LOCUS HSU03688 5102 bp mRNA linear HUM 06-JUL-1994
DEFINITION Human dioxin-inducible cytochrome P450 (CYP1B1) mRNA, complete cds.
ACCESSION U03688
VERSION U03688.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5102)
AUTHORS Sutter,T.R., Tang,Y.M., Hayes,C.L., Wo,Y.Y., Jabs,E.W., Li,X.,
Yin,H., Cody,C.W. and Greenlee,W.F.
TITLE Complete cDNA sequence of a human dioxin-inducible mRNA identifies
a new gene subfamily of cytochrome P450 that maps to chromosome 2
JOURNAL J. Biol. Chem. 269 (18), 13092-13099 (1994)
PUBMED 8175734
REFERENCE 2 (bases 1 to 5102)
AUTHORS Sutter,T.R., Guzman,K., Dold,K.M. and Greenlee,W.F.
TITLE Targets for dioxin: genes for plasminogen activator inhibitor-2 and
interleukin-1 beta
JOURNAL Science 254 (5030), 415-418 (1991)
PUBMED 1925598
REFERENCE 3 (bases 1 to 5102)
AUTHORS Sutter,T.R.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-1993) Thomas R. Sutter, Environmental Health
Sciences, Johns Hopkins University, Division of Toxicological
Sciences, 615 N. Wolfe Street, Baltimore, MD 21205, USA
FEATURES Location/Qualifiers
source 1..5102
/db_xref="H-InvDB:HIT000217518"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/clone="cDNA clones 1, 141, 34, 56, 128, 247"
/cell_type="Human keratinocyte cell line SCC12-F:subclone
c12c2"
/clone_lib="cDNA library prepared by Sutter et al. (1991)"
gene 1..5102
/gene="CYP1B1"
CDS 347..1978
/gene="CYP1B1"
/codon_start=1
/product="cytochrome P450"
/protein_id="AAA19567.1"
/translation="MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRR
RQLRSAPPGPFAWPLIGNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERA
IHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQP
RSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDD
PEFRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKF
LRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDT
LSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFS
SFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKWPNPENFDPARFLDKDG
LINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEPAKMNFSYG
LTIKPKSFKVNVTLRESMELLDSAVQNLQAKETCQ"
BASE COUNT 1423 a 1100 c 1154 g 1425 t
ORIGIN
1 gcttctgcga ctccagttgt gagagccgca agggcatggg aattgacgcc actcaccgac
61 ccccagtctc aatctcaacg ctgtgaggaa acctcgactt tgccaggtcc ccaagggcag
121 cggggctcgg cgagcgaggc acccttctcc gtccccatcc caatccaagc gctcctggca
181 ctgacgacgc caagagactc gagtgggagt taaagcttcc agtgagggca gcaggtgtcc
241 aggccgggcc tgcgggttcc tgttgacgtc ttgccctagg caaaggtccc agttccttct
301 cggagccggc tgtcccgcgc cactggaaac cgcacctccc cgcagcatgg gcaccagcct
361 cagcccgaac gacccttggc cgctaaaccc gctgtccatc cagcagacca cgctcctgct
421 actcctgtcg gtgctggcca ctgtgcatgt gggccagcgg ctgctgaggc aacggaggcg
481 gcagctccgg tccgcgcccc cgggcccgtt tgcgtggcca ctgatcggaa acgcggcggc
541 ggtgggccag gcggctcacc tctcgttcgc tcgcctggcg cggcgctacg gcgacgtttt
601 ccagatccgc ctgggcagct gccccatagt ggtgctgaat ggcgagcgcg ccatccacca
661 ggccctggtg cagcagggct cggccttcgc cgaccggccg gccttcgcct ccttccgtgt
721 ggtgtccggc ggccgcagca tggctttcgg ccactactcg gagcactgga aggtgcagcg
781 gcgcgcagcc cacagcatga tgcgcaactt cttcacgcgc cagccgcgca gccgccaagt
841 cctcgagggc cacgtgctga gcgaggcgcg cgagctggtg gcgctgctgg tgcgcggcag
901 cgcggacggc gccttcctcg acccgaggcc gctgaccgtc gtggccgtgg ccaacgtcat
961 gagtgccgtg tgtttcggct gccgctacag ccacgacgac cccgagttcc gtgagctgct
1021 cagccacaac gaagagttcg ggcgcacggt gggcgcgggc agcctggtgg acgtgatgcc
1081 ctggctgcag tacttcccca acccggtgcg caccgttttc cgcgaattcg agcagctcaa
1141 ccgcaacttc agcaacttca tcctggacaa gttcttgagg cactgcgaaa gccttcggcc
1201 cggggccgcc ccccgcgaca tgatggacgc ctttatcctc tctgcggaaa agaaggcggc
1261 cggggactcg cacggtggtg gcgcgcggct ggatttggag aacgtaccgg ccactatcac
1321 tgacatcttc ggcgccagcc aggacaccct gtccaccgcg ctgcagtggc tgctcctcct
1381 cttcaccagg tatcctgatg tgcagactcg agtgcaggca gaattggatc aggtcgtggg
1441 gagggaccgt ctgccttgta tgggtgacca gcccaacctg ccctatgtcc tggccttcct
1501 ttatgaagcc atgcgcttct ccagctttgt gcctgtcact attcctcatg ccaccactgc
1561 caacacctct gtcttgggct accacattcc caaggacact gtggtttttg tcaaccagtg
1621 gtctgtgaat catgacccag tgaagtggcc taacccggag aactttgatc cagctcgatt
1681 cttggacaag gatggcctca tcaacaagga cctgaccagc agagtgatga ttttttcagt
1741 gggcaaaagg cggtgcattg gcgaagaact ttctaagatg cagctttttc tcttcatctc
1801 catcctggct caccagtgcg atttcagggc caacccaaat gagcctgcga aaatgaattt
1861 cagttatggt ctaaccatta aacccaagtc atttaaagtc aatgtcactc tcagagagtc
1921 catggagctc cttgatagtg ctgtccaaaa tttacaagcc aaggaaactt gccaataaga
1981 agcaagaggc aagctgaaat tttagaaata ttcacatctt cggagatgag gagtaaaatt
2041 cagttttttt ccagttcctc ttttgtgctg cttctcaatt agcgtttaag gtgagcataa
2101 atcaactgtc catcaggtga ggtgtgctcc atacccagcg gttcttcatg agtagtgggc
2161 tatgcaggag cttctgggag atttttttga gtcaaagact taaagggccc aatgaattat
2221 tatatacata ctgcatcttg gttatttctg aaggtagcat tctttggagt taaaatgcac
2281 atatagacac atacacccaa acacttacac caaactactg aatgaagaag tattttggta
2341 accaggccat ttttggtggg aatccaagat tggtctccca tatgcagaaa tagacaaaaa
2401 gtatattaaa caaagtttca gagtatattg ttgaagagac agagacaagt aatttcagtg
2461 taaagtgtgt gattgaaggt gataagggaa aagataaaga ccagaaattc ccttttcacc
2521 ttttcaggaa aataacttag actctagtat ttatgggtgg atttatcctt ttgccttctg
2581 gtatacttcc ttacttttaa ggataaatca taaagtcagt tgctcaaaaa gaaatcaata
2641 gttgaattag tgagtatagt ggggttccat gagttatcat gaattttaaa gtatgcatta
2701 ttaaattgta aaactccaag gtgatgttgt acctcttttg cttgccaaag tacagaattt
2761 gaattatcag caaagaaaaa aaaaaaagcc agccaagctt taaattatgt gaccataatg
2821 tactgatttc agtaagtctc ataggttaaa aaaaaaagtc accaaatagt gtgaaatata
2881 ttacttaact gtccgtaagc agtatattag tattatcttg ttcaggaaaa ggttgaataa
2941 tatatgcctt gtgtaatatt gaaaattgaa aagtacaact aacgcaacca agtgtgctaa
3001 aaatgagctt gattaaatca accacctatt tttgacatgg aaatgaagca gggtttcttt
3061 tcttcactca aattttggcg aatctcaaaa ttagatccta agatgtgttc ttatttttat
3121 aacatcttta ttgaaattct atttataata cagaatcttg ttttgaaaat aacctaatta
3181 atatattaaa attccaaatt catggcatgc ttaaatttta actaaatttt aaagccattc
3241 tgattattga gttccagttg aagttagtgg aaatctgaac attctcctgt ggaaggcaga
3301 gaaatctaag ctgtgtctgc ccaatgaata atggaaaatg ccatgaatta cctggatgtt
3361 ctttttacga ggtgacaaga gttggggaca gaactcccat tacaactgac caagtttctc
3421 ttctagatga ttttttgaaa gttaacatta atgcctgctt tttggaaagt cagaatcaga
3481 agatagtctt ggaagctgtt tggaaaagac agtggagatg aggtcagttg tgttttttaa
3541 gatggcaatt actttggtag ctgggaaagc ataaagctca aatgaaatgt atgcattcac
3601 atttagaaaa gtgaattgaa gtttcaagtt ttaaagttca ttgcaattaa acttccaaag
3661 aaagttctac agtgtcctaa gtgctaagtg cttattacat tttattaagc tttttggaat
3721 ctttgtacca aaattttaaa aaagggagtt tttgatagtt gtgtgtatgt gtgtgtgggg
3781 tggggggatg gtaagagaaa agagagaaac actgaaaaga aggaaagatg gttaaacatt
3841 ttcccactca ttctgaatta attaatttgg agcacaaaat tcaaagcatg gacatttaga
3901 agaaagatgt ttggcgtagc agagttaaat ctcaaatagg ctattaaaaa agtctacaac
3961 atagcagatc tgttttgtgg tttggaatat taaaaaactt catgtaattt tattttaaaa
4021 tttcatagct gtacttcttg aatataaaaa atcatgccag tatttttaaa ggcattagag
4081 tcaactacac aaagcaggct tgcccagtac atttaaattt tttggcactt gccattccaa
4141 aatattatgc cccaccaagg ctgagacagt gaatttgggc tgctgtagcc tattttttta
4201 gattgagaaa tgtgtagctg caaaaataat catgaaccaa tctggatgcc tcattatgtc
4261 aaccaggtcc agatgtgcta taatctgttt ttacgtatgt aggcccagtc gtcatcagat
4321 gcttgcggca aaagaaagct gtgtttatat ggaagaaagt aaggtgcttg gagtttacct
4381 ggcttattta atatgcttat aacctagtta aagaaaggaa aagaaaacaa aaaacgaatg
4441 aaaataactg aatttggagg ctggagtaat cagattactg ctttaatcag aaaccctcat
4501 tgtgtttcta ccggagagag aatgtatttg ctgacaacca ttaaagtcag aagttttact
4561 ccaggttatt gcaataaagt ataatgttta ttaaatgctt catttgtatg tcaaagcttt
4621 gactctataa gcaaattgct tttttccaaa acaaaaagat gtctcaggtt tgttttgtga
4681 attttctaaa agctttcatg tcccagaact tagcctttac ctgtgaagtg ttactacagc
4741 cttaatattt tcctagtaga tctatattag atcaaatagt tgcatagcag tatatgttaa
4801 tttgtgtgtt tttagctgtg acacaactgt gtgattaaaa ggtatacttt agtagacatt
4861 tataactcaa ggataccttc ttatttaatc ttttcttatt tttgtacttt atcatgaatg
4921 cttttagtgt gtgcataata gctacagtgc atagttgtag acaaagtaca ttctggggaa
4981 acaacattta tatgtagcct ttactgtttg atataccaaa ttaaaaaaaa attgtatctc
5041 attacttata ctgggacacc attaccaaaa taataaaaat cactttcata atcttgaaaa
5101 aa
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