LOCUS HSU03858 1080 bp mRNA linear HUM 19-JUL-1994
DEFINITION Human flt3 ligand mRNA, complete cds.
ACCESSION U03858
VERSION U03858.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1080)
AUTHORS Lyman,S.D., James,L., Johnson,L., Brasel,K., de Vries,P.,
Escobar,S.S., Downey,H., Splett,R.R., Beckmann,M.P. and
McKenna,H.J.
TITLE Cloning of the human homologue of the murine flt3 ligand: a growth
factor for early hematopoietic progenitor cells
JOURNAL Blood 83 (10), 2795-2801 (1994)
PUBMED 8180375
REFERENCE 2 (bases 1 to 1080)
AUTHORS Lyman,S.D.
TITLE Direct Submission
JOURNAL Submitted (30-NOV-1993) Stewart D. Lyman, Immunex Research and
Development Corporation, 51, University St., Seattle, WA 98101, USA
FEATURES Location/Qualifiers
source 1..1080
/db_xref="H-InvDB:HIT000217523"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="clone 22 (T cell)"
/clone_lib="expression, cDNA"
5'UTR 1..83
CDS 84..791
/function="stimulates proliferation of early hematopoietic
cells"
/standard_name="FMS-like tyrosine kinase-3 ligand"
/note="ligand for the flt3/flk-2 tyrosine kinase receptor"
/codon_start=1
/product="flt3 ligand"
/protein_id="AAA19825.1"
/translation="MTVLAPAWSPTTYLLLLLLLSSGLSGTQDCSFQHSPISSDFAVK
IRELSDYLLQDYPVTVASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVN
TEIHFVTKCAFQPPPSCLRFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQP
DSSTLPPPWSPRPLEATAPTAPQPPLLLLLLLPVGLLLLAAAWCLHWQRTRRRTPRPG
EQVPPVPSPQDLLLVEH"
sig_peptide 84..161
misc_feature 162..629
/note="extracellular domain"
misc_feature 630..698
/note="transmembrane domain"
misc_feature 699..788
/note="cytoplasmic domain"
3'UTR 792..1080
misc_feature 1015..1080
/note="ATTTA mRNA instability motif"
regulatory 1059..1064
/regulatory_class="polyA_signal_sequence"
polyA_site 1080
/note="32 A residues"
BASE COUNT 204 a 384 c 290 g 202 t
ORIGIN
1 ccggggggca tgagggtccg agacttgttc ttctgtccct tccaagaccc ggcgacagga
61 ggcatgaggg gcccccggcc gaaatgacag tgctggcgcc agcctggagc ccaacaacct
121 atctcctcct gctgctgctg ctgagctcgg gactcagtgg gacccaggac tgctccttcc
181 aacacagccc catctcctcc gacttcgctg tcaaaatccg tgagctgtct gactacctgc
241 ttcaagatta cccagtcacc gtggcctcca acctgcagga cgaggagctc tgcgggggcc
301 tctggcggct ggtcctggca cagcgctgga tggagcggct caagactgtc gctgggtcca
361 agatgcaagg cttgctggag cgcgtgaaca cggagataca ctttgtcacc aaatgtgcct
421 ttcagccccc ccccagctgt cttcgcttcg tccagaccaa catctcccgc ctcctgcagg
481 agacctccga gcagctggtg gcgctgaagc cctggatcac tcgccagaac ttctcccggt
541 gcctggagct gcagtgtcag cccgactcct caaccctgcc acccccatgg agtccccggc
601 ccctggaggc cacagccccg acagccccgc agccccctct gctcctccta ctgctgctgc
661 ccgtgggcct cctgctgctg gccgctgcct ggtgcctgca ctggcagagg acgcggcgga
721 ggacaccccg ccctggggag caggtgcccc ccgtccccag tccccaggac ctgctgcttg
781 tggagcactg acctggccaa ggcctcatcc tgcggagcct taaacaacgc agtgagacag
841 acatctatca tcccatttta caggggagga tactgaggca cacagagggg agtcaccagc
901 cagaggatgt atagcctgga cacagaggaa gttggctaga ggccggtccc ttccttgggc
961 ccctctcatt ccctccccag aatggaggca acgccagaat ccagcaccgg ccccatttac
1021 ccaactctga acaaagccct tgcccccatg aaattgttta taaatcatcc ttttctccca
//