LOCUS HSU04840 3671 bp mRNA linear HUM 20-OCT-2008
DEFINITION Human onconeural ventral antigen-1 (Nova-1) mRNA, complete cds.
ACCESSION U04840 S66174
VERSION U04840.1
KEYWORDS Brain; Motor Neuron; Paraneoplastic Antigen; RNA-Binding Protein;
Breast Cancer.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3671)
AUTHORS Buckanovich,R.J., Posner,J.B. and Darnell,R.B.
TITLE Nova, the paraneoplastic Ri antigen, is homologous to an
RNA-binding protein and is specifically expressed in the developing
motor system
JOURNAL Neuron 11 (4), 657-672 (1993)
PUBMED 8398153
REFERENCE 2 (bases 1 to 3671)
AUTHORS Darnell,R.B.
TITLE Direct Submission
JOURNAL Submitted (05-JAN-1994) Molecular Neuro-Oncology, The Rockefeller
University, 1230 York Avenue, New York, NY 10021-6399, USA
COMMENT On Jan 14, 1994 this sequence version replaced gi:435800.
FEATURES Location/Qualifiers
source 1..3671
/db_xref="H-InvDB:HIT000217569"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="nova-1"
/tissue_type="cerebellum and hippocampus"
/clone_lib="lambda ZAP; Stratagene"
/dev_stage="adult"
gene 1..3671
/gene="Nova-1"
CDS 61..1593
/gene="Nova-1"
/note="brain protein specifically expressed in the
developing ventral brainstem and spinal cord recognized by
sera of patients with paraneoplastic opsoclonus and breast
cancer; paraneoplastic Ri antigen"
/codon_start=1
/product="onconeural ventral antigen-1"
/protein_id="AAA16022.1"
/translation="MMAAAPIQQNGTHTGVPIDLDPPDSRKRPLEAPPEAGSTKRTNT
GEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKLSKSKDFYPGTTERV
CLIQGTVEALNAVHGFIAEKIREMPQNVAKTEPVSILQPQTTVNPDRIKQTLPSSPTT
TKSSPSDPMTTSRANQVKIIVPNSTAGLIIGKGGATVKAVMEQSGAWVQLSQKPDGIN
LQERVVTVSGEPEQNRKAVELIIQKIQEDPQSGSCLNISYANVTGPVANSNPTGSPYA
NTAEVLPTAAAAAGLLGHANLAGVAAFPAVLSGFTGNDLVAITSALNTLASYGYNLNT
LGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTFALGSLA
AATAATNGYFGAASPLAASAILGTEKSTDGSKDVVEIAVPENLVGAILGKGGKTLVEY
QELTGARIQISKKGEFVPGTRNRKVTITGTPAATQAAQYLITQRITYEQGVRAANPQK
VG"
repeat_region 214..321
/gene="Nova-1"
/note="RiTE1; KH domain; putative RNA binding domain"
misc_feature 322..330
/gene="Nova-1"
/note="alternative splice"
misc_feature 517..588
/gene="Nova-1"
/note="alternative exon"
repeat_region 589..696
/gene="Nova-1"
/note="RiTE2; KH domain; putative RNA binding domain"
repeat_region 1339..1446
/gene="Nova-1"
/note="RiTE3; KH domain; putative RNA binding domain"
BASE COUNT 1068 a 778 c 763 g 1062 t
ORIGIN
1 gaattccgac aaaacaaaag ggagaacctt ctcccggtag cagcggcagg aactgcaaac
61 atgatggcgg cagctcccat ccagcagaac gggacccaca ctggggttcc catagacctg
121 gacccgccgg actcgcggaa aaggccgctg gaagcccccc ctgaagccgg cagcaccaag
181 aggaccaata cgggcgaaga cggccagtat tttctaaagg ttctcatacc tagttatgct
241 gctggatcta taattgggaa gggaggacag acaattgttc agttgcaaaa agaaactgga
301 gccaccatca agctgtctaa gctgtctaag tccaaagatt tttacccagg tactactgag
361 cgagtgtgct tgatccaggg aacggttgaa gcactgaatg cagttcatgg attcattgca
421 gaaaaaattc gagaaatgcc ccaaaatgtg gccaagacag aaccagtcag cattctacaa
481 ccccagacca ccgttaatcc agatcgcatc aaacaaacat tgccatcttc cccaactacc
541 accaagtcct ctccatctga tcccatgacc acctccagag ctaatcaggt aaagattata
601 gttcccaaca gcacagcagg tctgataata gggaagggag gtgctactgt gaaggctgta
661 atggagcagt caggggcttg ggtgcagctt tcccagaaac ctgatgggat caacttgcaa
721 gagagggttg tcactgtgag tggagaacct gaacaaaacc gaaaagctgt tgaacttatc
781 atccagaaga tacaagagga tccacaaagt ggcagctgtc tcaatatcag ttatgccaat
841 gtgacaggtc cagtggcaaa ttccaatcca accggatctc cttatgcaaa cactgctgaa
901 gtgttaccaa ctgctgcagc agctgcaggg ctattaggac atgctaacct tgctggcgtt
961 gcagcctttc cagcagtttt atctggcttc acaggcaatg acctggtggc catcacctct
1021 gcacttaata cattagccag ctatggatat aatctcaaca ctttaggttt aggtctcagt
1081 caagcagcag caacaggggc tttggctgca gcagctgcca gtgccaaccc agcagcagca
1141 gcagccaatt tattggccac ctatgccagt gaagcctcag ccagtggcag cacagctggt
1201 ggtacggcgg ggacatttgc attaggtagc ctggctgctg ctactgctgc aaccaatgga
1261 tattttggag ctgcttctcc cctagctgcc agtgccattc taggaacaga aaagtccaca
1321 gatggatcca aggatgtagt tgaaatagca gtgccagaaa acttagttgg tgcaatactt
1381 ggcaaaggag ggaaaacatt agtggaatac caggagttga ctggtgcaag gatacagatc
1441 tccaaaaaag gagaattcgt acctggcaca aggaatcgga aggtaaccat tactggaaca
1501 ccagctgcaa cacaggctgc tcaatattta attacacaaa ggatcacata tgagcaagga
1561 gttcgggctg ccaatcctca gaaagtgggt tgagtgcccc agttacacat cagattgttt
1621 taacccctcc tttaccccat tttcaagaag gatgtactgt actttgcaga agtgaagttt
1681 ttctgttatt aatatataat tatgcaaatg aatgcgacta tgttgacaat gtgtatatgt
1741 aaataatatg tgttttacca gatgtttcat agaaagaatt ttttcttgat ctgttttgtt
1801 ctctatactt tgcttgtgta tatttgtcag aggtgtttct agtgtaagat ttaagcctgc
1861 cattttacca gcattattgt agtttaatga ttgaatgtag acagggatat gcgtatagtt
1921 ttcagtatta gttctagata acactaaatt aactactgtt aggttgagta tggtggggtc
1981 agtgacctaa aatggagtga ggccaaagca ctgtcctgta agtcttactt cctgcttagg
2041 gcacagtgaa gtaggaaaca atattttgaa aataagtttt aaatttaaaa tgatcaaaaa
2101 gcaatatagt tgcataaaag cactgtaaaa tatttaaaag gttaaaactg tggaaaatta
2161 tattggtaag tttacagatc aataaaagca cctgttctcc atctgaacta gacaatggaa
2221 ataatgctgc atgctgccat ggcccattct tcatcatttg taagttcaac aaaagttctc
2281 acatggagtc ccacctcttc agaggttgca catttgtttt taagactgaa ttcactactg
2341 atcccatcgc ctggccgaga cagtcattac tccattaaca tcctcactgt ttagacacat
2401 aactgtggta caggattgga aattataaac aaaagtgaaa gtgccaacaa attattgata
2461 gctgataatg tttcatatct gcaactgctt gataagtatg ttgcatttta agagcttata
2521 attgtgtata atttgttaac actagaaacc tattagtatt gtgaatgtag attttactgt
2581 gaagctatct gtgatttagc tgtttgctcc catgatggag tctttgcagc atggcgctag
2641 cagccaatgc agtttctaat actcggtaat ttgcatgttt tgtggagcat ttttatgtca
2701 ccaaccagac agtatttcct gcatgcttat ttagaagagg cagcttatct tgagaggtag
2761 tgttatctac ctttgtcagg ctttttgaca ggtcatttca gagtaagcct ttgttcccaa
2821 gacccaacaa ctgtcaccct cttctgtacc tctcctgagt gccaactgtc caggccattt
2881 gacacaccat ctgttaacct ctgagtttgc ccactcaagg ccactcatag gggcatccta
2941 gccctgtgca ctcagcactc ataggatcat ccagactctc atgcggcatg cagtctaatc
3001 atgacaaata atgctgctac tctgatatct ggctgagcaa ctgaattaca aaagagaatt
3061 acttccatct caacttcaac ccattgatta cgtccatcct agcaagctaa atggcatccc
3121 agctgctcct ttctgtgcaa ccaattaaag aacaatgagt gtgatgctcc atgtctgaat
3181 ttcgtccagc ctctctctga actgtgatct ttgtcctcat gaactttccc ttttgttcat
3241 tgaactatat ggactcttca tttcatattg atttactgtg caatttactt ttggacattg
3301 agaacttgaa attatttcct gatcccttcc ccttccacta ttaataattc atttctgtca
3361 aactgtaaga gtagactcat tttttttttt tttagttttt aacattggac tgttatttca
3421 tttagagttc tctatctcta aatatttatt tagagaatga ttttaaaagg gaatgatatg
3481 cttgtttaaa tgaaagagaa aagctgtagt aaactgtgtt aattggtaat gactatttat
3541 cgtcgatact ctgtagctgt gtaagttttg acaaatagtg tatctcgtgg aatcagtggt
3601 tagcattgcc gctattatat ttactcattt tatcattata aatgtgttta gttcatcatg
3661 tagcatcaaa a
//