LOCUS HSIL12R 2100 bp mRNA linear HUM 07-SEP-1994
DEFINITION Human IL12 receptor component mRNA, complete cds.
ACCESSION U03187
VERSION U03187.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 65 to 2050)
AUTHORS Chua,A.O., Chizzonite,R., Desai,B.B., Truitt,T.P., Nunes,P.,
Minetti,L.J., Warrier,R.R., Presky,D.H., Levine,J.F., Gately,M.K.
and Gubler,U.
TITLE Expression cloning of a human IL-12 receptor component. A new
member of the cytokine receptor superfamily with strong homology to
gp130
JOURNAL J. Immunol. 153 (1), 128-136 (1994)
PUBMED 7911493
REFERENCE 2 (bases 1 to 2100)
AUTHORS Gubler,U.
TITLE Direct Submission
JOURNAL Submitted (05-NOV-1993) Ueli Gubler, Hoffmann La Roche Inc., 340
Kingsland Street, Nutley, NJ 07110, USA
FEATURES Location/Qualifiers
source 1..2100
/db_xref="H-InvDB:HIT000217487"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="PHA activated lymphoblasts"
CDS 65..2053
/codon_start=1
/product="IL12 receptor component"
/protein_id="AAA21340.1"
/translation="MEPLVTWVVPLLFLFLLSRQGAACRTSECCFQDPPYPDADSGSA
SGPRDLRCYRISSDRYECSWQYEGPTAGVSHFLRCCLSSGRCCYFAAGSATRLQFSDQ
AGVSVLYTVTLWVESWARNQTEKSPEVTLQLYNSVKYEPPLGDIKVSKLAGQLRMEWE
TPDNQVGAEVQFRHRTPSSPWKLGDCGPQDDDTESCLCPLEMNVAQEFQLRRRQLGSQ
GSSWSKWSSPVCVPPENPPQPQVRFSVEQLGQDGRRRLTLKEQPTQLELPEGCQGLAP
GTEVTYRLQLHMLSCPCKAKATRTLHLGKMPYLSGAAYNVAVISSNQFGPGLNQTWHI
PADTHTEPVALNISVGTNGTTMYWPARAQSMTYCIEWQPVGQDGGLATCSLTAPQDPD
PAGMATYSWSRESGAMGQEKCYYITIFASAHPEKLTLWSTVLSTYHFGGNASAAGTPH
HVSVKNHSLDSVSVDWAPSLLSTCPGVLKEYVVRCRDEDSKQVSEHPVQPTETQVTLS
GLRAGVAYTVQVRADTAWLRGVWSQPQRFSIEVQVSDWLIFFASLGSFLSILLVGVLG
YLGLNRAARHLCPPLPTPCASSAIEFPGGKETWQWINPVDFQEEASLQEALVVEMSWD
KGERTEPLEKTELPEGAPELALDTELSLEDGDRCKAKM"
mat_peptide 137..2050
/product="IL12 receptor component"
misc_feature 218..220
/note="conserved cytokine receptor Cys"
misc_feature 248..256
/note="conserved cytokine receptor motif: CXW"
misc_feature 302..304
/note="conserved cytokine receptor Cys"
misc_feature 323..325
/note="conserved cytokine receptor Cys"
misc_feature 425..433
/note="potential N-linked glycosylation site"
misc_feature 728..742
/note="conserved cytokine receptor motif: WSXWS"
misc_feature 1049..1057
/note="potential N-linked glycosylation site"
misc_feature 1100..1108
/note="potential N-linked glycosylation site"
misc_feature 1118..1126
/note="potential N-linked glycosylation site"
misc_feature 1388..1396
/note="potential N-linked glycosylation site"
misc_feature 1430..1438
/note="potential N-linked glycosylation site"
misc_feature 1685..1777
/note="probable transmembrane region"
BASE COUNT 411 a 623 c 658 g 408 t
ORIGIN
1 ggtggctgaa cctcgcaggt ggcagagagg ctcccctggg gctgtggggc tctacgtgga
61 tccgatggag ccgctggtga cctgggtggt ccccctcctc ttcctcttcc tgctgtccag
121 gcagggcgct gcctgcagaa ccagtgagtg ctgttttcag gacccgccat atccggatgc
181 agactcaggc tcggcctcgg gccctaggga cctgagatgc tatcggatat ccagtgatcg
241 ttacgagtgc tcctggcagt atgagggtcc cacagctggg gtcagccact tcctgcggtg
301 ttgccttagc tccgggcgct gctgctactt cgccgccggc tcagccacca ggctgcagtt
361 ctccgaccag gctggggtgt ctgtgctgta cactgtcaca ctctgggtgg aatcctgggc
421 caggaaccag acagagaagt ctcctgaggt gaccctgcag ctctacaact cagttaaata
481 tgagcctcct ctgggagaca tcaaggtgtc caagttggcc gggcagctgc gtatggagtg
541 ggagaccccg gataaccagg ttggtgctga ggtgcagttc cggcaccgga cacccagcag
601 cccatggaag ttgggcgact gcggacctca ggatgatgat actgagtcct gcctctgccc
661 cctggagatg aatgtggccc aggaattcca gctccgacga cggcagctgg ggagccaagg
721 aagttcctgg agcaagtgga gcagccccgt gtgcgttccc cctgaaaacc ccccacagcc
781 tcaggtgaga ttctcggtgg agcagctggg ccaggatggg aggaggcggc tgaccctgaa
841 agagcagcca acccagctgg agcttccaga aggctgtcaa gggctggcgc ctggcacgga
901 ggtcacttac cgactacagc tccacatgct gtcctgcccg tgtaaggcca aggccaccag
961 gaccctgcac ctggggaaga tgccctatct ctcgggtgct gcctacaacg tggctgtcat
1021 ctcctcgaac caatttggtc ctggcctgaa ccagacgtgg cacattcctg ccgacaccca
1081 cacagaacca gtggctctga atatcagcgt cggaaccaac gggaccacca tgtattggcc
1141 agcccgggct cagagcatga cgtattgcat tgaatggcag cctgtgggcc aggacggggg
1201 ccttgccacc tgcagcctga ctgcgccgca agacccggat ccggctggaa tggcaaccta
1261 cagctggagt cgagagtctg gggcaatggg gcaggaaaag tgttactaca ttaccatctt
1321 tgcctctgcg caccccgaga agctcacctt gtggtctacg gtcctgtcca cctaccactt
1381 tgggggcaat gcctcagcag ctgggacacc gcaccacgtc tcggtgaaga atcatagctt
1441 ggactctgtg tctgtggact gggcaccatc cctgctgagc acctgtcccg gcgtcctaaa
1501 ggagtatgtt gtccgctgcc gagatgaaga cagcaaacag gtgtcagagc atcccgtgca
1561 gcccacagag acccaagtta ccctcagtgg cctgcgggct ggtgtagcct acacggtgca
1621 ggtgcgagca gacacagcgt ggctgagggg tgtctggagc cagccccagc gcttcagcat
1681 cgaagtgcag gtttctgatt ggctcatctt cttcgcctcc ctggggagct tcctgagcat
1741 ccttctcgtg ggcgtccttg gctaccttgg cctgaacagg gccgcacggc acctgtgccc
1801 gccgctgccc acaccctgtg ccagctccgc cattgagttc cctggaggga aggagacttg
1861 gcagtggatc aacccagtgg acttccagga agaggcatcc ctgcaggagg ccctggtggt
1921 agagatgtcc tgggacaaag gcgagaggac tgagcctctc gagaagacag agctacctga
1981 gggtgcccct gagctggccc tggatacaga gttgtccttg gaggatggag acaggtgcaa
2041 ggccaagatg tgatcgttga ggctcagaga gggtgagtga ctcgcccgag gctacgtagc
//