LOCUS HSU07932 3282 bp mRNA linear HUM 30-AUG-1994 DEFINITION Human AF-17 mRNA, complete cds. ACCESSION U07932 VERSION U07932.1 KEYWORDS t[11-17] chromosome translocation; oncogenes; protein-protein interactions. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3282) AUTHORS Prasad,R., Leshkowitz,D., Gu,Y., Alder,H., Nakamura,T., Saito,H., Huebner,K., Berger,R., Croce,C.M. and Canaani,E. TITLE Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (17), 8107-8111 (1994) PUBMED 8058765 REFERENCE 2 (bases 1 to 3282) AUTHORS Gu,Y. TITLE Direct Submission JOURNAL Submitted (22-MAR-1994) Yansong Gu, Jefferson Cancer Institute, Thomas Jefferson University, 233 South 10th. Street, Philadelphia, PA 19107, USA FEATURES Location/Qualifiers source 1..3282 /db_xref="H-InvDB:HIT000217812" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="17" /map="17q21" /clone="a4, cl1, cl3, cl13" /cell_line="ALL-1, KCL-22" /cell_type="Ph-positive acute lymphocytic leukemia myeloid acute phase of chronic myeloid leukemia" gene 1..3282 /gene="AF-17" CDS 1..3282 /gene="AF-17" /function="unknown" /codon_start=1 /protein_id="AAA21145.1" /translation="MKEMVGGCCVCSDERGWAENPLVYCDGHACSVAVHQACYGIVQV PTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVLT MEPIVLQYVPHDRFNKTCYICEETGRESKAASGACMTCNRHGCRQAFHVTCAQMAGLL CEEEVLEVDNVKYCGYCKYHFSKMKTSRHSSGGGGGGAGGGGGSMGGGGSGFISGRRS RSASPSTQQEKHPTHHERGQKKSRKDKERLKQKHKKRPESPPSILTPPVVPTADKVSS SASSSSHHEASTQETSESSRESKGKKSSSHSLSHKGKKLSSGKGVSSFTSASSSSSSS SSSSGGPFQPAVSSLQSSPDFSAFPKLEQPEEDKYSKPTAPAPSAPPSPSAPEPPKAD LFEQKVVFSGFGPIMRFSTTTSSSGRARAPSPGDYKSPHVTGSGASAGTHKRMPALSA TPVPADETPETGLKEKKHKASKRSRHGPGRPKGSRNKEGTGGPAAPSLPSAQLAGFTA TAASPFSGGSLVSSGLGGLSSRTFGPSGSLPSLSLESPLLGAGIYTSNKDPISHSGGM LRAVCSTPLSSSLLGPPGTSALPRLSRSPFTSTLPSSSASISTTQVFSLAGSTFSLPS THIFGTPMGAVNPLLSQAESSHTEPDLEDCSFRCRGTSPQESLSSMSPISSLPALFDQ TASAPCGGGQLDPAAPGTTNMEQLLEKQGDGEAGVNIVEMLKALHALQKENQRLQEQI LSLTAKKERLQILNVQLSVPFPALPAALPAANGPVPGPYGLPPQAGSSDSLSTSKSPP GKSSLGLDNSLSTSSEDPHSGCPSRSSSSLSFHSTPPPLPLLQQSPATLPLALPGAPA PLPPQPQNGLGRAPGAAGLGAMPMAEGLLGGLAGSGGLPLNGLLGGLNGAAAPNPASL SQAGGAPTLQLPGCLNSLTEQQRHLLQQQEQQLQQLQQLLASPQLTPEHQTVVYQMIQ QIQQKRELQRLQMAGGSQLPMASLLAGSSTPLLSAGTPGLLPTASAPPLLPAGALVAP SLGNNTSLMAAAAAAAAVAAAGGPPVLTAQTNPFLSLSGAEGSGGGPKGGTADKGASA NQEKG" misc_feature 2185..2292 /gene="AF-17" /note="encodes a leucine zipper motif, amino acids 729-764" BASE COUNT 628 a 1141 c 959 g 554 t ORIGIN 1 atgaaggaga tggtaggagg ctgctgcgta tgttcggacg agaggggctg ggccgagaac 61 ccgctggtct actgcgatgg gcacgcgtgc agcgtggccg tccaccaagc ttgctatggc 121 atcgttcagg tgccaacggg accctggttc tgccggaaat gtgaatctca ggagcgagca 181 gccagggtga ggtgtgagct gtgcccacac aaagacgggg cattgaagag gactgataat 241 ggaggctggg cacacgtggt gtgtgccctc tacatccccg aggtgcaatt tgccaacgtg 301 ctcaccatgg agcccatcgt gctgcagtac gtgcctcatg atcgcttcaa caagacctgt 361 tacatctgcg aggagacggg ccgggagagc aaggcggcct cgggagcctg catgacctgt 421 aaccgccatg gatgtcgaca agctttccac gtcacctgtg cccaaatggc aggcttgctg 481 tgtgaggaag aagtgctgga ggtggacaac gtcaagtact gcggctactg caaataccac 541 ttcagcaaga tgaagacatc ccggcacagc agcgggggag gcggaggagg cgctggagga 601 ggaggtggca gcatgggggg aggtggcagt ggtttcatct ctgggaggag aagccggtca 661 gcctcaccat ccacgcagca ggagaagcac cccacccacc acgagagggg ccagaagaag 721 agtcgaaagg acaaagaacg ccttaagcag aagcacaaga agcggcctga gtcgcccccc 781 agcatcctca ccccgcccgt ggtccccact gctgacaagg tctcctcctc ggcttcctct 841 tcctcccacc acgaggccag cacgcaggag acctctgaga gcagcaggga gtcaaagggg 901 aaaaagtctt ccagccatag cctgagtcat aaagggaaga aactgagcag tgggaaaggt 961 gtgagcagtt ttacctccgc ctcctcttct tcctcctcct cttcctcctc ctctgggggg 1021 cccttccagc ctgcagtctc gtccctgcag agctcccctg acttctctgc attccccaag 1081 ctggagcagc cagaggagga caagtactcc aagcccacag cccccgcccc ttcagcccct 1141 ccttctccct cagctcccga gccccccaag gctgaccttt ttgagcagaa ggtggtcttc 1201 tctggctttg ggcccatcat gcgcttctcc accaccacct ccagctcagg ccgggcccgg 1261 gcgccctccc ctggggacta taagtctccc cacgtcacgg ggtctggggc ctcggcaggc 1321 acccacaaac ggatgcccgc actgagtgcc acccctgtgc ctgctgatga gacccctgag 1381 acaggcctga aggagaagaa gcacaaagcc agcaagagga gccgccatgg gccaggccgt 1441 cccaagggca gccggaacaa ggagggcact gggggcccag ctgccccatc cttgcccagt 1501 gcccagctgg ctggctttac cgccactgct gcctcaccct tctctggagg ttccctggtc 1561 agctccggcc tgggaggtct gtcctcccga acctttgggc cttctgggag cttgcccagc 1621 ttgagcctgg agtccccctt actaggggca ggcatctaca ccagtaataa ggaccccatc 1681 tcccacagtg gcgggatgct gcgggctgtc tgcagcaccc ctctctcctc cagcctcctg 1741 gggcccccag ggacctcggc cctgccccgc ctcagccgct ccccgttcac cagcaccctc 1801 ccctcctctt ctgcttctat ctccaccact caggtgtttt ctctggctgg ctctaccttt 1861 agcctccctt ctacccacat ctttggaacc cccatgggtg ccgttaatcc cctcctctcc 1921 caagctgaga gcagccacac agagccagac ctggaggact gcagcttccg gtgtcggggg 1981 acctcccctc aggagagtct gtcttccatg tcccccatca gcagcctccc cgcactcttc 2041 gaccagacag cctctgcacc ctgtgggggc ggccagttag acccggcggc cccagggacg 2101 actaacatgg agcagcttct ggagaagcag ggcgacgggg aggccggcgt caacatcgtg 2161 gagatgctga aggcgctgca cgcgctgcag aaggagaacc agcggctgca agagcagatc 2221 ctgagcctga cggccaaaaa ggagcggctg cagattctca acgtgcagct ctctgtgccc 2281 ttccctgccc tgcctgctgc cctgcctgcc gccaacggcc ctgtccctgg gccctatggc 2341 ctgcctcccc aagccgggag cagcgactcc ttgagcacca gcaagagccc tccgggaaag 2401 agcagcctcg gcctggacaa ctcgctgtcc acttcttctg aggacccaca ctcaggctgc 2461 ccgagccgca gcagctcgtc gctgtccttc cacagcacgc ccccaccgct gcccctcctc 2521 cagcagagcc ctgccactct gcccctggcc ctgcctgggg cccctgcccc actcccgccc 2581 cagccgcaga acgggttggg ccgggcaccc ggggcagcgg ggctgggggc catgcccatg 2641 gctgaggggc tgttgggggg gctggcaggc agtgggggcc tgcccctcaa tgggctcctt 2701 ggggggttga atggggccgc tgcccccaac cccgcaagct tgagccaggc tggcggggcc 2761 cccacgctgc agctgccagg ctgtctcaac agccttacag agcagcagag acatctcctt 2821 cagcagcaag agcagcagct ccagcaactc cagcagctcc tggcctcccc gcagctgacc 2881 ccggaacacc agactgttgt ctaccagatg atccagcaga tccagcagaa acgggagctg 2941 cagcgtctgc agatggctgg gggctcccag ctgcccatgg ccagcctgct ggcaggaagc 3001 tccaccccgc tgctgtctgc gggtacccct ggcctgctgc ccacagcgtc tgctccaccc 3061 ctgctgcccg ctggagccct agtggctccc tcgcttggca acaacacaag tctcatggcc 3121 gcagcagctg cagctgcagc agtagcagca gcaggcggac ctccagtcct cactgcccag 3181 accaacccct tcctcagcct gtcgggagca gagggcagtg gcggtggccc caaaggaggg 3241 accgctgaca aaggagcctc agccaaccag gaaaaaggct aa //