LOCUS HSU02882 5706 bp mRNA linear HUM 14-MAY-1994
DEFINITION Human rolipram-sensitive 3',5'-cyclic AMP phosphodiesterase mRNA,
complete cds.
ACCESSION U02882
VERSION U02882.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5706)
AUTHORS Baecker,P.A., Obernolte,R., Bach,C., Yee,C. and Shelton,E.R.
TITLE Isolation of a cDNA encoding a human rolipram-sensitive cyclic AMP
phosphodiesterase (PDE IVD)
JOURNAL Gene 138 (1-2), 253-256 (1994)
PUBMED 8125310
REFERENCE 2 (bases 1 to 5706)
AUTHORS Baecker,P.A.
TITLE Direct Submission
JOURNAL Submitted (25-OCT-1993) Preston A. Baecker, Department of Molecular
Biology, Syntex Discovery Research, 3401 Hillview Avenue, Palo
Alto, CA 94304, USA
FEATURES Location/Qualifiers
source 1..5706
/db_xref="H-InvDB:HIT000217478"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="heart"
/clone_lib="random primed cDNA library in lambda Zap II"
CDS 109..1923
/EC_number="3.1.4.17"
/note="rolipram-sensitive"
/codon_start=1
/product="3',5'-cyclic AMP phosphodiesterase"
/protein_id="AAC13745.1"
/translation="MSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDR
APSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNK
FKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQIS
GVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVI
MHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTP
ALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVG
FKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSS
GVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFPQGDRERERGME
ISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIP
QSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQ
DSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT"
3'UTR 1921..5698
regulatory 3727..3732
/regulatory_class="polyA_signal_sequence"
regulatory 3871..3876
/regulatory_class="polyA_signal_sequence"
regulatory 4155..4160
/regulatory_class="polyA_signal_sequence"
regulatory 4283..4288
/regulatory_class="polyA_signal_sequence"
regulatory 4480..4485
/regulatory_class="polyA_signal_sequence"
regulatory 4485..4490
/regulatory_class="polyA_signal_sequence"
regulatory 4552..4557
/regulatory_class="polyA_signal_sequence"
regulatory 4755..4760
/regulatory_class="polyA_signal_sequence"
BASE COUNT 1764 a 1100 c 1080 g 1762 t
ORIGIN
1 ggaattccat tttccctccc ttttctccaa gcaaattttg tccacagtca acgacgggag
61 tccttcctgt atcgatccga cagcgattat gacctctctc caaagtctat gtcccggaac
121 tcctccattg ccagtgatat acacggagat gacttgattg tgactccatt tgctcaggtc
181 ttggccagtc tgcgaactgt acgaaacaac tttgctgcat taactaattt gcaagatcga
241 gcacctagca aaagatcacc catgtgcaac caaccatcca tcaacaaagc caccataaca
301 gaggaggcct accagaaact ggccagcgag accctggagg agctggactg gtgtctggac
361 cagctagaga ccctacagac caggcactcc gtcagtgaga tggcctccaa caagtttaaa
421 aggatgctta atcgggagct cacccatctc tctgaaatga gtcggtctgg aaatcaagtg
481 tcagagttta tatcaaacac attcttagat aagcaacatg aagtggaaat tccttctcca
541 actcagaagg aaaaggagaa aaagaaaaga ccaatgtctc agatcagtgg agtcaagaaa
601 ttgatgcaca gctctagtct gactaattca agtatcccaa ggtttggagt taaaactgaa
661 caagaagatg tccttgccaa ggaactagaa gatgtgaaca aatggggtct tcatgttttc
721 agaatagcag agttgtctgg taaccggccc ttgactgtta tcatgcacac catttttcag
781 gaacgggatt tattaaaaac atttaaaatt ccagtagata ctttaattac atatcttatg
841 actctcgaag accattacca tgctgatgtg gcctatcaca acaatatcca tgctgcagat
901 gttgtccagt ctactcatgt gctattatct acacctgctt tggaggctgt gtttacagat
961 ttggagattc ttgcagcaat ttttgccagt gcaatacatg atgtagatca tcctggtgtg
1021 tccaatcaat ttctgatcaa tacaaactct gaacttgcct tgatgtacaa tgattcctca
1081 gtcttagaga accatcattt ggctgtgggc tttaaattgc ttcaggaaga aaactgtgac
1141 attttccaga atttgaccaa aaaacaaaga caatctttaa ggaaaatggt cattgacatc
1201 gtacttgcaa cagatatgtc aaaacacatg aatctactgg ctgatttgaa gactatggtt
1261 gaaactaaga aagtgacaag ctctggagtt cttcttcttg ataattattc cgataggatt
1321 caggttcttc agaatatggt gcactgtgca gatctgagca acccaacaaa gcctctccag
1381 ctgtaccgcc agtggacgga ccggataatg gaggagttct tcccccaagg agaccgagag
1441 agggaacgtg gcatggagat aagccccatg tgtgacaagc acaatgcttc cgtggaaaaa
1501 tcacaggtgg gcttcataga ctatattgtt catcccctct gggagacatg ggcagacctc
1561 gtccaccctg acgcccagga tattttggac actttggagg acaatcgtga atggtaccag
1621 agcacaatcc ctcagagccc ctctcctgca cctgatgacc cagaggaggg ccggcagggt
1681 caaactgaga aattccagtt tgaactaact ttagaggaag atggtgagtc agacacggaa
1741 aaggacagtg gcagtcaagt ggaagaagac actagctgca gtgactccaa gactctttgt
1801 actcaagact cagagtctac tgaaattccc cttgatgaac aggttgaaga ggaggcagta
1861 ggggaagaag aggaaagcca gcctgaagcc tgtgtcatag atgatcgttc tcctgacacg
1921 taacagtgca aaaactttca tgcctttttt ttttttaagt agaaaaattg tttccaaagt
1981 gcatgtcaca tgccacaacc acggtcacac ctcactgtca tctgccagga cgtttgttga
2041 acaaaactga ccttgactac tcagtccagc gctcaggaat atcgtaacca gttttttcac
2101 ctccatgtca tccgagcaag gtggacatct tcacgaacag cgtttttaac aaaatttcag
2161 cttggtagag ctgacaaagc agataaaatc tactccaaat tattttcaag agagtgtgac
2221 tcatcaggca gcccaaaagt ttattggact tggggtttct attccttttt atttgtttgc
2281 aatattttca gaagaaaggc attgcacaga gtgaacttaa tggacgaagc aacaaatatg
2341 tcaagaacag gacatagcac gaatctgtta ccagtaggag gaggatgagc cacagaaatt
2401 gcataatttt ctaatttcaa gtcttcctga tacatgactg aatagtgtgg ttcagtgagc
2461 tgcactgacc tctacatttt gtatgatatg taaaacagat tttttgtaga gcttactttt
2521 attattaaat gtattgaggt attatattta aaaaaaacta tgttcagaac ttcatctgcc
2581 actggttatt tttttctaag gagtaacttg caagttttca gtacaaatct gtgctacact
2641 ggataaaaat ctaatttatg aattttactt gcaccttata gttcatagca attaactgat
2701 ttgtagtgat tcattgtttg ttttatatac caatgacttc catattttaa aagagaaaaa
2761 caactttatg ttgcaggaaa ccctttttgt aagtctttat tattcacttt gcattttgtt
2821 tcactctttc cagataagca gagttgctct tcaccagtgt ttttcttcat gtgcaaagtg
2881 actatttgtt ctataatact tttatgtgtg ttatatcaaa tgtgtcttaa gcttcatgca
2941 aactcagtca tcagttcgtg ttgtctgaag caagtgggaa atatataaat acccagtagc
3001 taaaatggtc agtctttttt agatgttttc ctacttagta tctcctaata acgttttgct
3061 gtgtcactag atgttcattt cacaagtgca tgtctttcta ataatccaca catttcatgc
3121 tctaataatc cacacatttc atgctcattt ttattgtttt tacagccagt tatagcaaga
3181 aaaaggtttt tccccttgtg ctgctttata atttagcgtg tgtctgaacc ttatccatgt
3241 ttgctagatg aggtcttgtc aaatatatca ctaccattgt caccggtgaa aagaaacagg
3301 tagttaagtt agggttaaca ttcatttcaa ccacgaggtt gtatatcatg actagctttt
3361 actcttggtt tacagagaaa agttaaacaa ccaactaggc agtttttaag aatattaaca
3421 atatattaac aaacaccaat acaactaatc ctatttggtt ttaatgattt caccatggga
3481 ttaagaacta tatcaggaac atccctgaga aacggcttta agtgtagcaa ctactcttcc
3541 ttaatggaca gccacataac gtgtaggaag tcctttatca cttatcctcg atccataagc
3601 atatcttgca gaggggaact acttctttaa acacatggag ggaaagaaga tgatgccact
3661 ggcaccagag ggttagtact gtgatgcatc ctaaaatatt tattatattg gtaaaaattc
3721 tggttaaata aaaaattaga gatcactctt ggctgatttc agcaccagga actgtattac
3781 agttttagag attaattcct agtgtttacc tgattatagc agttggcatc atggggcatt
3841 taattctgac tttatcccca cgtcagcctt aataaagtct tctttacctt ctctatgaag
3901 actttaaagc ccaaataatc atttttcaca ttgatattca agaattgaga tagatagaag
3961 ccaaagtggg tatctgacaa gtggaaaatc aaacgtttaa gaagaattac aactctgaaa
4021 agcatttata tgtggaactt ctcaaggagc ctcctgggga ctggaaagta agtcatcagc
4081 caggcaaatg actcatgctg aagagagtcc ccatttcagt cccctgagat ctagctgatg
4141 cttagatcct ttgaaataaa aattatgtct ttataactct gatcttttac ataaagcaga
4201 agaggaatca actagttaat tgcaaggttt ctactctgtt tcctctgtaa agatcagatg
4261 gtaatctttc aaataagaaa aaaataaaga cgtatgtttg accaagtagt ttcacaagaa
4321 tatttgggaa cttgtttctt ttaattttat ttgtccctga gtgaagtcta gaaagaaagg
4381 taaagagtct agagtttatt cctctttcca aaacattctc attcctctcc tccctacact
4441 tagtatttcc cccacagagt gcctagaatc ttaataatga ataaaataaa aagcagcaat
4501 atgtcattaa caaatccaga cctgaaaggg taaagggttt ataactgcac taataaagag
4561 aggctctttt tttttcttcc agtttgttgg tttttaatgg taccgtgttg taaagatacc
4621 cactaatgga caatcaaatt gcagaaaagg ctcaatatcc aagagacagg gactaatgca
4681 ctgtacaatc tgcttatcct tgcccttctc tcttgccaaa gtgtgcttca gaaatatata
4741 ctgctttaaa aaagaataaa agaatatcct tttacaagtg gctttacatt tcctaaaatg
4801 ccataagaaa atgcaatatc tgggtactgt atggggaaaa aaatgtccaa gtttgtgtaa
4861 aaccagtgca tttcagcttg caagttactg aacacaataa tgctgtttta attttgtttt
4921 atatcagtta aaattcacaa taatgtagat agaacaaatt acagacaagg aaagaaaaaa
4981 cttgaatgaa atggatttta cagaaagctt tatgataatt tttgaatgca ttatttattt
5041 tttgtgccat gcattttttt tctcaccaaa tgaccttacc tgtaatacag tcttgtttgt
5101 ctgtttacaa ccatgtattt attgcaatgt acatactgta atgttaattg taaattatct
5161 gttcttatta aaacatcatc ccatgatggg gtggtgttga tatatttgga aactcttggt
5221 gagagaatga atggtgtgta tacatactct gtacattttt cttttctcct gtaatatagt
5281 cttgtcacct tagagcttgt ttatggaaga ttcaagaaaa ctataaaata cttaaagata
5341 tataaattta aaaaaacata gctgcaggtc tttggtccca gggctgtgcc ttaactttaa
5401 ccaatatttt cttctgtttt gctgcatttg aaaggtaaca gtggagctag ggctgggcat
5461 tttacatcca ggcttttaat tgattagaat tctgccaata ggtggatttt acaaaaccac
5521 agacaacctc tgaaagattc tgagaccctt ttgagacaga agctcttaag tacttcttgc
5581 cagggagcag cactgcatgt gtgatggttg tttgccatct gttgatcagg aactacttca
5641 gctacttgca tttgattatt tccttttttt ttttttttaa ctcggaaaca caactggggg
5701 aattcc
//