LOCUS HSU04897 1863 bp mRNA linear HUM 07-MAR-1995
DEFINITION Human orphan hormone nuclear receptor RORalpha1 mRNA, complete cds.
ACCESSION U04897
VERSION U04897.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1773)
AUTHORS Giguere,V., Tini,M., Flock,G., Ong,E., Evans,R.M. and
Otulakowski,G.
TITLE Isoform-specific amino-terminal domains dictate DNA-binding
properties of ROR alpha, a novel family of orphan hormone nuclear
receptors
JOURNAL Genes Dev. 8 (5), 538-553 (1994)
PUBMED 7926749
REFERENCE 2 (bases 1 to 1863)
AUTHORS Giguere,V.
TITLE Direct Submission
JOURNAL Submitted (06-JAN-1994) Vincent Giguere, Endocrine Research,
Research Institute, Hospital for Sick Children, 555 University
Avenue, Toronto, Ontario M5G 1X8, Canada
FEATURES Location/Qualifiers
source 1..1863
/db_xref="H-InvDB:HIT000217572"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="lambda hR5"
/tissue_type="retina"
/clone_lib="lamda gt11 from J. Nathans"
/dev_stage="adult"
5'UTR 1..101
CDS 102..1673
/codon_start=1
/product="RORalpha1"
/protein_id="AAA62658.1"
/translation="MESAPAAPDPAASEPGSSGADAAAGSRETPLNQESARKSEPPAP
VRRQSYSSTSRGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQ
SNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEV
QKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAV
SSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHL
AQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYV
VEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFK
SLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQ
LALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYK
ELFTSEFEPAMQIDG"
3'UTR 1674..1863
regulatory 1839..1844
/regulatory_class="polyA_signal_sequence"
BASE COUNT 571 a 436 c 428 g 428 t
ORIGIN
1 gttttttttt tttttttggt accatagagt tgctctgaaa acagaagata gagggagtct
61 cggagctcgc atctccagcg atctctacat tgggaaaaaa catggagtca gctccggcag
121 cccccgaccc cgccgccagc gagccaggca gcagcggcgc ggacgcggcc gccggctcca
181 gggagacccc gctgaaccag gaatccgccc gcaagagcga gccgcctgcc ccggtgcgca
241 gacagagcta ttccagcacc agcagaggta tctcagtaac gaagaagaca catacatctc
301 aaattgaaat tattccatgc aagatctgtg gagacaaatc atcaggaatc cattatggtg
361 tcattacatg tgaaggctgc aagggctttt tcaggagaag tcagcaaagc aatgccacct
421 actcctgtcc tcgtcagaag aactgtttga ttgatcgaac cagtagaaac cgctgccaac
481 actgtcgatt acagaaatgc cttgccgtag ggatgtctcg agatgctgta aaatttggcc
541 gaatgtcaaa aaagcagaga gacagcttgt atgcagaagt acagaaacac cggatgcagc
601 agcagcagcg cgaccaccag cagcagcctg gagaggctga gccgctgacg cccacctaca
661 acatctcggc caacgggctg acggaacttc acgacgacct cagtaactac attgacgggc
721 acacccctga ggggagtaag gcagactccg ccgtcagcag cttctacctg gacatacagc
781 cttccccaga ccagtcaggt cttgatatca atggaatcaa accagaacca atatgtgact
841 acacaccagc atcaggcttc tttccctact gttcgttcac caacggcgag acttccccaa
901 ctgtgtccat ggcagaatta gaacaccttg cacagaatat atctaaatcg catctggaaa
961 cctgccaata cttgagagaa gagctccagc agataacgtg gcagaccttt ttacaggaag
1021 aaattgagaa ctatcaaaac aagcagcggg aggtgatgtg gcaattgtgt gccatcaaaa
1081 ttacagaagc tatacagtat gtggtggagt ttgccaaacg cattgatgga tttatggaac
1141 tgtgtcaaaa tgatcaaatt gtgcttctaa aagcaggttc tctagaggtg gtgtttatca
1201 gaatgtgccg tgcctttgac tctcagaaca acaccgtgta ctttgatggg aagtatgcca
1261 gccccgacgt cttcaaatcc ttaggttgtg aagactttat tagctttgtg tttgaatttg
1321 gaaagagttt atgttctatg cacctgactg aagatgaaat tgcattattt tctgcatttg
1381 tactgatgtc agcagatcgc tcatggctgc aagaaaaggt aaaaattgaa aaactgcaac
1441 agaaaattca gctagctctt caacacgtcc tacagaagaa tcaccgagaa gatggaatac
1501 taacaaagtt aatatgcaag gtgtctacat taagagcctt atgtggacga catacagaaa
1561 agctaatggc atttaaagca atatacccag acattgtgcg acttcatttt cctccattat
1621 acaaggagtt gttcacttca gaatttgagc cagcaatgca aattgatggg taaatgttat
1681 cacctaagca cttctagaat gtctgaagta caaacatgaa aaacaaacaa aaaaattaac
1741 cgagacactt tatatggccc tgcacagacc tggagcgcca cacactgcac atcttttggt
1801 gatcggggtc aggcaaagga ggggaaacaa tgaaaacaaa taaagttgaa cttgtttttc
1861 tca
//