagaa acgggagctg
     2941 cagcgtctgc agatggctgg gggctcccag ctgcccatgg ccagcctgct ggcaggaagc
     3001 tccaccccgc tgctgtctgc gggtacccct ggcctgctgc ccacagcgtc tgctccaccc
     3061 ctgctgcccg ctggagccct agtggctccc tcgcttggca acaacacaag tctcatggcc
     3121 gcagcagctg cagctgcagc agtagcagca gcaggcggac ctccagtcct cactgcccag
     3181 accaacccct tcctcagcct gtcgggagca gagggcagtg gcggtggccc caaaggaggg
     3241 accgctgaca aaggagcctc agccaaccag gaaaaaggct aa
//