LOCUS       AY299456               24578 bp    DNA     linear   HUM 03-NOV-2006
DEFINITION  Homo sapiens NRH:quinone oxidoreductase 2 (NQO2) gene, complete
            cds.
ACCESSION   AY299456 AH005367 U07729 U07730 U07731 U07732 U07733 U07734 U07735
            U07736
VERSION     AY299456.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 24578)
  AUTHORS   Jaiswal,A.K.
  TITLE     Human NAD(P)H:quinone oxidoreductase2. Gene structure, activity,
            and tissue-specific expression
  JOURNAL   J. Biol. Chem. 269 (20), 14502-14508 (1994)
   PUBMED   8182056
REFERENCE   2  (bases 1 to 24578)
  AUTHORS   Wang,W. and Jaiswal,A.K.
  TITLE     Sp3 repression of polymorphic human NRH:quinone oxidoreductase 2
            gene promoter
  JOURNAL   Free Radic. Biol. Med. 37 (8), 1231-1243 (2004)
   PUBMED   15451063
REFERENCE   3  (bases 1 to 24578)
  AUTHORS   Jaiswal,A.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-1994) Fox Chase Cancer Center, 7701 Burholme
            Avenue, Philadelphia, PA 19111, USA
REFERENCE   4  (bases 1 to 24578)
  AUTHORS   Wang,W. and Jaiswal,A.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-MAY-2003) Pharmacology, Baylor College of Medicine,
            One Baylor Plaza, Houston, TX 77030, USA
COMMENT     On or before Jun 17, 2003 this sequence version replaced U07729.1,
            U07730.1, U07731.1, U07732.1, U07733.1, U07734.1, U07735.1,
            U07736.1, AH005367.2.
FEATURES             Location/Qualifiers
     source          1..24578
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p25"
                     /tissue_type="liver"
                     /dev_stage="adult"
     gene            1..23661
                     /gene="NQO2"
     regulatory      1..3798
                     /regulatory_class="promoter"
                     /gene="NQO2"
     misc_feature    3512..3772
                     /gene="NQO2"
                     /note="GC-rich region containing several SP1 binding sites
                     at -286 to -26"
     mRNA            join(3799..3984,10367..10458,13924..14088,16443..16573,
                     19431..19544,20785..20886,23380..23661)
                     /gene="NQO2"
                     /product="NRH:quinone oxidoreductase 2"
     CDS             join(10452..10458,13924..14088,16443..16573,19431..19544,
                     20785..20886,23380..23556)
                     /gene="NQO2"
                     /function="catalyzes metabolism of quinones including
                     menadione"
                     /note="NQO2; cytosolic protein; uses dihydronicotinamide
                     riboside (NRH) as electron donor"
                     /codon_start=1
                     /product="NRH:quinone oxidoreductase 2"
                     /protein_id="AAB60642.3"
                     /translation="MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYA
                     MNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQF
                     PLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTG
                     VNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKE
                     EPIPCTAHWHFGQ"
BASE COUNT         6378 a         5882 c         5761 g         6557 t
ORIGIN      
        1 ctttgggagg ccgacgtggg cggatcacct aaggtcggga gtttgagacc aggctgacca
       61 acatggagaa accctgtctc tactaaaaat ataaaattag ccaggcgtgg tggcgtattc
      121 ccgtaatccc agctactcgg gaggctgagg cataagaatc acttgaaccc aggaggcgga
      181 ggttgcggtg agccgagatc tcgccattgc actccagcct gggcaacaag agcaaaactc
      241 cgtctcaaaa aacaaacaaa aaacctacaa ctcaacaaca aatagacaaa caacccaatt
      301 aaatggtcaa caaaggactt gaatagacat ttctccaagg aaggtataca aatggccagt
      361 aagcacatga aaagatgctc aaagtcatta gtccttaggg aaatgcaaat caaaaccaca
      421 atgagatacc acttcgcact tgctaggatg gctataattt agagggaaaa aaaagaaaca
      481 taacaaatgt gcgtgagaat gtagagaagt tggaacctgt gtacattgtt ggtgaaaatg
      541 tgaaatggtg tagacgctgt ggaaaacagt ttggctgttc ctcagaaagc taaacataga
      601 atgaccatag aattgtaata ccgacaattc cactccaagg tgtataacca aaattattga
      661 acacagggac tgaaacagat acttgtacac caataatcat tgcaatatta ttcacaatag
      721 tcaaacaaca gatgagtgga taaacaatgc ctggtaccct tccttccttc cttccttcct
      781 tccttccttc cttccttcct tccttccttc cttccttcct ttctttttct ttctctcttt
      841 cttctttctt ttctttctgt cagtcttgct cttgttgccc aggcttgagt gcaatgacac
      901 aatctcagct caccgccacc tctgcctcct gggttcaagt gattctcctg cctcagcctc
      961 ccgagtagct gggactacag gtgcacacca ccatgcccag ctaatttttg tgtttttagt
     1021 agagatgggg tttccccacg ttggccaggc ggtatacaca tttttctatt attcggccat
     1081 aaaaaggaat gaagttctga tgcatactac aacatggatg aaactcagca acaaggtttt
     1141 tgaggaaaaa aagcttagtg aaaaggccac atcttgtagg attccactta tatgaaatac
     1201 atgcaataga caaattcatg gagacagaaa gtagattaga ggctaccagg agtggaagga
     1261 ggggagaatg gggatttatt atccaatgag tgcagtgttt ctatttgttt ttgtttttgt
     1321 ttgagacagg gtctcgctct gtcatccagg ctggagtgca gtgccacgat ctcagctcac
     1381 tgcagcctcc gcctcctggg ttcaagcaat tctcctgcct cagcctctga gtagctggga
     1441 ttacaggtgt acaccacctg gcaaattttt gtagagatgg ggtttcgcca tgttggccag
     1501 gctggtctca aacttttgac ctcaggtgat ctgcatgcct ctgcctccca aagtgctggg
     1561 attacaggcg tgatctatgg cccctgaccc aagtgtttct atttgggatg atgaaaacgt
     1621 tttgaaaata aatagttgta atggttgcac agcactctaa aggtaattta tgccactgaa
     1681 ttgtacactt aaaatggtga aaatagaaaa tttcatgtta tacagatttt gctacccaaa
     1741 aaacaaaaca aaaaatccaa aacctttatg ttattatgaa gaagcagttt tccaaaggaa
     1801 tagggatgct ggtagcagaa gggaaagaaa tctcattaaa taaaaacaaa agcaatgacc
     1861 tcttcaggag gtggctcagc tagtttagct ttaccttagc accatgatgg ttcattttat
     1921 tcagaaatag aaacatgggg cgttggggag aagaggagat gtgtacctgc ctcacctgcc
     1981 tccctgccca gaatgccgac tccgactctt gctttccact aaggctgggg attaaatgaa
     2041 aagtgagaat ctggaaaccc ccagagatga tgtttgtcgt tggagctgat tttatctcat
     2101 tttagtagca tgacctcctc ctcaaactca ggatgcaatt atggtcaatc tcattagtgt
     2161 gcagtaattg ctcagcccca ataccagatt agcaggaagt tctgttattt tccttttgag
     2221 gatgggctcc tactgaactg tcctggaatc taccaccatt caggttacaa aagacccagg
     2281 gaactaggcc agtccagctc ccaaccccaa gcagggagca acttgctcag tccacgttgt
     2341 gatagctcct cgctgccaca aggtggtgat gttgcatcac acacgcgcat gatgggcgcg
     2401 caggcgccaa tgctcccagg acctgctgtt ccattcctaa atgaaagttg ttcccaggat
     2461 ctggactcac aagacaaggc agcctattcc ctgctgggga gctcaggggc aagagggcat
     2521 ctcggaggga gggcacattc tcacctctga agacaaggag aacatcatca gcacatagac
     2581 caatcccagc agtgcacctt aggatgggga gggccactgt gagttacagc aaaatgaacg
     2641 aatgaatgaa ccaataaatg tctgagaggg aaagtcccaa cgaccctcag gaggtacaat
     2701 caagagttgc agttattttc gttaggaacg ttctaaacac aggggaaacc ttccttcctt
     2761 ctgctctatt gttggagtgg ggccatcccg ggacaccaga aatcaaggaa ttgagtttgg
     2821 agaagggact tggggaggtc acagtggcag gtgactgcca aatgaggtgg cagaagccag
     2881 caagcgctgg aaaaagtcgg cccaaactgt tcaccagcac cgccccccat aactccccac
     2941 ctgctctggt ttcaagactt tccgttttct aggtatttcc ttggccttaa accattttcc
     3001 tttaaacgaa ctttttctgt ggagccatcc ggtttccccc gatagtggca tctcacaaag
     3061 gacagtccag tatcccaaca gcgtgttgcg ttccgcggga cgcagatttc cttcacaggc
     3121 accccccggg ttgcgttttt atagccacac ccacccgccc ccctatctcc tgggcactgc
     3181 taatgagtcc tgcatttctc tcctttggtc tttggataaa tgaaccatcc gtgcgtgacc
     3241 tttgcgaggg catcttgcat aataccagta caccagcggc gccgtcggtg agtgaccttt
     3301 gggactggtt tctctcacca gcgtaactcc ccgggagatc cgagcaagct gatgagtgta
     3361 tcagtggctc attctttctg ttgcaccacg gaccgtcatt ctgtaaccgg gataccagcc
     3421 agggatgggg agcgggaggc gcagggcagg ggcgtccctc ctctcagcac agcctccccg
     3481 cgctggattt ctatcaatcc agtttccacc tgcctggaag tcagcagggt cctccgcagt
     3541 cccagatcgc cgggcgaggc cccagatgga cctcaggggc ggggagtggg cggagcttag
     3601 gggccgaggc gaggtgtggg tggggcggga cgccgctgtg gaggcggggc ctgggcgcgg
     3661 acgggcgcgg agcgaggcac cgcaccgccg gggcggggag tgggcggggc tcacgggcgg
     3721 ggcgggtgag tgggcggggc ctcggcgtgg taggcgcgct gcgtaaagag gcctgcagtc
     3781 ccgcggcgcg gggcaggttc cgggctgctt aggttggcac cggtccgtgg tccccggggg
     3841 cgcagtcgca gcgctcccgc cctccaggcg tcagcgagtg cgcggtccag tgcggccgga
     3901 acctggcgca actcctagag cggtccttgg ggagacgcgg gtcccagtcc tgcggctcct
     3961 actggggcgt gcgctggtcg gaaggtgagt gatcccctgt cggggaccgg gggacttggg
     4021 aaggacagtt cccggactgg acggccagaa cgctctcagg gatttcagct ggccggccat
     4081 atggccctgt gggtcgtcgc gcccgggcca gggaccattc tgtacatagg atcgtgcttg
     4141 gctctcacgg aacgcgccca cacgcagggt cccggtgtcg aatcgtctgg tggaatctgc
     4201 cctcaaccct atggagcggg tgctggtatc atagtcatat tacaagtagg aatcagcggg
     4261 cccaaggtca gtctgtaaag ggggtaccgg ggtttaggcc cgtgcgctgc ccagcgctgc
     4321 cctgaaggcg cggctgaacc actggtttgc gctgcctttg tcaaggacat tgtggcactg
     4381 tggaaaaaat gaaaaatcag cttctctaac ctataatctc tctgggaaaa aaaaaaatca
     4441 gctttttttt ttttccccga gacggagtct cactctgtcg cccaggctgg agtgcagtgg
     4501 cacgatttcg gctcactgca acctccgcct cccgggttca agcaattctc ctgcctcagc
     4561 ctcccgagta cctgggatta taggggcgtg ccaccacgcc tggctaattt tttgtatgtt
     4621 tagtagagac gggtttcatg ttggtcaggc tggtctcaaa ctcctgacct cgtgatccgc
     4681 ccgcctgggc ctcccaaagt gctgggattg caggcgtgag ccactgctcc cggccctctt
     4741 tttctttttt cttttttttt tagaagagtc tcactctgtt gcccaggctg gagtgcagtg
     4801 gggcaatctc agctcactgc aacctttgcc ttccaggttc aagcgattct cccccctcag
     4861 ccccttgagt agctgggatt acaggcgcct gccaccatgc ccggctaatt tttgtatttt
     4921 tagtacaggt gggagtttca ccatattggc caggctggtc ttgaactcat tcttcttcct
     4981 ttctttttct tttttttttt tttttgagat ggagtttcac tcttattgcc caagctggag
     5041 tgcaatggca caatctcagc tcactgcaac ctctgcctcc cgggttcaag ctattctcct
     5101 gcctcagtct cccgagtagc tgggattaca ggtgcgtgcc actacaccca gctaattttt
     5161 ggtattttta gtagaaatgg agtttcacca tattagtcag gctggtctca aactcctgac
     5221 ctcaggtgat ccgcctgcct cggcctccca gagtgctggg attaatgaac cactgcgccc
     5281 ggccaaaaat cagcttcttt aacctttaat ctctgaaaaa ataaatcagt ttaaccttta
     5341 atctccgaag atcacagcca aagaaataca tgaaaaggaa caagtattaa ataatatata
     5401 cttctagctg tgctgtttat agttttggga aaaaaatgga aataacctaa ggtcccagaa
     5461 ataggaaaat gggcacaaaa gggtatgcag gcaatggttt agctgccgca tgaatacaca
     5521 ctgaatacac tgtgagatgt tgtctgttag aatgcccagc acggggactg tccacatgga
     5581 aagaggcaca ggaaaaaaag tgaaaacatt ataaaataac ttcttaaaat taaataatgt
     5641 acacgtcaaa aatatcagag cccacttgac ctggtatata cagtttaata accacatggc
     5701 tcttttttcc tgtaggcctg ggtaggtgca tagtttctaa aaagggagag aactgtcact
     5761 gctgtggatg gggtgccaag ggaagtgcct ggggtcaagt gaacagtgac acaactgcaa
     5821 gtcaagagcc tgtgttggag tctttcccca ctatttcaaa tagtatagaa aatagagctg
     5881 agtcactcaa atagagctga gttagtcact cagctcttgg acctcagatt cttattctta
     5941 accgctaggg ggatggagac agaagtcaca aactcacatg ccaccagcca tatgatgtaa
     6001 acatgtaaac tgggccaagg aatacaaaag ggagtggtga gctggggaca ctgaagaatg
     6061 gatgccctgt ctagaggagt gaaaatgaag catttcatac aaacaacatg atttcgggca
     6121 atcactttgg gaatcaggat aaggtgttcc cccagtctgc agaaacactg gcaacattta
     6181 caaaggtaaa tcatttcata tcactctatt ttctttttct tttttgagac agagtcttgc
     6241 tctgttgccc aggctggagt gcaatggcac aatcttgact cactgcaacc tccacctccc
     6301 aggttcaagt gattctcctg cctcagcctc ccaagtagct gggactacag gcacatgcca
     6361 ccatacccgg ataatttttg tattttttag tagagatggt gttttgccac attgaccagg
     6421 ctggtttcaa actcctgacc tcaggtgatc cccccacctc ggccccccaa aatgctggga
     6481 ttacaggtgt gagccaccac aactggcgat cattccatat tactctccag cttaagaggc
     6541 tccaagggct ttctgtcagg cttagaataa aatcctcacc cctaccctag gaggggtcag
     6601 gtcagacccc tcccacctcc ctgactgcat ctaccaccat ccactctttt tttttttgaa
     6661 ccacagttca gccaaacagg ctttcttttt tttcttttac tttctctttt ttcttgaaac
     6721 agagcctaac tctgtcaccc agtctggagt ggagcaatcc tctaatctca gccccctgag
     6781 tagctgggat tacaggcatg caccaccaca cctggctaat ttttaaaaat ctttggtaga
     6841 gatgggatct cactatgttg cccgggctgg tctcaaattc ctaggctcaa gtgatctcct
     6901 gcctcagcct ctcaaagtgc tgggccttct gcttccctgg gctttgccag gcctccctat
     6961 gcattgtgat agccaaagtt tgctttctac aaagtcacct ccaggcagtg actgtccacc
     7021 agggcactgt agagcctccc agctaatgat gaagtcactc actctcctct ctttttcctt
     7081 taagataatc cctttccaga cccgccattt tggctcaccc tgtaagttac agccccactt
     7141 ctcactgcca agtgtgggtg tcactgctgg ctcagggagc atggatcctg taaacttgcc
     7201 tcatcgggag gctttgagga gtgaccccca ggaactagac aagtaacttg ttcttcacaa
     7261 tcactgccct cccaagaaca tccaggattt cagcctcagt gttaagacaa ccatgtctct
     7321 ccctgacaca tgctcgctgc tgagaatttt aggaaaagca gagggctgtg caggcgcccc
     7381 tgcccctagg ctaggagagc tggcaaatgc ctggagaccc aaaggcctca tcctcagggc
     7441 ggccaactct tctgttttag tgatatacag actatctttt attgtgattt atagtgcaac
     7501 ttaccggttc aaacaatact acctgtattc ataaactttc tttttccttt ccttcctcac
     7561 tgcccagctt taggttcatt cttgtaagtg ttgctggtgt cagaatagga acctccctgc
     7621 gctttgaagg gatgaatgtg acctctccca cattctccgg tgctgtgatg taccttaaac
     7681 acagcaaggt acttggacac aaagcctgtg cctggagcac tttcagacag acagtgcatg
     7741 gccctcgcta cagactcagt gccattgtag atgtttctgc atggaaaata cataaacaca
     7801 aatatctgca gttgccaatc caccaccatc ttgcagcccc aagagagccc cgggaatcca
     7861 ggttcctttg gtatttctgc tccctgccct tggtgcatag cctccatccc caggacgaca
     7921 agaaggctga ctgagcccta acatcatccc acagtccagc tgggaagaga gccagcgaca
     7981 aagccagagg gagctagctc ccacacctcc cagccccagc tgagttcgct tcttgagggt
     8041 atttcttgga agccccgcct gtgacttctg ctgacacctc actggccatc tcaactgcaa
     8101 ggcagcctag gaaatgtagt gcttacctgt acacgtggat tcctggaatc aattcagggt
     8161 ctgtccttgg ggaaccagag tggggatatt cagtcactaa agatgcaggt tcccagctgt
     8221 ccagtgaagt caagcgaatg gggaaggatt tgaagtcacc tttgggtgtt tggagtgatc
     8281 agagctgtct gccctcttgg ggagtgacag tgccccactc tgttaagtcc catgcctgcc
     8341 cccaactcag cttcagccac aatgatgtag cctcttttcc tttccatcca cagggcacct
     8401 ggcctgggtg gagcccactc ctcagcaccc acctcacttc ttgcagtatt ctgcagaccc
     8461 cagccctgtg cctgtgctcc tggacagctg gagataagga gtgggccctg gaagatgctc
     8521 attcaggccc tgctcaagat tccagtcctg gtggggataa gcaccacttt tgtgtgtctc
     8581 tgtgcttttt gttttgctgt aaagacacac tgataggttc acgttgtcgt ttggacacaa
     8641 catgcgcgat gcgtgtcttc acactaagcc ctagtcacac tctctgcatt gtttttttat
     8701 cccatttttt cctactgtgg tacagaacat ctcacataaa attgaccatt ttaaccactt
     8761 tttttgtttg tttgtttttt gtgtttttgg acagagtctc gctctgtctc agcctcccga
     8821 gtagctggga ttacaggtgc acaccaccac gcccggctaa tttttgtatt tttagtagag
     8881 acggagtttc gccatgttgg ccaggctggt ctcggactcc tgacctcagg taatccacct
     8941 gcctcagcct cccaaagtgc tgggattaca ggtgtgagcc acggtgcctg acctcatttt
     9001 agccactttt aagggtagaa ttttctggct gttttcattc atgtactgat agacacttgg
     9061 gttgcttcca tgttttagct gttgtggaaa atgctgcttt gaacatgggt gggcaagtgg
     9121 ttttcaagac cctgctttca gttttttggg ttcagagtaa cgaatggaat tgctgagtca
     9181 tatgttaatt ctcatttttc taattgtaat ttttgggggc acagcacctc tccagcagcg
     9241 gcagcactcg acctttcccc agcggtgcac ggggttccaa cttctccgca tcctcaccta
     9301 cgtgtgtttt gttttttggt agtagtagcc attctaatgc gtgtgatatg ggatctcatt
     9361 gtggttttga tttgcatttc cctaatgatt agtgatgcta agcatctttt catggcttac
     9421 tgaccattca tacatctttg gagaaaagcc tacacaagcc ttctgcccat ttttgcattg
     9481 agttgtttgc tttgttgttg ttaagtttta tctgagctgt ttttttatgg tagggagagt
     9541 gggtttgttg gagtctcctt gtatctccca gaaggaagcc agaatttcag agatggccag
     9601 gagggggtga ggccaaaggc tcccctgggg agaactcacg tttttccaga gccccattgt
     9661 gtgccagcca ccgcacatag caactgtctc tctctcactc ttctgggcca tgctgtgact
     9721 ttgttgatga ggaggttgag gcacagaggg gtggagggat gtgctgcagg gcccacagct
     9781 acaatgggca gagctggaaa ttgcaccaag tctgtctgat gcgggggtct cctctgctcc
     9841 tctggcctcc gctgcatccc tggagaatct ctgagacttc tggttagagc ctgggtctaa
     9901 gccaactccc attattttca agtgagggga agggccgaca actgccagtg ctggcccacc
     9961 agagtctggc accagccgag gagtgcacgc acccattggt ggtgtggcgg ttcactgatc
    10021 ccccagcctt ctgctcgatc tacggggaaa actggggaag gcaggaaggc caaggaggct
    10081 caactcctgc ttcctaccgt ggctcatttc ctgggtcctt tgctgtatga ctgtctggat
    10141 ggaaggttca gagtcctctc aaaaaaggaa aaaagtatgg gttttgacat cctgcgtggc
    10201 ttgtcctctg aggcctaaat ctccagaaga ttcctggcct ctcttgagag gtctttctct
    10261 gatgtgtttg cgtgtctgtc aggaagcagc agtgatgcct agatgtggta cattcgacct
    10321 cacctatgcc tctccccacc ccctctgggt tcgttttgtc ttccagattg ctggactcgc
    10381 tgaagagaga ctacgcagga aagccccagc cacccatcaa atcagagaga aggaatccac
    10441 cttcttacgc tatggcaggt aatgattcac tattgtggag taagactttt ttttttttga
    10501 gatgggattt tgttgtattg cccaggctgg tctcaaactc ctgagctcaa gtgaccctcc
    10561 cacattgacc ttccaggtgg gagttagact cttaatcaga aattggatac attgttgtaa
    10621 aaaatccaag ccacgtggaa gtgtataaac tatctggaat tatcttgttt tctatgttct
    10681 cacttgtttc attgttcctt tcgactccct ccagaattta ggttcctcaa aagtggggcc
    10741 ctgcctatcc tgtctttgct gtgcctccag gccctgaaat tctccctggg ctgtagcagg
    10801 ggctcaagtg aatgaacccc aggaggcatc ttgggtaaaa attcagtacg attctatctt
    10861 tgcttttgca actgcttatc atgcacatat acatgaacat gcaatctctc aactttttaa
    10921 tttcacctaa cgatataaca tggagagcct ttcgtgttag aacgcacagg ttcaccttac
    10981 tctatacatt atggtgtaga ttcggatttt cgcccttggc accactgaca ttctgggcca
    11041 gataatccta tgttttgggg ggtcatcctg tgcaccctgt ttagcaccta gcaccatccc
    11101 tggcctctgc ccaccagatg ccagtagcac ccctccccca ccggctgtga caaaccaaaa
    11161 tgtctccagg cattgagaaa cgtcccctag caggcacaac actgccccag ttgagaacca
    11221 ttggtgtagg tatttcattt gcatctattc tcctgttaag cccctaagta tagttccttt
    11281 attgaaacaa gagtctgaga aagtaaaatt aaaatgttaa ccatgaatct aacttatgga
    11341 attcaacctt tgtagccagc tcaatgccct gaaacccatt gcttcaaact gatacgtgta
    11401 tcttttcctt aaagtgtcat tatgaaaaat ttaaatcaag agtttaacat cttcttaaag
    11461 gtgaccaggg taaatttaat taagcaaatc accaggctgc ctcccagacg aagtcagtat
    11521 ataagcctgg agactctttc caatgaggaa aatactgctt cagaagcccc tggtgtgaac
    11581 gatactgcca gtgccaggag ggcctgactc ttcctagagt cctctttgtt atcagcatca
    11641 ccactgaaag atgggctcca tgtggccctg ccttcccatg agaccagcgg gtctgattcc
    11701 tcatgttttg tttaagtgtc agatttgatg gactggggga gatggaagca gaactgtgcc
    11761 acactgaaag gtgcctgtag ctgatatctg caaatgtagg gttagcatgg aagactaatt
    11821 ccagcagttc tttattttgg tgttagggag ctggtctaaa ccttcttaca gaggataacc
    11881 aaattaggtt gggcttttaa aagatttagt ggtggtattt ttgaggagat ataatttgac
    11941 ccattgtatt gtgatgttga gctatgaata actggatttt taaaatgccc attgctttaa
    12001 aactgccacc tattagaaag tttggtattt ctggggccag gtgctgtggc tcataccagt
    12061 aatcccagca ctctgggagg ccaaggtggg cagatcacct gaggtcggga gttcgagacc
    12121 agcttgacca acatggagaa acccggtctt aactaaaaat acaaaaaatt atccgggcgt
    12181 ggtggcgcat gcctgtaatc ccagctactc aggaggctga ggtaggagaa ttgcttgaac
    12241 ccgggaggca gaggttgcag tgagctggga tcgttgctcc agcctgggca acaagagcga
    12301 aactctgttt caaaaaaaaa aaaaaagaaa aagaaaaaag gaaagaaaag aaagtttggt
    12361 gtttctggcc aagtgcggtg gctcatgcct gtaatcccag cactttggga ggccaaggcg
    12421 ggtggatcac ttgaggccag gagttcaaga ccagcctggc caacatggca aaatcccatc
    12481 tgtactaaaa atacaaaaaa ttagctgggc gtagtggcac acatctatcg ggggaaattc
    12541 agccagatat tgggcgaaat tcacccccaa tatttcacgt aggttctttt ctatatttcc
    12601 taagtgtcgg ccggtctgag aaataaacgg acagagtaca aaagagagaa attttaaagc
    12661 tgggtgtcca ggggagacat cacatgtcgg caggttccgt gatgccccca agccgtaaaa
    12721 ccagcaagtt tttattagtg attttccaaa ggggagggag tgtacaaata gagtgtgggt
    12781 cacagagatc acatgcttca caaggtaata gaatatcaca aagcaaatgg aggcagggcg
    12841 agatcacagg accacgggac ggggcgaaat taaaattgct aatgaagttt tgggcaccat
    12901 tgtcattgag aacatcttat caggagccag ggtttgagag cagacaaccg atctgaccaa
    12961 aatttattag gcaggaattt ccttgtctta ataagcctgg gagcgctacg ggagactggg
    13021 gcttatttca tccctacagc tggaccataa aagacagctg ccgccccgaa gcgggcattt
    13081 cagaggccca ccctcaggga cgcattctct ttctcaggga tgttccttgc tgagaaaaag
    13141 aattcaccga tatttctccc atttgctttt gaaagaagag aaatatgtct ctgttccgcc
    13201 tggctcaccg gcagtgagag tttaaggtta tctctcttgt tccctgaaca ttgctgttat
    13261 cctgttcttt tttcaaggtg cccagatttc atattgttca aacacacatg ctctgcaaac
    13321 aatttgtgca gttaacacaa tcatcacagg gtcctgaggc aatatacatc ctcctcagct
    13381 tatgaagatg atgggattaa gagattaaag taaagacaag cataggaaat cacatgggta
    13441 ttgattgggg aagtgataac tgtccatgaa atcttcacaa tttacgttca gagattgcag
    13501 taaagacagg cataagaaat tacaaaagta ttaatttggg gaactaataa atgtccacga
    13561 aatcttcaca atttatattc ttctgccatg gcctcagcca gttgctccgt tcggggtccc
    13621 tgacttccca cgaaacacac ctgtagtccc agctagtcag gagactgagg catgagaatc
    13681 acttgaacct gggaggcaga ggttgcagtg agctgagatc atgccactgc attccagcct
    13741 gggtgacaga gtgagactgt ctaaaaaaaa gagagagaaa gagacagaaa gaaaagaaaa
    13801 tttgatattt cttagcttca attactatga tgcacctgaa cattcaattt tcatcttagt
    13861 cttcattgaa tttggcagag agaggttgtt cttcaagagg aactgtttct tatcctgatt
    13921 taggtaagaa agtactcatt gtctatgcac accaggaacc caagtctttc aacggatcct
    13981 tgaagaatgt ggctgtagat gaactgagca ggcagggctg caccgtcaca gtgtctgatt
    14041 tgtatgccat gaactttgag ccgagggcca cagacaaaga tatcactggt gagtcatggg
    14101 ataaatgctc tatttataaa aactatcttt atgtttttta ctttaaaaaa tgttgacttc
    14161 cagctgcaaa atggcattat agaagcaagc tagcttcact ttccaaaaac aaatagatag
    14221 cactgggatt atcaccagca gtatcccaga agtcaaatat gaagatgaaa tagttcccaa
    14281 gaccacacat aagtgaaaca actccaagca gacggtaaga gattggacta tcatatccac
    14341 gacacccctc cccacaaact acccagcacc agctgtgtgg gaaatttcct cccaagtcac
    14401 aggttctaca ctggaaaaga gatcaagggg gacaatcagc ttctcaattt tctggggttc
    14461 ccagaaacag gcaggaagga gacctgttcc tgcctcaacc cacaggaagc atcaggagtg
    14521 cctaaaggga gaaatatccc tgacaacagc cagagacaaa ggagggagat gggaatattg
    14581 tccccagccc tggaaactct gatctgtaac ttagccaaag gagatgccaa accagagtgg
    14641 ctgttcagca gcaccacact gtaggaggta cattctgcag gtttcctggg catgagctgc
    14701 tagccagcct tcccacacta ccatgctatc ccctttggaa cctctcatat tcaggactgg
    14761 cacactctga acagtaggtt actagagctg aggcaaacgt gggcataaac caccatctag
    14821 tgccaaaaag caggtggtgg cttagtagag gaaaaaaaaa aaatttaata agaaagttgc
    14881 aaagactttc taagcaaata tatgtaataa aaatgaaaac aagtcagaca tagaagactg
    14941 aaataaatag atgtcatcca caagaaacaa cagtaaacag ggaaccatga cctctccaca
    15001 cagacaaagc aaggaaccag tgactgaacc taacgagacg gcactgtttg gactctctga
    15061 ccaagaattc agaatagcac ttttaaggaa atgtggtaat cctcaagatc acacagaaaa
    15121 gcagttcaga aatttatcag ttaaatttta caaagagatt gaaataattt ttaaaaaatc
    15181 aaacagaaat cttggaacta gaaatacatt tgctgaaaaa ttcattagag gctctcaaca
    15241 gcagaatgga tgaagcagaa gaaaaaatca gtgaactcaa aggcaggtga tttgaaaata
    15301 cacagaggag aaaaaagaaa aaggtatgga gatttcttac aaaatataga aaattacctc
    15361 aaaagaccaa atctaagaat gattggtgct taagaggaag ctgagcaaga gcaaggcata
    15421 gcaagcttat tcaaagaaat aataacagaa aaattttcca aaacttcaga aagagataaa
    15481 tatcctggta gaggaaggtc atagaataaa cagatttgac tcaaatagga ctaccccaag
    15541 gcatataatt attaaactct caaaggtcaa gaacaaaaag aggatcctaa aagcaaataa
    15601 catgtaacag agctccagtt catctggcaa cagacttctc aacagaaaac atataggcca
    15661 ggaggtagtg ggacattttc aaagtgctga aagaacaaaa ctgtcaacca agaatactgt
    15721 acccagcaaa tctagccttc aactctgaaa gagagagagt ctttcccaaa caaagaaaag
    15781 ctgagaaaat gcaccaccac cagacccacc ttacaagaaa tgctaaaggg aattcaataa
    15841 gaaagaaaaa cactaatgtg caaaaagaaa acatttgaag atgtaaaacc cactggtaaa
    15901 agtaagtaca cagaacactc taatactgta attgtgtaca gtccactcat tactagtatt
    15961 aagtctaaca gacaaatcta tcaaaaacaa taatcactac gtgacctgtt aagagccaaa
    16021 gataagcaat ataaaatatg taaatcaaga cacagatact caaaaatgtg gaggtgagca
    16081 tgaaattaaa gcgtagagtt tattttttta gacctgtttg gcattgaaca agacatccag
    16141 cctctcttgg gtgtcagttt gctctctggt aaattgggaa atacaccagt ctcaccagtt
    16201 gttatgaaga aaggtgatgt gtgtagagca cagcacctgc taggtagcaa gtgctcaatc
    16261 agcagccctc ccagactgct tctctttccc tagctcggac ccagggtgca gcttctggtc
    16321 aggttgcagc aaatgtcttt gacttgtctg aggagtccgg tatacacagt gctactggga
    16381 tggttgggat gggctgtgga tgcccaccta ggagtgagaa tgtttggcct cttccccgac
    16441 aggtactctt tctaatcctg aggttttcaa ttatggagtg gaaacccacg aagcctacaa
    16501 gcaaaggtct ctggctagcg acatcactga tgagcagaaa aaggttcggg aggctgacct
    16561 agtgatattt caggtttgtt tttctctaat taatatattg aatcagattc atcttatgta
    16621 caaactcttt ctgaatattg agttttgtgc tgcttctgga agtggcatca atgttttgag
    16681 cacagttgca cacttactga gcaaatattg taacctggtt acaacacacc tagttacaac
    16741 atttcaccta gttacaccac ttcacctagt tacaacactt cacctagtta caacacttca
    16801 tctagttaca acactacttt aaacactgta cgtagatgta acactacttt tttttttttt
    16861 tttttttttt ttttgagacg gagtctcgct ctgtcgccca ggctggagtg cagtggcggg
    16921 atctcggctc actgcaagct ccgcctcccg ggttcacgcc attctcccgc ctcagcctcc
    16981 cgagtagctg ggactacagg cgcccgccac cacgcccggc tagttttttg tatttttagt
    17041 agagaccggg tttcaccgtg ttagccagga tggtctcgat ctcctgacct cgtgatccac
    17101 ccgcctcggc ctcccaaagt gctgggatta caggcgtgag ccaccgcgcc cggccgatgt
    17161 aacactactt taaacacttt acctaattgg gtaaagatat ccacgtagcc aatatcactc
    17221 actccaaatc ccgactgcca tgtaaatagg aatgaaggat atttccatta ttccagtggt
    17281 ccaagaatca tctgaaacct gccagtcttg ttgcttccct tctcttcccg ttcctgccct
    17341 gagacattct ggggctgctt gagaaccaca tttatctgca caaatgttta tcagggtaaa
    17401 tcaggccaaa tgcatctcct taaatatcct gccttaaata tcctgatcat taagaggaaa
    17461 atctctggtt tctaccctct cagtggttgc ttcaccccca gcccagccac cttcctgtat
    17521 ttgttcacaa ggaggtgatg ccactgcaga gtgaactggc ccagcaaaat gccctccagg
    17581 agtgctgact catcaggcca cttcccgcca ctgcaaggaa gatgtgcagg catggctgtg
    17641 gctgtgtaaa cctggcagca gagtacgcac atgagctttg agggaattgt tgggtgacag
    17701 aaattcctgt ccaactagaa ggaaagggga atctattata agggctctgg tcacttgggc
    17761 ctcctggatc ccaaggacag agctgtagct gctctcgtcc acagattccc atctgctcct
    17821 ttctgcctct tggctctgtt ctctctcact gcttgccagg gactggatcc cctagatcca
    17881 gaatttccaa ccaagggatc tgattggttc agatcatttc tgttttccaa ccctgcttga
    17941 ggatgcggag tgggcaggag aacgagagca ctgttcgcat gagtccgcca tgtgagggca
    18001 aggcaggggg tgagcggcat gtgaccactt tccagacaaa accacctttc cagaatgatg
    18061 aggttcccaa gccttcataa aagcaacctg catgtgcggg aagagggctg cctcatccct
    18121 gcccaggctt gcctctgcac accccttccc gacaccagcc ctttctttac tcagtgacct
    18181 tgagctgcta atctgaccaa agtgcaggac gtcctttgtc ctaattacag gtgggtggac
    18241 tcatagtcct caggcctagg tgaccatgtg gtttaccatc tccgtcttaa taccatgcca
    18301 gtatgacggg cctgtatcct ggggtgcgtg gtcccagcag agccacgctg agctctctgc
    18361 tctgcttctc ctgtccccct tgggtcggcc ggccacgtgg agcccgcttt cctcctcgca
    18421 cccactccac tcccataacc cggtggctgg gtaggctaag acctggcctt tctataatgg
    18481 cctttctttt gtttcacttc atttcactcc atttccctac tttccctttt tttctgatag
    18541 tttgtccaga gggtctgcat tataagttat tcttttattc aacattaata aaaatttcat
    18601 tcatcactac tgcactacta atatcagagc ccaccactca ctgagcattg attctgtttt
    18661 gggcactgtg gtgtgtcttc gaatcctcac caggatgctg tgagctgtga actattagta
    18721 gccctatttg atgaatcagg aaaaaggagg cacagggagg tcaagtaact tgccaatgtc
    18781 acacagcagc aggtcgtgga gcttgggttt caatgccaag tcctgagttt gttttatatg
    18841 gaaagcacaa gagacattgg cttccacctt tggtaacaga tgattgccta tgtttatttc
    18901 ccttcccagg cggtaacact ggatgtaatg ttagggcatc tatgggatag ggagatctta
    18961 gcgctggtct aaggaataca aacatgactt tagttggtgt ctaaatccat agatgctcag
    19021 caccgaactc agtctgactt ccagatgcta acaacacacc ccaggcaggc gaaggggcat
    19081 gcttttccat actcttcctt ttgactggct tgatcacaga ctgctgctcc aaagctggtg
    19141 ttacgcacag ctcctcgtcc cctccctgcc tgcccagggc cagcatcagg ggctgtcatc
    19201 actgggggat gcagagctac ctgtaacagc aacaaggacc attgtcaact ccgttcccgt
    19261 ctgacaccca cactgcacct ttcagagctg accataaggg ttaccctcac ctgcccagct
    19321 gccagggaag aggagggctg tgggcttcat tccgaatcac cagataaact aaactaggaa
    19381 acctgaggcg agccgcagcc tcagtttctc tttggtgttg ccgcccacag ttcccgctgt
    19441 actggttcag cgtgccagcc atcctgaagg gctggatgga tagggtgctg tgccagggct
    19501 ttgcctttga catcccagga ttctacgatt ccggtttgct ccaggtatgt gctcttggat
    19561 aaggatcact atggatagtt ggagggaggg gacagaggat gcgtcttcta tcaagttata
    19621 tttctagttt ccttcctttt cttagcaaat atcgattgag cacccactat gtacaaagca
    19681 ccatgtgctg cacacgggtg gacacagcat cgtttctgaa atcatggagc tttttgtctg
    19741 gtggggctgc gaacacatcc acagcatact acacgcatgg caaacaaggg agtgggtcag
    19801 gtgtcaggtg acgggggacc tgggcaacct tatgtgggca acccggtggc cagccctggc
    19861 tccagagaga gtatctccct ggtgcagagc ccagccctgg cctggcacaa gttcaccccc
    19921 ttgagcatca tgtgcctgct gtgagaaaag accatgcgac acccacgtgg caggatgagg
    19981 agggcatgga atctggtaga tgtgccacat gtggtagcta tgaattctta ctaaaacaat
    20041 gatttttaag gctgggtgca gtggctcacg cctgtaatcc cagcaatttg ggaggccgag
    20101 gagggtggat cacttgaggc caggagttca agaccagcct ggccgacatg gtgaaacccc
    20161 atctctacta aaaatacaaa aattagccgg gcatggtggt aggcgcctgt agtcccagct
    20221 acttgggagg ccgaggcagg agactggttt gaacctggga ggtggaggtt gcagtgagcc
    20281 aaaatcgcac cattgcattc cagcctgggt gacaaagcga gactctgtct caaaaaaaaa
    20341 aaaaaaaaaa aggaacgatt tttaaattct aaaagcttca gaaaataaat gcacgtaagg
    20401 gaaacatact gagtaaccaa gatgtgtctt ggaccatgaa tggtgctacc acttactgag
    20461 cagccctgtg tgctgggaac cttgtcctgt ggtcagtgcc tcggccgtat ccatcacaca
    20521 tggtgtcatg gaaaccaggt ttccaccagc aacctgggca tgttagagct tctgtgtctg
    20581 cttggtccat tcacttggat tgtctcctcc tcctcttggg atgtcattgt cacctatgga
    20641 tgggagtgtt gcatttgtcc atccctggag ggtgtccaca cgcatgttcc ctgctggctg
    20701 tgctgagccc gtgtgctgga ggctcagcaa catttctgtc ctcttctgga gtccacacaa
    20761 atgcatctgc tttctccctt gcagggtaaa ctagcgctcc tttccgtaac cacgggaggc
    20821 acggccgaga tgtacacgaa gacaggagtc aatggagatt ctcgatactt cctgtggcca
    20881 ctccaggtag accagctgcg agtggctccc ttgcttgttg gcacacgcac acacagacac
    20941 acacatgcac acatgcatac acacacacac gcacacacat acatgccctc agctccccga
    21001 ggggtgagat gagatgggat ggaagcgtga tgccccacac cattttgact cccctggata
    21061 caagaaaatt ataacatttt gcccctttta aatgctttac ttgacagatt tgaaaagctt
    21121 gaccaatagg gaaaacatgc cctaattata gcttttgata tggtttgggc agaagctaag
    21181 ccaaacctgc ttagcttggt cagcagaatg gccccaaggt ggccctgcgt gtgttgtgat
    21241 acgtgcgggt ggaggccatc catatggctc tggcagtgct tggtgagggc agcactgccc
    21301 ttggaccctg gcaagtggca ccccaggccc tgcattctga tggccgcatg ctggtctctg
    21361 ctggccatgc caacccccac aggggcaagg ggcctatgga gccagcacac acccacctcc
    21421 cagtccgcag gcccctccca ggcctgcttc cccaggggac ctcttggtgc ctgcgtgagt
    21481 gtccctgggc ctgaaatgtg gccgagtagt ggccacctgc caaagggaag gtggtgggca
    21541 gagcagttcc aacgtgctgg ggtgtcccac gaaggaaccc ctggtgaggg gtggcagagg
    21601 gagggagtgg ggagcagact ccaggtcagg ggctccaggg aacccagaaa cctaggggtc
    21661 aactgttctt ccaggttgtt taagggaggt ttgtcgagac agggggagag ctcgttcttg
    21721 aggggtaggg agtttgctgg gaaaatgcac gcgtcacccc ttttctgtga actctctcta
    21781 ggtgcacgtg ccttgcccat gtcctattgg tttggtattt tttaattttc tatttgtcag
    21841 tgctcttcat atatcagaga aattaatcct attatgtcct ttcaaaacac aatgattttt
    21901 ccttctacag gcagtgcaca ttgactaagt tcattccttg cttttgttgt tgtttgctat
    21961 tataaatagg attttgtctt caattatatc ttctaaaagt tcttttgatt ggtgaaagct
    22021 attgattgct gaatattggt ttttgacccc gaccatttgc tgttttctcc tcctaatcat
    22081 aattttttct tagttggttt ccagtaataa agtcatgttg tctgaagctg ggtgcggtgg
    22141 ctcacgcctg taattccagc actctgggag gctgaggcag tggatcacct gaggtcagga
    22201 gtttgagacc agcctggcca acatggcgaa accccatctc tactaaaaca caaaaattag
    22261 ccgagtgtgg tggcggacac ctgtagtccc agctacttgg gaggctgagg cagcagaatc
    22321 gcttgaacct gagagacgga ggttgcagtg agccaggatt gcaccactgc actccagcct
    22381 gggcaacaga atgagaatcc acctcaaaaa caagcaaaca aacaaacaaa taaataaaat
    22441 gatgttgcct gaggaaaaaa atgtggatag tggtgtgtgg gcctctcact ccccacctga
    22501 cagggcaggc ctggatgagg gtgtgggttt taaagaaagt aatgcagagg attgagtgtg
    22561 acatttttag aaaaaaagtg gtcctctttg aaagaaaaaa gtacgtgatt ccagttactg
    22621 atagtctact gaaggaaatg ataatttata aacctgacct tgcttcttca caggccaact
    22681 ggtctcttat gtgtcattag ccaagttcaa attcttcttg cttttaaaaa aatctttttt
    22741 tttttcagtt tgcagaagta catattatgg ccaaaaaaaa aagagacaat atgaaatata
    22801 aaaagagaaa atccctttaa tccctcccac ctcagaaaga atcactttaa atggtttgat
    22861 ttattttctt agggcctata tattttctca catacataat ttttattata ggtttattac
    22921 atttactgct cttttacatg aatggtatat cataaatacg gcttaaaatt tgtttgttat
    22981 tttcatttaa cagatatctt gaacaaactt ccatggtata tattatagct agaataacct
    23041 cattctggaa taatctatag tgtgaatgta ccataatttg cccaatcaag cagaactata
    23101 atgtttggca tctgaatcag ttgcaaagat tgtaggttaa ttgcagttat aaaaatagag
    23161 cttggaaatt gcaactgccc caagttcttc acggctctta tgcaaggctg tgtcctaaag
    23221 ccatagggaa gtttagcttt cagttgcctg taacattaag gttgtttcat gattttttga
    23281 aggtttgttt cacaccattt ccccccttaa atcatttaac tgaatggtat gtaacaggtg
    23341 tagtttctaa tgagttcttt tcttcccctg tggctttagc atggcacatt acacttctgt
    23401 ggatttaaag tccttgcccc tcagatcagc tttgctcctg aaattgcatc cgaagaagaa
    23461 agaaagggga tggtggctgc gtggtcccag aggctgcaga ccatctggaa ggaagagccc
    23521 atcccctgca cagcccactg gcacttcggg caataactct gtggcacgtg ggcatcacgt
    23581 aagcagcaca ctaggaggcc caggcgcagg caaagagaag atggtgctgt catgaaataa
    23641 aattacaaca tagctacctg gggatacttt tttctttctg ttttttgttt gtttttaatt
    23701 ttagctttaa ggagcacatg gccagtactg tttcagggga atattgggtg gcgctggggt
    23761 ttgggcttct attgatccca tcacccaaac agtgagcata gttcccaata gatagttttt
    23821 caacacttcc tttcctccct tccttcccgc ttttggattc ccagcatcta ttgatcccgt
    23881 cttttcaccc ctgtgtaccc aatgtttagt tcccacttat aagttagaac atggggaatt
    23941 tggttttgtt tctgtgttga ttcacttagg ataatgacct ccagctgcat ccacgttact
    24001 gcaaaggaca ggatttcatg tttttttatg gctgcatagt attccatggc gtccgtgtac
    24061 cacactttct ttatccagtc cactgttgat gggcacctgg gttgattcca tgtctttgct
    24121 actgtaaata gttctgtgat gaacatacaa gtgcaggcat cttttcatag aatgattttt
    24181 tttttccttt tggtagatac ccagtaatgg gattgctggg ttgaagggta attctatttt
    24241 tagcaaacta gaaatattta atgaagtaca tgaatgagtg tcttcagaat tgtacacagt
    24301 gagatcaaat attttaataa tgagcttgtt atgttgaatt ctattctgac catcactcac
    24361 tgagattttc ttttctttct ttcttttctt ttctttcttt tttaaagaga cagagtttca
    24421 ctatgttgcc cgggctggtc tcaaacccct tgcctcaagt aatcttccca ccttgggcct
    24481 cccaaagtgc tgggattgca ggtgtgagcc accacacctg gcccagattt tctttaatat
    24541 ttgtctaata tctttccatc tccctatatt caagcttc
//