LOCUS HSU04045 2947 bp mRNA linear HUM 02-FEB-1995
DEFINITION Human (hMSH2) mRNA, complete cds.
ACCESSION U04045
VERSION U04045.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2947)
AUTHORS Leach,F.S., Nicolaides,N.C., Papadopoulos,N., Liu,B., Jen,J.,
Parsons,R., Peltomaki,P., Sistonen,P., Aaltonen,L.A.,
Nystrom-Lahti,M., de la Chapelle,A., Kinzler,K.W. and Vogelstein,B.
TITLE Mutations of a mutS homolog in hereditary nonpolyposis colorectal
cancer
JOURNAL Cell 75 (6), 1215-1225 (1993)
PUBMED 8261515
REFERENCE 2 (bases 1 to 2947)
AUTHORS Kinzler,K.
TITLE Direct Submission
JOURNAL Submitted (06-DEC-1993) K. Kinzler, Johns Hopkins University School
of Medicine, 424 North Bond Street, Room 109, Baltimore, MD 21231
USA
FEATURES Location/Qualifiers
source 1..2947
/db_xref="H-InvDB:HIT000217537"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..2947
/gene="hMSH2"
CDS 69..2873
/gene="hMSH2"
/note="homolog of bacterial MutS proteins [Swiss-Prot
accession numbers P23909, P10339, and P27345]; germline
mutations are responsible for hereditary nonpolyposis
colon cancer (HNPCC)"
/codon_start=1
/protein_id="AAA61870.1"
/translation="MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYT
AHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEV
YKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQ
VGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQ
RGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKF
LELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCK
TPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAK
KFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKF
QEMIETTLDMDQVENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPG
KQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSKLTSLNEEYTKN
KTEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLAQLDAVVSFAHVSNGAPVPYVRPAI
LEKGQGRIILKASRHACVEVQDEIAFIPNDVYFEKDKQMFHIITGPNMGGKSTYIRQT
GVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSAT
KDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMFATHFHELTALANQIPTVN
NLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPKHVIECAKQKALELEEFQY
IGESQGYDIMEPAAKKCYLEREQGEKIIQEFLSKVKQMPFTEMSEENITIKLKQLKAE
VIAKNNSFVNEIISRIKVTT"
BASE COUNT 930 a 526 c 688 g 803 t
ORIGIN
1 ggcgggaaac agcttagtgg gtgtggggtc gcgcattttc ttcaaccagg aggtgaggag
61 gtttcgacat ggcggtgcag ccgaaggaga cgctgcagtt ggagagcgcg gccgaggtcg
121 gcttcgtgcg cttctttcag ggcatgccgg agaagccgac caccacagtg cgccttttcg
181 accggggcga cttctatacg gcgcacggcg aggacgcgct gctggccgcc cgggaggtgt
241 tcaagaccca gggggtgatc aagtacatgg ggccggcagg agcaaagaat ctgcagagtg
301 ttgtgcttag taaaatgaat tttgaatctt ttgtaaaaga tcttcttctg gttcgtcagt
361 atagagttga agtttataag aatagagctg gaaataaggc atccaaggag aatgattggt
421 atttggcata taaggcttct cctggcaatc tctctcagtt tgaagacatt ctctttggta
481 acaatgatat gtcagcttcc attggtgttg tgggtgttaa aatgtccgca gttgatggcc
541 agagacaggt tggagttggg tatgtggatt ccatacagag gaaactagga ctgtgtgaat
601 tccctgataa tgatcagttc tccaatcttg aggctctcct catccagatt ggaccaaagg
661 aatgtgtttt acccggagga gagactgctg gagacatggg gaaactgaga cagataattc
721 aaagaggagg aattctgatc acagaaagaa aaaaagctga cttttccaca aaagacattt
781 atcaggacct caaccggttg ttgaaaggca aaaagggaga gcagatgaat agtgctgtat
841 tgccagaaat ggagaatcag gttgcagttt catcactgtc tgcggtaatc aagtttttag
901 aactcttatc agatgattcc aactttggac agtttgaact gactactttt gacttcagcc
961 agtatatgaa attggatatt gcagcagtca gagcccttaa cctttttcag ggttctgttg
1021 aagataccac tggctctcag tctctggctg ccttgctgaa taagtgtaaa acccctcaag
1081 gacaaagact tgttaaccag tggattaagc agcctctcat ggataagaac agaatagagg
1141 agagattgaa tttagtggaa gcttttgtag aagatgcaga attgaggcag actttacaag
1201 aagatttact tcgtcgattc ccagatctta accgacttgc caagaagttt caaagacaag
1261 cagcaaactt acaagattgt taccgactct atcagggtat aaatcaacta cctaatgtta
1321 tacaggctct ggaaaaacat gaaggaaaac accagaaatt attgttggca gtttttgtga
1381 ctcctcttac tgatcttcgt tctgacttct ccaagtttca ggaaatgata gaaacaactt
1441 tagatatgga tcaggtggaa aaccatgaat tccttgtaaa accttcattt gatcctaatc
1501 tcagtgaatt aagagaaata atgaatgact tggaaaagaa gatgcagtca acattaataa
1561 gtgcagccag agatcttggc ttggaccctg gcaaacagat taaactggat tccagtgcac
1621 agtttggata ttactttcgt gtaacctgta aggaagaaaa agtccttcgt aacaataaaa
1681 actttagtac tgtagatatc cagaagaatg gtgttaaatt taccaacagc aaattgactt
1741 ctttaaatga agagtatacc aaaaataaaa cagaatatga agaagcccag gatgccattg
1801 ttaaagaaat tgtcaatatt tcttcaggct atgtagaacc aatgcagaca ctcaatgatg
1861 tgttagctca gctagatgct gttgtcagct ttgctcacgt gtcaaatgga gcacctgttc
1921 catatgtacg accagccatt ttggagaaag gacaaggaag aattatatta aaagcatcca
1981 ggcatgcttg tgttgaagtt caagatgaaa ttgcatttat tcctaatgac gtatactttg
2041 aaaaagataa acagatgttc cacatcatta ctggccccaa tatgggaggt aaatcaacat
2101 atattcgaca aactggggtg atagtactca tggcccaaat tgggtgtttt gtgccatgtg
2161 agtcagcaga agtgtccatt gtggactgca tcttagcccg agtaggggct ggtgacagtc
2221 aattgaaagg agtctccacg ttcatggctg aaatgttgga aactgcttct atcctcaggt
2281 ctgcaaccaa agattcatta ataatcatag atgaattggg aagaggaact tctacctacg
2341 atggatttgg gttagcatgg gctatatcag aatacattgc aacaaagatt ggtgcttttt
2401 gcatgtttgc aacccatttt catgaactta ctgccttggc caatcagata ccaactgtta
2461 ataatctaca tgtcacagca ctcaccactg aagagacctt aactatgctt tatcaggtga
2521 agaaaggtgt ctgtgatcaa agttttggga ttcatgttgc agagcttgct aatttcccta
2581 agcatgtaat agagtgtgct aaacagaaag ccctggaact tgaggagttt cagtatattg
2641 gagaatcgca aggatatgat atcatggaac cagcagcaaa gaagtgctat ctggaaagag
2701 agcaaggtga aaaaattatt caggagttcc tgtccaaggt gaaacaaatg ccctttactg
2761 aaatgtcaga agaaaacatc acaataaagt taaaacagct aaaagctgaa gtaatagcaa
2821 agaataatag ctttgtaaat gaaatcattt cacgaataaa agttactacg tgaaaaatcc
2881 cagtaatgga atgaaggtaa tattgataag ctattgtctg taatagtttt atattgtttt
2941 atattaa
//