LOCUS HSU07225 2025 bp mRNA linear HUM 16-OCT-2000
DEFINITION Homo sapiens P2U nucleotide receptor mRNA, complete cds.
ACCESSION U07225 S74902
VERSION U07225.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2025)
AUTHORS Parr,C.E., Sullivan,D.M., Paradiso,A.M., Lazarowski,E.R.,
Burch,L.H., Olsen,J.C., Erb,L., Weisman,G.A., Boucher,R.C. and
Turner,J.T.
TITLE Cloning and expression of a human P2U nucleotide receptor, a target
for cystic fibrosis pharmacotherapy
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (8), 3275-3279 (1994)
PUBMED 8159738
REFERENCE 2 (bases 1 to 2025)
AUTHORS Parr,C.E.
TITLE Direct Submission
JOURNAL Submitted (01-MAR-1994) Claude E. Parr, University of North
Carolina, Dept. of Medicine, Pulmonary Diseases, 724 Burnett-Womack
Bldg., Chapel Hill, NC 27599, USA
COMMENT On or before Oct 16, 2000 this sequence version replaced S74902.1,
gi:487152.
FEATURES Location/Qualifiers
source 1..2025
/db_xref="H-InvDB:HIT000217652"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="5A2116"
/cell_line="CF/T43"
/cell_type="epithelial cell"
/tissue_type="airway epithelium"
5'UTR 1..245
CDS 246..1379
/function="G protein-coupled surface membrane receptor"
/note="P2U receptor; similar to mouse ATP receptor,
GenBank Accession Number L14751"
/codon_start=1
/product="P2U nucleotide receptor"
/protein_id="AAC04923.1"
/translation="MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVC
VLGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFS
TVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVL
VLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCY
VLMARRLLKPAYGTSGGLPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDL
SCHTLNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARR
RLGLRRSDRTDMQRIGDVLGSSEDFRRTESTPAGSENTKDIRL"
3'UTR 1380..2017
BASE COUNT 388 a 616 c 596 g 425 t
ORIGIN
1 cggcacgagg caccccgaga ggagaagcgc agcgcagtgg cgagaggagc cccttgtggc
61 agcagcacta cctgcccaga aaaatgctgg aggctgggcg tggccccagg cctggggacc
121 tgtttttcct gtttcccgca gagttccctg cagcccggtc caggtccagg cgtgtgcatt
181 catgagtgag gaacccgtgc aggcgctgag catcctgacc tggagagcag gggctggtca
241 gggcgatggc agcagacctg ggcccctgga atgacaccat caatggcacc tgggatgggg
301 atgagctggg ctacaggtgc cgcttcaacg aggacttcaa gtacgtgctg ctgcctgtgt
361 cctacggcgt ggtgtgcgtg cttgggctgt gtctgaacgc cgtggcgctc tacatcttct
421 tgtgccgcct caagacctgg aatgcgtcca ccacatatat gttccacctg gctgtgtctg
481 atgcactgta tgcggcctcc ctgccgctgc tggtctatta ctacgcccgc ggcgaccact
541 ggcccttcag cacggtgctc tgcaagctgg tgcgcttcct cttctacacc aacctttact
601 gcagcatcct cttcctcacc tgcatcagcg tgcaccggtg tctgggcgtc ttacgacctc
661 tgcgctccct gcgctggggc cgggcccgct acgctcgccg ggtggccggg gccgtgtggg
721 tgttggtgct ggcctgccag gcccccgtgc tctactttgt caccaccagc gcgcgcgggg
781 gccgcgtaac ctgccacgac acctcggcac ccgagctctt cagccgcttc gtggcctaca
841 gctcagtcat gctgggcctg ctcttcgcgg tgccctttgc cgtcatcctt gtctgttacg
901 tgctcatggc tcggcgactg ctaaagccag cctacgggac ctcgggcggc ctccctaggg
961 ccaagcgcaa gtccgtgcgc accatcgccg tggtgctggc tgtcttcgcc ctctgcttcc
1021 tgccattcca cgtcacccgc accctctact actccttccg ctcgctggac ctcagctgcc
1081 acaccctcaa cgccatcaac atggcctaca aggttacccg gccgctggcc agtgctaaca
1141 gttgccttga ccccgtgctc tacttcctgg ctgggcagag gctcgtacgc tttgcccgag
1201 atgccaagcc acccactggc cccagccctg ccaccccggc tcgccgcagg ctgggcctgc
1261 gcagatccga cagaactgac atgcagagga taggagatgt gttgggcagc agtgaggact
1321 tcaggcggac agagtccacg ccggctggta gcgagaacac taaggacatt cggctgtagg
1381 agcagaacac ttcagcctgt gcaggtttat attgggaagc tgtagaggac caggacttgt
1441 gcagacgcca cagtctcccc agatatggac catcagtgac tcatgctgga tgaccccatg
1501 ctccgtcatt tgacaggggc tcaggatatt cactctgtgg tccagagtca actgttccca
1561 taacccctag tcatcgtttg tgtgtataag ttgggggaat taagtttcaa gaaaggcaag
1621 agctcaaggt caatgacacc cctggcctga ctcccatgca agtagctggc tgtactgcca
1681 aggtacctag gttggagtcc agcctaatca agtcaaatgg agaaacaggc ccagagagga
1741 aggtggctta ccaagatcac ataccagagt ctggagctga gctacctggg gtgggggcca
1801 agtcacaggt tggccagaaa accctggtaa gtaatgaggg ctgagtttgc acagtggtct
1861 ggaatggact gggtgccacg gtggacttag ctctgaggag tacccccagc ccaagagatg
1921 aacatctggg gactaatatc atagacccat ctggaggctc ccatgggcta ggagcagtgt
1981 gaggctgtaa cttatactaa aggttgtgtt gcctgctaaa aaaaa
//