LOCUS HSU03911 3080 bp mRNA linear HUM 06-JUN-1994 DEFINITION Human mutator gene (hMSH2) mRNA, complete cds. ACCESSION U03911 VERSION U03911.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3080) AUTHORS Fishel,R., Lescoe,M.K., Rao,M.R., Copeland,N.G., Jenkins,N.A., Garber,J., Kane,M. and Kolodner,R. TITLE The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer JOURNAL Cell 75 (5), 1027-1038 (1993) PUBMED 8252616 REFERENCE 2 (bases 1 to 3080) AUTHORS Travers,A.A., Ner,S.S. and Churchill,M.E. TITLE DNA chaperones: a solution to a persistence problem? JOURNAL Cell 77 (2), 167-169 (1994) PUBMED 8168125 REFERENCE 3 (bases 1 to 3080) AUTHORS Kolodner,R.D. TITLE Direct Submission JOURNAL Submitted (02-DEC-1993) Richard D. Kolodner, Cell and Molecular Biology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA COMMENT On Feb 15, 1994 this sequence version replaced gi:439404. FEATURES Location/Qualifiers source 1..3080 /db_xref="H-InvDB:HIT000217535" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="2" /map="2p22-21" gene 1..3080 /gene="hMSH2" CDS 4..2808 /gene="hMSH2" /note="homolog of S. cerevisiae Msh2p [Swiss-Prot accession number P25847] and bacterial MutS proteins [Swiss-Prot accession numbers P23909, P10339, and P27345]" /codon_start=1 /protein_id="AAA18643.1" /translation="MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYT AHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEV YKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQ VGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQ RGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKF LELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCK TPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAK KFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKF QEMIETTLDMDQVENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPG KQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSKLTSLNEEYTKN KTEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLAQLDAVVSFAHVSNGAPVPYVRPAI LEKGQGRIILKASRHACVEVQDEIAFIPNDVYFEKDKQMFHIITGPNMGGKSTYIRQT GVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSAT KDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMFATHFHELTALANQIPTVN NLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPKHVIECAKQKALELEEFQY IGESQGYDIMEPAAKKCYLEREQGEKIIQEFLSKVKQMPFTEMSEENITIKLKQLKAE VIAKNNSFVNEIISRIKVTT" polyA_site 3059 /gene="hMSH2" BASE COUNT 981 a 538 c 699 g 862 t ORIGIN 1 gacatggcgg tgcagccgaa ggagacgctg cagttggaga gcgcggccga ggtcggcttc 61 gtgcgcttct ttcagggcat gccggagaag ccgaccacca cagtgcgcct tttcgaccgg 121 ggcgacttct atacggcgca cggcgaggac gcgctgctgg ccgcccggga ggtgttcaag 181 acccaggggg tgatcaagta catggggccg gcaggagcaa agaatctgca gagtgttgtg 241 cttagtaaaa tgaattttga atcttttgta aaagatcttc ttctggttcg tcagtataga 301 gttgaagttt ataagaatag agctggaaat aaggcatcca aggagaatga ttggtatttg 361 gcatataagg cttctcctgg caatctctct cagtttgaag atattctctt tggtaacaat 421 gatatgtcag cttccattgg tgttgtgggt gttaaaatgt ccgcagttga tggccagaga 481 caggttggag ttgggtatgt ggattccata cagaggaaac taggactgtg tgaattccct 541 gataatgatc agttctccaa tcttgaggct ctcctcatcc agattggacc aaaggaatgt 601 gttttacccg gaggagagac tgctggagac atggggaaac tgagacagat aattcaaaga 661 ggaggaattc tgatcacaga aagaaaaaaa gctgactttt ccacaaaaga catttatcag 721 gacctcaacc ggttgttgaa aggcaaaaag ggagagcaga tgaatagtgc tgtattgcca 781 gaaatggaga atcaggttgc agtttcatca ctgtctgcgg taatcaagtt tttagaactc 841 ttatcagatg attccaactt tggacagttt gaactgacta cttttgactt cagccagtat 901 atgaaattgg atattgcagc agtcagagcc cttaaccttt ttcagggttc tgttgaagat 961 accactggct ctcagtctct ggctgccttg ctgaataagt gtaaaacccc tcaaggacaa 1021 agacttgtta accagtggat taagcagcct ctcatggata agaacagaat agaggagaga 1081 ttgaatttag tggaagcttt tgtagaagat gcagaattga ggcagacttt acaagaagat 1141 ttacttcgtc gattcccaga tcttaaccga cttgccaaga agtttcaaag acaagcagca 1201 aacttacaag attgttaccg actctatcag ggtataaatc aactacctaa tgttatacag 1261 gctctggaaa aacatgaagg aaaacaccag aaattattgt tggcagtttt tgtgactcct 1321 cttactgatc ttcgttctga cttctccaag tttcaggaaa tgatagaaac aactttagat 1381 atggatcagg tggaaaacca tgaattcctt gtaaaacctt catttgatcc taatctcagt 1441 gaattaagag aaataatgaa tgacttggaa aagaagatgc agtcaacatt aataagtgca 1501 gccagagatc ttggcttgga ccctggcaaa cagattaaac tggattccag tgcacagttt 1561 ggatattact ttcgtgtaac ctgtaaggaa gaaaaagtcc ttcgtaacaa taaaaacttt 1621 agtactgtag atatccagaa gaatggtgtt aaatttacca acagcaaatt gacttcttta 1681 aatgaagagt ataccaaaaa taaaacagaa tatgaagaag cccaggatgc cattgttaaa 1741 gaaattgtca atatttcttc aggctatgta gaaccaatgc agacactcaa tgatgtgtta 1801 gctcagctag atgctgttgt cagctttgct cacgtgtcaa atggagcacc tgttccatat 1861 gtacgaccag ccattttgga gaaaggacaa ggaagaatta tattaaaagc atccaggcat 1921 gcttgtgttg aagttcaaga tgaaattgca tttattccta atgacgtata ctttgaaaaa 1981 gataaacaga tgttccacat cattactggc cccaatatgg gaggtaaatc aacatatatt 2041 cgacaaactg gggtgatagt actcatggcc caaattgggt gttttgtgcc atgtgagtca 2101 gcagaagtgt ccattgtgga ctgcatctta gcccgagtag gggctggtga cagtcaattg 2161 aaaggagtct ccacgttcat ggctgaaatg ttggaaactg cttctatcct caggtctgca 2221 accaaagatt cattaataat catagatgaa ttgggaagag gaacttctac ctacgatgga 2281 tttgggttag catgggctat atcagaatac attgcaacaa agattggtgc tttttgcatg 2341 tttgcaaccc attttcatga acttactgcc ttggccaatc agataccaac tgttaataat 2401 ctacatgtca cagcactcac cactgaagag accttaacta tgctttatca ggtgaagaaa 2461 ggtgtctgtg atcaaagttt tgggattcat gttgcagagc ttgctaattt ccctaagcat 2521 gtaatagagt gtgctaaaca gaaagccctg gaacttgagg agtttcagta tattggagaa 2581 tcgcaaggat atgatatcat ggaaccagca gcaaagaagt gctatctgga aagagagcaa 2641 ggtgaaaaaa ttattcagga gttcctgtcc aaggtgaaac aaatgccctt tactgaaatg 2701 tcagaagaaa acatcacaat aaagttaaaa cagctaaaag ctgaagtaat agcaaagaat 2761 aatagctttg taaatgaaat catttcacga ataaaagtta ctacgtgaaa aatcccagta 2821 atggaatgaa ggtaatattg ataagctatt gtctgtaata gttttatatt gttttatatt 2881 aacccttttt ccatagtgtt aactgtcagt gcccatgggc tatcaactta ataagatatt 2941 tagtaatatt ttactttgag gacattttca aagattttta ttttgaaaaa tgagagctgt 3001 aactgaggac tgtttgcaat tgacataggc aataataagt gatgtgctga attttataaa 3061 taaaatcatg tagtttgtgg //