LOCUS HSU07819 3314 bp mRNA linear HUM 06-JUN-1995
DEFINITION Human contactin 1 precursor (CNTN1) mRNA, complete cds.
ACCESSION U07819
VERSION U07819.1
KEYWORDS cell adhesion molecule; immunoglobulin gene family; nervous system.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3314)
AUTHORS Berglund,E.O. and Ranscht,B.
TITLE Molecular cloning and in situ localization of the human contactin
gene (CNTN1) on chromosome 12q11-q12
JOURNAL Genomics 21 (3), 571-582 (1994)
PUBMED 7959734
REFERENCE 2 (bases 1 to 3314)
AUTHORS Berglund,E.O.
TITLE Human Contactin (Gp135) - Isolation, Molecular Cloning and Gene
Localization of a New Brain Glycoprotein
JOURNAL Thesis (1993) Dept. of Medical Chemistry, Umea University, Sweden,
and Neurobiology, La Jolla Cancer Research Foundation
REFERENCE 3 (bases 1 to 3314)
AUTHORS Berglund,E.O. and Ranscht,B.
TITLE Direct Submission
JOURNAL Submitted (17-MAR-1994) Erik O. Berglund and Barbara Ranscht, La
Jolla Cancer Research Foundation, 10901 North Torrey Pines Road, La
Jolla, CA 92037, USA
FEATURES Location/Qualifiers
source 1..3314
/db_xref="H-InvDB:HIT000217804"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q11-q12"
/clone="11A1"
/tissue_type="brain"
/dev_stage="fetus"
gene 1..3314
/gene="CNTN1"
CDS 1..3057
/gene="CNTN1"
/function="immunoglobulin-like cell adhesion molecule"
/codon_start=1
/product="h-contactin 1 precursor"
/protein_id="AAA67920.1"
/translation="MKMWLLVSHLVIISITTCLAEFTWYRRYGHGVSEEDKGFGPIFE
EQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINN
PDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDP
PYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSI
TKSVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWR
KVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWV
EHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYHKGELRLYDVTFENAGMYQCI
AENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSK
GTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRII
LAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNG
ELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTW
SRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVV
ATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNF
GYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLV
AVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIVESYQIRYWAAHDKEEAANR
VQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISS
VRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIEVPIPRDGEY
VVEVRAHSDGGDGVVSQVKISGAPTLSPSLLGLLLPAFGILVYLEF"
sig_peptide 1..60
/gene="CNTN1"
mat_peptide 61..2979
/gene="CNTN1"
/product="h-contactin 1"
/function="immunoglobulin-like cell adhesion molecule"
misc_feature 193..342
/gene="CNTN1"
/note="encodes disulfide loop of immunoglobulin type
C2-like domain; Ig-domain"
/citation=[1]
/citation=[2]
misc_feature 472..633
/gene="CNTN1"
/note="encodes disulfide loop of immunoglobulin type
C2-like domain; Ig-domain"
/citation=[1]
/citation=[2]
/number=2
misc_feature 622..624
/gene="CNTN1"
/note="codon for potential Asn-linked glycosylation;
Asn-glycosyl"
/citation=[1]
/citation=[2]
misc_feature 772..774
/gene="CNTN1"
/note="codon for potential Asn-linked glycosylation;
Asn-glycosyl"
/citation=[1]
/citation=[2]
misc_feature 787..930
/gene="CNTN1"
/note="encodes disulfide loop of immunoglobulin type
C2-like domain; Ig-domain"
/citation=[1]
/citation=[2]
misc_feature 1012..1014
/gene="CNTN1"
/note="codon for potential Asn-linked glycosylation;
Asn-glycosyl"
/citation=[1]
/citation=[2]
misc_feature 1054..1173
/gene="CNTN1"
/note="encodes disulfide loop of immunoglobulin type
C2-like domain; Ig-domain"
/citation=[1]
/citation=[2]
misc_feature 1306..1452
/gene="CNTN1"
/note="encodes disulfide loop of immunoglobulin type
C2-like domain; Ig-domain"
misc_feature 1369..1371
/gene="CNTN1"
/note="codon for potential Asn-linked glycosylation;
Asn-glycosyl"
/citation=[1]
/citation=[2]
misc_feature 1414..1416
/gene="CNTN1"
/note="codon for potential Asn-linked glycosylation;
Asn-glycosyl"
/citation=[1]
/citation=[2]
misc_feature 1480..1482
/gene="CNTN1"
/note="codon for potential Asn-linked glycosylation;
Asn-glycosyl"
/citation=[1]
/citation=[2]
misc_feature 1561..1563
/gene="CNTN1"
/note="codon for potential Asn-linked glycosylation;
Asn-glycosyl"
/citation=[1]
/citation=[2]
misc_feature 1576..1749
/gene="CNTN1"
/note="encodes disulfide loop of immunoglobulin type
C2-like domain; Ig-domain"
/citation=[1]
/citation=[2]
misc_feature 1771..1773
/gene="CNTN1"
/note="codon for potential Asn-linked glycosylation;
Asn-glycosyl"
/citation=[1]
/citation=[2]
misc_feature 1870..2031
/gene="CNTN1"
/note="encodes fibronectin type III-like repeat;
FNIII-repeat"
/citation=[1]
/citation=[2]
misc_feature 1888..1890
/gene="CNTN1"
/note="codon for potential Asn-linked glycosylation;
Asn-glycosyl"
/citation=[1]
/citation=[2]
misc_feature 2179..2340
/gene="CNTN1"
/note="encodes fibronectin type III-like repeat;
FNIII-repeat"
/citation=[1]
/citation=[2]
misc_feature 2485..2631
/gene="CNTN1"
/note="encodes fibronectin type III-like repeat;
FNIII-repeat"
/citation=[1]
/citation=[2]
misc_feature 2773..2916
/gene="CNTN1"
/note="encodes fibronectin type III-like repeat;
FNIII-repeat"
/citation=[1]
/citation=[2]
misc_feature 2797..2799
/gene="CNTN1"
/note="codon for potential Asn-linked glycosylation;
Asn-glycosyl"
/citation=[1]
/citation=[2]
misc_feature 2977..2979
/gene="CNTN1"
/note="codon for potential GPI-linkage; GPI-anchor"
/citation=[1]
/citation=[2]
regulatory 3004..3054
/regulatory_class="other"
/gene="CNTN1"
/note="coding region for COOH-terminal hydrophobic region;
C-termPep"
/citation=[1]
/citation=[2]
3'UTR 3058..3314
/gene="CNTN1"
regulatory 3160..3165
/regulatory_class="polyA_signal_sequence"
/gene="CNTN1"
regulatory 3244..3249
/regulatory_class="polyA_signal_sequence"
/gene="CNTN1"
BASE COUNT 1028 a 698 c 737 g 851 t
ORIGIN
1 atgaaaatgt ggttgctggt cagtcatctt gtgataatat ctattactac ctgtttagca
61 gagtttacat ggtatagaag atatggtcat ggagtttctg aggaagacaa aggatttgga
121 ccaatttttg aagagcagcc aatcaatacc atttatccag aggaatcact ggaaggaaaa
181 gtctcactca actgtagggc acgagccagc cctttcccgg tttacaaatg gagaatgaat
241 aatggggacg ttgatctcac aagtgatcga tacagtatgg taggaggaaa ccttgttatc
301 aacaaccctg acaaacagaa agatgctgga atatactact gtttagcatc taataactac
361 gggatggtca gaagcactga agcaaccctg agctttggat atcttgatcc tttcccacct
421 gaggaacgtc ctgaggtcag agtaaaagaa gggaaaggaa tggtgcttct ctgtgacccc
481 ccataccatt ttccagatga tcttagctat cgctggcttc taaatgaatt tcctgtattt
541 atcacaatgg ataaacggcg atttgtgtct cagacaaatg gcaatctcta cattgcaaat
601 gttgaggctt ccgacaaagg caattattcc tgctttgttt ccagtccttc tattacaaag
661 agcgtgttca gcaaattcat cccactcatt ccaatacctg aacgaacaac aaaaccatat
721 cctgctgata ttgtagttca gttcaaggat gtatatgcat tgatgggcca aaatgtgacc
781 ttagaatgtt ttgcacttgg aaatcctgtt ccggatatcc gatggcggaa ggttctagaa
841 ccaatgccaa gcactgctga gattagcacc tctggggctg ttcttaagat cttcaatatt
901 cagctagaag atgaaggcat ctatgaatgt gaggctgaga acattagagg aaaggataaa
961 catcaagcaa gaatttatgt tcaagcattc cctgagtggg tagaacacat caatgacaca
1021 gaggtggaca taggcagtga tctctactgg ccttgtgtgg ccacaggaaa gcccatccct
1081 acaatccgat ggttgaaaaa tggatatgcg tatcataaag gggaattaag actgtatgat
1141 gtgacttttg aaaatgccgg aatgtatcag tgcatagctg aaaacacata tggagccatt
1201 tatgcaaatg ctgagttgaa gatcttggcg ttggctccaa cttttgaaat gaatcctatg
1261 aagaaaaaga tcctggctgc taaaggtgga agggtgataa ttgaatgcaa acctaaagct
1321 gcaccgaaac caaagttttc atggagtaaa gggacagagt ggcttgtcaa tagcagcaga
1381 atactcattt gggaagatgg tagcttggaa atcaataaca ttacaaggaa tgatggaggt
1441 atctatacat gctttgcaga aaataacaga gggaaagcta atagcactgg aacccttgtt
1501 atcacagatc ctacgcgaat tatattggcc ccaattaatg ccgatatcac agttggagaa
1561 aacgccacca tgcagtgtgc tgcgtccttt gatcctgcct tggatctcac atttgtttgg
1621 tccttcaatg gctatgtgat cgattttaac aaagagaata ttcactacca gaggaatttt
1681 atgctggatt ccaatgggga attactaatc cgaaatgcgc agctgaaaca tgctggaaga
1741 tacacatgca ctgcccagac aattgtggac aattcttcag cttcagctga ccttgtagtg
1801 agaggccctc caggccctcc aggtggtctg agaatagaag acattagagc cacttctgtg
1861 gcacttactt ggagccgtgg ttcagacaat catagtccta tttctaaata cactatccag
1921 accaagacta ttctttcaga tgactggaaa gatgcaaaga cagatccccc aattattgaa
1981 ggaaatatgg aggcagcaag agcagtggac ttaatcccat ggatggagta tgaattccgc
2041 gtggtagcaa ccaatacact gggtagagga gagcccagta taccatctaa cagaattaaa
2101 acagacggtg ctgcaccaaa tgtggctcct tcagatgtag gaggtggagg tggaagaaac
2161 agagagctga ccataacatg ggcgcctttg tcaagagaat accactatgg caacaatttt
2221 ggttacatag tggcatttaa gccatttgat ggagaagaat ggaaaaaagt cacagttact
2281 aatcctgata ctggccgata tgtccataaa gatgaaacca tgagcccttc cactgcattt
2341 caagttaaag tcaaggcctt caacaacaaa ggagatggac cttacagcct agtagcagtc
2401 attaattcag cacaagacgc tcccagtgaa gccccaacag aagtaggtgt aaaagtctta
2461 tcatcttctg agatatctgt tcattgggaa catgttttag aaaaaatagt ggaaagctat
2521 cagattcggt attgggctgc ccatgacaaa gaagaagctg caaacagagt tcaagtcacc
2581 agccaagagt actcggccag gctcgagaac cttctgccag acacccagta ttttatagaa
2641 gtcggggcct gcaatagtgc agggtgtgga cctccaagtg acatgattga ggctttcacc
2701 aagaaagcac ctcctagcca gcctccaagg atcatcagtt cagtaaggtc tggttcacgc
2761 tatataatca cctgggatca tgtcgttgca ctatcaaatg aatctacagt gacgggatat
2821 aaggtactct acagacctga tggccagcat gatggcaagc tgtattcaac tcacaaacac
2881 tccatagaag tcccaatccc cagagatgga gaatacgttg tggaggttcg cgcgcacagt
2941 gatggaggag atggagtggt gtctcaagtc aaaatttcag gtgcacccac cctatcccca
3001 agtcttctcg gcttactgct gcctgccttt ggcatccttg tctacttgga attctgaatg
3061 tgttgtgaca gctgctgttc ccatcccagc tcagaagaca cccttcaacc ctgggatgac
3121 cacaattcct tccaatttct gcggctccat cctaagccaa ataaattata ctttaacaaa
3181 ctattcaact gatttacaac acacatgatg actgaggcat tcaggaaccc cttcatccaa
3241 aagaataaac ttttaaatgg atataaatga tttttaactc gttccaatat gccttataaa
3301 ccacttaacc tgat
//