LOCUS       HSU03911                3080 bp    mRNA    linear   HUM 06-JUN-1994
DEFINITION  Human mutator gene (hMSH2) mRNA, complete cds.
ACCESSION   U03911
VERSION     U03911.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3080)
  AUTHORS   Fishel,R., Lescoe,M.K., Rao,M.R., Copeland,N.G., Jenkins,N.A.,
            Garber,J., Kane,M. and Kolodner,R.
  TITLE     The human mutator gene homolog MSH2 and its association with
            hereditary nonpolyposis colon cancer
  JOURNAL   Cell 75 (5), 1027-1038 (1993)
   PUBMED   8252616
REFERENCE   2  (bases 1 to 3080)
  AUTHORS   Travers,A.A., Ner,S.S. and Churchill,M.E.
  TITLE     DNA chaperones: a solution to a persistence problem?
  JOURNAL   Cell 77 (2), 167-169 (1994)
   PUBMED   8168125
REFERENCE   3  (bases 1 to 3080)
  AUTHORS   Kolodner,R.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-DEC-1993) Richard D. Kolodner, Cell and Molecular
            Biology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA
            02115, USA
COMMENT     On Feb 15, 1994 this sequence version replaced gi:439404.
FEATURES             Location/Qualifiers
     source          1..3080
                     /db_xref="H-InvDB:HIT000217535"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22-21"
     gene            1..3080
                     /gene="hMSH2"
     CDS             4..2808
                     /gene="hMSH2"
                     /note="homolog of S. cerevisiae Msh2p [Swiss-Prot
                     accession number P25847] and bacterial MutS proteins
                     [Swiss-Prot accession numbers P23909, P10339, and P27345]"
                     /codon_start=1
                     /protein_id="AAA18643.1"
                     /translation="MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYT
                     AHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEV
                     YKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQ
                     VGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQ
                     RGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKF
                     LELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCK
                     TPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAK
                     KFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKF
                     QEMIETTLDMDQVENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPG
                     KQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSKLTSLNEEYTKN
                     KTEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLAQLDAVVSFAHVSNGAPVPYVRPAI
                     LEKGQGRIILKASRHACVEVQDEIAFIPNDVYFEKDKQMFHIITGPNMGGKSTYIRQT
                     GVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSAT
                     KDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMFATHFHELTALANQIPTVN
                     NLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPKHVIECAKQKALELEEFQY
                     IGESQGYDIMEPAAKKCYLEREQGEKIIQEFLSKVKQMPFTEMSEENITIKLKQLKAE
                     VIAKNNSFVNEIISRIKVTT"
     polyA_site      3059
                     /gene="hMSH2"
BASE COUNT          981 a          538 c          699 g          862 t
ORIGIN      
        1 gacatggcgg tgcagccgaa ggagacgctg cagttggaga gcgcggccga ggtcggcttc
       61 gtgcgcttct ttcagggcat gccggagaag ccgaccacca cagtgcgcct tttcgaccgg
      121 ggcgacttct atacggcgca cggcgaggac gcgctgctgg ccgcccggga ggtgttcaag
      181 acccaggggg tgatcaagta catggggccg gcaggagcaa agaatctgca gagtgttgtg
      241 cttagtaaaa tgaattttga atcttttgta aaagatcttc ttctggttcg tcagtataga
      301 gttgaagttt ataagaatag agctggaaat aaggcatcca aggagaatga ttggtatttg
      361 gcatataagg cttctcctgg caatctctct cagtttgaag atattctctt tggtaacaat
      421 gatatgtcag cttccattgg tgttgtgggt gttaaaatgt ccgcagttga tggccagaga
      481 caggttggag ttgggtatgt ggattccata cagaggaaac taggactgtg tgaattccct
      541 gataatgatc agttctccaa tcttgaggct ctcctcatcc agattggacc aaaggaatgt
      601 gttttacccg gaggagagac tgctggagac atggggaaac tgagacagat aattcaaaga
      661 ggaggaattc tgatcacaga aagaaaaaaa gctgactttt ccacaaaaga catttatcag
      721 gacctcaacc ggttgttgaa aggcaaaaag ggagagcaga tgaatagtgc tgtattgcca
      781 gaaatggaga atcaggttgc agtttcatca ctgtctgcgg taatcaagtt tttagaactc
      841 ttatcagatg attccaactt tggacagttt gaactgacta cttttgactt cagccagtat
      901 atgaaattgg atattgcagc agtcagagcc cttaaccttt ttcagggttc tgttgaagat
      961 accactggct ctcagtctct ggctgccttg ctgaataagt gtaaaacccc tcaaggacaa
     1021 agacttgtta accagtggat taagcagcct ctcatggata agaacagaat agaggagaga
     1081 ttgaatttag tggaagcttt tgtagaagat gcagaattga ggcagacttt acaagaagat
     1141 ttacttcgtc gattcccaga tcttaaccga cttgccaaga agtttcaaag acaagcagca
     1201 aacttacaag attgttaccg actctatcag ggtataaatc aactacctaa tgttatacag
     1261 gctctggaaa aacatgaagg aaaacaccag aaattattgt tggcagtttt tgtgactcct
     1321 cttactgatc ttcgttctga cttctccaag tttcaggaaa tgatagaaac aactttagat
     1381 atggatcagg tggaaaacca tgaattcctt gtaaaacctt catttgatcc taatctcagt
     1441 gaattaagag aaataatgaa tgacttggaa aagaagatgc agtcaacatt aataagtgca
     1501 gccagagatc ttggcttgga ccctggcaaa cagattaaac tggattccag tgcacagttt
     1561 ggatattact ttcgtgtaac ctgtaaggaa gaaaaagtcc ttcgtaacaa taaaaacttt
     1621 agtactgtag atatccagaa gaatggtgtt aaatttacca acagcaaatt gacttcttta
     1681 aatgaagagt ataccaaaaa taaaacagaa tatgaagaag cccaggatgc cattgttaaa
     1741 gaaattgtca atatttcttc aggctatgta gaaccaatgc agacactcaa tgatgtgtta
     1801 gctcagctag atgctgttgt cagctttgct cacgtgtcaa atggagcacc tgttccatat
     1861 gtacgaccag ccattttgga gaaaggacaa ggaagaatta tattaaaagc atccaggcat
     1921 gcttgtgttg aagttcaaga tgaaattgca tttattccta atgacgtata ctttgaaaaa
     1981 gataaacaga tgttccacat cattactggc cccaatatgg gaggtaaatc aacatatatt
     2041 cgacaaactg gggtgatagt actcatggcc caaattgggt gttttgtgcc atgtgagtca
     2101 gcagaagtgt ccattgtgga ctgcatctta gcccgagtag gggctggtga cagtcaattg
     2161 aaaggagtct ccacgttcat ggctgaaatg ttggaaactg cttctatcct caggtctgca
     2221 accaaagatt cattaataat catagatgaa ttgggaagag gaacttctac ctacgatgga
     2281 tttgggttag catgggctat atcagaatac attgcaacaa agattggtgc tttttgcatg
     2341 tttgcaaccc attttcatga acttactgcc ttggccaatc agataccaac tgttaataat
     2401 ctacatgtca cagcactcac cactgaagag accttaacta tgctttatca ggtgaagaaa
     2461 ggtgtctgtg atcaaagttt tgggattcat gttgcagagc ttgctaattt ccctaagcat
     2521 gtaatagagt gtgctaaaca gaaagccctg gaacttgagg agtttcagta tattggagaa
     2581 tcgcaaggat atgatatcat ggaaccagca gcaaagaagt gctatctgga aagagagcaa
     2641 ggtgaaaaaa ttattcagga gttcctgtcc aaggtgaaac aaatgccctt tactgaaatg
     2701 tcagaagaaa acatcacaat aaagttaaaa cagctaaaag ctgaagtaat agcaaagaat
     2761 aatagctttg taaatgaaat catttcacga ataaaagtta ctacgtgaaa aatcccagta
     2821 atggaatgaa ggtaatattg ataagctatt gtctgtaata gttttatatt gttttatatt
     2881 aacccttttt ccatagtgtt aactgtcagt gcccatgggc tatcaactta ataagatatt
     2941 tagtaatatt ttactttgag gacattttca aagattttta ttttgaaaaa tgagagctgt
     3001 aactgaggac tgtttgcaat tgacataggc aataataagt gatgtgctga attttataaa
     3061 taaaatcatg tagtttgtgg
//