LOCUS HSU07343 2484 bp mRNA linear HUM 03-FEB-2003 DEFINITION Homo sapiens DNA mismatch repair protein homolog (MLH1) mRNA, complete cds. ACCESSION U07343 VERSION U07343.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2484) AUTHORS Bronner,C.E., Baker,S.M., Morrison,P.T., Warren,G., Smith,L.G., Lescoe,M.K., Kane,M., Earibino,C., Lipford,J., Linblom,A., Tannergard,P., Bollag,R.J., Godwin,A.R., Ward,D.C., Nordenskjold,M., Fishel,R., Kolodner,R.D. and Liskay,R.M. TITLE Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer JOURNAL Nature 368 (6468), 258-261 (1994) PUBMED 8145827 REFERENCE 2 (bases 1 to 2484) AUTHORS Morrison,P.T. TITLE Direct Submission JOURNAL Submitted (02-MAR-1994) Paul T. Morrison, Molecular Biology Core Facility, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 002115, USA FEATURES Location/Qualifiers source 1..2484 /db_xref="H-InvDB:HIT000217657" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="3" /map="3p22-p23" gene 1..2484 /gene="MLH1" CDS 22..2292 /gene="MLH1" /note="homolog of S. cerevisiae PMS1 (Swiss-Prot Accession Number P14242), S. cerevisiae MLH1 (GenBank Accession Number U07187), E. coli MUTL (Swiss-Prot Accession Number P23367), Salmonella typhimurium MUTL (Swiss-Prot Accession Number P14161) and Streptococcus pneumoniae (Swiss-Prot Accession Number P14160)" /codon_start=1 /product="DNA mismatch repair protein homolog" /protein_id="AAC50285.1" /translation="MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKS TSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGE ALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIA TRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRS IFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAI ETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKL LGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQK LDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGD TTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLS LQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIY DFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLAD YFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAM FYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNI LQLANLPDLYKVFERC" BASE COUNT 720 a 535 c 594 g 635 t ORIGIN 1 cttggctctt ctggcgccaa aatgtcgttc gtggcagggg ttattcggcg gctggacgag 61 acagtggtga accgcatcgc ggcgggggaa gttatccagc ggccagctaa tgctatcaaa 121 gagatgattg agaactgttt agatgcaaaa tccacaagta ttcaagtgat tgttaaagag 181 ggaggcctga agttgattca gatccaagac aatggcaccg ggatcaggaa agaagatctg 241 gatattgtat gtgaaaggtt cactactagt aaactgcagt cctttgagga tttagccagt 301 atttctacct atggctttcg aggtgaggct ttggccagca taagccatgt ggctcatgtt 361 actattacaa cgaaaacagc tgatggaaag tgtgcataca gagcaagtta ctcagatgga 421 aaactgaaag cccctcctaa accatgtgct ggcaatcaag ggacccagat cacggtggag 481 gacctttttt acaacatagc cacgaggaga aaagctttaa aaaatccaag tgaagaatat 541 gggaaaattt tggaagttgt tggcaggtat tcagtacaca atgcaggcat tagtttctca 601 gttaaaaaac aaggagagac agtagctgat gttaggacac tacccaatgc ctcaaccgtg 661 gacaatattc gctccatctt tggaaatgct gttagtcgag aactgataga aattggatgt 721 gaggataaaa ccctagcctt caaaatgaat ggttacatat ccaatgcaaa ctactcagtg 781 aagaagtgca tcttcttact cttcatcaac catcgtctgg tagaatcaac ttccttgaga 841 aaagccatag aaacagtgta tgcagcctat ttgcccaaaa acacacaccc attcctgtac 901 ctcagtttag aaatcagtcc ccagaatgtg gatgttaatg tgcaccccac aaagcatgaa 961 gttcacttcc tgcacgagga gagcatcctg gagcgggtgc agcagcacat cgagagcaag 1021 ctcctgggct ccaattcctc caggatgtac ttcacccaga ctttgctacc aggacttgct 1081 ggcccctctg gggagatggt taaatccaca acaagtctga cctcgtcttc tacttctgga 1141 agtagtgata aggtctatgc ccaccagatg gttcgtacag attcccggga acagaagctt 1201 gatgcatttc tgcagcctct gagcaaaccc ctgtccagtc agccccaggc cattgtcaca 1261 gaggataaga cagatatttc tagtggcagg gctaggcagc aagatgagga gatgcttgaa 1321 ctcccagccc ctgctgaagt ggctgccaaa aatcagagct tggaggggga tacaacaaag 1381 gggacttcag aaatgtcaga gaagagagga cctacttcca gcaaccccag aaagagacat 1441 cgggaagatt ctgatgtgga aatggtggaa gatgattccc gaaaggaaat gactgcagct 1501 tgtacccccc ggagaaggat cattaacctc actagtgttt tgagtctcca ggaagaaatt 1561 aatgagcagg gacatgaggt tctccgggag atgttgcata accactcctt cgtgggctgt 1621 gtgaatcctc agtgggcctt ggcacagcat caaaccaagt tataccttct caacaccacc 1681 aagcttagtg aagaactgtt ctaccagata ctcatttatg attttgccaa ttttggtgtt 1741 ctcaggttat cggagccagc accgctcttt gaccttgcca tgcttgcctt agatagtcca 1801 gagagtggct ggacagagga agatggtccc aaagaaggac ttgctgaata cattgttgag 1861 tttctgaaga agaaggctga gatgcttgca gactatttct ctttggaaat tgatgaggaa 1921 gggaacctga ttggattacc ccttctgatt gacaactatg tgcccccttt ggagggactg 1981 cctatcttca ttcttcgact agccactgag gtgaattggg acgaagaaaa ggaatgtttt 2041 gaaagcctca gtaaagaatg cgctatgttc tattccatcc ggaagcagta catatctgag 2101 gagtcgaccc tctcaggcca gcagagtgaa gtgcctggct ccattccaaa ctcctggaag 2161 tggactgtgg aacacattgt ctataaagcc ttgcgctcac acattctgcc tcctaaacat 2221 ttcacagaag atggaaatat cctgcagctt gctaacctgc ctgatctata caaagtcttt 2281 gagaggtgtt aaatatggtt atttatgcac tgtgggatgt gttcttcttt ctctgtattc 2341 cgatacaaag tgttgtatca aagtgtgata tacaaagtgt accaacataa gtgttggtag 2401 cacttaagac ttatacttgc cttctgatag tattccttta tacacagtgg attgattata 2461 aataaataga tgtgtcttaa cata //