LOCUS AY299456 24578 bp DNA linear HUM 03-NOV-2006 DEFINITION Homo sapiens NRH:quinone oxidoreductase 2 (NQO2) gene, complete cds. ACCESSION AY299456 AH005367 U07729 U07730 U07731 U07732 U07733 U07734 U07735 U07736 VERSION AY299456.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 24578) AUTHORS Jaiswal,A.K. TITLE Human NAD(P)H:quinone oxidoreductase2. Gene structure, activity, and tissue-specific expression JOURNAL J. Biol. Chem. 269 (20), 14502-14508 (1994) PUBMED 8182056 REFERENCE 2 (bases 1 to 24578) AUTHORS Wang,W. and Jaiswal,A.K. TITLE Sp3 repression of polymorphic human NRH:quinone oxidoreductase 2 gene promoter JOURNAL Free Radic. Biol. Med. 37 (8), 1231-1243 (2004) PUBMED 15451063 REFERENCE 3 (bases 1 to 24578) AUTHORS Jaiswal,A.K. TITLE Direct Submission JOURNAL Submitted (14-MAR-1994) Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA REFERENCE 4 (bases 1 to 24578) AUTHORS Wang,W. and Jaiswal,A.K. TITLE Direct Submission JOURNAL Submitted (15-MAY-2003) Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA COMMENT On or before Jun 17, 2003 this sequence version replaced U07729.1, U07730.1, U07731.1, U07732.1, U07733.1, U07734.1, U07735.1, U07736.1, AH005367.2. FEATURES Location/Qualifiers source 1..24578 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /chromosome="6" /map="6p25" /tissue_type="liver" /dev_stage="adult" gene 1..23661 /gene="NQO2" regulatory 1..3798 /regulatory_class="promoter" /gene="NQO2" misc_feature 3512..3772 /gene="NQO2" /note="GC-rich region containing several SP1 binding sites at -286 to -26" mRNA join(3799..3984,10367..10458,13924..14088,16443..16573, 19431..19544,20785..20886,23380..23661) /gene="NQO2" /product="NRH:quinone oxidoreductase 2" CDS join(10452..10458,13924..14088,16443..16573,19431..19544, 20785..20886,23380..23556) /gene="NQO2" /function="catalyzes metabolism of quinones including menadione" /note="NQO2; cytosolic protein; uses dihydronicotinamide riboside (NRH) as electron donor" /codon_start=1 /product="NRH:quinone oxidoreductase 2" /protein_id="AAB60642.3" /translation="MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYA MNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQF PLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTG VNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKE EPIPCTAHWHFGQ" BASE COUNT 6378 a 5882 c 5761 g 6557 t ORIGIN 1 ctttgggagg ccgacgtggg cggatcacct aaggtcggga gtttgagacc aggctgacca 61 acatggagaa accctgtctc tactaaaaat ataaaattag ccaggcgtgg tggcgtattc 121 ccgtaatccc agctactcgg gaggctgagg cataagaatc acttgaaccc aggaggcgga 181 ggttgcggtg agccgagatc tcgccattgc actccagcct gggcaacaag agcaaaactc 241 cgtctcaaaa aacaaacaaa aaacctacaa ctcaacaaca aatagacaaa caacccaatt 301 aaatggtcaa caaaggactt gaatagacat ttctccaagg aaggtataca aatggccagt 361 aagcacatga aaagatgctc aaagtcatta gtccttaggg aaatgcaaat caaaaccaca 421 atgagatacc acttcgcact tgctaggatg gctataattt agagggaaaa aaaagaaaca 481 taacaaatgt gcgtgagaat gtagagaagt tggaacctgt gtacattgtt ggtgaaaatg 541 tgaaatggtg tagacgctgt ggaaaacagt ttggctgttc ctcagaaagc taaacataga 601 atgaccatag aattgtaata ccgacaattc cactccaagg tgtataacca aaattattga 661 acacagggac tgaaacagat acttgtacac caataatcat tgcaatatta ttcacaatag 721 tcaaacaaca gatgagtgga taaacaatgc ctggtaccct tccttccttc cttccttcct 781 tccttccttc cttccttcct tccttccttc cttccttcct ttctttttct ttctctcttt 841 cttctttctt ttctttctgt cagtcttgct cttgttgccc aggcttgagt gcaatgacac 901 aatctcagct caccgccacc tctgcctcct gggttcaagt gattctcctg cctcagcctc 961 ccgagtagct gggactacag gtgcacacca ccatgcccag ctaatttttg tgtttttagt 1021 agagatgggg tttccccacg ttggccaggc ggtatacaca tttttctatt attcggccat 1081 aaaaaggaat gaagttctga tgcatactac aacatggatg aaactcagca acaaggtttt 1141 tgaggaaaaa aagcttagtg aaaaggccac atcttgtagg attccactta tatgaaatac 1201 atgcaataga caaattcatg gagacagaaa gtagattaga ggctaccagg agtggaagga 1261 ggggagaatg gggatttatt atccaatgag tgcagtgttt ctatttgttt ttgtttttgt 1321 ttgagacagg gtctcgctct gtcatccagg ctggagtgca gtgccacgat ctcagctcac 1381 tgcagcctcc gcctcctggg ttcaagcaat tctcctgcct cagcctctga gtagctggga 1441 ttacaggtgt acaccacctg gcaaattttt gtagagatgg ggtttcgcca tgttggccag 1501 gctggtctca aacttttgac ctcaggtgat ctgcatgcct ctgcctccca aagtgctggg 1561 attacaggcg tgatctatgg cccctgaccc aagtgtttct atttgggatg atgaaaacgt 1621 tttgaaaata aatagttgta atggttgcac agcactctaa aggtaattta tgccactgaa 1681 ttgtacactt aaaatggtga aaatagaaaa tttcatgtta tacagatttt gctacccaaa 1741 aaacaaaaca aaaaatccaa aacctttatg ttattatgaa gaagcagttt tccaaaggaa 1801 tagggatgct ggtagcagaa gggaaagaaa tctcattaaa taaaaacaaa agcaatgacc 1861 tcttcaggag gtggctcagc tagtttagct ttaccttagc accatgatgg ttcattttat 1921 tcagaaatag aaacatgggg cgttggggag aagaggagat gtgtacctgc ctcacctgcc 1981 tccctgccca gaatgccgac tccgactctt gctttccact aaggctgggg attaaatgaa 2041 aagtgagaat ctggaaaccc ccagagatga tgtttgtcgt tggagctgat tttatctcat 2101 tttagtagca tgacctcctc ctcaaactca ggatgcaatt atggtcaatc tcattagtgt 2161 gcagtaattg ctcagcccca ataccagatt agcaggaagt tctgttattt tccttttgag 2221 gatgggctcc tactgaactg tcctggaatc taccaccatt caggttacaa aagacccagg 2281 gaactaggcc agtccagctc ccaaccccaa gcagggagca acttgctcag tccacgttgt 2341 gatagctcct cgctgccaca aggtggtgat gttgcatcac acacgcgcat gatgggcgcg 2401 caggcgccaa tgctcccagg acctgctgtt ccattcctaa atgaaagttg ttcccaggat 2461 ctggactcac aagacaaggc agcctattcc ctgctgggga gctcaggggc aagagggcat 2521 ctcggaggga gggcacattc tcacctctga agacaaggag aacatcatca gcacatagac 2581 caatcccagc agtgcacctt aggatgggga gggccactgt gagttacagc aaaatgaacg 2641 aatgaatgaa ccaataaatg tctgagaggg aaagtcccaa cgaccctcag gaggtacaat 2701 caagagttgc agttattttc gttaggaacg ttctaaacac aggggaaacc ttccttcctt 2761 ctgctctatt gttggagtgg ggccatcccg ggacaccaga aatcaaggaa ttgagtttgg 2821 agaagggact tggggaggtc acagtggcag gtgactgcca aatgaggtgg cagaagccag 2881 caagcgctgg aaaaagtcgg cccaaactgt tcaccagcac cgccccccat aactccccac 2941 ctgctctggt ttcaagactt tccgttttct aggtatttcc ttggccttaa accattttcc 3001 tttaaacgaa ctttttctgt ggagccatcc ggtttccccc gatagtggca tctcacaaag 3061 gacagtccag tatcccaaca gcgtgttgcg ttccgcggga cgcagatttc cttcacaggc 3121 accccccggg ttgcgttttt atagccacac ccacccgccc ccctatctcc tgggcactgc 3181 taatgagtcc tgcatttctc tcctttggtc tttggataaa tgaaccatcc gtgcgtgacc 3241 tttgcgaggg catcttgcat aataccagta caccagcggc gccgtcggtg agtgaccttt 3301 gggactggtt tctctcacca gcgtaactcc ccgggagatc cgagcaagct gatgagtgta 3361 tcagtggctc attctttctg ttgcaccacg gaccgtcatt ctgtaaccgg gataccagcc 3421 agggatgggg agcgggaggc gcagggcagg ggcgtccctc ctctcagcac agcctccccg 3481 cgctggattt ctatcaatcc agtttccacc tgcctggaag tcagcagggt cctccgcagt 3541 cccagatcgc cgggcgaggc cccagatgga cctcaggggc ggggagtggg cggagcttag 3601 gggccgaggc gaggtgtggg tggggcggga cgccgctgtg gaggcggggc ctgggcgcgg 3661 acgggcgcgg agcgaggcac cgcaccgccg gggcggggag tgggcggggc tcacgggcgg 3721 ggcgggtgag tgggcggggc ctcggcgtgg taggcgcgct gcgtaaagag gcctgcagtc 3781 ccgcggcgcg gggcaggttc cgggctgctt aggttggcac cggtccgtgg tccccggggg 3841 cgcagtcgca gcgctcccgc cctccaggcg tcagcgagtg cgcggtccag tgcggccgga 3901 acctggcgca actcctagag cggtccttgg ggagacgcgg gtcccagtcc tgcggctcct 3961 actggggcgt gcgctggtcg gaaggtgagt gatcccctgt cggggaccgg gggacttggg 4021 aaggacagtt cccggactgg acggccagaa cgctctcagg gatttcagct ggccggccat 4081 atggccctgt gggtcgtcgc gcccgggcca gggaccattc tgtacatagg atcgtgcttg 4141 gctctcacgg aacgcgccca cacgcagggt cccggtgtcg aatcgtctgg tggaatctgc 4201 cctcaaccct atggagcggg tgctggtatc atagtcatat tacaagtagg aatcagcggg 4261 cccaaggtca gtctgtaaag ggggtaccgg ggtttaggcc cgtgcgctgc ccagcgctgc 4321 cctgaaggcg cggctgaacc actggtttgc gctgcctttg tcaaggacat tgtggcactg 4381 tggaaaaaat gaaaaatcag cttctctaac ctataatctc tctgggaaaa aaaaaaatca 4441 gctttttttt ttttccccga gacggagtct cactctgtcg cccaggctgg agtgcagtgg 4501 cacgatttcg gctcactgca acctccgcct cccgggttca agcaattctc ctgcctcagc 4561 ctcccgagta cctgggatta taggggcgtg ccaccacgcc tggctaattt tttgtatgtt 4621 tagtagagac gggtttcatg ttggtcaggc tggtctcaaa ctcctgacct cgtgatccgc 4681 ccgcctgggc ctcccaaagt gctgggattg caggcgtgag ccactgctcc cggccctctt 4741 tttctttttt cttttttttt tagaagagtc tcactctgtt gcccaggctg gagtgcagtg 4801 gggcaatctc agctcactgc aacctttgcc ttccaggttc aagcgattct cccccctcag 4861 ccccttgagt agctgggatt acaggcgcct gccaccatgc ccggctaatt tttgtatttt 4921 tagtacaggt gggagtttca ccatattggc caggctggtc ttgaactcat tcttcttcct 4981 ttctttttct tttttttttt tttttgagat ggagtttcac tcttattgcc caagctggag 5041 tgcaatggca caatctcagc tcactgcaac ctctgcctcc cgggttcaag ctattctcct 5101 gcctcagtct cccgagtagc tgggattaca ggtgcgtgcc actacaccca gctaattttt 5161 ggtattttta gtagaaatgg agtttcacca tattagtcag gctggtctca aactcctgac 5221 ctcaggtgat ccgcctgcct cggcctccca gagtgctggg attaatgaac cactgcgccc 5281 ggccaaaaat cagcttcttt aacctttaat ctctgaaaaa ataaatcagt ttaaccttta 5341 atctccgaag atcacagcca aagaaataca tgaaaaggaa caagtattaa ataatatata 5401 cttctagctg tgctgtttat agttttggga aaaaaatgga aataacctaa ggtcccagaa 5461 ataggaaaat gggcacaaaa gggtatgcag gcaatggttt agctgccgca tgaatacaca 5521 ctgaatacac tgtgagatgt tgtctgttag aatgcccagc acggggactg tccacatgga 5581 aagaggcaca ggaaaaaaag tgaaaacatt ataaaataac ttcttaaaat taaataatgt 5641 acacgtcaaa aatatcagag cccacttgac ctggtatata cagtttaata accacatggc 5701 tcttttttcc tgtaggcctg ggtaggtgca tagtttctaa aaagggagag aactgtcact 5761 gctgtggatg gggtgccaag ggaagtgcct ggggtcaagt gaacagtgac acaactgcaa 5821 gtcaagagcc tgtgttggag tctttcccca ctatttcaaa tagtatagaa aatagagctg 5881 agtcactcaa atagagctga gttagtcact cagctcttgg acctcagatt cttattctta 5941 accgctaggg ggatggagac agaagtcaca aactcacatg ccaccagcca tatgatgtaa 6001 acatgtaaac tgggccaagg aatacaaaag ggagtggtga gctggggaca ctgaagaatg 6061 gatgccctgt ctagaggagt gaaaatgaag catttcatac aaacaacatg atttcgggca 6121 atcactttgg gaatcaggat aaggtgttcc cccagtctgc agaaacactg gcaacattta 6181 caaaggtaaa tcatttcata tcactctatt ttctttttct tttttgagac agagtcttgc 6241 tctgttgccc aggctggagt gcaatggcac aatcttgact cactgcaacc tccacctccc 6301 aggttcaagt gattctcctg cctcagcctc ccaagtagct gggactacag gcacatgcca 6361 ccatacccgg ataatttttg tattttttag tagagatggt gttttgccac attgaccagg 6421 ctggtttcaa actcctgacc tcaggtgatc cccccacctc ggccccccaa aatgctggga 6481 ttacaggtgt gagccaccac aactggcgat cattccatat tactctccag cttaagaggc 6541 tccaagggct ttctgtcagg cttagaataa aatcctcacc cctaccctag gaggggtcag 6601 gtcagacccc tcccacctcc ctgactgcat ctaccaccat ccactctttt tttttttgaa 6661 ccacagttca gccaaacagg ctttcttttt tttcttttac tttctctttt ttcttgaaac 6721 agagcctaac tctgtcaccc agtctggagt ggagcaatcc tctaatctca gccccctgag 6781 tagctgggat tacaggcatg caccaccaca cctggctaat ttttaaaaat ctttggtaga 6841 gatgggatct cactatgttg cccgggctgg tctcaaattc ctaggctcaa gtgatctcct 6901 gcctcagcct ctcaaagtgc tgggccttct gcttccctgg gctttgccag gcctccctat 6961 gcattgtgat agccaaagtt tgctttctac aaagtcacct ccaggcagtg actgtccacc 7021 agggcactgt agagcctccc agctaatgat gaagtcactc actctcctct ctttttcctt 7081 taagataatc cctttccaga cccgccattt tggctcaccc tgtaagttac agccccactt 7141 ctcactgcca agtgtgggtg tcactgctgg ctcagggagc atggatcctg taaacttgcc 7201 tcatcgggag gctttgagga gtgaccccca ggaactagac aagtaacttg ttcttcacaa 7261 tcactgccct cccaagaaca tccaggattt cagcctcagt gttaagacaa ccatgtctct 7321 ccctgacaca tgctcgctgc tgagaatttt aggaaaagca gagggctgtg caggcgcccc 7381 tgcccctagg ctaggagagc tggcaaatgc ctggagaccc aaaggcctca tcctcagggc 7441 ggccaactct tctgttttag tgatatacag actatctttt attgtgattt atagtgcaac 7501 ttaccggttc aaacaatact acctgtattc ataaactttc tttttccttt ccttcctcac 7561 tgcccagctt taggttcatt cttgtaagtg ttgctggtgt cagaatagga acctccctgc 7621 gctttgaagg gatgaatgtg acctctccca cattctccgg tgctgtgatg taccttaaac 7681 acagcaaggt acttggacac aaagcctgtg cctggagcac tttcagacag acagtgcatg 7741 gccctcgcta cagactcagt gccattgtag atgtttctgc atggaaaata cataaacaca 7801 aatatctgca gttgccaatc caccaccatc ttgcagcccc aagagagccc cgggaatcca 7861 ggttcctttg gtatttctgc tccctgccct tggtgcatag cctccatccc caggacgaca 7921 agaaggctga ctgagcccta acatcatccc acagtccagc tgggaagaga gccagcgaca 7981 aagccagagg gagctagctc ccacacctcc cagccccagc tgagttcgct tcttgagggt 8041 atttcttgga agccccgcct gtgacttctg ctgacacctc actggccatc tcaactgcaa 8101 ggcagcctag gaaatgtagt gcttacctgt acacgtggat tcctggaatc aattcagggt 8161 ctgtccttgg ggaaccagag tggggatatt cagtcactaa agatgcaggt tcccagctgt 8221 ccagtgaagt caagcgaatg gggaaggatt tgaagtcacc tttgggtgtt tggagtgatc 8281 agagctgtct gccctcttgg ggagtgacag tgccccactc tgttaagtcc catgcctgcc 8341 cccaactcag cttcagccac aatgatgtag cctcttttcc tttccatcca cagggcacct 8401 ggcctgggtg gagcccactc ctcagcaccc acctcacttc ttgcagtatt ctgcagaccc 8461 cagccctgtg cctgtgctcc tggacagctg gagataagga gtgggccctg gaagatgctc 8521 attcaggccc tgctcaagat tccagtcctg gtggggataa gcaccacttt tgtgtgtctc 8581 tgtgcttttt gttttgctgt aaagacacac tgataggttc acgttgtcgt ttggacacaa 8641 catgcgcgat gcgtgtcttc acactaagcc ctagtcacac tctctgcatt gtttttttat 8701 cccatttttt cctactgtgg tacagaacat ctcacataaa attgaccatt ttaaccactt 8761 tttttgtttg tttgtttttt gtgtttttgg acagagtctc gctctgtctc agcctcccga 8821 gtagctggga ttacaggtgc acaccaccac gcccggctaa tttttgtatt tttagtagag 8881 acggagtttc gccatgttgg ccaggctggt ctcggactcc tgacctcagg taatccacct 8941 gcctcagcct cccaaagtgc tgggattaca ggtgtgagcc acggtgcctg acctcatttt 9001 agccactttt aagggtagaa ttttctggct gttttcattc atgtactgat agacacttgg 9061 gttgcttcca tgttttagct gttgtggaaa atgctgcttt gaacatgggt gggcaagtgg 9121 ttttcaagac cctgctttca gttttttggg ttcagagtaa cgaatggaat tgctgagtca 9181 tatgttaatt ctcatttttc taattgtaat ttttgggggc acagcacctc tccagcagcg 9241 gcagcactcg acctttcccc agcggtgcac ggggttccaa cttctccgca tcctcaccta 9301 cgtgtgtttt gttttttggt agtagtagcc attctaatgc gtgtgatatg ggatctcatt 9361 gtggttttga tttgcatttc cctaatgatt agtgatgcta agcatctttt catggcttac 9421 tgaccattca tacatctttg gagaaaagcc tacacaagcc ttctgcccat ttttgcattg 9481 agttgtttgc tttgttgttg ttaagtttta tctgagctgt ttttttatgg tagggagagt 9541 gggtttgttg gagtctcctt gtatctccca gaaggaagcc agaatttcag agatggccag 9601 gagggggtga ggccaaaggc tcccctgggg agaactcacg tttttccaga gccccattgt 9661 gtgccagcca ccgcacatag caactgtctc tctctcactc ttctgggcca tgctgtgact 9721 ttgttgatga ggaggttgag gcacagaggg gtggagggat gtgctgcagg gcccacagct 9781 acaatgggca gagctggaaa ttgcaccaag tctgtctgat gcgggggtct cctctgctcc 9841 tctggcctcc gctgcatccc tggagaatct ctgagacttc tggttagagc ctgggtctaa 9901 gccaactccc attattttca agtgagggga agggccgaca actgccagtg ctggcccacc 9961 agagtctggc accagccgag gagtgcacgc acccattggt ggtgtggcgg ttcactgatc 10021 ccccagcctt ctgctcgatc tacggggaaa actggggaag gcaggaaggc caaggaggct 10081 caactcctgc ttcctaccgt ggctcatttc ctgggtcctt tgctgtatga ctgtctggat 10141 ggaaggttca gagtcctctc aaaaaaggaa aaaagtatgg gttttgacat cctgcgtggc 10201 ttgtcctctg aggcctaaat ctccagaaga ttcctggcct ctcttgagag gtctttctct 10261 gatgtgtttg cgtgtctgtc aggaagcagc agtgatgcct agatgtggta cattcgacct 10321 cacctatgcc tctccccacc ccctctgggt tcgttttgtc ttccagattg ctggactcgc 10381 tgaagagaga ctacgcagga aagccccagc cacccatcaa atcagagaga aggaatccac 10441 cttcttacgc tatggcaggt aatgattcac tattgtggag taagactttt ttttttttga 10501 gatgggattt tgttgtattg cccaggctgg tctcaaactc ctgagctcaa gtgaccctcc 10561 cacattgacc ttccaggtgg gagttagact cttaatcaga aattggatac attgttgtaa 10621 aaaatccaag ccacgtggaa gtgtataaac tatctggaat tatcttgttt tctatgttct 10681 cacttgtttc attgttcctt tcgactccct ccagaattta ggttcctcaa aagtggggcc 10741 ctgcctatcc tgtctttgct gtgcctccag gccctgaaat tctccctggg ctgtagcagg 10801 ggctcaagtg aatgaacccc aggaggcatc ttgggtaaaa attcagtacg attctatctt 10861 tgcttttgca actgcttatc atgcacatat acatgaacat gcaatctctc aactttttaa 10921 tttcacctaa cgatataaca tggagagcct ttcgtgttag aacgcacagg ttcaccttac 10981 tctatacatt atggtgtaga ttcggatttt cgcccttggc accactgaca ttctgggcca 11041 gataatccta tgttttgggg ggtcatcctg tgcaccctgt ttagcaccta gcaccatccc 11101 tggcctctgc ccaccagatg ccagtagcac ccctccccca ccggctgtga caaaccaaaa 11161 tgtctccagg cattgagaaa cgtcccctag caggcacaac actgccccag ttgagaacca 11221 ttggtgtagg tatttcattt gcatctattc tcctgttaag cccctaagta tagttccttt 11281 attgaaacaa gagtctgaga aagtaaaatt aaaatgttaa ccatgaatct aacttatgga 11341 attcaacctt tgtagccagc tcaatgccct gaaacccatt gcttcaaact gatacgtgta 11401 tcttttcctt aaagtgtcat tatgaaaaat ttaaatcaag agtttaacat cttcttaaag 11461 gtgaccaggg taaatttaat taagcaaatc accaggctgc ctcccagacg aagtcagtat 11521 ataagcctgg agactctttc caatgaggaa aatactgctt cagaagcccc tggtgtgaac 11581 gatactgcca gtgccaggag ggcctgactc ttcctagagt cctctttgtt atcagcatca 11641 ccactgaaag atgggctcca tgtggccctg ccttcccatg agaccagcgg gtctgattcc 11701 tcatgttttg tttaagtgtc agatttgatg gactggggga gatggaagca gaactgtgcc 11761 acactgaaag gtgcctgtag ctgatatctg caaatgtagg gttagcatgg aagactaatt 11821 ccagcagttc tttattttgg tgttagggag ctggtctaaa ccttcttaca gaggataacc 11881 aaattaggtt gggcttttaa aagatttagt ggtggtattt ttgaggagat ataatttgac 11941 ccattgtatt gtgatgttga gctatgaata actggatttt taaaatgccc attgctttaa 12001 aactgccacc tattagaaag tttggtattt ctggggccag gtgctgtggc tcataccagt 12061 aatcccagca ctctgggagg ccaaggtggg cagatcacct gaggtcggga gttcgagacc 12121 agcttgacca acatggagaa acccggtctt aactaaaaat acaaaaaatt atccgggcgt 12181 ggtggcgcat gcctgtaatc ccagctactc aggaggctga ggtaggagaa ttgcttgaac 12241 ccgggaggca gaggttgcag tgagctggga tcgttgctcc agcctgggca acaagagcga 12301 aactctgttt caaaaaaaaa aaaaaagaaa aagaaaaaag gaaagaaaag aaagtttggt 12361 gtttctggcc aagtgcggtg gctcatgcct gtaatcccag cactttggga ggccaaggcg 12421 ggtggatcac ttgaggccag gagttcaaga ccagcctggc caacatggca aaatcccatc 12481 tgtactaaaa atacaaaaaa ttagctgggc gtagtggcac acatctatcg ggggaaattc 12541 agccagatat tgggcgaaat tcacccccaa tatttcacgt aggttctttt ctatatttcc 12601 taagtgtcgg ccggtctgag aaataaacgg acagagtaca aaagagagaa attttaaagc 12661 tgggtgtcca ggggagacat cacatgtcgg caggttccgt gatgccccca agccgtaaaa 12721 ccagcaagtt tttattagtg attttccaaa ggggagggag tgtacaaata gagtgtgggt 12781 cacagagatc acatgcttca caaggtaata gaatatcaca aagcaaatgg aggcagggcg 12841 agatcacagg accacgggac ggggcgaaat taaaattgct aatgaagttt tgggcaccat 12901 tgtcattgag aacatcttat caggagccag ggtttgagag cagacaaccg atctgaccaa 12961 aatttattag gcaggaattt ccttgtctta ataagcctgg gagcgctacg ggagactggg 13021 gcttatttca tccctacagc tggaccataa aagacagctg ccgccccgaa gcgggcattt 13081 cagaggccca ccctcaggga cgcattctct ttctcaggga tgttccttgc tgagaaaaag 13141 aattcaccga tatttctccc atttgctttt gaaagaagag aaatatgtct ctgttccgcc 13201 tggctcaccg gcagtgagag tttaaggtta tctctcttgt tccctgaaca ttgctgttat 13261 cctgttcttt tttcaaggtg cccagatttc atattgttca aacacacatg ctctgcaaac 13321 aatttgtgca gttaacacaa tcatcacagg gtcctgaggc aatatacatc ctcctcagct 13381 tatgaagatg atgggattaa gagattaaag taaagacaag cataggaaat cacatgggta 13441 ttgattgggg aagtgataac tgtccatgaa atcttcacaa tttacgttca gagattgcag 13501 taaagacagg cataagaaat tacaaaagta ttaatttggg gaactaataa atgtccacga 13561 aatcttcaca atttatattc ttctgccatg gcctcagcca gttgctccgt tcggggtccc 13621 tgacttccca cgaaacacac ctgtagtccc agctagtcag gagactgagg catgagaatc 13681 acttgaacct gggaggcaga ggttgcagtg agctgagatc atgccactgc attccagcct 13741 gggtgacaga gtgagactgt ctaaaaaaaa gagagagaaa gagacagaaa gaaaagaaaa 13801 tttgatattt cttagcttca attactatga tgcacctgaa cattcaattt tcatcttagt 13861 cttcattgaa tttggcagag agaggttgtt cttcaagagg aactgtttct tatcctgatt 13921 taggtaagaa agtactcatt gtctatgcac accaggaacc caagtctttc aacggatcct 13981 tgaagaatgt ggctgtagat gaactgagca ggcagggctg caccgtcaca gtgtctgatt 14041 tgtatgccat gaactttgag ccgagggcca cagacaaaga tatcactggt gagtcatggg 14101 ataaatgctc tatttataaa aactatcttt atgtttttta ctttaaaaaa tgttgacttc 14161 cagctgcaaa atggcattat agaagcaagc tagcttcact ttccaaaaac aaatagatag 14221 cactgggatt atcaccagca gtatcccaga agtcaaatat gaagatgaaa tagttcccaa 14281 gaccacacat aagtgaaaca actccaagca gacggtaaga gattggacta tcatatccac 14341 gacacccctc cccacaaact acccagcacc agctgtgtgg gaaatttcct cccaagtcac 14401 aggttctaca ctggaaaaga gatcaagggg gacaatcagc ttctcaattt tctggggttc 14461 ccagaaacag gcaggaagga gacctgttcc tgcctcaacc cacaggaagc atcaggagtg 14521 cctaaaggga gaaatatccc tgacaacagc cagagacaaa ggagggagat gggaatattg 14581 tccccagccc tggaaactct gatctgtaac ttagccaaag gagatgccaa accagagtgg 14641 ctgttcagca gcaccacact gtaggaggta cattctgcag gtttcctggg catgagctgc 14701 tagccagcct tcccacacta ccatgctatc ccctttggaa cctctcatat tcaggactgg 14761 cacactctga acagtaggtt actagagctg aggcaaacgt gggcataaac caccatctag 14821 tgccaaaaag caggtggtgg cttagtagag gaaaaaaaaa aaatttaata agaaagttgc 14881 aaagactttc taagcaaata tatgtaataa aaatgaaaac aagtcagaca tagaagactg 14941 aaataaatag atgtcatcca caagaaacaa cagtaaacag ggaaccatga cctctccaca 15001 cagacaaagc aaggaaccag tgactgaacc taacgagacg gcactgtttg gactctctga 15061 ccaagaattc agaatagcac ttttaaggaa atgtggtaat cctcaagatc acacagaaaa 15121 gcagttcaga aatttatcag ttaaatttta caaagagatt gaaataattt ttaaaaaatc 15181 aaacagaaat cttggaacta gaaatacatt tgctgaaaaa ttcattagag gctctcaaca 15241 gcagaatgga tgaagcagaa gaaaaaatca gtgaactcaa aggcaggtga tttgaaaata 15301 cacagaggag aaaaaagaaa aaggtatgga gatttcttac aaaatataga aaattacctc 15361 aaaagaccaa atctaagaat gattggtgct taagaggaag ctgagcaaga gcaaggcata 15421 gcaagcttat tcaaagaaat aataacagaa aaattttcca aaacttcaga aagagataaa 15481 tatcctggta gaggaaggtc atagaataaa cagatttgac tcaaatagga ctaccccaag 15541 gcatataatt attaaactct caaaggtcaa gaacaaaaag aggatcctaa aagcaaataa 15601 catgtaacag agctccagtt catctggcaa cagacttctc aacagaaaac atataggcca 15661 ggaggtagtg ggacattttc aaagtgctga aagaacaaaa ctgtcaacca agaatactgt 15721 acccagcaaa tctagccttc aactctgaaa gagagagagt ctttcccaaa caaagaaaag 15781 ctgagaaaat gcaccaccac cagacccacc ttacaagaaa tgctaaaggg aattcaataa 15841 gaaagaaaaa cactaatgtg caaaaagaaa acatttgaag atgtaaaacc cactggtaaa 15901 agtaagtaca cagaacactc taatactgta attgtgtaca gtccactcat tactagtatt 15961 aagtctaaca gacaaatcta tcaaaaacaa taatcactac gtgacctgtt aagagccaaa 16021 gataagcaat ataaaatatg taaatcaaga cacagatact caaaaatgtg gaggtgagca 16081 tgaaattaaa gcgtagagtt tattttttta gacctgtttg gcattgaaca agacatccag 16141 cctctcttgg gtgtcagttt gctctctggt aaattgggaa atacaccagt ctcaccagtt 16201 gttatgaaga aaggtgatgt gtgtagagca cagcacctgc taggtagcaa gtgctcaatc 16261 agcagccctc ccagactgct tctctttccc tagctcggac ccagggtgca gcttctggtc 16321 aggttgcagc aaatgtcttt gacttgtctg aggagtccgg tatacacagt gctactggga 16381 tggttgggat gggctgtgga tgcccaccta ggagtgagaa tgtttggcct cttccccgac 16441 aggtactctt tctaatcctg aggttttcaa ttatggagtg gaaacccacg aagcctacaa 16501 gcaaaggtct ctggctagcg acatcactga tgagcagaaa aaggttcggg aggctgacct 16561 agtgatattt caggtttgtt tttctctaat taatatattg aatcagattc atcttatgta 16621 caaactcttt ctgaatattg agttttgtgc tgcttctgga agtggcatca atgttttgag 16681 cacagttgca cacttactga gcaaatattg taacctggtt acaacacacc tagttacaac 16741 atttcaccta gttacaccac ttcacctagt tacaacactt cacctagtta caacacttca 16801 tctagttaca acactacttt aaacactgta cgtagatgta acactacttt tttttttttt 16861 tttttttttt ttttgagacg gagtctcgct ctgtcgccca ggctggagtg cagtggcggg 16921 atctcggctc actgcaagct ccgcctcccg ggttcacgcc attctcccgc ctcagcctcc 16981 cgagtagctg ggactacagg cgcccgccac cacgcccggc tagttttttg tatttttagt 17041 agagaccggg tttcaccgtg ttagccagga tggtctcgat ctcctgacct cgtgatccac 17101 ccgcctcggc ctcccaaagt gctgggatta caggcgtgag ccaccgcgcc cggccgatgt 17161 aacactactt taaacacttt acctaattgg gtaaagatat ccacgtagcc aatatcactc 17221 actccaaatc ccgactgcca tgtaaatagg aatgaaggat atttccatta ttccagtggt 17281 ccaagaatca tctgaaacct gccagtcttg ttgcttccct tctcttcccg ttcctgccct 17341 gagacattct ggggctgctt gagaaccaca tttatctgca caaatgttta tcagggtaaa 17401 tcaggccaaa tgcatctcct taaatatcct gccttaaata tcctgatcat taagaggaaa 17461 atctctggtt tctaccctct cagtggttgc ttcaccccca gcccagccac cttcctgtat 17521 ttgttcacaa ggaggtgatg ccactgcaga gtgaactggc ccagcaaaat gccctccagg 17581 agtgctgact catcaggcca cttcccgcca ctgcaaggaa gatgtgcagg catggctgtg 17641 gctgtgtaaa cctggcagca gagtacgcac atgagctttg agggaattgt tgggtgacag 17701 aaattcctgt ccaactagaa ggaaagggga atctattata agggctctgg tcacttgggc 17761 ctcctggatc ccaaggacag agctgtagct gctctcgtcc acagattccc atctgctcct 17821 ttctgcctct tggctctgtt ctctctcact gcttgccagg gactggatcc cctagatcca 17881 gaatttccaa ccaagggatc tgattggttc agatcatttc tgttttccaa ccctgcttga 17941 ggatgcggag tgggcaggag aacgagagca ctgttcgcat gagtccgcca tgtgagggca 18001 aggcaggggg tgagcggcat gtgaccactt tccagacaaa accacctttc cagaatgatg 18061 aggttcccaa gccttcataa aagcaacctg catgtgcggg aagagggctg cctcatccct 18121 gcccaggctt gcctctgcac accccttccc gacaccagcc ctttctttac tcagtgacct 18181 tgagctgcta atctgaccaa agtgcaggac gtcctttgtc ctaattacag gtgggtggac 18241 tcatagtcct caggcctagg tgaccatgtg gtttaccatc tccgtcttaa taccatgcca 18301 gtatgacggg cctgtatcct ggggtgcgtg gtcccagcag agccacgctg agctctctgc 18361 tctgcttctc ctgtccccct tgggtcggcc ggccacgtgg agcccgcttt cctcctcgca 18421 cccactccac tcccataacc cggtggctgg gtaggctaag acctggcctt tctataatgg 18481 cctttctttt gtttcacttc atttcactcc atttccctac tttccctttt tttctgatag 18541 tttgtccaga gggtctgcat tataagttat tcttttattc aacattaata aaaatttcat 18601 tcatcactac tgcactacta atatcagagc ccaccactca ctgagcattg attctgtttt 18661 gggcactgtg gtgtgtcttc gaatcctcac caggatgctg tgagctgtga actattagta 18721 gccctatttg atgaatcagg aaaaaggagg cacagggagg tcaagtaact tgccaatgtc 18781 acacagcagc aggtcgtgga gcttgggttt caatgccaag tcctgagttt gttttatatg 18841 gaaagcacaa gagacattgg cttccacctt tggtaacaga tgattgccta tgtttatttc 18901 ccttcccagg cggtaacact ggatgtaatg ttagggcatc tatgggatag ggagatctta 18961 gcgctggtct aaggaataca aacatgactt tagttggtgt ctaaatccat agatgctcag 19021 caccgaactc agtctgactt ccagatgcta acaacacacc ccaggcaggc gaaggggcat 19081 gcttttccat actcttcctt ttgactggct tgatcacaga ctgctgctcc aaagctggtg 19141 ttacgcacag ctcctcgtcc cctccctgcc tgcccagggc cagcatcagg ggctgtcatc 19201 actgggggat gcagagctac ctgtaacagc aacaaggacc attgtcaact ccgttcccgt 19261 ctgacaccca cactgcacct ttcagagctg accataaggg ttaccctcac ctgcccagct 19321 gccagggaag aggagggctg tgggcttcat tccgaatcac cagataaact aaactaggaa 19381 acctgaggcg agccgcagcc tcagtttctc tttggtgttg ccgcccacag ttcccgctgt 19441 actggttcag cgtgccagcc atcctgaagg gctggatgga tagggtgctg tgccagggct 19501 ttgcctttga catcccagga ttctacgatt ccggtttgct ccaggtatgt gctcttggat 19561 aaggatcact atggatagtt ggagggaggg gacagaggat gcgtcttcta tcaagttata 19621 tttctagttt ccttcctttt cttagcaaat atcgattgag cacccactat gtacaaagca 19681 ccatgtgctg cacacgggtg gacacagcat cgtttctgaa atcatggagc tttttgtctg 19741 gtggggctgc gaacacatcc acagcatact acacgcatgg caaacaaggg agtgggtcag 19801 gtgtcaggtg acgggggacc tgggcaacct tatgtgggca acccggtggc cagccctggc 19861 tccagagaga gtatctccct ggtgcagagc ccagccctgg cctggcacaa gttcaccccc 19921 ttgagcatca tgtgcctgct gtgagaaaag accatgcgac acccacgtgg caggatgagg 19981 agggcatgga atctggtaga tgtgccacat gtggtagcta tgaattctta ctaaaacaat 20041 gatttttaag gctgggtgca gtggctcacg cctgtaatcc cagcaatttg ggaggccgag 20101 gagggtggat cacttgaggc caggagttca agaccagcct ggccgacatg gtgaaacccc 20161 atctctacta aaaatacaaa aattagccgg gcatggtggt aggcgcctgt agtcccagct 20221 acttgggagg ccgaggcagg agactggttt gaacctggga ggtggaggtt gcagtgagcc 20281 aaaatcgcac cattgcattc cagcctgggt gacaaagcga gactctgtct caaaaaaaaa 20341 aaaaaaaaaa aggaacgatt tttaaattct aaaagcttca gaaaataaat gcacgtaagg 20401 gaaacatact gagtaaccaa gatgtgtctt ggaccatgaa tggtgctacc acttactgag 20461 cagccctgtg tgctgggaac cttgtcctgt ggtcagtgcc tcggccgtat ccatcacaca 20521 tggtgtcatg gaaaccaggt ttccaccagc aacctgggca tgttagagct tctgtgtctg 20581 cttggtccat tcacttggat tgtctcctcc tcctcttggg atgtcattgt cacctatgga 20641 tgggagtgtt gcatttgtcc atccctggag ggtgtccaca cgcatgttcc ctgctggctg 20701 tgctgagccc gtgtgctgga ggctcagcaa catttctgtc ctcttctgga gtccacacaa 20761 atgcatctgc tttctccctt gcagggtaaa ctagcgctcc tttccgtaac cacgggaggc 20821 acggccgaga tgtacacgaa gacaggagtc aatggagatt ctcgatactt cctgtggcca 20881 ctccaggtag accagctgcg agtggctccc ttgcttgttg gcacacgcac acacagacac 20941 acacatgcac acatgcatac acacacacac gcacacacat acatgccctc agctccccga 21001 ggggtgagat gagatgggat ggaagcgtga tgccccacac cattttgact cccctggata 21061 caagaaaatt ataacatttt gcccctttta aatgctttac ttgacagatt tgaaaagctt 21121 gaccaatagg gaaaacatgc cctaattata gcttttgata tggtttgggc agaagctaag 21181 ccaaacctgc ttagcttggt cagcagaatg gccccaaggt ggccctgcgt gtgttgtgat 21241 acgtgcgggt ggaggccatc catatggctc tggcagtgct tggtgagggc agcactgccc 21301 ttggaccctg gcaagtggca ccccaggccc tgcattctga tggccgcatg ctggtctctg 21361 ctggccatgc caacccccac aggggcaagg ggcctatgga gccagcacac acccacctcc 21421 cagtccgcag gcccctccca ggcctgcttc cccaggggac ctcttggtgc ctgcgtgagt 21481 gtccctgggc ctgaaatgtg gccgagtagt ggccacctgc caaagggaag gtggtgggca 21541 gagcagttcc aacgtgctgg ggtgtcccac gaaggaaccc ctggtgaggg gtggcagagg 21601 gagggagtgg ggagcagact ccaggtcagg ggctccaggg aacccagaaa cctaggggtc 21661 aactgttctt ccaggttgtt taagggaggt ttgtcgagac agggggagag ctcgttcttg 21721 aggggtaggg agtttgctgg gaaaatgcac gcgtcacccc ttttctgtga actctctcta 21781 ggtgcacgtg ccttgcccat gtcctattgg tttggtattt tttaattttc tatttgtcag 21841 tgctcttcat atatcagaga aattaatcct attatgtcct ttcaaaacac aatgattttt 21901 ccttctacag gcagtgcaca ttgactaagt tcattccttg cttttgttgt tgtttgctat 21961 tataaatagg attttgtctt caattatatc ttctaaaagt tcttttgatt ggtgaaagct 22021 attgattgct gaatattggt ttttgacccc gaccatttgc tgttttctcc tcctaatcat 22081 aattttttct tagttggttt ccagtaataa agtcatgttg tctgaagctg ggtgcggtgg 22141 ctcacgcctg taattccagc actctgggag gctgaggcag tggatcacct gaggtcagga 22201 gtttgagacc agcctggcca acatggcgaa accccatctc tactaaaaca caaaaattag 22261 ccgagtgtgg tggcggacac ctgtagtccc agctacttgg gaggctgagg cagcagaatc 22321 gcttgaacct gagagacgga ggttgcagtg agccaggatt gcaccactgc actccagcct 22381 gggcaacaga atgagaatcc acctcaaaaa caagcaaaca aacaaacaaa taaataaaat 22441 gatgttgcct gaggaaaaaa atgtggatag tggtgtgtgg gcctctcact ccccacctga 22501 cagggcaggc ctggatgagg gtgtgggttt taaagaaagt aatgcagagg attgagtgtg 22561 acatttttag aaaaaaagtg gtcctctttg aaagaaaaaa gtacgtgatt ccagttactg 22621 atagtctact gaaggaaatg ataatttata aacctgacct tgcttcttca caggccaact 22681 ggtctcttat gtgtcattag ccaagttcaa attcttcttg cttttaaaaa aatctttttt 22741 tttttcagtt tgcagaagta catattatgg ccaaaaaaaa aagagacaat atgaaatata 22801 aaaagagaaa atccctttaa tccctcccac ctcagaaaga atcactttaa atggtttgat 22861 ttattttctt agggcctata tattttctca catacataat ttttattata ggtttattac 22921 atttactgct cttttacatg aatggtatat cataaatacg gcttaaaatt tgtttgttat 22981 tttcatttaa cagatatctt gaacaaactt ccatggtata tattatagct agaataacct 23041 cattctggaa taatctatag tgtgaatgta ccataatttg cccaatcaag cagaactata 23101 atgtttggca tctgaatcag ttgcaaagat tgtaggttaa ttgcagttat aaaaatagag 23161 cttggaaatt gcaactgccc caagttcttc acggctctta tgcaaggctg tgtcctaaag 23221 ccatagggaa gtttagcttt cagttgcctg taacattaag gttgtttcat gattttttga 23281 aggtttgttt cacaccattt ccccccttaa atcatttaac tgaatggtat gtaacaggtg 23341 tagtttctaa tgagttcttt tcttcccctg tggctttagc atggcacatt acacttctgt 23401 ggatttaaag tccttgcccc tcagatcagc tttgctcctg aaattgcatc cgaagaagaa 23461 agaaagggga tggtggctgc gtggtcccag aggctgcaga ccatctggaa ggaagagccc 23521 atcccctgca cagcccactg gcacttcggg caataactct gtggcacgtg ggcatcacgt 23581 aagcagcaca ctaggaggcc caggcgcagg caaagagaag atggtgctgt catgaaataa 23641 aattacaaca tagctacctg gggatacttt tttctttctg ttttttgttt gtttttaatt 23701 ttagctttaa ggagcacatg gccagtactg tttcagggga atattgggtg gcgctggggt 23761 ttgggcttct attgatccca tcacccaaac agtgagcata gttcccaata gatagttttt 23821 caacacttcc tttcctccct tccttcccgc ttttggattc ccagcatcta ttgatcccgt 23881 cttttcaccc ctgtgtaccc aatgtttagt tcccacttat aagttagaac atggggaatt 23941 tggttttgtt tctgtgttga ttcacttagg ataatgacct ccagctgcat ccacgttact 24001 gcaaaggaca ggatttcatg tttttttatg gctgcatagt attccatggc gtccgtgtac 24061 cacactttct ttatccagtc cactgttgat gggcacctgg gttgattcca tgtctttgct 24121 actgtaaata gttctgtgat gaacatacaa gtgcaggcat cttttcatag aatgattttt 24181 tttttccttt tggtagatac ccagtaatgg gattgctggg ttgaagggta attctatttt 24241 tagcaaacta gaaatattta atgaagtaca tgaatgagtg tcttcagaat tgtacacagt 24301 gagatcaaat attttaataa tgagcttgtt atgttgaatt ctattctgac catcactcac 24361 tgagattttc ttttctttct ttcttttctt ttctttcttt tttaaagaga cagagtttca 24421 ctatgttgcc cgggctggtc tcaaacccct tgcctcaagt aatcttccca ccttgggcct 24481 cccaaagtgc tgggattgca ggtgtgagcc accacacctg gcccagattt tctttaatat 24541 ttgtctaata tctttccatc tccctatatt caagcttc //